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Katherine A. Cheng
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Journal Articles

Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

Aaron N. Hata, Alan Yeo, Anthony C. Faber, Eugene Lifshits, Zhao Chen, Katherine A. Cheng, Zandra Walton, Kristopher A. Sarosiek, Anthony Letai, Rebecca S. Heist, Mari Mino-Kenudson, Kwok-Kin Wong, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2014) 74 (11): 3146–3156.
https://doi.org/10.1158/0008-5472.CAN-13-3728
Published: 29 May 2014
View article titled, Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
Open the PDF for Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Takeshi Shimamura, Zhao Chen, Margaret Soucheray, Julian Carretero, Eiki Kikuchi, Jeremy H. Tchaicha, Yandhi Gao, Katherine A. Cheng, Travis J. Cohoon, Jun Qi, Esra A. Akbay, Alec C. Kimmelman, Andrew L. Kung, James E. Bradner, Kwok Kin Wong
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1126.
https://doi.org/10.1158/1538-7445.AM2013-1126
Published: 15 April 2013
View article titled, Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.
Journal Articles

Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET

Lu Xu, Eiki Kikuchi, Chunxiao Xu, Hiromichi Ebi, Dalia Ercan, Katherine A. Cheng, Robert Padera, Jeffrey A. Engelman, Pasi A. Jänne, Geoffrey I. Shapiro, Takeshi Shimamura, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3302–3311.
https://doi.org/10.1158/0008-5472.CAN-11-3720
Published: 01 July 2012
View article titled, Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET
Open the PDF for Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET in another window
Includes: Supplementary data
Journal Articles

Abstract 875: Marked in vivo efficacy of combined BCLXL and MEK inhibition in KRAS mutant cancers revealed by a pooled shRNA-drug screen for genes that are “synthetically lethal” with MEK inhibitors

Ryan B. Corcoran, Katherine A. Cheng, Kwok-Kin Wong, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 875.
https://doi.org/10.1158/1538-7445.AM2012-875
Published: 15 April 2012
View article titled, Abstract 875: Marked <em>in vivo</em> efficacy of combined BCLXL and MEK inhibition in KRAS mutant cancers revealed by a pooled shRNA-drug screen for genes that are “synthetically lethal” with MEK inhibitors