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Journal Articles

Abstract 2162: A potent and highly selective HPK1 inhibitor as a combination strategy to improve the clinical response of the immune checkpoint inhibitor

Free
Joonseok Byun, Jong Hyun Lee, Seungjin Jo, Doyoung Kim, Hyunwoo Shin, Jong Ryoul Choi, Seunghee Ji, Hye-Jung Kim, Donghyun Kim, Bong Tae Kim
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2162.
https://doi.org/10.1158/1538-7445.AM2025-2162
Published: 21 April 2025
View article titled, Abstract 2162: A potent and highly selective HPK1 inhibitor as a combination strategy to improve the clinical response of the immune checkpoint inhibitor
Journal Articles

Abstract 4305: Targeting the exonuclease domain of POLE to induce synthetic lethality in highly aneuploidic tumor cells

Free
Meng He, Eun Jung Kim, Yangmeng Wang, Alejandro Chibly, Kristel Dorighi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4305.
https://doi.org/10.1158/1538-7445.AM2025-4305
Published: 21 April 2025
View article titled, Abstract 4305: Targeting the exonuclease domain of POLE to induce synthetic lethality in highly aneuploidic tumor cells
Journal Articles

Abstract 5406: Evaluation of antitumor effects of plogosertib, PLK1 inhibitor in biliary tract cancer with BUBR1 as a potential biomarker

Free
Yoojin Jeong, Ah-Rong Nam, Kyoung-Seok Oh, Jae-Min Kim, Ju-Hee Bang, Sea Young Choo, Hyo Jung Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5406.
https://doi.org/10.1158/1538-7445.AM2025-5406
Published: 21 April 2025
View article titled, Abstract 5406: Evaluation of antitumor effects of plogosertib, PLK1 inhibitor in biliary tract cancer with BUBR1 as a potential biomarker
Journal Articles

Abstract 7430: Multicenter study on an artificial intelligence model for predicting NSCLC recurrence

Free
Junho Lee, Daehwan Lee, Kiwon Lee, Ho Yun Lee, Tae Jung Kim, Yeong Jeong Jeon, Junghee Lee, Seong Yong Park, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Hyun Ae Jung
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7430.
https://doi.org/10.1158/1538-7445.AM2025-7430
Published: 21 April 2025
View article titled, Abstract 7430: Multicenter study on an artificial intelligence model for predicting NSCLC recurrence
Journal Articles

Abstract 6766: Tetraarsenic hexoxide augments the anticancer effects of Artemisia annua polyphenols on both naive and oxaliplatin-resistant HCT116 colorectal cancer cells by downregulating CD44, EGFR and cyclinD1, and increasing DNA damages and intracellular vesicles

Free
Won Sup Lee, Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6766.
https://doi.org/10.1158/1538-7445.AM2025-6766
Published: 21 April 2025
View article titled, Abstract 6766: Tetraarsenic hexoxide augments the anticancer effects of Artemisia annua polyphenols on both naive and oxaliplatin-resistant HCT116 colorectal cancer cells by downregulating CD44, EGFR and cyclinD1, and increasing DNA damages and intracellular vesicles
Journal Articles

Abstract 386: High CRBN expression in neuroendocrine cancer creates a vulnerability to GSPT1 molecular glue degraders: Target indication selection for CYRS1542 development

Free
Jaewoo Park, Min Sung Joo, JaeYung Lee, Eun-Jung Kim, Dong Hyuk Ki, Hunmi Choi, Wooseok Han, Keon Wook Kang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 386.
https://doi.org/10.1158/1538-7445.AM2025-386
Published: 21 April 2025
View article titled, Abstract 386: High CRBN expression in neuroendocrine cancer creates a vulnerability to GSPT1 molecular glue degraders: Target indication selection for CYRS1542 development
Journal Articles

Abstract 4891: Genome-first approach identifies shelterin complex gene variants and associated cancers

Free
Akanksha Nagarkar, Hasset Nurelegne, Jung Kim, Kelvin C. de Andrade, Sharon A. Savage
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4891.
https://doi.org/10.1158/1538-7445.AM2025-4891
Published: 21 April 2025
View article titled, Abstract 4891: Genome-first approach identifies shelterin complex gene variants and associated cancers
Journal Articles

Abstract 3732: Associations between gut microbiome changes and quality of life in colorectal cancer patients: a pre- and post-surgery comparison

