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Kaiko Kunii
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Journal Articles

Abstract 3260: Potentiation of Type I interferon signaling leads to in vivo efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397

Kaiko Kunii, Jeff J. Song, Danielle Zimmerman, Chang Liu, Kristy G. Kuplast-Barr, Jonathan J. Novak, Sunaina P. Nayak, Joseph M. Gozgit, Melissa M. Vasbinder, Kristen McEachern, Kevin W. Kuntz, Heike Keilhack, Jennifer R. Molina
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3260.
https://doi.org/10.1158/1538-7445.AM2023-3260
Published: 04 April 2023
View article titled, Abstract 3260: Potentiation of Type I interferon signaling leads to <em>in vivo</em> efficacy achieved with combination of chemotherapy and the PARP7 inhibitor RBN-2397
Journal Articles

Abstract 625: PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance

Chun Wai Wong, Christos Evangelou, Kieran N. Sefton, Rotem Leshem, Kleita Sergiou, Macarena Lucia Fernandez Carro, Erez Uzuner, Holly Mole, Brian A. Telfer, Daniel J. Wilcock, Michael P. Smith, Kaiko Kunii, Nicholas R. Perl, Paul Lorigan, Kaye J. Williams, Patricia E. Rao, Raghavendar T. Nagaraju, Mario Niepel, Adam F. Hurlstone
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 625.
https://doi.org/10.1158/1538-7445.AM2023-625
Published: 04 April 2023
View article titled, Abstract 625: PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven adaptive resistance
Journal Articles

Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models

Jennifer R. Molina, Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko kunii, Kristy G. Kuplast-Barr, Bin Gui, Sunaina P. Nayak, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Alvin Z. Lu, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Ellen Bamberg, Mario Niepel, Jan-Rung Mo, William D. Church, Ahmed S. Mady, Jeff Song, Zacharenia A. Varsamis, Luke Utley, Patricia E. Rao, Timoty J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Kristen McEachern, Heike Keilhack
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2154.
https://doi.org/10.1158/1538-7445.AM2022-2154
Published: 15 June 2022
View article titled, Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models
Journal Articles

Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko Kunii, Kristy G. Kuplast-Barr, Bin Gui, Alvin Z. Lu, Jennifer R. Molina, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Mario Niepel, Ellen Bamberg, Jan-Rung Mo, David Church, Jeff Song, Luke Utley, Patricia E. Rao, Timothy J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Heike Keilhack
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 48.
https://doi.org/10.1158/1538-7445.AM2021-48
Published: 01 July 2021
View article titled, Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells
Journal Articles

Abstract 1344: Small molecule inhibitor of CD38 modulates its intra- and extracellular functions leading to antitumor activity

Prashant Shambharkar, Danielle J. Blackwell, Melissa M. Vasbinder, Laurie B. Schenkel, Kaiko Kunii, Jenkins L. Lemera, Kristy G. Kuplast-Barr, Yue Ren, Ellen Bamberg, W. David Church, Christina R. Majer, Luke Utley, Kristen McEachern, Mario Niepel, Tim J. Wigle, Kevin W. Kuntz, Victoria M. Richon, Heike Keilhack, Joseph M. Gozgit
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1344.
https://doi.org/10.1158/1538-7445.AM2021-1344
Published: 01 July 2021
View article titled, Abstract 1344: Small molecule inhibitor of CD38 modulates its intra- and extracellular functions leading to antitumor activity
Journal Articles

Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko Kunii, Kristy G. Kuplast-Barr, Bin Gui, Alvin Z. Lu, Kerren K. Swinger, Tim J. Wigle, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Mario Niepel, Zacharenia A. Varsamis, Sunaina P. Nayak, Ellen Bamberg, Jan-Rung Mo, William Church, Jeff Song, Luke Utley, Patricia E. Rao, Timothy J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Heike Keilhack
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3405.
https://doi.org/10.1158/1538-7445.AM2020-3405
Published: 15 August 2020
View article titled, Abstract 3405: PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition leads to tumor regression
Journal Articles

Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways

Melissa M. Vasbinder, Joseph M. Gozgit, Ryan P. Abo, Kaiko Kunii, Kristy G. Kuplast-Barr, Bin Gui, Alvin Z. Lu, Kerren K. Swinger, Tim J. Wigle, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Mario Niepel, Zacharenia A. Varsamis, Sunaina P. Nayak, Ellen Bamberg, Jan-Rung Mo, W David Church, Jeff Song, Luke Utley, Patricia E. Rao, Timothy J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Heike Keilhack
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): DDT02-01.
https://doi.org/10.1158/1538-7445.AM2020-DDT02-01
Published: 15 August 2020
View article titled, Abstract DDT02-01: RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways
Journal Articles

Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers

Silvia Buonamici, Akihide Yoshimi, Michael Thomas, Michael Seiler, Betty Chan, Benjamin Caleb, Fred Csibi, Rachel Darman, Peter Fekkes, Craig Karr, Gregg Keaney, Amy Kim, Virginia Klimek, Pavan Kumar, Kaiko Kunii, Stanley Chun-Wei Lee, Xiang Liu, Crystal MacKenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Sudeep Prajapati, Nathalie Rioux, Justin Taylor, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel-Wahab, Peter Smith
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1185.
https://doi.org/10.1158/1538-7445.AM2017-1185
Published: 01 July 2017
View article titled, Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers
Journal Articles

Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation

Eun Sun Park, Michelle Aicher, Daniel Aird, Silvia Buonamici, Betty Chan, Cheryl Eifert, Peter Fekkes, Craig Furman, Baudouin Gerard, Craig Karr, Gregg Keaney, Kaiko Kunii, Linda Lee, Ermira Pazolli, Sudeep Prajapati, Takashi Satoh, Peter Smith, John Yuan Wang, Karen Wang, Markus Warmuth, Lihua Yu, Ping Zhu, Yoshiharu Mizui, Laura B. Corson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2941.
https://doi.org/10.1158/1538-7445.AM2015-2941
Published: 01 August 2015
View article titled, Abstract 2941: Targeting MCL1-dependent cancers through RNA splicing modulation
Journal Articles

Abstract 2932: SF3B1 mutations induce aberrant mRNA splicing in cancer and confer sensitivity to spliceosome inhibition

Silvia Buonamici, Kian Huat Lim, Jacob Feala, Eunice Park, Laura Corson, Michelle Aicher, Daniel Aird, Betty Chan, Erik Corcoran, Rachel Darman, Peter Fekkes, Gregg Keaney, Pavan Kumar, Kaiko Kunii, Linda Lee, Xiaoling Puyang, Jose Rodrigues, Anand Selvaraj, Michael Thomas, John Wang, Markus Warmuth, Lihua Yu, Ping Zhu, Peter Smith, Yoshiharu Mizui
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2932.
https://doi.org/10.1158/1538-7445.AM2014-2932
Published: 01 October 2014
View article titled, Abstract 2932: SF3B1 mutations induce aberrant mRNA splicing in cancer and confer sensitivity to spliceosome inhibition
Journal Articles

PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models

Katharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, Brian Dolinski, Yamicia Connor, Kun Hu, Kumiko Nagashima, Erin O'Hare, Yusuf Erkul, Alessandra Di Bacco, Diana Gargano, Nirah H. Shomer, Minilik Angagaw, Erica Leccese, Paula Andrade, Melissa Hurd, Myung K. Shin, Thomas F. Vogt, Alan Northrup, Ekaterina V. Bobkova, Shailaja Kasibhatla, Roderick T. Bronson, Martin L. Scott, Giulio Draetta, Victoria Richon, Nancy Kohl, Peter Blume-Jensen, Jannik N. Andersen, Manfred Kraus
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3052–3065.
https://doi.org/10.1158/0008-5472.CAN-10-2282
Published: 13 April 2011
View article titled, PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
Open the PDF for PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models in another window
Includes: Supplementary data
Journal Articles

MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor

Bo-Sheng Pan, Grace K.Y. Chan, Melissa Chenard, An Chi, Lenora J. Davis, Sujal V. Deshmukh, Jackson B. Gibbs, Susana Gil, Gaozhen Hang, Harold Hatch, James P. Jewell, Ilona Kariv, Jason D. Katz, Kaiko Kunii, Wei Lu, Bart A. Lutterbach, Cloud P. Paweletz, Xianlu Qu, John F. Reilly, Alexander A. Szewczak, Qinwen Zeng, Nancy E. Kohl, Christopher J. Dinsmore
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1524–1533.
https://doi.org/10.1158/0008-5472.CAN-09-2541
Published: 14 February 2010
View article titled, MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor
Open the PDF for MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor in another window
Includes: Supplementary data
Journal Articles

Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth in vitro and in vivo

Elizabeth Harrington, Grace Chan, Melissa Chenard, William Dahlberg, Lenora Davis, Sujal Deshmukh, Christopher Dinsmore, Clayton Efferson, Gaozhen Hang, Harold Hatch, Nancy Kohl, Kaiko Kunii, Wei Lu, Bart Lutterbach, Pradip Majumder, Alan Northrup, Xianlu Qu, John Reilly, Craig Rosenstein, Alexander Szewczak, Jennifer Tammam, Christopher Ware, Qinwen Zheng, Bo-Sheng Pan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1751.
Published: 01 May 2009
View article titled, Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Attenuation of Notch signaling pathway by gamma-secretase inhibitor exerts antitumor effects in T-ALL through apoptotic mechanisms.

Jennifer Tammam, Christopher Ware, Clay Efferson, Xianlu Qu, Hellen Kim, Julie Gorenstein, Minilik Angagaw, Candia Kenific, Kaiko Kunii, Jun Zhao, Cem Elbi, Linda Bristow, John Reilly, George Nikov, Nancy Kohl, Peter Strack, Pradip Majumder
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-23.
Published: 01 May 2008
View article titled, Attenuation of Notch signaling pathway by gamma-secretase inhibitor exerts antitumor effects in T-ALL through apoptotic mechanisms.
Journal Articles

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival

Bart Lutterbach, Kaiko Kunii, Lenora Davis, Harold Hatch, Julie Gorenstein, Masakazu Yashiro, Victoria Richon, Nancy Kohl, Cem Elbi, Wei Lu, Bo-Sheng Pan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4874.
Published: 01 May 2008
View article titled, <em>FGFR2</em>-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
Journal Articles

FGFR2-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival

Kaiko Kunii, Lenora Davis, Julie Gorenstein, Harold Hatch, Masakazu Yashiro, Alessandra Di Bacco, Cem Elbi, Bart Lutterbach
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2340–2348.
https://doi.org/10.1158/0008-5472.CAN-07-5229
Published: 01 April 2008
View article titled, <em>FGFR2</em>-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival
Open the PDF for <em>FGFR2</em>-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival in another window
Includes: Supplementary data
Journal Articles

In vitro and in vivo anti-tumor activities of a novel c-Met kinase inhibitor

Bo-Sheng Pan, Melissa Chenard, Lenora Davis, Sujal Deshmukh, Jackson Gibbs, Gaozhen Hang, Harold Hatch, James Jewell, Jason Katz, Kaiko Kunii, Wei Lu, Bart Lutterbach, Xianlu Qu, John Reilly, Alexander Szewczak, Qinwen Zeng, Nancy Kohl, Christopher Dinsmore
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2368.
Published: 01 May 2007
View article titled, In vitro and in vivo anti-tumor activities of a novel c-Met kinase inhibitor