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Kari Alitalo
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Journal Articles

Lymphatic Vessels in Tumor Dissemination versus Immunotherapy

Kari Vaahtomeri, Kari Alitalo
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3463–3465.
https://doi.org/10.1158/0008-5472.CAN-20-0156
Published: 02 September 2020
View article titled, Lymphatic Vessels in Tumor Dissemination versus Immunotherapy
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Journal Articles

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Yanyu Zhang, Jessica Cedervall, Anahita Hamidi, Melanie Herre, Kati Viitaniemi, Gabriela D'Amico, Zuoxiu Miao, Ragaseema Valsala Madhavan Unnithan, Alessandra Vaccaro, Luuk van Hooren, Maria Georganaki, Åsa Thulin, Qi Qiao, Johanna Andrae, Agneta Siegbahn, Carl-Henrik Heldin, Kari Alitalo, Christer Betsholtz, Anna Dimberg, Anna-Karin Olsson
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3345–3358.
https://doi.org/10.1158/0008-5472.CAN-19-3533
Published: 14 August 2020
View article titled, Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
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Includes: Supplementary data
Journal Articles

Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation

Pauliina Kallio, Elina Jokinen, Jenny Högström, Suvendu Das, Sarika Heino, Marianne Lähde, Jefim Brodkin, Emilia A. Korhonen, Kari Alitalo
Journal: Cancer Research
Cancer Res (2020) 80 (12): 2639–2650.
https://doi.org/10.1158/0008-5472.CAN-20-0497
Published: 15 June 2020
View article titled, Blocking Angiopoietin-2 Promotes Vascular Damage and Growth Inhibition in Mouse Tumors Treated with Small Doses of Radiation
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Includes: Supplementary data
Journal Articles

Abstract LB-094: Systemic RSPO1 delivery leads to regression of intestinal adenomas via activation of the TGFβ/SMAD pathway

Marianne Lähde, Sarika Heino, Jenny Högström, Veli-Matti Leppänen, Seppo Kaijalainen, Olli Ritvos, Owen Sansom, Kari Alitalo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-094.
https://doi.org/10.1158/1538-7445.AM2019-LB-094
Published: 01 July 2019
View article titled, Abstract LB-094: Systemic RSPO1 delivery leads to regression of intestinal adenomas via activation of the TGFβ/SMAD pathway
Journal Articles

Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem–like Cells

Jenny Högström, Sarika Heino, Pauliina Kallio, Marianne Lähde, Veli-Matti Leppänen, Diego Balboa, Zoltán Wiener, Kari Alitalo
Journal: Cancer Research
Cancer Res (2018) 78 (20): 5820–5832.
https://doi.org/10.1158/0008-5472.CAN-18-0451
Published: 15 October 2018
View article titled, Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem–like Cells
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Includes: Supplementary data
Journal Articles

Abstract 1143: Prox1 and Notch mark distinct colorectal cancer stem cell populations

Jenny Högström, Sarika Heino, Pauliina Kallio, Marianne Lähde, Veli-Matti Leppänen, Seppo Kaijalainen, Diego Balboa, Timo Otonkoski, Sylvie Robine, Zoltan Wiener, Kari Alitalo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1143.
https://doi.org/10.1158/1538-7445.AM2018-1143
Published: 01 July 2018
View article titled, Abstract 1143: Prox1 and Notch mark distinct colorectal cancer stem cell populations
Journal Articles

Abstract 861: Angiopoietin-2 blocking antibodies improve tumor growth inhibition and survival in mice treated with low doses of radiation

Pauliina Kallio, Elina Jokinen, Suvendu Das, Jenny Högström, Sarika Heino, Marianne Lähde, Kari Alitalo
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 861.
https://doi.org/10.1158/1538-7445.AM2018-861
Published: 01 July 2018
View article titled, Abstract 861: Angiopoietin-2 blocking antibodies improve tumor growth inhibition and survival in mice treated with low doses of radiation
Journal Articles

Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas

Zoltan Wiener, Jenny Högström, Ville Hyvönen, Pauliina Kallio, Sarika Heino, Kari Alitalo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2320.
https://doi.org/10.1158/1538-7445.AM2015-2320
Published: 01 August 2015
View article titled, Abstract 2320: Prox1 marks a stem cell population that promotes tumor progression in intestinal adenomas
Journal Articles

MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

Olga Tatti, Erika Gucciardo, Pirita Pekkonen, Tanja Holopainen, Riku Louhimo, Pauliina Repo, Pilvi Maliniemi, Jouko Lohi, Ville Rantanen, Sampsa Hautaniemi, Kari Alitalo, Annamari Ranki, Päivi M. Ojala, Jorma Keski-Oja, Kaisa Lehti
Journal: Cancer Research
Cancer Res (2015) 75 (10): 2083–2094.
https://doi.org/10.1158/0008-5472.CAN-14-1923
Published: 13 May 2015
View article titled, MMP16 Mediates a Proteolytic Switch to Promote Cell–Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
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Includes: Supplementary data
Journal Articles

Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth

Zoltan Wiener, Ville Hyvönen, Jenny Högström, Tanja Holopainen, Arja Band, Pauliina Kallio, Olli Dufva, Caj Haglund, Olli Kruuna, Guillermo Oliver, Yinon Ben-Neriah, Kari Alitalo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1908.
https://doi.org/10.1158/1538-7445.AM2014-1908
Published: 01 October 2014
View article titled, Abstract 1908: The Wnt-target Prox1 promotes colorectal cancer stem cell survival to fuel tumor growth
Journal Articles

Deletion of the Endothelial Bmx Tyrosine Kinase Decreases Tumor Angiogenesis and Growth

