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Abstract 4496: Induction of immunogenicity in tumor cells by small molecule drugs that destabilize nucleosomes

Katerina Leonova, Alfiya Safina, Andrei V. Gudkov, Katerina V. Gurova

Cancer Res (2020) 80 (16_Supplement): 4496.

DOI: https://doi.org/10.1158/1538-7445.AM2020-4496

Published: 15 August 2020

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Journal Articles

Abstract 1747: Induction of nucleosome disassembly with small molecules as a novel anti-cancer approach

Alfiya Safina, Poorva Sandlesh, Jianmin Wang, Katerina V. Gurova

Cancer Res (2020) 80 (16_Supplement): 1747.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1747

Published: 15 August 2020

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Journal Articles

Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs

Elimelech Nesher, Alfiya Safina, Ieman Aljahdali, Scott Portwood, Eunice S. Wang, Igor Koman, Jianmin Wang, Katerina V. Gurova

Cancer Res (2018) 78 (6): 1431–1443.

DOI: https://doi.org/10.1158/0008-5472.CAN-17-2690

Published: 14 March 2018

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Includes: Supplementary data

Journal Articles

Abstract 13: Chromatin unfolding small molecules as a novel type of anticancer agents

Katerina V. Gurova

Cancer Res (2017) 77 (13_Supplement): 13.

DOI: https://doi.org/10.1158/1538-7445.AM2017-13

Published: 01 July 2017

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Journal Articles

Abstract 809: A novel woodchuck model of hepatic artery infusion (HAI) with FACT complex targeted drug CBL0137

Minhyung Kim, Leslie I. Curtin, Colin A. Powers, Sandra Sexton, Katerina V. Gurova, Andrei V. Gudkov, Renuka V. Iyer

Cancer Res (2017) 77 (13_Supplement): 809.

DOI: https://doi.org/10.1158/1538-7445.AM2017-809

Published: 01 July 2017

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Journal Articles

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Minhyung Kim, Nickolay Neznanov, Chandler D. Wilfong, Daria I. Fleyshman, Andrei A. Purmal, Gary Haderski, Patricia Stanhope-Baker, Catherine A. Burkhart, Katerina V. Gurova, Andrei V. Gudkov, Joseph J. Skitzki

Cancer Res (2016) 76 (22): 6620–6630.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-2764

Published: 14 November 2016

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Includes: Supplementary data

Journal Articles

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models

Josephine Kam Tai Dermawan, Masahiro Hitomi, Daniel J. Silver, Qiulian Wu, Poorva Sandlesh, Andrew E. Sloan, Andrei A. Purmal, Katerina V. Gurova, Jeremy N. Rich, Justin D. Lathia, George R. Stark, Monica Venere

Cancer Res (2016) 76 (8): 2432–2442.

DOI: https://doi.org/10.1158/0008-5472.CAN-15-2162

Published: 14 April 2016

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Includes: Supplementary data

Journal Articles

Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Daniel R. Carter, Belamy B. Cheung, Tao Liu, Carol Au, Murray D. Norris, Michelle Haber, Jayne Murray, Katerina V. Gurova, Andrei V. Gudkov, Glenn M. Marshall

Cancer Res (2013) 73 (8_Supplement): 5043.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5043

Published: 15 April 2013

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Journal Articles

Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Michelle Haber, Jayne Murray, Ashleigh Carnegie-Clark, Hannah Webber, Glenn M. Marshall, Katerina V. Gurova, Catherine A. Burkhart, Andrei Purmal, Andrei V. Gudkov, Murray D. Norris

Cancer Res (2013) 73 (8_Supplement): 2759.

DOI: https://doi.org/10.1158/1538-7445.AM2013-2759

Published: 15 April 2013

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Journal Articles

Abstract 3843: Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice

Katerina V. Gurova, Henry Garcia, Mairead Commane, Alfiya Safina

Cancer Res (2012) 72 (8_Supplement): 3843.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3843

Published: 15 April 2012

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Journal Articles

Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers

Naoyuki G. Saito, Mairead Commane, Kellee F. Greene, Liliya R. Novototskaya, Andrei A. Purmal, Zhou Wang, Katerina V. Gurova, Andrei V. Gudkov

Cancer Res (2010) 70 (8_Supplement): LB-166.

DOI: https://doi.org/10.1158/1538-7445.AM10-LB-166

Published: 15 April 2010

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Journal Articles

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

Catherine A. Burkhart, Fujiko Watt, Jayne Murray, Marina Pajic, Anatoly Prokvolit, Chengyuan Xue, Claudia Flemming, Janice Smith, Andrei Purmal, Nadezhda Isachenko, Pavel G. Komarov, Katerina V. Gurova, Alan C. Sartorelli, Glenn M. Marshall, Murray D. Norris, Andrei V. Gudkov, Michelle Haber

Cancer Res (2009) 69 (16): 6573–6580.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-1075

Published: 12 August 2009

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Includes: Supplementary data

Journal Articles

p53 Determines Multidrug Sensitivity of Childhood Neuroblastoma

Chengyuan Xue, Michelle Haber, Claudia Flemming, Glenn M. Marshall, Richard B. Lock, Karen L. MacKenzie, Katerina V. Gurova, Murray D. Norris, Andrei V. Gudkov

Cancer Res (2007) 67 (21): 10351–10360.

DOI: https://doi.org/10.1158/0008-5472.CAN-06-4345

Published: 01 November 2007

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Journal Articles

p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant Mechanism

Katerina V. Gurova, Jason E. Hill, Olga V. Razorenova, Peter M. Chumakov, Andrei V. Gudkov

Cancer Res (2004) 64 (6): 1951–1958.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-1541

Published: 16 March 2004

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Journal Articles

Cooperation of Two Mutant p53 Alleles Contributes to Fas Resistance of Prostate Carcinoma Cells

Katerina V. Gurova, Oskar W. Rokhlin, Andrei V. Budanov, Ludmila G. Burdelya, Peter M. Chumakov, Michael B. Cohen, Andrei V. Gudkov

Cancer Res (2003) 63 (11): 2905–2912.

Published: 01 June 2003

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NARROW

Abstract 4496: Induction of immunogenicity in tumor cells by small molecule drugs that destabilize nucleosomes

Abstract 1747: Induction of nucleosome disassembly with small molecules as a novel anti-cancer approach

Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs

Abstract 13: Chromatin unfolding small molecules as a novel type of anticancer agents

Abstract 809: A novel woodchuck model of hepatic artery infusion (HAI) with FACT complex targeted drug CBL0137

Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas

Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models

Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.

Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.

Abstract 3843: Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice

Abstract LB-166: Characterization of a novel class of carbazole based radiation sensitizers

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of Neuroblastoma

p53 Determines Multidrug Sensitivity of Childhood Neuroblastoma

p53 Pathway in Renal Cell Carcinoma Is Repressed by a Dominant Mechanism

Cooperation of Two Mutant p53 Alleles Contributes to Fas Resistance of Prostate Carcinoma Cells

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