Free
Hyeree Park, Donghyeok Seol, Ji Won Park, Min Jung Kim, Seung-Yong Jeong, Aesun Shin, Eun Sung Jung, Sunyoung Lee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3732.
https://doi.org/10.1158/1538-7445.AM2025-3732
Published: 21 April 2025
View article titled, Abstract 3732: Associations between gut microbiome changes and quality of life in colorectal cancer patients: a pre- and post-surgery comparison
Journal Articles

Abstract 5990: Pertuzumab enhances the antitumor activity of T-DXd in HER2-positive gastric cancer cells

Free
Minsu Kang, Kui-Jin Kim, Ji Hea Sung, Milang Nam, Sung-Hyun Hwang, Eun Hee Jung, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Keun-Wook Lee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5990.
https://doi.org/10.1158/1538-7445.AM2025-5990
Published: 21 April 2025
View article titled, Abstract 5990: Pertuzumab enhances the antitumor activity of T-DXd in HER2-positive gastric cancer cells
Journal Articles

Abstract 1886: Proteogenomic insights into chemotherapy resistance and therapeutic strategies in triple-negative breast cancer

Free
Dong Ki Lee, Min Hwan Kim, Yumi Hwang, Seul-Gi Kim, Gun Min Kim, Kyung-Hee Kim, Jong Bae Park, Min Jung Kim, Jee Ye Kim, Hyung Seok Park, Seho Park, Seung Il Kim, Heon Yung Gee, Joohyuk Sohn
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1886.
https://doi.org/10.1158/1538-7445.AM2025-1886
Published: 21 April 2025
View article titled, Abstract 1886: Proteogenomic insights into chemotherapy resistance and therapeutic strategies in triple-negative breast cancer
Journal Articles

Abstract 5026: Discovery of oncogenic mediator genes in rectal cancer chemotherapy response using gene expression data from matched tumor and patient-derived organoids

Free
Hanchen Huang, Wini Zambare, Chao Wu, Antonio Colaprico, Janet Alvarez, Min Jung Kim, Aron Bercz, Paulina Bleu, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5026.
https://doi.org/10.1158/1538-7445.AM2025-5026
Published: 21 April 2025
View article titled, Abstract 5026: Discovery of oncogenic mediator genes in rectal cancer chemotherapy response using gene expression data from matched tumor and patient-derived organoids
Journal Articles

Abstract 1497: PERK as a biomarker to optimize therapy of GRP78 inhibitor, BOLD-100, in gastric cancer

Free
Sea Young Choo, Ah-Rong Nam, Kyoung-Seok Oh, Jae-Min Kim, Ju-Hee Bang, Yoojin Jeong, Hyo Jung Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1497.
https://doi.org/10.1158/1538-7445.AM2025-1497
Published: 21 April 2025
View article titled, Abstract 1497: PERK as a biomarker to optimize therapy of GRP78 inhibitor, BOLD-100, in gastric cancer
Journal Articles

Abstract LB168: A selective, potent, and orally bioavailable CDK7 inhibitor demonstrates superior anti-cancer activity in colorectal cancer models

Free
Heuijoon Park, Kyoungwan Seo, Jihyun Yu, Jieun Kim, Min Sung Joo, Sungeun Kim, Joonhyung Lee, Jeonghyeon Lee, Eun-Jung Kim, Joonwoo Nam, Wooseok Han
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB168.
https://doi.org/10.1158/1538-7445.AM2024-LB168
Published: 05 April 2024
View article titled, Abstract LB168: A selective, potent, and orally bioavailable CDK7 inhibitor demonstrates superior anti-cancer activity in colorectal cancer models
Journal Articles

Abstract 1822: Artemisia annua Lpolyphenols augment b-lapachone effects on oxaliplatin-resistant HCT 116 colorectal cancer cells by downregulating TERT, CD44, EGFR and oxaliplatin resistance-related proteins of OXP-R-Hct 116 cells

Free
Won Sup Lee, Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1822.
https://doi.org/10.1158/1538-7445.AM2024-1822
Published: 22 March 2024
View article titled, Abstract 1822: Artemisia annua Lpolyphenols augment b-lapachone effects on oxaliplatin-resistant HCT 116 colorectal cancer cells by downregulating TERT, CD44, EGFR and oxaliplatin resistance-related proteins of OXP-R-Hct 116 cells
Journal Articles

