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Justus Duyster
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Journal Articles

Abstract PR009: Decitabine/venetoclax reduced-toxicity induction: a very effective bridge-to-transplant in older AML patients with non-favorable genetics

Free
Michael Lübbert, David Alber, Christoph Rummelt, Francesca Biavasco, Gabriele Ihorst, Reinhard Marks, Justus Duyster, Ralph Wäsch, Claudia Wehr, Jürgen Finke
Journal: Cancer Research
Cancer Res (2025) 85 (3_Supplement): PR009.
https://doi.org/10.1158/1538-7445.DNAMETHYLATION-PR009
Published: 01 February 2025
View article titled, Abstract PR009: Decitabine/venetoclax reduced-toxicity induction: a very effective bridge-to-transplant in older AML patients with non-favorable genetics
Journal Articles

Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment

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Dominik Schmidt, Cornelia Endres, Rouven Hoefflin, Geoffroy Andrieux, Melissa Zwick, Nikolaos Karantzelis, Hans F. Staehle, Janaki Manoja Vinnakota, Sandra Duquesne, Miriam Mozaffari Jovein, Dietmar Pfeifer, Heiko Becker, Bruce R. Blazar, Alexander Zähringer, Justus Duyster, Tilman Brummer, Melanie Boerries, Julian Baumeister, Khalid Shoumariyeh, Juan Li, Anthony R. Green, Florian H. Heidel, Itay Tirosh, Heike L. Pahl, Nils Leimkühler, Natalie Köhler, Marcelo A.S. de Toledo, Steffen Koschmieder, Robert Zeiser
Journal: Cancer Research
Cancer Res (2024) 84 (18): 2985–3003.
https://doi.org/10.1158/0008-5472.CAN-23-3553
Published: 16 September 2024
View article titled, Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 4497: Efficacy of Jak1/2 inhibition in murine myeloproliferative neoplasms is mediated by targeting nonmalignant cells

Free
Sivahari Prasad Gorantla, Michael Rassner Rassner, Tony Andreas Müller, Teresa Poggio, Kirstyn Anne Crossley, Anna-Lena Denecke, Kornelia R Fritsch, Geoffroy Andrieux, Helen Kleinfelder, Shifa Khaja Saleem, Sudheer Madan Mohan Gambheer, Irene Gonzalez Menendez, Detlef Bentrop, Rainer Trittler, Svetlana Rylova, Dietmar Pfeifer, Leticia Quintanilla Martinez, Christine Dierks, Robert Zeiser, Anna Lena Illert, Nikolas von Bubnoff, Justus Duyster
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4497.
https://doi.org/10.1158/1538-7445.AM2023-4497
Published: 04 April 2023
View article titled, Abstract 4497: Efficacy of Jak1/2 inhibition in murine myeloproliferative neoplasms is mediated by targeting nonmalignant cells
Journal Articles

CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia

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Jesús Duque-Afonso, Chiou-Hong Lin, Kyuho Han, David W. Morgens, Edwin E. Jeng, Ziming Weng, Johan Jeong, Stephen Hon Kit Wong, Li Zhu, Michael C. Wei, Hee-Don Chae, Martin Schrappe, Gunnar Cario, Justus Duyster, Xiangshu Xiao, Kathleen M. Sakamoto, Michael C. Bassik, Michael L. Cleary
Journal: Cancer Research
Cancer Res (2018) 78 (22): 6497–6508.
https://doi.org/10.1158/0008-5472.CAN-18-1703
Published: 15 November 2018
View article titled, CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Abstract 1887: Targeting oncoprotein stability overcomes lapatinib-resistance due to ERBB2 kinase domain mutations

Free
Rama Krishna Kancha, Franziska Blaeschke, Natalie Bartosch, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1887.
https://doi.org/10.1158/1538-7445.AM2012-1887
Published: 15 April 2012
View article titled, Abstract 1887: Targeting oncoprotein stability overcomes lapatinib-resistance due to ERBB2 kinase domain mutations
Journal Articles

ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer

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Anja Baumgart, Stefan Seidl, Petros Vlachou, Lars Michel, Nadya Mitova, Nicole Schatz, Katja Specht, Ina Koch, Tibor Schuster, Rebekka Grundler, Marcus Kremer, Falko Fend, Jens T. Siveke, Christian Peschel, Justus Duyster, Tobias Dechow
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5368–5378.
https://doi.org/10.1158/0008-5472.CAN-09-3763
Published: 30 June 2010
View article titled, ADAM17 Regulates Epidermal Growth Factor Receptor Expression through the Activation of Notch1 in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract 19: Identification of a novel mode of kinase inhibitor resistance: An F604S exchange in FIP1L1-PDGFRA modulates FIP1L1-PDGFRA protein stability in a SHP-2 and SRC-dependent manner

Free
Gorantla P. Sivahari, Nikolas Von Bubnoff, Ana Lena Illert, Nicolas Schneider, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 19.
https://doi.org/10.1158/1538-7445.AM10-19
Published: 15 April 2010
View article titled, Abstract 19: Identification of a novel mode of kinase inhibitor resistance: An F604S exchange in FIP1L1-PDGFRA modulates FIP1L1-PDGFRA protein stability in a SHP-2 and SRC-dependent manner
Journal Articles

Abstract 4433: A Phase I study of two dosing regimens of oral AS703569, an inhibitor of aurora kinase and other kinases, in patients with hematologic malignancies

