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Journal Articles

Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy

Free
Jing Qian, Melinda Soeung, Xinmiao Yan, Kai Yu, Ciro Zanca, Li Zhang, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca Slack Tidwell, Hania Khan, Fei Duan, Menuka Karki, Rong He, Courtney N. Le, Truong N.A. Lam, Nirjar Bhattacharya, Mariah N. Williams, David H. Peng, Rutvi Shah, I-Lin Ho, Ningping Feng, Niki Millward Zacharias, Rahul Anil Sheth, Tharakeswara K. Bathala, Priya Rao, Najat C. Daw, Durga N. Tripathi, Cheryl L. Walker, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya S. Jadhav, Wenhua Lang, Claudio A. Arrechedera, Leticia Campos Clemente, Hsinyi Lu, Cara L. Haymaker, Ignacio I. Wistuba, Andrew Futreal, Andrea Viale, Timothy Heffernan, Giulio F. Draetta, Nazir M. Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 646.
https://doi.org/10.1158/1538-7445.AM2025-646
Published: 21 April 2025
View articletitled, Abstract 646: Unravelling the mechanisms of resistance and hyperprogression of renal medullary carcinoma to immune checkpoint therapy
Journal Articles

Abstract 3971: Single-cell transcriptomic insights into tumor and immune dynamics driving resistance to sitravatinib, nivolumab, and ipilimumab in advanced clear cell renal cell carcinoma

Free
Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul Annil Sheth, Priya Rao, Kanishka Sircar, Amishi Yogesh Shah, Amado Zurita-Saavedra, Giannincola Genovesa, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis Chin, Nizar M Tannir, Linghua Wang, Jianjun Gao, Pavlos Msaouel
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3971.
https://doi.org/10.1158/1538-7445.AM2025-3971
Published: 21 April 2025
View articletitled, Abstract 3971: Single-cell transcriptomic insights into tumor and immune dynamics driving resistance to sitravatinib, nivolumab, and ipilimumab in advanced clear cell renal cell carcinoma
Journal Articles

Abstract 763: Multimodal spatial-omics atlas of lung premalignancy and adenocarcinoma reveals tumor initiating interplay between alveolar progenitors and inflammation

Free
Fuduan Peng, Ansam Sinjab, Sujuan Yang, Yibo Dai, Minyue Chen, Warapen Treekitkarnmongkol, Tieling Zhou, Alejandra G. Serrano, Jianlong Liao, GuangSheng Pei, Yunhe Liu, Yang Liu, Jiahui Jiang, Kyung Serk Cho, Yanshuo Chu, Kai Yu, Ruiping Wang, Jiping Feng, Zahraa Rahal, Lorena I. Gomez Bolanos, Guangchun Han, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Akshay Basi, Avrum Spira, Steven Dubinett, Tomokazu Itoh, Takashi Yao, Kenji Suzuki, Luisa M. Solis, Stephen Swisher, Mingyao Li, Junya Fujimoto, Ignacio I. Wistuba, Jared Burks, Kadir Akdemir, Jeffrey Myers, Linghua Wang, Humam Kadara
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 763.
https://doi.org/10.1158/1538-7445.AM2025-763
Published: 21 April 2025
View articletitled, Abstract 763: Multimodal spatial-omics atlas of lung premalignancy and adenocarcinoma reveals tumor initiating interplay between alveolar progenitors and inflammation
Journal Articles

Abstract 759: Spatial transcriptomics identifies unique tumor and microenvironment pathomic programs that are associated with the lung premalignancy and adenocarcinoma continuum

Free
Yibo Dai, Fuduan Peng, Ansam Sinjab, Sujuan Yang, Minyue Chen, Warapen Treekitkarnmongkol, Lorena I. Gomez Bolanos, Tieling Zhou, Alejandra G. Serrano, Jianlong Liao, Guangsheng Pei, Yunhe Liu, Yang Liu, Jiahui Jiang, Kyung Serk Cho, Yanshuo Chu, Kai Yu, Ruiping Wang, Jiping Feng, Zahraa Rahal, Guangchun Han, Naoe Jimbo, Takuo Hayashi, Satsuki Kishikawa, Kazuya Takamochi, Akshay Basi, Avrum Spira, Steven Dubinett, Tomokazu Itoh, Takashi Yao, Kenji Suzuki, Luisa M. Solis, Stephen Swisher, Mingyao Li, Junya Fujimoto, Ignacio I. Wistuba, Jared Burks, Kadir Akdemir, Hind Refai, Katy Rezvani, Jeffrey Myers, Humam Kadara, Linghua Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 759.
https://doi.org/10.1158/1538-7445.AM2025-759
Published: 21 April 2025
View articletitled, Abstract 759: Spatial transcriptomics identifies unique tumor and microenvironment pathomic programs that are associated with the lung premalignancy and adenocarcinoma continuum
Journal Articles

