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Karuppiah Kannan
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Journal Articles

Abstract 5687: CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors

Tomoko Yamamori Morita, Jie Yu, Yukie Kashima, Kosuke Tanaka, Tatsunori Minamide, Chiaki Mashima, Yumi Hakozaki, Shun-ichiro Kageyama, Akito Nakamura, Eric Lightcap, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5687.
https://doi.org/10.1158/1538-7445.AM2022-5687
Published: 15 June 2022
View article titled, Abstract 5687: CDC7 inhibitor-induced replication stress generates inflamed aneuploid cells to sensitize immune checkpoint inhibitors
Journal Articles

Abstract CT139: Intratumoral (IT) microdosing of the investigational SUMOylation Inhibitor TAK-981 in a phase 0 CIVO trial demonstrates the reactivation of type I Interferon (IFN1) signaling in head and neck squamous cell carcinoma (HNSCC)

Jeffrey Houlton, Harrison Cash, Haodong Xu, Paul L. Swiecicki, Keith Casper, Steven B. Chinn, Daniel R. Clayburgh, Ryan J. Li, Robert J. Christian, Aaron Halfpenny, Annemieke van Zante, Beryl A. Hatton, Kimberly Sottero, Marc O. Grenley, Connor Burns, Jason Frazier, Jonathan Derry, Gloria Kung, Emily Beirne, Nathan J. Schauer, Atticus Turner, Wendy Jenkins, Kirsten Anderson, Richard A. Klinghoffer, Dennis Huszar, Allison Berger, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT139.
https://doi.org/10.1158/1538-7445.AM2022-CT139
Published: 15 June 2022
View article titled, Abstract CT139: Intratumoral (IT) microdosing of the investigational SUMOylation Inhibitor TAK-981 in a phase 0 CIVO trial demonstrates the reactivation of type I Interferon (IFN1) signaling in head and neck squamous cell carcinoma (HNSCC)
Journal Articles

Abstract 3844: TAK-659, a SYK kinase inhibitor, demonstrates preclinical antitumor activity in solid tumor models

Jessica J. Sappal, Matthew Theisen, Zhongmin Xiang, Stephen Tirrell, Rudy Christmas, Jie Yu, Mengkun Zhang, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3844.
https://doi.org/10.1158/1538-7445.AM2018-3844
Published: 01 July 2018
View article titled, Abstract 3844: TAK-659, a SYK kinase inhibitor, demonstrates preclinical antitumor activity in solid tumor models
Journal Articles

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

James W. Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy Kohl, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8949–8957.
https://doi.org/10.1158/0008-5472.CAN-09-1544
Published: 30 November 2009
View article titled, <em>De novo</em> Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel <em>In vivo</em> Breast Tumor Model
Open the PDF for <em>De novo</em> Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel <em>In vivo</em> Breast Tumor Model in another window
Includes: Supplementary data
Journal Articles

Abstract #4979: Identification of a gene signature of epithelial to mesenchymal transition

Julie Kan, Gretchen Argast, Stuart Thomson, John Haley, Richard Nicoletti, James Abraham, Matthew O'Connor, Regina Sennello, G. David Young, Maryland Rosenfeld-Franklin, Karuppiah Kannan, Joerg Heyer, M. Isabel Chiu, David Epstein, Murray Robinson
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4979.
Published: 01 May 2009
View article titled, Abstract #4979: Identification of a gene signature of epithelial to mesenchymal transition
Journal Articles

Abstract #4922: Population based in vivo genetic models of tumor metastasis

Carol Meeske, Joseph Growney, Arnold Sengooba, Sireesha Yalavarthi, Lingxin Kong, Ruojie Wang, Richard Nicoletti, Bin Feng, Murray Robinson, M Chiu, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4922.
Published: 01 May 2009
View article titled, Abstract #4922: Population based <em>in vivo</em> genetic models of tumor metastasis
Journal Articles

Abstract #1348: Fibroblast growth factor receptor-2 cancer models for biomarker discovery and therapeutic response prediction

Omar Kabbarah, Lorena Lerner, Zakir Siddiquee, Guangmu Li, Jianhua Zhao, John Yang, Jodi Zarycki, Zhigang Weng, Sriram Kollipara, Karuppiah Kannan, Sireesha Yalavarthi, Steven Clark, Jeno Gyuris, Murray Robinson, M Chiu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1348.
Published: 01 May 2009
View article titled, Abstract #1348: Fibroblast growth factor receptor-2 cancer models for biomarker discovery and therapeutic response prediction
Journal Articles

Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Ruojie Wang, Lu Li, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3615.
Published: 01 May 2008
View article titled, Predicting rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
Journal Articles

Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer

Karuppiah Kannan, Sireesha Yalavarthi, Jie Lin, Richard Nicoletti, Ruojie Wang, William Rideout, Yinghui Zhou, Joerg Heyer, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1734.
Published: 01 May 2008
View article titled, Human cancer relevant genomic alterations in a population based genetically engineered murine model of human breast cancer
Journal Articles

Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model

Karuppiah Kannan, Jie Lin, Sireesha Yalavarthi, Nan Liu, Ruojie Wang, Angela Bressel, Tong Zi, Yinghui Zhou, Joerg Heyer, Spring Cheng, James Watters, Robert Phillips, Isabel Chiu, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2230.
Published: 01 May 2007
View article titled, Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to rapamycin in a HER2 driven breast model
Journal Articles

Directed complementation of inducible tumor models: an approach to generate broad panels of tumors with defined genetic contexts

Lorena Lerner, Jie Lin, Omar Kabbarah, John Yang, Nan Liu, Fanglei You, Jianhua Zhou, Jodi Zarycki, Ti Cai, Karuppiah Kannan, Sireesha Yalavarthi, Isabel Chiu, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3070.
Published: 01 May 2007
View article titled, Directed complementation of inducible tumor models: an approach to generate broad panels of tumors with defined genetic contexts
Journal Articles

Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis

Isabel Chiu, Lorena Lerner, Ti Cai, Jodi Zarycki, Omar Kabbarah, John Yang, Wei Hu, Sireesha Yalavarthi, Karuppiah Kannan, David Bailey, Kathryn Sun, Dmitri Bichko, Fanglei You, Jianhua Zhao, Sylvie Vincent, Steve Bottega, Ronan O'Hagan, Alisa Bell, Heidi Okamura, Yinghui Zhou, William Rideout, Min Wu, Joerg Heyer, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5686.
Published: 01 May 2007
View article titled, Comprehensive <em>in vivo</em> genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis
Journal Articles

Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma

Rónán C. O’Hagan, Cameron W. Brennan, Andrew Strahs, Xuegong Zhang, Karuppiah Kannan, Melissa Donovan, Craig Cauwels, Norman E. Sharpless, Wing Hung Wong, Lynda Chin
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5352–5356.
Published: 18 September 2003
View article titled, Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma
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