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Karen Rex
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Journal Articles

Abstract 2150: LKB1 loss rewires JNK-induced apoptotic protein dynamics through NUAKs and sensitizes KRAS-mutant non-small cell lung cancers to combined KRAS G12C + MCL-1 blockade

Chendi Li, Mohammed Usman Syed, Yi Shen, Audris Oh, Cameron Fraser, Johannes Kreuzer, Christopher Nabel, Kaitlyn Webster, Robert Morris, Sean Caenepeel, Anne Y. Saiki, Karen Rex, J. Russell Lipford, Wilhelm Hass, Kristopher Sarosiek, Paul E. Hughes, Aaron Hata
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2150.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2150
Published: 15 June 2022
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Journal Articles

Abstract 1050: Efficacy of AMG 176 in combination with gilteritinib in preclinical models of acute myeloid leukemia

Xiaoyue Chen, Sean Caenepeel, Brian Belmontes, Patricia L. McElroy, Karen Rex, Tao Osgood, Paul Hughes
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1050.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1050
Published: 01 July 2021
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Journal Articles

Abstract 982: LKB1 loss rewires stress signaling-induced apoptotic protein dynamics and sensitizes KRAS-mutant non-small cell lung cancers to combined MAPK + MCL-1 blockade

Chendi Li, Yi Shen, Mohammed Usman Syed, Audris Oh, Cameron Fraser, Johannes Kreuzer, Kaitlyn Webster, Robert Morris, Sean Caenepeel, Anne Y. Saiki, Karen Rex, James Lipford, Wilhelm Hass, Kristopher Sarosiek, Paul E. Hughes, Aaron N. Hata
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 982.
DOI: https://doi.org/10.1158/1538-7445.AM2021-982
Published: 01 July 2021
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Journal Articles

Abstract 1285: In vitro characterization of sotorasib and other RAS ‘His95-groove' binders and investigation of resistance mechanisms

Anne Y. Saiki, Deanna Mohn, Yu Li, Tao Osgood, Karen Rex, Hui-Ling Wang, Ivonne Archibeque, Christopher Mohr, Pragathi Achanta, Andres Plata Stapper, Aaron S. Rapaport, Jude Canon, Victor J. Cee, Brian A. Lanman, J. Russell Lipford
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1285.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1285
Published: 01 July 2021
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Journal Articles

Abstract 1057: Combination of the KRASG12C inhibitor sotorasib with targeted agents improves anti-tumor efficacy in KRAS p.G12C cancer models

Karen Rex, Anne Y. Saiki, Tyler Holt, Alla Verlinsky, Patricia L. McElroy, Tao Osgood, Ji-Rong Sun, Marwan G. Fakih, Upendra P. Dahal, Bernd Bruenner, Victor J. Cee, Brian A. Lanman, Jude Canon, J. Russell Lipford
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1057.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1057
Published: 01 July 2021
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Journal Articles

Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models

Karen Rex, Anne Y. Saiki, Ji-Rong Sun, Tyler Holt, Neelima Koppada, Brian A. Lanman, Laurie P. Volak, Robert S. Foti, Victor J. Cee, J. Russell Lipford, Jude Canon
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3090.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3090
Published: 01 July 2019
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Journal Articles

Abstract 4484: Discovery and in vitro characterization of AMG 510–a potent and selective covalent small-molecule inhibitor of KRASG12C

Anne Y. Saiki, Kevin Gaida, Karen Rex, Pragathi Achanta, Tisha San Miguel, Neelima Koppada, Dhanashri Bagal, Brian A. Lanman, Robert S. Foti, John D. McCarter, Laurie P. Volak, Jude Canon, Victor J. Cee, J. Russell Lipford
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4484.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4484
Published: 01 July 2019
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Journal Articles

Abstract 4455: Discovery of AMG 510, a first-in-human covalent inhibitor of KRASG12C for the treatment of solid tumors

Brian A. Lanman, Jian Jeffrey Chen, Longbin Liu, Patricia Lopez, Alexander J. Pickrell, Anthony B. Reed, Hui-Ling Wang, Pragathi Achanta, Jude Canon, Daniel A. Erlanson, Raymond V. Fucini, Joon Won Jeong, Christopher Mohr, Anne Y. Saiki, Victor J. Cee, J. Russell Lipford, Karen Rex, Laurie P. Volak
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4455.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4455
Published: 01 July 2019
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Journal Articles

Abstract 2077: Selective MET kinase inhibition in MET-dependent glioma models

Corina van den Heuvel, Anna Navis, Houshang Amiri, Kiek Verrijp, Arend Heerschap, Karen Rex, Isabelle Dussault, Sean Caenepeel, Angela Coxon, Pieter Wesseling, William Leenders
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2077.
DOI: https://doi.org/10.1158/1538-7445.AM2017-2077
Published: 01 July 2017
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Journal Articles

Abstract 55: Generation of half-life extended anti-CD33 BiTE® antibody constructs compatible with once-weekly dosing

Tara L. Arvedson, Mercedesz Balazs, Pamela Bogner, Kurt Black, Kevin Graham, Anja Henn, Matthias Friedrich, Patrick Hoffmann, Roman Kischel, Peter Kufer, Ralf Lutterbuese, Markus Muenz, Tobias Raum, Benno Rattel, Karen Rex, Dan Rock, Oliver Thomas, Joachim Wahl, Andreas Wolf, Angela Coxon
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 55.
DOI: https://doi.org/10.1158/1538-7445.AM2017-55
Published: 01 July 2017
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Journal Articles

Abstract 5391: Preclinical evaluation of AMG 337, a highly selective small molecule MET inhibitor, in hepatocellular carcinoma

