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Karmele Valencia
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Journal Articles

Abstract 5159: From subcutaneous to orthotopic: Bridging the gap to human disease in lung cancer research

Free
Daniel Orive, Beñat Picabea, Maeva Houry, Ane Álava, Covadonga Rodriguez-Suarez, Alfonso Calvo, Luis M. Montuenga, Karmele Valencia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5159.
https://doi.org/10.1158/1538-7445.AM2025-5159
Published: 21 April 2025
View articletitled, Abstract 5159: From subcutaneous to orthotopic: Bridging the gap to human disease in lung cancer research
Journal Articles

Abstract 5688: DSTYK dependent regulation of autophagy protects against TNF alpha induced apoptosis in lung cancer

Free
Andrea Pasquier, Cristina Viu-Idocin, Andrea Arricibita, Mirari Echepare, Beñat Picabea, Ane Álava, Joaquín Fernández-Irigoyen, Enrique Santamaría, Eva Molina, Antonio Pineda-Lucena, Luis Montuenga, Karmele Valencia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5688.
https://doi.org/10.1158/1538-7445.AM2025-5688
Published: 21 April 2025
View articletitled, Abstract 5688: DSTYK dependent regulation of autophagy protects against TNF alpha induced apoptosis in lung cancer
Journal Articles

PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells

Available to Purchase
Francisco Exposito, Miriam Redrado, Maeva Houry, Katherine Hastings, Magdalena Molero-Abraham, Teresa Lozano, Jose Luis Solorzano, Julian Sanz-Ortega, Vera Adradas, Ramon Amat, Esther Redin, Sergio Leon, Naroa Legarra, Javier Garcia, Diego Serrano, Karmele Valencia, Camila Robles-Oteiza, Giorgia Foggetti, Nerea Otegui, Enriqueta Felip, Juan J. Lasarte, Luis Paz-Ares, Jon Zugazagoitia, Katerina Politi, Luis Montuenga, Alfonso Calvo
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2513–2526.
https://doi.org/10.1158/0008-5472.CAN-22-3023
Published: 01 August 2023
View articletitled, PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Open the PDF for PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1124: PTEN loss confers resistance to anti-PD-1 therapy in NSCLC by increasing tumor infiltration of T regulatory cells

Free
Francisco Exposito, Miriam Redrado, Maeva Houry, Katherine Hastings, Magdalena Molero-Abraham, Teresa Lozano, Jose L. Solorzano, Julian Sanz Ortega, Vera Andradas, Ramon Amat, Esther Redin, Sergio Leon, Naroa Legarra, Javier García, Diego Serrano, Karmele Valencia, Camila Robles-Oteiza, Giorgia Foggetti, Enriqueta Felip, Juan J. Lasarte, Luis Paz-Ares, Jon Zugazagoitia, Katerina Politi, Luis M Montuenga, Alfonso Calvo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1124.
https://doi.org/10.1158/1538-7445.AM2023-1124
Published: 04 April 2023
View articletitled, Abstract 1124: PTEN loss confers resistance to anti-PD-1 therapy in NSCLC by increasing tumor infiltration of T regulatory cells
Journal Articles

Abstract 5117: Combined treatment with the epigenetic drug CM272 and an anti-BCL-XL proapoptotic drug sensitizes solid tumors to immune checkpoint blockade

Free
Yaiza Senent, Vicente Fresquet, Victoria Jimenez, Karmele Valencia, Ana Remirez, Francisco Exposito, Marisol Gonzalez-Huarriz, Borja Ruiz-Fernandez de Cordoba, Haritz Moreno, Daniel Ajona, Marta M Alonso, Fernando Lecanda, Antonio Pineda-Lucena, Felipe Prosper, Alfonso Calvo, Jose Angel Martinez-Climent, Ruben Pio
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5117.
https://doi.org/10.1158/1538-7445.AM2023-5117
Published: 04 April 2023
View articletitled, Abstract 5117: Combined treatment with the epigenetic drug CM272 and an anti-BCL-XL proapoptotic drug sensitizes solid tumors to immune checkpoint blockade
Journal Articles

Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy

Available to Purchase
Alvaro Teijeira, Saray Garasa, Carlos Luri-Rey, Carlos de Andrea, Maria Gato, Carmen Molina, Tsuneyasu Kaisho, Assunta Cirella, Arantza Azpilikueta, Steffanie K. Wculek, Josune Egea, Irene Olivera, Inmaculada Rodriguez, Ana Rouzaut, Vladislav Verkhusha, Karmele Valencia, David Sancho, Pedro Berraondo, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4373–4385.
https://doi.org/10.1158/0008-5472.CAN-22-1046
Published: 02 December 2022
View articletitled, Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy
Open the PDF for Depletion of Conventional Type-1 Dendritic Cells in Established Tumors Suppresses Immunotherapy Efficacy in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 3989: DSTYK inhibition sensitizes lung cancer cells to immunotherapy by collapsing cytoprotective autophagy and destroying mitochondrial wellness

Free
Karmele Valencia, Mirari Echepare, Andrea Pasquier, Alvaro Teijeira, Cristina Bertolo, Cristina Sainz, Graziella Bosco, Roman K. Thomas, Jackeline Agorreta, Jose Maria Lopez-Picazo, Joan Frigola, Ramon Amat, Alfonso Calvo, Enriqueta Felip, Luis M. Montuenga
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3989.
https://doi.org/10.1158/1538-7445.AM2022-3989
Published: 15 June 2022
View articletitled, Abstract 3989: DSTYK inhibition sensitizes lung cancer cells to immunotherapy by collapsing cytoprotective autophagy and destroying mitochondrial wellness
Journal Articles

Abstract 2028: Spatially resolved proteomic profiling identifies tumor cell CD44 as a novel indicative biomarker of sensitivity to PD-1 axis blockade in advanced non-small cell lung cancer (NSCLC)

Free
Myrto Moutafi, Magdalena Molero, Sandra Martinez-Morilla, Javier Baena, Ioannis Vathiotis, Niki Gavrielatou, Laura Castro, Gorka Ruiz de Garibay, Vera Adradas, Daniel Orive, Karmele Valencia, Alfonso Galvo, Luis M. Montuenga, Santiago Ponce, Kurt Schalper, Luis Paz-Ares, David L. Rimm, Jon Zugazagoitia
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2028.
https://doi.org/10.1158/1538-7445.AM2022-2028
Published: 15 June 2022
View articletitled, Abstract 2028: Spatially resolved proteomic profiling identifies tumor cell CD44 as a novel indicative biomarker of sensitivity to PD-1 axis blockade in advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 839: YES1 is a novel druggable oncogene in small cell lung cancer

Free
Esther Redin, Eva M. Garrido-Martin, Karmele Valencia, Miriam Redrado, Jose Luis Solorzano, Rafael Carias, Franscisco Exposito, Diego Serrano, Nerea Otegui, Luis Paz Ares, Katerina Politi, Luis M. Montuenga, Alfonso Calvo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 839.
https://doi.org/10.1158/1538-7445.AM2022-839
Published: 15 June 2022
View articletitled, Abstract 839: YES1 is a novel druggable oncogene in small cell lung cancer
Journal Articles

Abstract PO-089: Identification of a LAMC2-regulated network featuring targetable effectors for dual therapies in pancreatic cancer

Free
Shruthi Narayanan, Oihane Erice, Iker Feliu, Caterina Vicentini, Rodrigo Entrialgo-Cadierno, Karmele Valencia, Elisabet Guruceaga, Purvesh Khatri, Vicenzo Corbo, Silvestre Vicent Cambra, Mariano Ponz-Sarvise
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-089.
https://doi.org/10.1158/1538-7445.PANCA21-PO-089
Published: 15 November 2021
View articletitled, Abstract PO-089: Identification of a LAMC2-regulated network featuring targetable effectors for dual therapies in pancreatic cancer
Journal Articles

Abstract 6041: LAMC2 as a therapeutic target in pancreatic ductal adenocarcinoma

Free
Oihane Erice, Ester Blanco, Karmele Valencia, Elizabeth Guruceaga, Haritz Moreno, Fernando Lecanda, Vincenzo Corbo, Daniel Ölund, Mariano Ponz-Sarvise, Vicent Silve
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6041.
https://doi.org/10.1158/1538-7445.AM2020-6041
Published: 15 August 2020
View articletitled, Abstract 6041: LAMC2 as a therapeutic target in pancreatic ductal adenocarcinoma