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Kai Breuhahn
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Journal Articles

SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma

Shan Wan, Quan-Yao He, Yun Yang, Feng Liu, Xue Zhang, Xin Guo, Hui Niu, Yi Wang, Yi-Xuan Liu, Wen-Long Ye, Xiu-Ming Li, Xue-Mei ZhuanSun, Pu Sun, Xiao-Shun He, Guang Hu, Kai Breuhahn, Hua Zhao, Guo-Qiang Wu, Hua Wu
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1872–1888.
https://doi.org/10.1158/0008-5472.CAN-23-2889
Published: 04 June 2024
View article titled, SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis

Stefan Thomann, Sofia M.E. Weiler, Simone Marquard, Fabian Rose, Claudia R. Ball, Marcell Tóth, Teng Wei, Carsten Sticht, Sarah Fritzsche, Stephanie Roessler, Carolina De La Torre, Eduard Ryschich, Olga Ermakova, Carolin Mogler, Daniel Kazdal, Norbert Gretz, Hanno Glimm, Eugen Rempel, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2020) 80 (24): 5502–5514.
https://doi.org/10.1158/0008-5472.CAN-20-0242
Published: 15 December 2020
View article titled, YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis
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Includes: Supplementary data
Journal Articles

Abstract 3089: YAP and TAZ induce MCM protein expression to facilitate tumor-supporting properties in liver cancer

Maria Knaub, Sofia Weiler, Stefan Thomann, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3089.
https://doi.org/10.1158/1538-7445.AM2018-3089
Published: 01 July 2018
View article titled, Abstract 3089: YAP and TAZ induce MCM protein expression to facilitate tumor-supporting properties in liver cancer
Journal Articles

Abstract 2050: Tumor stage-dependent transcriptomic signatures of endothelial cells reveal an intense paracrine crosstalk in liver capillarization

Stefan Thomann, Sofia Weiler, Martin Dittmer, Daniel Kazdal, Simone Marquard, Stephanie Roessler, Carsten Sticht, Norbert Gretz, Carolin Mogler, Claudia Ball, Hanno Glimm, Eduard Ryschich, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2050.
https://doi.org/10.1158/1538-7445.AM2018-2050
Published: 01 July 2018
View article titled, Abstract 2050: Tumor stage-dependent transcriptomic signatures of endothelial cells reveal an intense paracrine crosstalk in liver capillarization
Journal Articles

Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma

Benita Wolf, Kathrin Krieg, Christine Falk, Kai Breuhahn, Hildegard Keppeler, Tilo Biedermann, Evi Schmid, Steven Warmann, Joerg Fuchs, Silvia Vetter, Dennis Thiele, Maike Nieser, Meltem Avci-Adali, Yulia Skokowa, Ludger Schöls, Stefan Hauser, Marc Ringelhan, Tetyana Yevsa, Mathias Heikenwalder, Uta Kossatz-Boehlert
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5550–5561.
https://doi.org/10.1158/0008-5472.CAN-15-3453
Published: 15 September 2016
View article titled, Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
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Includes: Supplementary data
Journal Articles

Abstract 1945: Identification of a miRNA/mRNA network driving non-small cell lung cancer (NSCLC) dissemination

Margarita González-Vallinas, Marco Albrecht, Adriana Pitea, Manuel Rodríguez-Paredes, Damian Stichel, Steffen Sass, Julian Gutekunst, Jennifer Schmitt, Thomas Muley, Michael Meister, Arne Warth, Peter Schirmacher, Fabian J. Theis, Nikola S. Müller, Franziska Matthäus, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1945.
https://doi.org/10.1158/1538-7445.AM2016-1945
Published: 15 July 2016
View article titled, Abstract 1945: Identification of a miRNA/mRNA network driving non-small cell lung cancer (NSCLC) dissemination
Journal Articles

Abstract 1130: Subcellular localization of the cell polarity protein Scribble defines its oncogenic activity in hepatocellular carcinoma

Shan Wan, Anne-Sophie Meyer, Sofia Weiler, Teresa Lutz, Stephanie Roessler, Peter Schirmacher, Federico Pinna, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1130.
https://doi.org/10.1158/1538-7445.AM2016-1130
Published: 15 July 2016
View article titled, Abstract 1130: Subcellular localization of the cell polarity protein Scribble defines its oncogenic activity in hepatocellular carcinoma
Journal Articles

