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Karsten Boehnke
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Journal Articles

Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer

Changxin Wan, Matthew P. Keany, Han Dong, Linah F. Al-Alem, Unnati M. Pandya, Suzan Lazo, Karsten Boehnke, Katherine N. Lynch, Rui Xu, Dominique T. Zarrella, Shengqing Gu, Paloma Cejas, Klothilda Lim, Henry W. Long, Kevin M. Elias, Neil S. Horowitz, Colleen M. Feltmate, Michael G. Muto, Michael J. Worley, Jr, Ross S. Berkowitz, Ursula A. Matulonis, Marisa R. Nucci, Christopher P. Crum, Bo R. Rueda, Myles Brown, Xiaole Shirley Liu, Sarah J. Hill
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (1): 158–173.
https://doi.org/10.1158/0008-5472.CAN-20-1674
Published: 04 January 2021
View article titled, Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer
Open the PDF for Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4525: Modulating chemoresistance: Uncovering the role of mutant SMAD4R361H in colorectal cancer using PDO and PDX models

Ulrike Pfohl, Alessandra Silvestri, Dirk Schumacher, Karsten Boehnke, Johannes Haybaeck, Sanam Bashir, Ralf Kühn, Marlen Keil, Reinhold Schäfer, Wolfgang Walther, Christian Regenbrecht
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4525.
https://doi.org/10.1158/1538-7445.AM2019-4525
Published: 01 July 2019
View article titled, Abstract 4525: Modulating chemoresistance: Uncovering the role of mutant SMAD4<sup>R361H</sup> in colorectal cancer using PDO and PDX models
Journal Articles

Abstract 3508: Combination of the Chk1 inhibitor (prexasertib) with a PI3K/mTOR inhibitor (LY3023414) induces synergistic anti-tumor activity in triple negative breast cancer (TNBC) models

Wenjuan Wu, Greg Donoho, Philip Iversen, Jack Dempsey, Andrew Capen, Mark Castanares, Jennifer Stephens, Karsten Boehnke, Christoph Reinhard Reinhard, Aimee Lin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3508.
https://doi.org/10.1158/1538-7445.AM2019-3508
Published: 01 July 2019
View article titled, Abstract 3508: Combination of the Chk1 inhibitor (prexasertib) with a PI3K/mTOR inhibitor (LY3023414) induces synergistic anti-tumor activity in triple negative breast cancer (TNBC) models
Journal Articles

Abstract 1852: Combination of the CDK4/6 inhibitor abemaciclib with xentuzumab, a humanized IGF-1 and IGF-2 ligand co-neutralizing monoclonal antibody, results in synergistic antineoplastic effects in human breast cancer cell lines

Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Susanne Schmittner, Xueqian Gong, Sean Buchanan, Richard P. Beckmann, Carlos Marugan, Raquel Torres, Karsten Boehnke, Maria Jose Lallena, Flavio Solca, Norbert Kraut, Thomas Bogenrieder
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1852.
https://doi.org/10.1158/1538-7445.AM2018-1852
Published: 01 July 2018
View article titled, Abstract 1852: Combination of the CDK4/6 inhibitor abemaciclib with xentuzumab, a humanized IGF-1 and IGF-2 ligand co-neutralizing monoclonal antibody, results in synergistic antineoplastic effects in human breast cancer cell lines
Journal Articles

Abstract LB-318: Characterization of the mechanism of action of abemaciclib in NSCLC cell lines harboring KRAS mutation

Raquel Torres-Guzmán, Carmen Baquero, Carlos Marugan, Cecilia Mur, Severine I. Gharbi, Sandra Gomez, Joaquín Amat, Karsten Boehnke, Philip W. Iversen, Alfonso deDios, Xueqian Gong, Sean Buchanan, Richard P. Beckman, Maria José J. Lallena
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-318.
https://doi.org/10.1158/1538-7445.AM2017-LB-318
Published: 01 July 2017
View article titled, Abstract LB-318: Characterization of the mechanism of action of abemaciclib in NSCLC cell lines harboring KRAS mutation
Journal Articles

Abstract 2412: Reconstructing intratumor heterogeneity: lessons from therapeutic intervention in patient-specific models

Dirk Schumacher, Karsten Boehnke, Marlen Keil, Alessandra Silvestri, Maxine Silvestrov, Jens Hoffman, Iduna Fichtner, Reinhold Schaefer, Christian RA Regenbrecht
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2412.
https://doi.org/10.1158/1538-7445.AM2016-2412
Published: 15 July 2016
View article titled, Abstract 2412: Reconstructing intratumor heterogeneity: lessons from therapeutic intervention in patient-specific models
Journal Articles

Abstract 2836: Characterization of the mechanism of action for abemaciclib with antiestrogen combined therapy in human breast cancer cell lines

Raquel Torres, Bruna Calsina, Ana Hermoso, Carmen Baquero, Cecilia Mur, Karsten Boehnke, Joaquín Amat, Alfonso De Dios, Xueqian Gong, Sean Buchanan, Richard Paul Beckmann, Maria Jose Lallena
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2836.
https://doi.org/10.1158/1538-7445.AM2016-2836
Published: 15 July 2016
View article titled, Abstract 2836: Characterization of the mechanism of action for abemaciclib with antiestrogen combined therapy in human breast cancer cell lines
Journal Articles

Abstract 2818: An unbiased tumor cell panel profiling method to identify drug-drug interactions reveals synergy between the CDK4 and CDK 6 inhibitor abemaciclib and the Raf dimer and pan-Raf inhibitor LY3009120 in Ras mutant cancers

Xueqian Gong, Wenjuan Wu, Li-Chun Chio, Susan Pratt, Constance King, Yue Webster, Maria Jose Lallena, Karsten Boehnke, Raquel Torres, Philip Iversen, Christoph Reinhard, Shih-Hsun Chen, Richard Bechmann, Sheng-Bin Peng, Sean Buchanan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2818.
https://doi.org/10.1158/1538-7445.AM2016-2818
Published: 15 July 2016
View article titled, Abstract 2818: An unbiased tumor cell panel profiling method to identify drug-drug interactions reveals synergy between the CDK4 and CDK 6 inhibitor abemaciclib and the Raf dimer and pan-Raf inhibitor LY3009120 in Ras mutant cancers
Journal Articles

Abstract 2829: Preclinical analysis and characterization of abemaciclib using three-dimensional patient-derived colorectal cancer organoid cultures

Karsten Boehnke, Bruna Calsina, Joaquín Amat, Ana Hermoso, Raquel Torres, Christoph Reinhard, Juan A. Velasco, Philip W. Iversen, Alfonso De Dios, Sean Buchanan, Richard P. Beckmann, Dirk Schumacher, Christian RA Regenbrecht, Marie-Laure Yaspo, Hans Lehrach, María José Lallena
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2829.
https://doi.org/10.1158/1538-7445.AM2016-2829
Published: 15 July 2016
View article titled, Abstract 2829: Preclinical analysis and characterization of abemaciclib using three-dimensional patient-derived colorectal cancer organoid cultures
Journal Articles

Abstract 977: 3D-models of patient-derived colon tumors for the identification of genetic factors important in the regulation of cancer stem cells

Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Karsten Boehnke, Ulrich Keilholz, Johannes Haybaeck, Hans Lehrach, David Henderson, Reinhold Schaefer, Christian R. Regenbrecht, Dominik Mumberg, Martin Lange
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 977.
https://doi.org/10.1158/1538-7445.AM2015-977
Published: 01 August 2015
View article titled, Abstract 977: 3D-models of patient-derived colon tumors for the identification of genetic factors important in the regulation of cancer stem cells
Journal Articles

Abstract 3101: In-vitro characterization of Abemaciclib pharmacology in ER+ breast cancer cell lines

Maria Jose Lallena, Karsten Boehnke, Raquel Torres, Ana Hermoso, Joaquin Amat, Bruna Calsina, Alfonso De Dios, Sean Buchanan, Jian Du, Richard Paul Beckmann, Xueqian Gong, Ann Mcnulty
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3101.
https://doi.org/10.1158/1538-7445.AM2015-3101
Published: 01 August 2015
View article titled, Abstract 3101: In-vitro characterization of Abemaciclib pharmacology in ER+ breast cancer cell lines
Journal Articles

Abstract 2978: Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* project

Maria Rivera, Marlen Keil, Karsten Boehnke, Martin Lange, Dirk Schumacher, Reinhold Schäfer, Christian R. Regenbrecht, David Henderson, Ulrich Keilholz, Alexander Kuehn, Amin El-Heliebi, Tabea Hohensee, Johannes Haybäck, Christoph Reinhard, Juan A. Velasco, Hans Lehrach, Pilar Garin-Chesa, Garry Beran, Jens Hoffmann
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2978.
https://doi.org/10.1158/1538-7445.AM2014-2978
Published: 01 October 2014
View article titled, Abstract 2978: Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* project
Journal Articles

Abstract 2018: A pipeline within the OncoTrack project for generating Patient-tumor-derived 3D cell cultures (PT3DC) and their application for individualized, targeted drug sensitivity assays

Dirk Schumacher, Karsten Boehnke, Martin Lange, Yvonne Welte, Cathrin Davies, Maria Rivera, Marlen Keil, Ulrich Keilholz, Johannes Haybaeck, Juan Angel Velasco, Marie-Laure Yaspo, Hans Lehrach, David Henderson, Christoph Reinhard, Jens Hoffmann, Reinhold Schaefer, Christian Regenbrecht
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2018.
https://doi.org/10.1158/1538-7445.AM2014-2018
Published: 01 October 2014
View article titled, Abstract 2018: A pipeline within the OncoTrack project for generating Patient-tumor-derived 3D cell cultures (PT3DC) and their application for individualized, targeted drug sensitivity assays
Journal Articles

Abstract 3875: Functional and molecular characterization of colon cancer stem cells in tumor heterogeneity and disease relapse using a 3D-model of patient-derived tumors

Joseph L. Regan, Dirk Schumacher, Karsten Boehnke, Cathrin Davies, Ulrich Keilholz, Johannes Haybaeck, Christoph Reinhard, Hans Lehrach, David Henderson, Reinhold Schaefer, Christian Regenbrecht, Martin Lange
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3875.
https://doi.org/10.1158/1538-7445.AM2014-3875
Published: 01 October 2014
View article titled, Abstract 3875: Functional and molecular characterization of colon cancer stem cells in tumor heterogeneity and disease relapse using a 3D-model of patient-derived tumors