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Journal Articles

Abstract 5249: In vitro co-culture CRISPR screen identifies SMG1 to potentiate T cell-mediated cytotoxicity in hepatocellular carcinoma

Ka Hei Lam, Tin Lok Wong, Kai Yu Ng, Vincent Tano, Jia Jian Loh, Ianto B. Huang, Guang Sheng Ling, Terence KW Lee, Lei Lei Chen, Stephanie KY Ma
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5249.
https://doi.org/10.1158/1538-7445.AM2025-5249
Published: 21 April 2025
View articletitled, Abstract 5249: In vitro co-culture CRISPR screen identifies SMG1 to potentiate T cell-mediated cytotoxicity in hepatocellular carcinoma
Journal Articles

Abstract 5437: Chemoproteomics-enabled discovery of covalent inhibitors targeted at AGPAT4: Unravelling tumor lineage plasticity to overcome drug resistance in hepatocellular carcinoma

Kai-Yu Ng, Tin-Yan Koo, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5437.
https://doi.org/10.1158/1538-7445.AM2024-5437
Published: 22 March 2024
View articletitled, Abstract 5437: Chemoproteomics-enabled discovery of covalent inhibitors targeted at AGPAT4: Unravelling tumor lineage plasticity to overcome drug resistance in hepatocellular carcinoma
Journal Articles

Abstract 1988: Mass spectrometry profiling identifies ENO2 as a driver of lenvatinib resistance in hepatocellular carcinoma

Sukbum Kim, Jia-Jian Loh, Huajian Yu, Ki-Fong Man, Kai-Yu Ng, Terence Kin-Wah Lee, Clive Yik-Sham Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1988.
https://doi.org/10.1158/1538-7445.AM2024-1988
Published: 22 March 2024
View articletitled, Abstract 1988: Mass spectrometry profiling identifies ENO2 as a driver of lenvatinib resistance in hepatocellular carcinoma
Journal Articles

Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling

Huajian Yu, Lei Zhou, Jane Ho-Chun Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor WS Ma, Yanyan Wang, Xiang Zhang, Terence K Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2023-2433
Published: 04 April 2023
View articletitled, Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling
Journal Articles

Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma

Kai Yu Ng, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2429.
https://doi.org/10.1158/1538-7445.AM2023-2429
Published: 04 April 2023
View articletitled, Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma
Journal Articles

Abstract 3315: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis

Steve Tin Chi Luk, Man Tong, Kai Yu Ng, Kevin Yuk-Lap Yip, Xin Yuan Guan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3315.
https://doi.org/10.1158/1538-7445.AM2018-3315
Published: 01 July 2018
View articletitled, Abstract 3315: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis
Journal Articles

Abstract 1349: Functional and mechanistic characterization of PRMT6 regulated autophagy in hepatocellular carcinoma

Noélia Che, Man Tong, Kai Yu Ng, Phillis WF Kau, Xin Yuan Guan, Michael SY Huen, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1349.
https://doi.org/10.1158/1538-7445.AM2018-1349
Published: 01 July 2018
View articletitled, Abstract 1349: Functional and mechanistic characterization of PRMT6 regulated autophagy in hepatocellular carcinoma
Journal Articles

Abstract 4479: Protein arginine methyltransferase PRMT6 regulates cancer stemness through CRAF methylation in hepatocellular carcinoma

LH Chan, L Zhou, Kai Yu Ng, TL Wong, TK Lee, YP Ching, YF Yuan, D Xie, S Richard, MS Huen, XY Guan, S Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4479.
https://doi.org/10.1158/1538-7445.AM2018-4479
Published: 01 July 2018
View articletitled, Abstract 4479: Protein arginine methyltransferase PRMT6 regulates cancer stemness through CRAF methylation in hepatocellular carcinoma
Journal Articles

FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Marco Chi-Chung Lau, Kai Yu Ng, Tin Lok Wong, Man Tong, Terence K. Lee, Xiao-Yan Ming, Simon Law, Nikki P. Lee, Annie L. Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin-Yuan Guan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5886–5899.
https://doi.org/10.1158/0008-5472.CAN-17-1411
Published: 31 October 2017
View articletitled, FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk
Open the PDF for FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk in another window
Includes: Supplementary data
Journal Articles

TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma

Kai-Yu Ng, Lok-Hei Chan, Stella Chai, Man Tong, Xin-Yuan Guan, Nikki P Lee, Yunfei Yuan, Dan Xie, Terence K Lee, Nelson J Dusetti, Alice Carrier, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (17): 4602–4612.
https://doi.org/10.1158/0008-5472.CAN-16-3456
Published: 31 August 2017
View articletitled, TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma
Open the PDF for TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4842: TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma

Kai Yu Ng, Lok Hei Chan, Stella Chai, Man Tong, Xin Yuan Guan, Nikki P Lee, Yun Fei Yuan, Dan Xie, Terence K Lee, Alice Carrier, Nelson J Dusetti, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4842.
https://doi.org/10.1158/1538-7445.AM2017-4842
Published: 01 July 2017
View articletitled, Abstract 4842: TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma
Journal Articles

Abstract 2895: Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells

Stella Chai, Kai-Yu Ng, Man Tong, Eunice Y. Lau, Terence K. Lee, Kwok Wah Chan, Yun Fei Yuan, Tan To Cheung, Siu Tim Cheung, Xiao Qi Wang, Nathalie Wong, Chung Mau Lo, Kwan Man, Xin Yuan Guan, Stephanie K. Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2895.
https://doi.org/10.1158/1538-7445.AM2017-2895
Published: 01 July 2017
View articletitled, Abstract 2895: Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells
Journal Articles

Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer

Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Stella Chai, Terence K Lee, Xin Yuan Guan, Yick Pang Ching, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H Yan, Suet Yi Leung, Stèphane Richard, Michael SY Huen, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-139.
https://doi.org/10.1158/1538-7445.AM2017-LB-139
Published: 01 July 2017
View articletitled, Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer
Journal Articles

Abstract 4352: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis

Steve Tin-Chi Luk, Man Tong, Kai Yu Ng, Kevin Yuk-Lap Yip, Xin Yuan Guan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4352.
https://doi.org/10.1158/1538-7445.AM2017-4352
Published: 01 July 2017
View articletitled, Abstract 4352: Identification of ZFP42/REX1 as a regulator of cancer stemness in CD133+ liver cancer stem cells by genome-wide DNA methylation analysis
Journal Articles

Abstract 2874: Regulatory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma

Stella Chai, Kai Yu Ng, Man Tong, Siu Tim Cheung, Xin-Yuan Guan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2874.
https://doi.org/10.1158/1538-7445.AM2015-2874
Published: 01 August 2015
View articletitled, Abstract 2874: Regulatory role of miRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Journal Articles

Abstract 2333: The tumor suppressive role of PRMT6 in regulating the pathogenesis of hepatocellular carcinoma

Lok Hei Chan, Kai Yu Ng, Stephanie Ma
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2333.
https://doi.org/10.1158/1538-7445.AM2015-2333
Published: 01 August 2015
View articletitled, Abstract 2333: The tumor suppressive role of PRMT6 in regulating the pathogenesis of hepatocellular carcinoma
Journal Articles

Abstract 2223: C-terminal truncated hepatitis B virus X protein promotes hepatocarcinogenesis through enhanced stemness and resistance to therapy

Kai Yu Ng, Stella Chai, Man Tong, Xin-Yuan Guan, Alfred S. Cheng, Stephanie Ma
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2223.
https://doi.org/10.1158/1538-7445.AM2015-2223
Published: 01 August 2015
View articletitled, Abstract 2223: C-terminal truncated hepatitis B virus X protein promotes hepatocarcinogenesis through enhanced stemness and resistance to therapy