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Kapil Bhalla
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Journal Articles

Abstract 3044: Novel agents with efficacy against germline mutant RUNX1 familial platelet disorder with myeloid malignancy (FPD-MM)

Christopher P. Mill, Warren C. Fiskus, Courtney D. DiNardo, Patrick K. Reville, John A. Davis, Christine E. Birdwell, Kaberi Das, Hanxi Hou, Koichi Takahashi, Sanam Loghavi, Joseph D. Khoury, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3044.
https://doi.org/10.1158/1538-7445.AM2024-3044
Published: 22 March 2024
View article titled, Abstract 3044: Novel agents with efficacy against germline mutant RUNX1 familial platelet disorder with myeloid malignancy (FPD-MM)
Journal Articles

Abstract 2122: The dual BRM/BRG1 (SMARCA2/4) inhibitor FHD-286 induces differentiation in preclinical models of AML

Mike Collins, Astrid Thomsen, Ashley Gartin, Gabriel J. Sandoval, Ammar Adam, Sarah Reilly, Laure Delestre, Virginie Penard-Lacronique, Warren Fiskus, Kapil Bhalla, Stephane de Botton, Sam Agresta, Jessica Piel, Murphy Hentemann
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2122.
https://doi.org/10.1158/1538-7445.AM2023-2122
Published: 04 April 2023
View article titled, Abstract 2122: The dual BRM/BRG1 (SMARCA2/4) inhibitor FHD-286 induces differentiation in preclinical models of AML
Journal Articles

Abstract 2078: Treatment with auranofin induces oxidative and lethal endoplasmic reticulum (ER) stress exerting single agent activity against mantle cell lymphoma cells

Rekha Rao Manepalli, Lata Chauhan, Warren Fiskus, Ramesh Balusu, Narasimha Nalabothula, Sreedhar Venkannagari, Siddhartha Ganguly, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2078.
https://doi.org/10.1158/1538-7445.AM2012-2078
Published: 15 April 2012
View article titled, Abstract 2078: Treatment with auranofin induces oxidative and lethal endoplasmic reticulum (ER) stress exerting single agent activity against mantle cell lymphoma cells
Journal Articles

Abstract 2076: HSF1 inhibition accentuates the lethal activity of proteasome inhibitor in human pancreatic cancer cells

Sreedhar Venkannagari, Rekha M. Rao, Warren Fiskus, Ramesh Balusu, Hongwei Ma, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2076.
https://doi.org/10.1158/1538-7445.AM2011-2076
Published: 15 April 2011
View article titled, Abstract 2076: HSF1 inhibition accentuates the lethal activity of proteasome inhibitor in human pancreatic cancer cells
Journal Articles

IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia

Xiaolin Hu, Dafeng Yang, Mary Zimmerman, Feiyan Liu, Jine Yang, Swati Kannan, Andreas Burchert, Zdzislaw Szulc, Alicja Bielawska, Keiko Ozato, Kapil Bhalla, Kebin Liu
Journal: Cancer Research
Cancer Res (2011) 71 (8): 2882–2891.
https://doi.org/10.1158/0008-5472.CAN-10-2493
Published: 13 April 2011
View article titled, IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia
Open the PDF for IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia in another window
Journal Articles

Abstract #1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells

Yonghua Yang, Rekha Rao, Warren Fiskus, Jianguang Chen, Sanjay Koul, Atul Joshi, Ramesh Balusu, Pravina Fernandez, Yongchao Wang, Kate Buckley, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1872.
Published: 01 May 2009
View article titled, Abstract #1872: Mechanistic role of acetylated heat shock protein 70 in the VPS34/Beclin-1 triggered autophagy in breast cancer cells
Journal Articles

Abstract #3722: Co-treatment with pan-HDAC inhibitor panobinostat or heat shock protein (hsp) 90 inhibitor AUY922 with JAK2 inhibitor TG101209 is highly active against bone marrow progenitor cells from myeloproliferative neoplasms (MPN)

