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Journal Articles

Abstract 1481: Targeting DNA damage responsive pathways in cancer therapy

Junjie Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1481.
https://doi.org/10.1158/1538-7445.AM2025-1481
Published: 21 April 2025
View articletitled, Abstract 1481: Targeting DNA damage responsive pathways in cancer therapy
Journal Articles

Abstract B008: Targeting DNA damage responsive pathways in cancer therapy

Junjie Chen
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): B008.
https://doi.org/10.1158/1538-7445.GENFUNC25-B008
Published: 11 March 2025
View articletitled, Abstract B008: Targeting DNA damage responsive pathways in cancer therapy
Journal Articles

Abstract PO2-24-03: Soluble E-cadherin promotes inflammatory breast cancer tumorigenesis via PDIA4-mediated suppression of ferroptosis

Xiaoding Hu, Yun Xiong, Emilly Villodre, Juhee Song, Debu Tripathy, Wendy Woodward, Savitri Krishnamurthy, Junjie Chen, Bisrat Debeb
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-24-03.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-24-03
Published: 02 May 2024
View articletitled, Abstract PO2-24-03: Soluble E-cadherin promotes inflammatory breast cancer tumorigenesis via PDIA4-mediated suppression of ferroptosis
Journal Articles

Abstract A035: Checkpoint is the control mechanism to ensure the strict order of cellular events during cell cycle. Here, we show that cells enter mitosis without completing DNA replication although with transient activation of known ATR/Chk1 checkpoint

Min Huang, Junjie Chen
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): A035.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-A035
Published: 09 January 2024
View articletitled, Abstract A035: Checkpoint is the control mechanism to ensure the strict order of cellular events during cell cycle. Here, we show that cells enter mitosis without completing DNA replication although with transient activation of known ATR/Chk1 checkpoint
Journal Articles

Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response

Mei Zhao, Tianxiao Wang, Frederico O. Gleber-Netto, Zhen Chen, Daniel J. McGrail, Javier A. Gomez, Wutong Ju, Mayur A. Gadhikar, Wencai Ma, Li Shen, Ximing Tang, Sen Pathak, Maria G. Raso, Jared Burks, Shiaw-Yih Lin, Jing Wang, Asha S. Multani, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2585.
https://doi.org/10.1158/1538-7445.AM2023-2585
Published: 04 April 2023
View articletitled, Abstract 2585: Mutant p53 gains oncogenic functions through a cytosolic DNA response
Journal Articles

Abstract 6189: Targeting DNA damage responsive pathways in cancer therapy

Junjie Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6189.
https://doi.org/10.1158/1538-7445.AM2023-6189
Published: 04 April 2023
View articletitled, Abstract 6189: Targeting DNA damage responsive pathways in cancer therapy
Journal Articles

Abstract 6098: Genome wide CRISPR screen reveals genetic vulnerabilities of next generation PARP1 inhibitor AZD5305

Ling Yin, Junjie Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6098.
https://doi.org/10.1158/1538-7445.AM2023-6098
Published: 04 April 2023
View articletitled, Abstract 6098: Genome wide CRISPR screen reveals genetic vulnerabilities of next generation PARP1 inhibitor AZD5305
Journal Articles

Abstract GS5-08: Soluble E-cadherin: a novel prognostic biomarker and driver of brain metastasis in inflammatory breast cancer

Xiaoding Hu, Yun Xiong, Emilly S. Villodre, Juhee Song, Ganiraju C Manyam, Moises J Tacam, Jing Wang, Chandra Bartholomeusz, Debu Tripathy, Naoto T. Ueno, Wendy Woodward, Savitri Krishnamurthy, Junjie Chen, Bisrat Debeb
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): GS5-08.
https://doi.org/10.1158/1538-7445.SABCS22-GS5-08
Published: 01 March 2023
View articletitled, Abstract GS5-08: Soluble E-cadherin: a novel prognostic biomarker and driver of brain metastasis in inflammatory breast cancer
Journal Articles

Abstract HER2-01: HER2-01 Clinical and Molecular Characteristics of HER2-low/zero Early Stage Triple-Negative Breast Cancer