Abstract A46: Cellular apoptosis susceptibility (CAS) regulates integrin-beta1 and is required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)

Juliane Winkler, Carsten Sticht, Amanda DiGuilio, Eva Maria Eiteneuer, Kerstin Holzer, Stephanie Rössler, Norbert Gretz, Kai Breuhahn, Peter Schirmacher, Alessandro Ori, Stephan Singer
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): A46.
https://doi.org/10.1158/1538-7445.FBCR15-A46
Published: 07 April 2016
View article titled, Abstract A46: Cellular apoptosis susceptibility (CAS) regulates integrin-beta1 and is required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)
Journal Articles

Abstract 2157: PI3K/AKT-induced stabilization of FUSE binding proteins (FBPs) in liver cancer cells

Jana Samarin, Ilan Stein, Elad Horwitz, Xin Chen, Mona Malz, Eli Pikarsky, Diego Calvisi, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2157.
https://doi.org/10.1158/1538-7445.AM2015-2157
Published: 01 August 2015
View article titled, Abstract 2157: PI3K/AKT-induced stabilization of FUSE binding proteins (FBPs) in liver cancer cells
Journal Articles

Abstract 4269: A gene signature defines chromosomal instability (CIN) and poor survival in liver cancer patients

Sofia Weiler, Thomas Wolf, Federico Pinna, Stephanie Roessler, Teresa Lutz, Shan Wan, Jens Marquardt, Hauke Lang, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4269.
https://doi.org/10.1158/1538-7445.AM2015-4269
Published: 01 August 2015
View article titled, Abstract 4269: A gene signature defines chromosomal instability (CIN) and poor survival in liver cancer patients
Journal Articles

Abstract 5235: A model for TNFα-mediated NFκB signalling: A systems biology study on hepatocytes and liver cancer cells.

Federico Pinna, Sven Sahle, Katharina Beuke, Michaela Bissinger, Selcan Tuncay, Lorenza D'Alessandro, Ralph Gauges, Andreas Raue, Jens Timmer, Ursula Klingmüller, Peter Schirmacher, Ursula Kummer, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5235.
https://doi.org/10.1158/1538-7445.AM2013-5235
Published: 15 April 2013
View article titled, Abstract 5235: A model for TNFα-mediated NFκB signalling: A systems biology study on hepatocytes and liver cancer cells.
Journal Articles

Abstract 1824: The non-coding RNA landscape of lung, liver and breast cancer reveals novel tumor-associated ncRNAs, concerted regulation and unexpected tissue specificity.

Maria Polycarpou-Schwarz, Tony Gutschner, Monika Hämmerle, Anna Roth, Ashish Goyal, Stefanie Grund, Catherina Hildenbrand, Arne Warth, Thomas Longerich, Sebastian Aulmann, Joachim Rom, Michael Meister, Thomas Muley, Heike Zabeck, Sabine Schmidt, Tomi Ivacevic, Vladimir Benes, Kai Breuhahn, Philipp Schnabel, Peter Sinn, Hans Hoffmann, Peter Schirmacher, Sven Diederichs
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1824.
https://doi.org/10.1158/1538-7445.AM2013-1824
Published: 15 April 2013
View article titled, Abstract 1824: The non-coding RNA landscape of lung, liver and breast cancer reveals novel tumor-associated ncRNAs, concerted regulation and unexpected tissue specificity.
Journal Articles

Abstract 1300: Far upstream element binding proteins (FBP)-1 and FBP-2 in non-small cell lung cancer: Key factors regulating tumor cell proliferation, migration, and invasion

Mona Malz, Michael Bovet, Jana Samarin, Esther Herpel, Arne Warth, Stephan Singer, Thomas Muley, Michael Meister, Hans Hoffmann, Philipp Schnabel, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1300.
https://doi.org/10.1158/1538-7445.AM2012-1300
Published: 15 April 2012
View article titled, Abstract 1300: Far upstream element binding proteins (FBP)-1 and FBP-2 in non-small cell lung cancer: Key factors regulating tumor cell proliferation, migration, and invasion
Journal Articles

Abstract 984: High-level expression of YAP induces protumorigenic Notch signalling in human hepatocarcinogenesis