Yongchao Wang, Warren Fiskus, Kavita Natarajan, Yonghua Yang, Rekha Rao, Jianguang Chen, Atul Joshi, Sanjay Koul, Sunil Upadhyay, Ramesh Balusu, Pravina Fernandez, Kate Buckley, Anand Jillella, Cornelia Quadt, Peter Atadja, Ross Levine, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3722.
Published: 01 May 2009
View article titled, Abstract #3722: Co-treatment with pan-HDAC inhibitor panobinostat or heat shock protein (hsp) 90 inhibitor AUY922 with JAK2 inhibitor TG101209 is highly active against bone marrow progenitor cells from myeloproliferative neoplasms (MPN)
Journal Articles

Abstract #2937: A purine scaffold heat shock protein 90 (Hsp90) inhibitor destabilizes BCL6 and has specific anti-tumor activity in BCL6 dependent lymphomas in vitro and in vivo

Leandro Cerchietti, Eloisi Lopes, Shao Ning Yang, Katerina Hatzi, Rita Shaknovich, Ana Robles, Jennifer Walling, Kapil Bhalla, Gabriela Chiosis, Ari Melnick
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2937.
Published: 01 May 2009
View article titled, Abstract #2937: A purine scaffold heat shock protein 90 (Hsp90) inhibitor destabilizes BCL6 and has specific anti-tumor activity in BCL6 dependent lymphomas <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract #4544: Synergistic pre-clinical activity of combined epigenetic therapy with the EZH2 antagonist 3-Deazaneplanocin   and HDAC inhibitor panobinostat against human AML and Mantle Cell Lymphoma cells

Warren Fiskus, Yongchao Wang, Rekha Rao, Yonghua Yang, Jianguang Chen, Atul Joshi, Sanjay Koul, Sunil Upadhyay, Ramesh Balusu, Pravina Fernandez, Rajeshree Joshi, Kate Buckley, Anand Jillella, Celalettin Ustun, Peter Atadja, Victor Marquez, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4544.
Published: 01 May 2009
View article titled, Abstract #4544: Synergistic pre-clinical activity of combined epigenetic therapy with the EZH2 antagonist 3-Deazaneplanocin   and HDAC inhibitor panobinostat against human AML and Mantle Cell Lymphoma cells
Journal Articles

Role of Acetylation and Extracellular Location of Heat Shock Protein 90α in Tumor Cell Invasion

Yonghua Yang, Rehka Rao, Jie Shen, Yun Tang, Warren Fiskus, John Nechtman, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (12): 4833–4842.
https://doi.org/10.1158/0008-5472.CAN-08-0644
Published: 16 June 2008
View article titled, Role of Acetylation and Extracellular Location of Heat Shock Protein 90α in Tumor Cell Invasion
Open the PDF for Role of Acetylation and Extracellular Location of Heat Shock Protein 90α in Tumor Cell Invasion in another window
Includes: Supplementary data
Journal Articles

Co-treatment with vorinostat and Aurora kinase inhibitor MK-0457 exerts synergistic antileukemia activity against AML and CML cells, including those expressing mutant Bcr-AblT315I

Warren Fiskus, Yongchao Wang, Rajeshree Joshi, Rekha Rao, Pearl Lee, Yonghua Yang, Kelly Eaton, Jianguang Chen, Ravindra Kolhe, Pravina Fernandez, Anand Jillella, Carolyn Buser, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2558.
Published: 01 May 2008
View article titled, Co-treatment with vorinostat and Aurora kinase inhibitor MK-0457 exerts synergistic antileukemia activity against AML and CML cells, including those expressing mutant Bcr-AblT315I
Journal Articles

LBH589 mediated depletion of HDAC7 and de-repression of Nur77 levels and pro-death activity: a mechanism underlying sensitivity of human CTCL cells to panobinostat (LBH589)

Jianguang Chen, Kelly Eaton, Warren Fiskus, Yongchao Wang, Rekha Rao, Pearl Lee, Rajeshree Joshi, Yonghua Yang, Ravindra Kolhe, Pravina Fernandez, Kavita Natarajan, Anand Jillella, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2441.
Published: 01 May 2008
View article titled, LBH589 mediated depletion of HDAC7 and de-repression of Nur77 levels and pro-death activity: a mechanism underlying sensitivity of human CTCL cells to panobinostat (LBH589)
Journal Articles

