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Karine Smans
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Journal Articles

Abstract 2023: Complex in vitro and in vivo prostate cancer models for the PREDECT consortium

Free
Suzana Vidic, Norbert Esser, Ronald de Hoogt, Ingrid Verberne, Ira Kogan-Sakin, Yan Stein, Varda Rotter, Michael Barbier, Yolanda Chong, Sabine D. Breucker, Karine Smans, Malin Akerfelt, Matthias Nees, Peter King, Ian Hickson, Wytske van Weerden, Ralph Graeser
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2023.
https://doi.org/10.1158/1538-7445.AM2014-2023
Published: 01 October 2014
View articletitled, Abstract 2023: Complex in vitro and in vivo prostate cancer models for the PREDECT consortium
Journal Articles

Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors

Free
Peter J. Connolly, Gilles Bignan, James Bischoff, Sabine De Breucker, Norbert Esser, Erwin Fraiponts, Ron Gilissen, Bruce Grasberger, Boudewijn Janssens, Tianbao Lu, Donald Ludovici, Lieven Meerpoel, Christophe Meyer, Michael Parker, Danielle Peeters, Carsten Schubert, Karine Smans, Luc Van Nuffel, Peter Vermeulen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2535.
https://doi.org/10.1158/1538-7445.AM2014-2535
Published: 01 October 2014
View articletitled, Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors
Journal Articles

Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

Free
Tianbao Lu, Richard Alexander, Gilles Bignan, James Bischoff, Peter Connolly, Max Cummings, Sabine De Breucker, Norbert Esser, Erwin Fraiponts, Ron Gilissen, Bruce Grasberger, Boudewijn Janssens, Donald Ludovici, Lieven Meerpoel, Christophe Meyer, Michael Parker, Danielle Peeters, Carsten Schubert, Karine Smans, Luc Van Nuffel, Peter Vermeulen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4747.
https://doi.org/10.1158/1538-7445.AM2014-4747
Published: 01 October 2014
View articletitled, Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer
Journal Articles

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

Free
Nousheen Zaidi, Johannes V. Swinnen, Karine Smans
Journal: Cancer Research
Cancer Res (2012) 72 (15): 3709–3714.
https://doi.org/10.1158/0008-5472.CAN-11-4112
Published: 31 July 2012
View articletitled, ATP-Citrate Lyase: A Key Player in Cancer Metabolism
Open the PDF for ATP-Citrate Lyase: A Key Player in Cancer Metabolism in another window
Journal Articles

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

Free
Evelien Rysman, Koen Brusselmans, Katryn Scheys, Leen Timmermans, Rita Derua, Sebastian Munck, Paul P. Van Veldhoven, David Waltregny, Veerle W. Daniëls, Jelle Machiels, Frank Vanderhoydonc, Karine Smans, Etienne Waelkens, Guido Verhoeven, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2010) 70 (20): 8117–8126.
https://doi.org/10.1158/0008-5472.CAN-09-3871
Published: 13 October 2010
View articletitled, De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Open the PDF for De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation in another window
Includes: Supplementary data
Journal Articles

Abstract #3301: Phenotypic kinase inhibitor screening: A systems biology approach to drug discovery.

Free
Karine Smans, Sabine De Breucker, Berthold Wroblowski, Miroslav Cik, Inez Van De Weyer, Ian Hickson, Eddy Freyne, Janine Arts, Martin Page
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3301.
Published: 01 May 2009
View articletitled, Abstract #3301: Phenotypic kinase inhibitor screening: A systems biology approach to drug discovery.
Journal Articles

Abstract #1924: Preclinical and clinical pharmacodynamic activity of JNJ-26854165: A novel hdm2 antagonist in clinical development

Free
Janine Arts, Karine Smans, Luc Andries, Wim Floren, Peter King, Luc van Nuffel, Ilse Goris, Hinrich Goehlmann, Brendan Rooney, Peter Palmer, Lut de Bie, Kees Bol, Silvija Kraljevic, Sen Hong Zhuang, Martin Page, Josep Tabernero, José Baselga, Luc Dirix, Patrick Schöffski, Hans Winkler
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1924.
Published: 01 May 2009
View articletitled, Abstract #1924: Preclinical and clinical pharmacodynamic activity of JNJ-26854165: A novel hdm2 antagonist in clinical development
Journal Articles

JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies

Free
Janine Arts, Martin Page, Annemie Valckx, Christine Blattner, Roman Kulikov, Wim Floren, Luc van Nuffel, Lut Janssen, Peter King, Stefan Masure, Karine Smans, Peter Verhasselt, Hinrich Goehlmann, Yannick Ligny, Delphine Lardeau, Imre Csoka, Luc Andries, Dirk Brehmer, Eddy Freyne, Eugen Leo, Michel Janicot, Christophe Meyer, Jean Lacrampe, Bruno Schoentjes
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1592.
Published: 01 May 2008
View articletitled, JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies