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Journal Articles

Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

Available to Purchase
Na Qin, Zhoufeng Wang, Xianfeng Xu, Yuan Xie, Yingjia Chen, Wenxin Luo, Pan Tang, Xin Wang, Lingfeng Bi, Linnan Gong, Zhe Li, Congcong Chen, Kai Wang, Songwei Guo, Zihuan Zhao, Jun Xiang, Meng Zhu, Yue Jiang, Yuanlin He, Juncheng Dai, Rong Yin, Cheng Wang, Zhibin Hu, Hongxia Ma, Weimin Li, Hongbing Shen
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-1799
Published: 06 June 2025
View articletitled, Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
Open the PDF for Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients in another window
Includes: Supplementary data
Journal Articles

Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer

Open Access
Yanyun Lin, Yanhong Zhang, Tianze Huang, Junguo Chen, Guanman Li, Bin Zhang, Liang Xu, Kai Wang, Hui He, Hao Chen, Danling Liu, Shuang Guo, Xiaosheng He, Ping Lan
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1663–1679.
https://doi.org/10.1158/0008-5472.CAN-24-1940
Published: 02 May 2025
View articletitled, Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer
Open the PDF for Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB413: Analysis of multimodal real world data from 1,248 breast cancer patients reveals distinct, novel consensus molecular segments associated with CDK4/6 inhibitor resistance

Free
Sahil Seth, Ha Dang, Matthew Ware, Milad R. Vahid, Chunan Liu, William Ashworth, Brendan O’Brien, Ana Lako, Rachel Webster, Micaela Tatman, Kwok-Kin Wong, Jiehui Deng, Nancy Chan, Alfonso Lopez, Kai Wang, Neil Bence, Rupal Bhatt, Gonzalo Lopez, Wei Zhang, Vipin Yadav, Konstantinos J. Mavrakis, Jason R. Dobson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB413.
https://doi.org/10.1158/1538-7445.AM2025-LB413
Published: 25 April 2025
View articletitled, Abstract LB413: Analysis of multimodal real world data from 1,248 breast cancer patients reveals distinct, novel consensus molecular segments associated with CDK4/6 inhibitor resistance
Journal Articles

Abstract 5329: Development of a novel selective CDK4 inhibitor for HR+/HER2- breast cancer

Free
Mei Hua Li, Apeng Liang, Kai Wang, Yi Long, Rui Wu, Hui Xu, Jian Zhu, Guangbin Liu, Ling Fang, Xi Wang, Chenjie Pan, Yiming Cai, Xiang Zhang, Shengli Dong, Yu Yu, Xinlong Yang, Chao Zhou, Wei Wu, Chengshan Niu, Mingyu Jiang, Shaoqing Chen, Jun Li, Yusheng Wu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5329.
https://doi.org/10.1158/1538-7445.AM2025-5329
Published: 21 April 2025
View articletitled, Abstract 5329: Development of a novel selective CDK4 inhibitor for HR+/HER2- breast cancer
Journal Articles

Abstract 3650: AI-based MTB assistant in cancer personalized treatment: Analysis from a real-world, multi-center retrospective study

Free
Minghui Wang, Yanhong Shang, Zhengang Yuan, Xin Huang, Qing Hao, Shaohua Yuan, Guobang Shi, Hui Chen, Wenjin Liu, Lili Wang, Shiwang Wen, Huilai Lv, Zhizheng Wang, Dong You, Yang Liu, Fei Pang, Wei Rao, Haitao Wang, Leilei Lu, Kai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3650.
https://doi.org/10.1158/1538-7445.AM2025-3650
Published: 21 April 2025
View articletitled, Abstract 3650: AI-based MTB assistant in cancer personalized treatment: Analysis from a real-world, multi-center retrospective study
Journal Articles

Abstract 1253: Single-cell analysis reveals intricate subclonal heterogeneity and evolution in response to standard of care treatments in glioblastoma

Free
Yueshan Zhao, Xiaoyu Lu, Verah Nyarige, Junfei Zhao, Gonzalo Lopez, Ann Forslund, Maria Ortiz-Estevez, Jorge Benitez-Hernandez, Wei Zhang, Celia Fontanillo, Kai Wang, Ha Dang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1253.
https://doi.org/10.1158/1538-7445.AM2025-1253
Published: 21 April 2025
View articletitled, Abstract 1253: Single-cell analysis reveals intricate subclonal heterogeneity and evolution in response to standard of care treatments in glioblastoma
Journal Articles

Abstract 821: A potent CDK7 inhibitor TY-2699a suppresses palbociclib-resistant breast cancer and has the potential for combination with chemotherapy or immunotherapy in solid tumors

Free
Shengli Dong, Apeng Liang, Shaoqing Chen, Zhengfei Guo, Jian Zhu, Huan Wang, Jing-Lan Mu, Yakun Qi, Meihua Li, Kai Wang, Hongqiang Li, Xinlong Yang, Chao Zhou, Zhiyong He, Zhengzhou, Henan Niu, Mingyu Jiang, Xiugui Chen, Jun Li, Yusheng Wu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 821.
https://doi.org/10.1158/1538-7445.AM2025-821
Published: 21 April 2025
View articletitled, Abstract 821: A potent CDK7 inhibitor TY-2699a suppresses palbociclib-resistant breast cancer and has the potential for combination with chemotherapy or immunotherapy in solid tumors
Journal Articles

Abstract 1364: Low density lipoprotein cholesterol modulates anti-tumor activity of NK cells within NSCLC tumor microenvironment

Free
Ying Yang, Kai Wang, Andreas Lundqvist
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1364.
https://doi.org/10.1158/1538-7445.AM2025-1364
Published: 21 April 2025
View articletitled, Abstract 1364: Low density lipoprotein cholesterol modulates anti-tumor activity of NK cells within NSCLC tumor microenvironment
Journal Articles

Abstract 4626: A machine learning model for predicting hyperprogressive disease risk in cancer immunotherapy: Integrating clinical and molecular data

Free
Haitao Wang, Lili Wang, Yu Zhang, Hongzheng Li, Nan Li, Qijie Jian, Yaxian Wang, Zhijian Song, Fei Pang, Kai Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4626.
https://doi.org/10.1158/1538-7445.AM2025-4626
Published: 21 April 2025
View articletitled, Abstract 4626: A machine learning model for predicting hyperprogressive disease risk in cancer immunotherapy: Integrating clinical and molecular data
Journal Articles

Abstract 4870: Defining metabolically healthy and unhealthy obesity in relation to cancer risk: A prospective cohort study by using a machine learning approach in comparison with conventional definitions in the UK Biobank

Free
Ziyi Zhou, Solange Parra-Soto, Yujia Lu, Zhe Fang, Kai Wang, Alaina Bever, Liyuan Tao, Fanny Petermann-Rocha, Jirapitcha Boonpor, Naveed Sattar, Carlos Celis-Morales, Jill P. Pell, Frederick K. Ho, Mingyang Song
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4870.
https://doi.org/10.1158/1538-7445.AM2024-4870
Published: 22 March 2024
View articletitled, Abstract 4870: Defining metabolically healthy and unhealthy obesity in relation to cancer risk: A prospective cohort study by using a machine learning approach in comparison with conventional definitions in the UK Biobank
Journal Articles

Abstract 152: Exploring the impact of heat shock protein 90 on the antitumor efficacy and stemness in medulloblastoma cells

Free
Shu-Mei Chen, Hsieng-Yun Huang, Chien-Kai Wang, Yi-Yuan Yang, Sy-Jye Leu, Ying-Ying Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 152.
https://doi.org/10.1158/1538-7445.AM2024-152
Published: 22 March 2024
View articletitled, Abstract 152: Exploring the impact of heat shock protein 90 on the antitumor efficacy and stemness in medulloblastoma cells
Journal Articles

Abstract 1775: The profiling of MTAP homozygous deletion (MTAPhd) in a Chinese pan-cancer cohort

Free
Shuirong Zhang, Wenjin Liu, Mingmin Wang, Caiping Chen, Xiaowei Dong, Aodi Wang, Kai Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1775.
https://doi.org/10.1158/1538-7445.AM2024-1775
Published: 22 March 2024
View articletitled, Abstract 1775: The profiling of MTAP homozygous deletion (MTAPhd) in a Chinese pan-cancer cohort
Journal Articles

Abstract 2315: AI-enabled precision oncology era: Advanced and interactive interpretation of next-gneneration sequencing (NGS) reports

Free
Hui Chen, Zanmei Xu, Lijuan Chen, Mingmin Wang, Peng Zhang, Fei Pang, Kai Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2315.
https://doi.org/10.1158/1538-7445.AM2024-2315
Published: 22 March 2024
View articletitled, Abstract 2315: AI-enabled precision oncology era: Advanced and interactive interpretation of next-gneneration sequencing (NGS) reports
Journal Articles

Abstract 3548: OKAIN: A comprehensive oncology knowledgebase for the interpretation of clinically actionable alterations