Perturbations in levels and hyperacetylation of GRP78: Role in panobinostat (LBH589)-induced unfolded protein response (UPR) and cell death of human breast cancer cells

Rekha Rao, Ravindra Kolhe, Yonghua Yang, Jianguang Chen, Pearl Lee, Warren Fiskus, Yongchao Wang, Kelly Eaton, Rajeshree Joshi, Pravina Fernandez, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2334.
Published: 01 May 2008
View article titled, Perturbations in levels and hyperacetylation of GRP78: Role in panobinostat (LBH589)-induced unfolded protein response (UPR) and cell death of human breast cancer cells
Journal Articles

Potent antileukemia activity of the combination of the heat shock protein 90 inhibitor NVP-AUY922 and the histone deacetylase inhibitor LBH589 (panobinostat) against human AML and CML cells

Warren Fiskus, Yongchao Wang, Rekha Rao, Jianguang Chen, Ravindra Kolhe, Yonghua Yang, Kelly Eaton, Pearl Lee, Rajeshree Joshi, Pravina Fernandez, Peter Atadja, Cornelia Quadt, Michael Rugaard Jensen, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5632.
Published: 01 May 2008
View article titled, Potent antileukemia activity of the combination of the heat shock protein 90 inhibitor NVP-AUY922 and the histone deacetylase inhibitor LBH589 (panobinostat) against human AML and CML cells
Journal Articles

A role for retinoblastoma protein Rb1 in protecting ER+ breast cancer cells from antiestrogen-induced autophagocytic cell death.

Patricia Schoenlein, Adam Singer, Julia Samaddar, Mallikarjun Patil, Kebin Liu, Kapil Bhalla, John Barrett, William Jackson
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3355.
Published: 01 May 2008
View article titled, A role for retinoblastoma protein Rb1 in protecting ER+ breast cancer cells from antiestrogen-induced autophagocytic cell death.
Journal Articles

Pan-HDAC inhibitor LBH589 depletes EZH2 and DNMT1 by inhibiting chaperone association of hsp90 with EZH2 and DNMT1.

Warren Fiskus, Bryan Herger, Rekha Rao, Peter Atadja, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2476.
Published: 01 May 2007
View article titled, Pan-HDAC inhibitor LBH589 depletes EZH2 and DNMT1 by inhibiting chaperone association of hsp90 with EZH2 and DNMT1.
Journal Articles

Dasatinib (BMS-354825) inhibits Src family kinases and downstream STAT5 signaling in chronic myelogenous leukemia cells

Sangkil Nam, Adina Vultur, Kapil Bhalla, Francis Lee, Richard Jove
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2564.
Published: 01 May 2007
View article titled, Dasatinib (BMS-354825) inhibits Src family kinases and downstream STAT5 signaling in chronic myelogenous leukemia cells
Journal Articles

Combination of histone deacetylase 6/heat shock protein 90 inhibition and bortezomib: a strategy to enhance ER-based UPR-mediated cytotoxicity in human mantle cell lymphoma cells

Rekha Rao, Bryan Herger, Warren Fiskus, Rajeshree Joshi, Kapil Bhalla, Angela Hatter
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 703.
Published: 01 May 2007
View article titled, Combination of histone deacetylase 6/heat shock protein 90 inhibition and bortezomib: a strategy to enhance ER-based UPR-mediated cytotoxicity in human mantle cell lymphoma cells
Journal Articles

Targeting mutant nucleophosmin (NPM)1 induces differentiation and loss of clonogenic survival of human AML cells.

Bryan Herger, Pravina Fernandez, Warren Fiskus, Rekha Rao, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4084.
Published: 01 May 2007
View article titled, Targeting mutant nucleophosmin (NPM)1 induces differentiation and loss of clonogenic survival of human AML cells.
Journal Articles

Identification and role of lysine acetylation sites in regulating chaperone function of heat shock protein 90α.

Yonghua Yang, Kapil Bhalla
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 712.
Published: 01 May 2007
View article titled, Identification and role of lysine acetylation sites in regulating chaperone function of heat shock protein 90α.