Abstract 7445: Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis

Free
Ze-Xian Liu, Kai Yu, Yongqiang Zheng, Jin-Fei Lin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7445.
https://doi.org/10.1158/1538-7445.AM2025-7445
Published: 21 April 2025
View articletitled, Abstract 7445: Deep learning prioritizes cancer mutations that alter protein nucleocytoplasmic shuttling to drive tumorigenesis
Journal Articles

Abstract 6209: Different types of diabetes and pancreatic ductal adenocarcinoma risk: A Mendelian randomization and pathway/gene-set analysis

Free
Ting Zhang, Xing Hua, Chirayu Mohindroo, Xiaoyu Wang, PanScan and PanC4 Consortium, Brian M. Wolpin, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Kai Yu, Haoyu Zhang, Rachael Z. Stolzenberg-Solomon
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6209.
https://doi.org/10.1158/1538-7445.AM2025-6209
Published: 21 April 2025
View articletitled, Abstract 6209: Different types of diabetes and pancreatic ductal adenocarcinoma risk: A Mendelian randomization and pathway/gene-set analysis
Journal Articles

Abstract 5249: In vitro co-culture CRISPR screen identifies SMG1 to potentiate T cell-mediated cytotoxicity in hepatocellular carcinoma

Free
Ka Hei Lam, Tin Lok Wong, Kai Yu Ng, Vincent Tano, Jia Jian Loh, Ianto B. Huang, Guang Sheng Ling, Terence KW Lee, Lei Lei Chen, Stephanie KY Ma
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5249.
https://doi.org/10.1158/1538-7445.AM2025-5249
Published: 21 April 2025
View articletitled, Abstract 5249: In vitro co-culture CRISPR screen identifies SMG1 to potentiate T cell-mediated cytotoxicity in hepatocellular carcinoma
Journal Articles

Abstract 3427: Serum metabolites and pancreatic ductal adenocarcinoma in two prospective cohorts

Free
Ting Zhang, Steven C. Moore, Sheng Fu, Kevin Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg-Solomon
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3427.
https://doi.org/10.1158/1538-7445.AM2024-3427
Published: 22 March 2024
View articletitled, Abstract 3427: Serum metabolites and pancreatic ductal adenocarcinoma in two prospective cohorts
Journal Articles

Abstract 4042: Cbl inhibition increases the response of cytotoxic T cells to sub-optimal stimulation and drives enhanced anti-tumor responses alone or in combination with PD-1 blockade

Free
Livia Yamashiro, Sachie Marubayashi, Rameshwari Rayaji, Anudari Battsooj, Karim Mrouj, Hema Singh, Yue Tong Lee, Ada Chen, Lunda Shen, Artur Mailyan, Kai Yu, Masha Podunavac, Julie Yu, Dongdong Liu, Clayton Hardman, Johnny Yin, Srikanth Gangam, Ken Lawson, Manmohan Leleti, Matthew Walters, Daniel DiRenzo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4042.
https://doi.org/10.1158/1538-7445.AM2024-4042
Published: 22 March 2024
View articletitled, Abstract 4042: Cbl inhibition increases the response of cytotoxic T cells to sub-optimal stimulation and drives enhanced anti-tumor responses alone or in combination with PD-1 blockade
Journal Articles

Abstract 947: A nanodroplet cell processing platform for identifying synergistic drug combinations for neuroblastoma treatment in TH-MYCN transgenic mice

Free
Yen-Tzu Liao, Zhi-Kai Yu, Ching-Te Kuo, Wen-Ming Hsu, Yi-Xun Huang, Hsinyu Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 947.
https://doi.org/10.1158/1538-7445.AM2024-947
Published: 22 March 2024
View articletitled, Abstract 947: A nanodroplet cell processing platform for identifying synergistic drug combinations for neuroblastoma treatment in TH-MYCN transgenic mice
Journal Articles

Abstract 5437: Chemoproteomics-enabled discovery of covalent inhibitors targeted at AGPAT4: Unravelling tumor lineage plasticity to overcome drug resistance in hepatocellular carcinoma

Free
Kai-Yu Ng, Tin-Yan Koo, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5437.
https://doi.org/10.1158/1538-7445.AM2024-5437
Published: 22 March 2024
View articletitled, Abstract 5437: Chemoproteomics-enabled discovery of covalent inhibitors targeted at AGPAT4: Unravelling tumor lineage plasticity to overcome drug resistance in hepatocellular carcinoma
Journal Articles