Free
Zhenhua Yang, Mingmin Wang, Hongli Qin, Yanfei Yu, Yufeng Zheng, Ziang Li, Xinxiu Meng, Xiaowei Dong, Liwei Wang, Kai Wang, Aodi Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3548.
https://doi.org/10.1158/1538-7445.AM2024-3548
Published: 22 March 2024
View articletitled, Abstract 3548: OKAIN: A comprehensive oncology knowledgebase for the interpretation of clinically actionable alterations
Journal Articles

Abstract 5981: TY-2699a is a highly potent CDK7 inhibitor to abolish dysfunctional tumor cell cycle for clinical development

Free
Shengli Dong, Apeng Liang, Jian Zhu, Huan Wang, Meihua Li, Kai Wang, Rongzhen Ni, Haoyun Li, Yundi Cao, Linglin Xiao, Hongqiang Li, Yian Tu, Chao Zhou, Aishen Gong, Shuyi Xu, Hui Su, Chengshan Niu, Mingyu Jiang, Feng Xing, Xiugui Chen, Shaoqing Chen, Jun Li, Yusheng Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5981.
https://doi.org/10.1158/1538-7445.AM2023-5981
Published: 04 April 2023
View articletitled, Abstract 5981: TY-2699a is a highly potent CDK7 inhibitor to abolish dysfunctional tumor cell cycle for clinical development
Journal Articles

MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis

Open Access
Cheng-Kai Wang, Tzu-Jou Chen, Grace Y.T. Tan, Fang-Pei Chang, Samyuktha Sridharan, Chen-Hsin Albert Yu, Yen-Hou Chang, Yi-Jen Chen, Li-Tzu Cheng, Wendy W. Hwang-Verslues
Journal: Cancer Research
Cancer Res (2023) 83 (2): 251–263.
https://doi.org/10.1158/0008-5472.CAN-22-1159
Published: 18 January 2023
View articletitled, MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis
Open the PDF for MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract PR002: Development and validation of a risk prediction model for post-polypectomy colorectal cancer in 4 prospective US cohorts

Free
Markus Dines Knudsen, Liang Wang, Kai Wang, Georgios Polychronidis, Paula Berstad, Kana Wu, Xiaosheng He, Dong Hang, Zhe Fang, Shuji Ogino, Andrew T. Chan, Edward L. Giovannucci, Molin Wang, Mingyang Song
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): PR002.
https://doi.org/10.1158/1538-7445.CRC22-PR002
Published: 01 December 2022
View articletitled, Abstract PR002: Development and validation of a risk prediction model for post-polypectomy colorectal cancer in 4 prospective US cohorts
Journal Articles

Abstract 28: New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis

Free
Hongmei Zeng, Chen Yuan, Jakub Morze, Ruiying Fu, Kai Wang, Liang Wang, Feng Sun, John S. Ji, Edward L. Giovannucci, Mingyang Song
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 28.
https://doi.org/10.1158/1538-7445.AM2022-28
Published: 15 June 2022
View articletitled, Abstract 28: New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis
Journal Articles

Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)

Free
Shun Lu, Yiping Zhang, Guojun Zhang, Jianying Zhou, Shundong Cang, Ying Cheng, Gang Wu, Peiguo Cao, Dongqing Lv, Xiangming Jin, Hong Jian, Chengshui Chen, Guanming Jiang, Panwen Tian, Kai Wang, Hui Zhao, Gongyan Chen, Qun Chen, Cuimin Ding, Junquan Yang, Renhua Guo, Guoping Sun, Bin Wang, Liyan Jiang, Wu Zhuang, Zhe Liu, Jian Fang, Yunpeng Liu, Jian Zhang, Jun Chen, Yueyin Pan, Qitao Yu, Min Zhao, Jiuwei Cui, Dianming Li, Tienan Yi, Zhuang Yu, Yan Yang, Yan Zhang, Xiuyi Zhi, Yunchao Huang, Rong Wu, Liangan Chen, Aimin Zang, Lejie Cao, Qingshan Li, Xiaoling Li, Yong Song, Donglin Wang, Shucai Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT170.
https://doi.org/10.1158/1538-7445.AM2021-CT170
Published: 01 July 2021
View articletitled, Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)
Journal Articles

Abstract 2283: Validation & application of next-generation sequencing panel YuanSu S for gene rearrangements/fusions detection

Free
Jiacheng Cai, Feng Li, Haiyan Wu, Weifeng Wang, Qiuyue Pan, Lin Zhang, Kai Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2283.
https://doi.org/10.1158/1538-7445.AM2021-2283
Published: 01 July 2021
View articletitled, Abstract 2283: Validation & application of next-generation sequencing panel YuanSu S for gene rearrangements/fusions detection