Darjus F. Tschaharganeh, Xin Chen Chen, Philipp Latzko, Mona Malz, Matthias Gaida, Klaus Felix, Stephan Singer, Federico Pinna, Norbert Gretz, Carsten Sticht, Salvatore Delogu, Matthias Evert, Fan Biao, Silvia Ribback, Lijie Jiang, Stefania Brozzetti, Frank Bergmann, Frank Dombrowski, Peter Schirmacher, Diego F. Calvisi, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 984.
https://doi.org/10.1158/1538-7445.AM2012-984
Published: 15 April 2012
View article titled, Abstract 984: High-level expression of YAP induces protumorigenic Notch signalling in human hepatocarcinogenesis
Journal Articles

Abstract #5317: FIR-induced elevated FBP-1 levels regulate the expression of microtubule-interacting factors in human carcinogenesis

Mona Malz, Stephan Singer, Achim Weber, Marc-Oliver Riener, Christopher Soll, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5317.
Published: 01 May 2009
View article titled, Abstract #5317: FIR-induced elevated FBP-1 levels regulate the expression of microtubule-interacting factors in human carcinogenesis
Journal Articles

Coordinated Expression of Stathmin Family Members by Far Upstream Sequence Element-Binding Protein-1 Increases Motility in Non–Small Cell Lung Cancer

Stephan Singer, Mona Malz, Esther Herpel, Arne Warth, Michaela Bissinger, Martina Keith, Thomas Muley, Michael Meister, Hans Hoffmann, Roland Penzel, Georg Gdynia, Volker Ehemann, Philipp Albert Schnabel, Ruprecht Kuner, Peter Huber, Peter Schirmacher, Kai Breuhahn
Journal: Cancer Research
Cancer Res (2009) 69 (6): 2234–2243.
https://doi.org/10.1158/0008-5472.CAN-08-3338
Published: 17 March 2009
View article titled, Coordinated Expression of Stathmin Family Members by Far Upstream Sequence Element-Binding Protein-1 Increases Motility in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Kallikrein 6 Induces E-Cadherin Shedding and Promotes Cell Proliferation, Migration, and Invasion

Britta Klucky, Regina Mueller, Ingeborg Vogt, Sibylle Teurich, Bettina Hartenstein, Kai Breuhahn, Christa Flechtenmacher, Peter Angel, Jochen Hess
Journal: Cancer Research
Cancer Res (2007) 67 (17): 8198–8206.
https://doi.org/10.1158/0008-5472.CAN-07-0607
Published: 05 September 2007
View article titled, Kallikrein 6 Induces E-Cadherin Shedding and Promotes Cell Proliferation, Migration, and Invasion
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Includes: Supplementary data
Journal Articles

Cyclooxygenase-2 Inhibition Induces Apoptosis Signaling via Death Receptors and Mitochondria in Hepatocellular Carcinoma

Michael A. Kern, Anke M. Haugg, Andreas F. Koch, Tobias Schilling, Kai Breuhahn, Henning Walczak, Binje Fleischer, Christian Trautwein, Christoph Michalski, Henning Schulze-Bergkamen, Helmut Friess, Wolfgang Stremmel, Peter H. Krammer, Peter Schirmacher, Martina Müller
Journal: Cancer Research
Cancer Res (2006) 66 (14): 7059–7066.
https://doi.org/10.1158/0008-5472.CAN-06-0325
Published: 18 July 2006
View article titled, Cyclooxygenase-2 Inhibition Induces Apoptosis Signaling via Death Receptors and Mitochondria in Hepatocellular Carcinoma
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Journal Articles

Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression

Kai Breuhahn, Sebastian Vreden, Ramsi Haddad, Susanne Beckebaum, Dirk Stippel, Peer Flemming, Tanja Nussbaum, Wolfgang H. Caselmann, Brian B. Haab, Peter Schirmacher
Journal: Cancer Research
Cancer Res (2004) 64 (17): 6058–6064.
https://doi.org/10.1158/0008-5472.CAN-04-0292
Published: 01 September 2004
View article titled, Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression
Open the PDF for Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression in another window
Journal Articles

Induction of epithelial cellular adhesion molecule (Ep-CAM) in chronic necroinflammatory liver diseases and hepatocellular carcinoma

Malte Peters, Kai Breuhahn, Katarina Petmecky, Ulrich Töx, Per Gjorstrup, Peter Schirmacher
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1138.
Published: 01 April 2004
View article titled, Induction of epithelial cellular adhesion molecule (Ep-CAM) in chronic necroinflammatory liver diseases and hepatocellular carcinoma