Abstract 1988: Mass spectrometry profiling identifies ENO2 as a driver of lenvatinib resistance in hepatocellular carcinoma

Free
Sukbum Kim, Jia-Jian Loh, Huajian Yu, Ki-Fong Man, Kai-Yu Ng, Terence Kin-Wah Lee, Clive Yik-Sham Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1988.
https://doi.org/10.1158/1538-7445.AM2024-1988
Published: 22 March 2024
View articletitled, Abstract 1988: Mass spectrometry profiling identifies ENO2 as a driver of lenvatinib resistance in hepatocellular carcinoma
Journal Articles

Abstract 5820: Chloroquine inhibited Rab11 mediated E-cadherin transport in collective colon cell migration in Dasatinib resistant cells

Free
Xiang-Ling Hou, Hui Min Koo, Chia-Wen Lin, Chien-Chi Huang, Yu-Chi Tseng, Kai-Yu Tseng, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5820.
https://doi.org/10.1158/1538-7445.AM2023-5820
Published: 04 April 2023
View articletitled, Abstract 5820: Chloroquine inhibited Rab11 mediated E-cadherin transport in collective colon cell migration in Dasatinib resistant cells
Journal Articles

Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling

Free
Huajian Yu, Lei Zhou, Jane Ho-Chun Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor WS Ma, Yanyan Wang, Xiang Zhang, Terence K Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2023-2433
Published: 04 April 2023
View articletitled, Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling
Journal Articles

Abstract 5722: The mutational signatures of 100,477 targeted sequenced tumors

Free
Donghyuk Lee, Min Hua, Difei Wang, Lei Song, Tongwu Zhang, Kai Yu, Xiaohong R. Yang, Jianxin Shi, Stephen J. Chanock, Maria Teresa Landi, Bin Zhu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5722.
https://doi.org/10.1158/1538-7445.AM2023-5722
Published: 04 April 2023
View articletitled, Abstract 5722: The mutational signatures of 100,477 targeted sequenced tumors
Journal Articles

Abstract 2795: A food effect and esomeprazole drug-drug interaction study of RLY-4008, a highly selective FGFR2 inhibitor, in healthy subjects

Free
Jinshan Shen, Rishikesh Sawant, Rick Blakesley, Kai Yu Jen, Fabien Ricard, Xiaoyan Li, Cassandra Key, Djuro Karanovic
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2795.
https://doi.org/10.1158/1538-7445.AM2023-2795
Published: 04 April 2023
View articletitled, Abstract 2795: A food effect and esomeprazole drug-drug interaction study of RLY-4008, a highly selective FGFR2 inhibitor, in healthy subjects
Journal Articles

Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma

Free
Kai Yu Ng, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2429.
https://doi.org/10.1158/1538-7445.AM2023-2429
Published: 04 April 2023
View articletitled, Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma
Journal Articles

Abstract 2365: Visualizing exosome structure in Dasatinib resistant colon cancer cells

Free
Hui Min Koo, Yi-Wen Lu, Yu-Chi Tseng, Kai-Yu Tseng, Yen-Tse Lu, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2365.
https://doi.org/10.1158/1538-7445.AM2023-2365
Published: 04 April 2023
View articletitled, Abstract 2365: Visualizing exosome structure in Dasatinib resistant colon cancer cells
Journal Articles

Abstract OT3-24-01: ReFocus: A Phase 1/2 Study of the Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with Advanced Solid Tumors Including Breast Cancer

Free
Suneel Kamath, David Tai, Irene Moreno, Hani Babiker, Zhaohui Jin, Changhoon Yoo, Fabien Ricard, Kai Yu Jen, Jim Coward, Jia Liu, Frans Opdam, Michael Millward, Mariano Ponz-Sarvise, Jeffrey Yachnin, Richard Kim, Joon Oh Park, Vivek Subbiah, Alison M. Schram
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): OT3-24-01.
https://doi.org/10.1158/1538-7445.SABCS22-OT3-24-01
Published: 01 March 2023
View articletitled, Abstract OT3-24-01: ReFocus: A Phase 1/2 Study of the Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with Advanced Solid Tumors Including Breast Cancer
Journal Articles

Abstract 2263: The role of E-Cadherin mediated cell division in promoting collective colon cancer cell migration

Free
Yu-Lin Li, Yu-Cheng Weng, Viriya Adhiguna Winarso, Yi-Wen Lu, Hui Min Koo, Xiang-Ling Hou, Kai-Yu Tseng, Wei-Ting Chao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2263.
https://doi.org/10.1158/1538-7445.AM2022-2263
Published: 15 June 2022
View articletitled, Abstract 2263: The role of E-Cadherin mediated cell division in promoting collective colon cancer cell migration