Zhiqiang Du, Sean Caenepeel, Yuqing Shen, Karen Rex, Yanni Zhang, En-Tzu Tang, Ouhong Wang, Wenge Zhong, Hui Zhou, Jacqueline Huang, Eric Huang, Liaoyuan Hu, Angela Coxon, Mingqiang Zhang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5391.
DOI: https://doi.org/10.1158/1538-7445.AM2015-5391
Published: 01 August 2015
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Journal Articles

Abstract 5396: Characterization of small molecule inhibitors of the PIM kinases in in vitro models of hematological malignancies

Christine E. Sastri, Nadia Guerrero, Dongyin Yu, Bethany Mattson, Ken Dellamaggiore, Yajing Yang, Paul Hughes, Hui-Ling Wang, Victor Cee, Brian A. Lanman, Liping Pettus, Anthony B. Reed, Bin Wu, Ryan Wurz, Andrew Tasker, Li-Ya Huang, Daniel Branstetter, Karen Rex, Jeffrey Winston, Teresa L. Burgess, Richard Kendall, J Russell Lipford
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5396.
DOI: https://doi.org/10.1158/1538-7445.AM2015-5396
Published: 01 August 2015
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Journal Articles

Abstract 5398: In vivo development of pan-Pim kinase small molecule inhibitors

Bethany Mattson, Christine. E. Sastri, Nadia Guerrero, Dean Hickman, Jie Chen, Tian Wu, Hui-Ling Wang, Andrew Taskar, Brian Lanman, Anthony B. Reed, Jude Canon, J. Russell Lipford, Karen Rex
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5398.
DOI: https://doi.org/10.1158/1538-7445.AM2015-5398
Published: 01 August 2015
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Journal Articles

Abstract 728: AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models

Paul E. Hughes, Yajing Yang, Karen Rex, Yihong Zhang, Paula J. Kaplan-Lefko, Sean Caenepeel, Jodi Moriguchi, Martin Broome, Deborah Choquette, Robert Radinsky, Richard Kendall, Angela Coxon, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 728.
DOI: https://doi.org/10.1158/1538-7445.AM2014-728
Published: 01 October 2014
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Journal Articles

Abstract LB-39: Sphingosine kinase activity is not required for tumor cell viability.

Holger Wesche, Matthew L. Brown, Timothy J. Carlson, Angela Coxon, Brendon Frank, Darin J. Gustin, Shawn Jeffries, Shyun Li, Yihong Li, Kurt Morgenstern, Kurt Morgenstern, Matthew Plant, Karen Rex, Joanna Schmidt, Shanling Shen, Nigel Walker, Dineli Wickramasinghe, Guifen Xu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-39.
DOI: https://doi.org/10.1158/1538-7445.AM2013-LB-39
Published: 15 April 2013
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Journal Articles

Abstract 5637: A cellular model of acquired resistance to rilotumumab (AMG 102) in glioblastoma.

Fabiola Cecchi, Karen Rex, Joanna Schmidt, Daniel Baker, Michael A. Damore, Angela Coxon, Teresa L. Burgess, Donald P. Bottaro
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5637.
DOI: https://doi.org/10.1158/1538-7445.AM2013-5637
Published: 15 April 2013
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Journal Articles

Abstract 3558: In vitro and in vivo profiling of class I and class II ATP-competitive c-Met kinase inhibitors defines potential c-Met-specific sensitivity biomarkers

Paula Kaplan-Lefko, Karen Rex, Yihong Zhang, Yajing Yang, Hue Kha, Beth Ziegler, Jodi Moriguchi, Mel Mallari, Xiaoning Zhao, Deborah Choquette, Richard Lewis, Jasmine Lin, Roman Shimanovich, Martin Broome, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3558.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3558
Published: 15 April 2011
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Journal Articles

Identification of a Novel Recepteur d'Origine Nantais/c-Met Small-Molecule Kinase Inhibitor with Antitumor Activity In vivo

Yihong Zhang, Paula J. Kaplan-Lefko, Karen Rex, Yajing Yang, Jodi Moriguchi, Tao Osgood, Bethany Mattson, Angela Coxon, Monica Reese, Tae-Seong Kim, Jasmine Lin, April Chen, Teresa L. Burgess, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2008) 68 (16): 6680–6687.
DOI: https://doi.org/10.1158/0008-5472.CAN-07-6782
Published: 12 August 2008
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Includes: Supplementary data
Journal Articles

AMG 458, a potent small molecule c-Met inhibitor, has significant anti-tumor activity in vivo

Paula Kaplan-Lefko, Karen Rex, Jodi Moriguchi, Yajing Yang, Yihong Zhang, April Chen, Jasmine Lin, Steve Kaufman, Tae-Seong Kim, Longbin Liu, Aaron Siegmund, Jean-Christophe Harmange, Roman Shimanovich, Teresa Burgess, Richard Kendall, Robert Radinsky, Angela Coxon, Isabelle Dussault
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4976.
Published: 01 May 2008
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Journal Articles

Discovery and optimization of a new series of potent and selective inhibitors of the c-Met kinase.

David Bauer, Jean-Christophe Harmange, Brian Albrecht, Loren Berry, Christiane Bode, Alessandro Boezio, April Chen, Deborah Choquette, Isabelle Dussault, Cary Fridrich, Satoko Hirai, Jay Larrow, Paula Kaplan-Lefko, Jasmine Lin, Julia Lohman, Alexander Long, Jodi Moriguchi, Anne O'Connor, Michele Potashman, Karen Rex, Aaron Siegmund, Kavita Shah, Roman Shimanovich, Stephanie Springer, Yohannes Teffera, Yajing Yang, Yihong Zhang, Steven Bellon
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1298.
Published: 01 May 2008
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