Tanja Holopainen, Vanessa López- Alpuche, Wei Zheng, Ritva Heljasvaara, Dennis Jones, Yun He, Denis Tvorogov, Gabriela D'Amico, Zoltan Wiener, Leif C. Andersson, Taina Pihlajaniemi, Wang Min, Kari Alitalo
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3512–3521.
https://doi.org/10.1158/0008-5472.CAN-11-1070
Published: 15 July 2012
View article titled, Deletion of the Endothelial Bmx Tyrosine Kinase Decreases Tumor Angiogenesis and Growth
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Includes: Supplementary data
Journal Articles

Abstract 2976: KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition

Pirita Pekkonen, Fang Cheng, Nami Sugiyama, Stephen Henderson, Ville Rantanen, Mervi Aavikko, Sampsa Hautaniemi, Lauri Aaltonen, Chris Boshoff, Kari Alitalo, Kaisa Lehti, Päivi M. Ojala
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2976.
https://doi.org/10.1158/1538-7445.AM2012-2976
Published: 15 April 2012
View article titled, Abstract 2976: KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition
Journal Articles

Abstract 3634: Selective targeting of tumor-associated angiogenic tip and stalk cells with immunoliposomes (ILs) directed against VEGFR-2 and VEGFR-3 expressing cells

Andreas Wicki, Christoph Rochlitz, Annette Orleth, Reto Ritschard, Kari Alitalo, Richard Herrmann, Gerhard Christofori, Christoph Mamot
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3634.
https://doi.org/10.1158/1538-7445.AM2011-3634
Published: 15 April 2011
View article titled, Abstract 3634: Selective targeting of tumor-associated angiogenic tip and stalk cells with immunoliposomes (ILs) directed against VEGFR-2 and VEGFR-3 expressing cells
Journal Articles

Abstract 4836: In vitro drug sensitivity testing along with full genome and transcriptome sequencing and phosphoproteomics: Comprehensive “next-generation” molecular oncology portrait of a sarcoma for facilitating treatment decisions

For the Individualized Medicine Collaboration, Caroline Heckman, Kari Alitalo, Leif Andersson, Peter Campbell, Henrik Edgren, Andy Futreal, Tanja Holopainen, Paul Huang, Heikki Joensuu, Olli Kallioniemi, Sara Kangaspeska, Sami Kilpinen, Jami Mandelin, Outi Monni, Astrid Murumägi, Daniel Nicorici, Arto Orpana, Merja Perälä, Maarit Sarlomo-Rikala, Mike Stratton, Forest White
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4836.
https://doi.org/10.1158/1538-7445.AM2011-4836
Published: 15 April 2011
View article titled, Abstract 4836: In vitro drug sensitivity testing along with full genome and transcriptome sequencing and phosphoproteomics: Comprehensive “next-generation” molecular oncology portrait of a sarcoma for facilitating treatment decisions
Journal Articles

Abstract LB-422: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis

Tuomas Tammela, Anne Saaristo, Tanja Holopainen, Seppo Ylä-Herttuala, Leif C. Andersson, Susanna Virolainen, Ilkka Immonen, Kari Alitalo
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-422.
https://doi.org/10.1158/1538-7445.AM2011-LB-422
Published: 15 April 2011
View article titled, Abstract LB-422: Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis
Journal Articles

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

Minah Kim, Young Jun Koh, Kyung Eun Kim, Bong Ihn Koh, Do-Hyun Nam, Kari Alitalo, Injune Kim, Gou Young Koh
Journal: Cancer Research
Cancer Res (2010) 70 (24): 10411–10421.
https://doi.org/10.1158/0008-5472.CAN-10-2591
Published: 14 December 2010
View article titled, CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche
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Includes: Supplementary data
Journal Articles

Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation

Nami Sugiyama, Markku Varjosalo, Pipsa Meller, Jouko Lohi, Marko Hyytiäinen, Sami Kilpinen, Olli Kallioniemi, Signe Ingvarsen, Lars H. Engelholm, Jussi Taipale, Kari Alitalo, Jorma Keski-Oja, Kaisa Lehti
Journal: Cancer Research
Cancer Res (2010) 70 (20): 7851–7861.
https://doi.org/10.1158/0008-5472.CAN-10-1223
Published: 13 October 2010
View article titled, Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
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Includes: Supplementary data
Journal Articles

Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment

Tanja Holopainen, Huilian Huang, Caiping Chen, Kyung Eun Kim, Luqing Zhang, Fei Zhou, Wencan Han, Chaojun Li, Jun Yu, Jun Wu, Gou Young Koh, Kari Alitalo, Yulong He
Journal: Cancer Research
Cancer Res (2009) 69 (11): 4656–4664.
https://doi.org/10.1158/0008-5472.CAN-08-4654
Published: 01 June 2009
View article titled, Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
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Includes: Supplementary data
Journal Articles

Abstract #SY05-1: Growth factor cues for angiogenic sprouting and vascular network formation

Kari Alitalo
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): SY05-1.
Published: 01 May 2009
View article titled, Abstract #SY05-1: Growth factor cues for angiogenic sprouting and vascular network formation
Journal Articles

Abstract #4019: Angiopoietin-1 modulates capillary endothelium to facilitate tumor cell dissemination and establishment

Tanja Holopainen, Huilian Huang, Caiping Chen, Kyung Kim, Luqing Zhang, Fei Zhou, Wencai Han, Chaojun Li, Jun Yu, Jun Wu, Goh Koh, Kari Alitalo, Yulong He
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4019.
Published: 01 May 2009
View article titled, Abstract #4019: Angiopoietin-1 modulates capillary endothelium to facilitate tumor cell dissemination and establishment