Free
Carlos Graux, Anne Sonet, Johan Maertens, Justus Duyster, Jochen Greiner, Yves Chalandon, Giovanni Martinelli, Dagmar Hess, Dominik Heim, Frank J. Giles, Athos Gianella-Borradori, Blandine Longerey, Narmyn Rejeb, Oliver G. Ottmann
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4433.
https://doi.org/10.1158/1538-7445.AM10-4433
Published: 15 April 2010
View article titled, Abstract 4433: A Phase I study of two dosing regimens of oral AS703569, an inhibitor of aurora kinase and other kinases, in patients with hematologic malignancies
Journal Articles

Abstract #1766: Study of transforming potential and drug sensitivity of ErbB2 variants identifies lapatinib-resistant kinase domain mutations

Free
Ramakrishna Kancha, Nikolas Bubnoff, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1766.
Published: 01 May 2009
View article titled, Abstract #1766: Study of transforming potential and drug sensitivity of ErbB2 variants identifies lapatinib-resistant kinase domain mutations
Journal Articles

FMS-Like Tyrosine Kinase 3–Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro

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Nikolas von Bubnoff, Richard A. Engh, Espen Åberg, Jana Sänger, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2009) 69 (7): 3032–3041.
https://doi.org/10.1158/0008-5472.CAN-08-2923
Published: 01 April 2009
View article titled, FMS-Like Tyrosine Kinase 3–Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro
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Includes: Supplementary data
Journal Articles

Enhanced Activation of Epidermal Growth Factor Receptor Caused by Tumor-Derived E-Cadherin Mutations

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Anja Bremm, Axel Walch, Margit Fuchs, Jörg Mages, Justus Duyster, Gisela Keller, Christine Hermannstädter, Karl-Friedrich Becker, Sandra Rauser, Rupert Langer, Claus Hann von Weyhern, Heinz Höfler, Birgit Luber
Journal: Cancer Research
Cancer Res (2008) 68 (3): 707–714.
https://doi.org/10.1158/0008-5472.CAN-07-1588
Published: 01 February 2008
View article titled, Enhanced Activation of Epidermal Growth Factor Receptor Caused by Tumor-Derived E-Cadherin Mutations
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Includes: Supplementary data
Journal Articles

Differential effect of gefitinib and erlotinib on epidermal growth factor receptor mutations observed in NSCLC

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Rama Kancha, Nikolas Bubnoff, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4019.
Published: 01 May 2007
View article titled, Differential effect of gefitinib and erlotinib on epidermal growth factor receptor mutations observed in NSCLC
Journal Articles

Targeting PIM Kinases Impairs Survival of Hematopoietic Cells Transformed by Kinase Inhibitor–Sensitive and Kinase Inhibitor–Resistant Forms of Fms-Like Tyrosine Kinase 3 and BCR/ABL

Free
Myriam Adam, Vanda Pogacic, Marina Bendit, Richard Chappuis, Martijn C. Nawijn, Justus Duyster, Casey J. Fox, Craig B. Thompson, Jan Cools, Juerg Schwaller
Journal: Cancer Research
Cancer Res (2006) 66 (7): 3828–3835.
https://doi.org/10.1158/0008-5472.CAN-05-2309
Published: 03 April 2006
View article titled, Targeting PIM Kinases Impairs Survival of Hematopoietic Cells Transformed by Kinase Inhibitor–Sensitive and Kinase Inhibitor–Resistant Forms of Fms-Like Tyrosine Kinase 3 and BCR/ABL
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Journal Articles

A cell-based screening strategy predicts Bcr-Abl mutations that cause resistance toward the second-generation Abl kinase inhibitor AMN107

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Nikolas Von Bubnoff, Paul Manley, Doriano Fabbro, Jana Sanger, Christian Peschel, Justus Duyster
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1408.
Published: 01 May 2005
View article titled, A cell-based screening strategy predicts Bcr-Abl mutations that cause resistance toward the second-generation Abl kinase inhibitor AMN107
Journal Articles

Activity and induction of apoptosis of the tyrosine kinase inhibitor AMN107 in bcr-abl + cell lines and in imatinib resistant primary cells from CML patients

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Philipp Le Coutre, Gökben Baskaynak, Ingo Tamm, Jörg Westermann, Justus Duyster, Malte Von Bonin, Stefan Pursche, Petra Mayer, Paul Manley, Jürgen Mestan, Eberhard Schleyer, Bernd Dörken
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1408–1409.
Published: 01 May 2005
View article titled, Activity and induction of apoptosis of the tyrosine kinase inhibitor AMN107 in bcr-abl + cell lines and in imatinib resistant primary cells from CML patients
Journal Articles

Inhibition of Wild-Type and Mutant Bcr-Abl by Pyrido-Pyrimidine-Type Small Molecule Kinase Inhibitors

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Nikolas von Bubnoff, Darren R. Veach, W. Todd Miller, Wanqing Li, Jana Sänger, Christian Peschel, William G. Bornmann, Bayard Clarkson, Justus Duyster
Journal: Cancer Research
Cancer Res (2003) 63 (19): 6395–6404.
Published: 14 October 2003
View article titled, Inhibition of Wild-Type and Mutant Bcr-Abl by Pyrido-Pyrimidine-Type Small Molecule Kinase Inhibitors
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