Clinton Yam, Ziyi Li, Anil Korkut, Wencai Ma, Elisabeth Kong, Holly A. Hill, Hussein Abbas, Sausan Abouharb, Beatriz Adrada, Banu K. Arun, Carlos H. Barcenas, Ajit Bisen, Daniel Booser, Aman Buzdar, Rosalind Candelaria, Junjie Chen, Alyson Clayborn, Senthil Damodaran, Qingqing Ding, Haven Garber, Gabriel N. Hortobagyi, Kelly K. Hunt, Nuhad K. Ibrahim, Adaeze Iheme, Meghan S. Karuturi, Kimberly Koenig, Rachel M. Layman, Jangsoon Lee, Jennifer K. Litton, Melissa Mitchell, Giancarlo Moscol, Jason Mouabbi, Rashmi K. Murthy, Oluchi Oke, Paula Pohlmann, David Ramirez, Elizabeth Ravenberg, Sadia Saleem, Mediget Teshome, Vicente Valero, Jason White, Madison Williams, Wendy Woodward, Chasity Yajima, Naoto T. Ueno, Ken Chen, Gaiane Rauch, Lei Huo, Debu Tripathy
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): HER2-01.
https://doi.org/10.1158/1538-7445.SABCS22-HER2-01
Published: 01 March 2023
View articletitled, Abstract HER2-01: HER2-01 Clinical and Molecular Characteristics of HER2-low/zero Early Stage Triple-Negative Breast Cancer
Journal Articles

CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2

Haoyan Li, Yin Wang, Kevin Lin, Varadha Balaji Venkadakrishnan, Martin Bakht, Wei Shi, Chenling Meng, Jie Zhang, Kaitlyn Tremble, Xin Liang, Jian H. Song, Xu Feng, Vivien Van, Pingna Deng, Jared K. Burks, Ana Aparicio, Khandan Keyomarsi, Junjie Chen, Yue Lu, Himisha Beltran, Di Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3088–3101.
https://doi.org/10.1158/0008-5472.CAN-22-0631
Published: 02 September 2022
View articletitled, CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2
Open the PDF for CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2 in another window
Includes: Supplementary data
Journal Articles

Abstract P5-08-15: Overcoming mTOR inhibitor resistance by targeting the lysosomal deregulation

Shengzhe Zhang, Sung Ho Lee, Litong Nie, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther M Lien, Junjie Chen, Jae-Il Park
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-08-15.
https://doi.org/10.1158/1538-7445.SABCS21-P5-08-15
Published: 15 February 2022
View articletitled, Abstract P5-08-15: Overcoming mTOR inhibitor resistance by targeting the lysosomal deregulation
Journal Articles

Abstract 5289: Gain-of-function mutant p53 predisposes head and neck keratinocytes and squamous cell carcinoma cells to replicative stress and genomic instability through minichromosome maintenance complex component 5

Mei Zhao, Tianxiao Wang, Chen Zhen, Jing Wang, Curtis R. Pickering, Junjie Chen, Jeffrey N. Myers, Ge Zhou
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5289.
https://doi.org/10.1158/1538-7445.AM2019-5289
Published: 01 July 2019
View articletitled, Abstract 5289: Gain-of-function mutant p53 predisposes head and neck keratinocytes and squamous cell carcinoma cells to replicative stress and genomic instability through minichromosome maintenance complex component 5
Journal Articles

Abstract 4473: Tumorigenesis by deregulation of CRAD-controlled cytoskeleton dynamics

Youn-Sang Jung, Wenqi Wang, Sohee Jun, Jie Zhang, Mrianl Srivastava, Moon Jong Kim, Esther M. Lien, Joan Shang, Pierre D. McCrea, Songlin Zhang, Junjie Chen, Jae-Il Park
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4473.
https://doi.org/10.1158/1538-7445.AM2018-4473
Published: 01 July 2018
View articletitled, Abstract 4473: Tumorigenesis by deregulation of CRAD-controlled cytoskeleton dynamics
Journal Articles

Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects

Li Wang, Peijing Zhang, David Molkentine, Jessica Molkentine, Uma Raju, David Valdecanas, Ramesh Tailor, Howard Thames, Thomas Buchholz, Junjie Chen, Li Ma, Kathy Mason, Raymond Meyn, Heath D. Skinner
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1661.
https://doi.org/10.1158/1538-7445.AM2016-1661
Published: 15 July 2016
View articletitled, Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects
Journal Articles

Abstract 3594: The TGF-β effector β2SP depletion abrogates DNA damage repair

Jian Chen, Vivek Shukla, Jiun-Sheng Chen, Raj K. Panditab, Yun Seong Jeong, Lior H Katz, Ji-Hyun Shin, YoungJin Gi, Lawrence N. Kwongc, Clayton R. Huntb, Patrizia Farci, Xiaoping Su, Jon White, Bibhuti Mishra, Asif Rashid, Milind Javle, Lei Li, Junjie Chen, John R Stroehlein, Marta Davila, Rehan Akbani, Keigo Machidao, Hidekazu Tsukamoto, Tej K. Pandita, Lopa Mishra
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3594.
https://doi.org/10.1158/1538-7445.AM2016-3594
Published: 15 July 2016
View articletitled, Abstract 3594: The TGF-β effector β2SP depletion abrogates DNA damage repair
Journal Articles

Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis

Alexey V. Sorokin, Binoj C. Nair, Yongkun Wei, Kathryn E. Aziz, Valentina Evdokimova, Mien-Chie Hung, Junjie Chen
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1846–1858.
https://doi.org/10.1158/0008-5472.CAN-14-2718
Published: 30 April 2015
View articletitled, Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis
Open the PDF for Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis in another window
Includes: Supplementary data
Journal Articles

Abstract 4895: P16INK4A, a surrogate marker of HPV infection and prognosis for head and neck cancer, delays DNA damage repair and enhances radiation response

Li Wang, Peijing Zhang, David P Molkentine, Hailong Piao, Chunyan Chen, Jessica M Molkentine, Jinsong Zhang, David R Valdecanas, Heath Skinner, Thomas A Buchholz, Junjie Chen, Li Ma, Kathy A Mason, Kie-kian Ang, Raymond E Meyn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4895.
https://doi.org/10.1158/1538-7445.AM2014-4895
Published: 01 October 2014
View articletitled, Abstract 4895: P16INK4A, a surrogate marker of HPV infection and prognosis for head and neck cancer, delays DNA damage repair and enhances radiation response
Journal Articles

Abstract 1775: High resolution characterization of human hepatocellular cancer (HCC) reveals a novel inactivating mutation in the TGF-β pathway that promotes alcohol induced HCC.

Vivek Shukla, Jian Chen, Jiun-Sheng Chen, Ying Li, Lior Katz, Avijit Majumdar, Lei Li, Walter Hittleman, Xiaoping Su, Junjie Chen, Xifeng Wu, Patrizia Farci, Lopa Mishra
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1775.
https://doi.org/10.1158/1538-7445.AM2013-1775
Published: 15 April 2013
View articletitled, Abstract 1775: High resolution characterization of human hepatocellular cancer (HCC) reveals a novel inactivating mutation in the TGF-β pathway that promotes alcohol induced HCC.
Journal Articles

Abstract 620: Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex.

Jingsong Yuan, Junjie Chen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 620.
https://doi.org/10.1158/1538-7445.AM2013-620
Published: 15 April 2013
View articletitled, Abstract 620: Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex.
Journal Articles

PNUTS Functions as a Proto-Oncogene by Sequestering PTEN

Sridhar Kavela, Swapnil R. Shinde, Raman Ratheesh, Kotapalli Viswakalyan, Murali D. Bashyam, Swarnalata Gowrishankar, Mohana Vamsy, Sujit Pattnaik, Subramanyeshwar Rao, Regulagadda A. Sastry, Mukta Srinivasulu, Junjie Chen, Subbareddy Maddika
Journal: Cancer Research
Cancer Res (2013) 73 (1): 205–214.
https://doi.org/10.1158/0008-5472.CAN-12-1394
Published: 01 January 2013
View articletitled, PNUTS Functions as a Proto-Oncogene by Sequestering PTEN
Open the PDF for PNUTS Functions as a Proto-Oncogene by Sequestering PTEN in another window
Includes: Supplementary data