Abstract 3327: L-pampo™, a TLR2/3 agonist, enhances anti-tumor immune responses and synergistically improves the anti-tumor efficacy of immune checkpoint inhibitors in cold tumors

Free
Guentae Kim, Yoonki Heo, Hye Jung Kim, Sejung Park, Byung Cheol Ahn, Won Suk Lee, Chan Kim, Hong Jae Chon, Eunyoung Chun, Jung Sun Yum
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3327.
https://doi.org/10.1158/1538-7445.AM2024-3327
Published: 22 March 2024
View article titled, Abstract 3327: L-pampo™, a TLR2/3 agonist, enhances anti-tumor immune responses and synergistically improves the anti-tumor efficacy of immune checkpoint inhibitors in cold tumors
Journal Articles

Abstract 3313: Discovery of a potent, selective, and orally available small molecule for disruption of the SOS1-RAS interaction

Free
Dong Hyuk Ki, Hana Yu, Donggeon Kim, Yeejin Jeon, Seongin Jo, Joonwoo Nam, Eun-Jung Kim, Sungeun Kim, Hunmi Choi, Jieun Kim, Jihyun Yu, Sungpil Choi, Wooseok Han
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3313.
https://doi.org/10.1158/1538-7445.AM2024-3313
Published: 22 March 2024
View article titled, Abstract 3313: Discovery of a potent, selective, and orally available small molecule for disruption of the SOS1-RAS interaction
Journal Articles

Abstract 3295: Pharmacological characterization of CYRS1542: A potent and orally available GSPT1 molecular glue degrader for the treatment of neuroendocrine solid cancer with a favorable safety profile

Free
Min Sung Joo, JaeYung Lee, Joonhyung Lee, Eun-Jung Kim, Seogbeom Song, Jeonghyeon Lee, Joonwoo Nam, Heuijoon Park, Jaewoo Park, Keon Wook Kang, Wooseok Han
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3295.
https://doi.org/10.1158/1538-7445.AM2024-3295
Published: 22 March 2024
View article titled, Abstract 3295: Pharmacological characterization of CYRS1542: A potent and orally available GSPT1 molecular glue degrader for the treatment of neuroendocrine solid cancer with a favorable safety profile
Journal Articles

Abstract 966: Longitudinal comparative analysis of circulating tumor DNA and matched tumor tissue DNA in patients with metastatic colorectal cancer receiving palliative first-line systemic anti-cancer therapy

Free
Ji-Won Kim, Seung-been Lee, Hong-Geun Kim, Sung-Hyun Hwang, Kui-Jin Kim, Ju Hyun Lee, Jeongmin Seo, Minsu Kang, Eun Hee Jung, Koung Jin Suh, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Nak-Jung Kwon, Keun-Wook Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 966.
https://doi.org/10.1158/1538-7445.AM2024-966
Published: 22 March 2024
View article titled, Abstract 966: Longitudinal comparative analysis of circulating tumor DNA and matched tumor tissue DNA in patients with metastatic colorectal cancer receiving palliative first-line systemic anti-cancer therapy
Journal Articles

Abstract 390: Direct interaction of Pin1 with HIF-prolyl hydroxylase 2: Implications for breast cancer cell growth and survival

Free
Yanymee Nimesia Guillen Quispe, Su-Jung Kim, Soma Saeidi, Gyo-Jin Choi, Chaithanya Chelakkot, Tianchi Zhou, Sang-Beom Bang, Tae-Won Kim, Young-Kee Shin, Young-Joon Surh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 390.
https://doi.org/10.1158/1538-7445.AM2024-390
Published: 22 March 2024
View article titled, Abstract 390: Direct interaction of Pin1 with HIF-prolyl hydroxylase 2: Implications for breast cancer cell growth and survival
Journal Articles

Abstract 2599: Trastuzumab deruxtecan reprograms immune response by stimulating cGAS-STING pathway in gastric cancer cells

Free
Kyoung-Seok Oh, Ah-Rong Nam, Ju-Hee Bang, Yoojin Jeong, Sea Young Choo, Hyo Jung Kim, Su In Lee, Jae-Min Kim, Jeesun Yoon, Tae-Yong Kim, Do-Youn Oh
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2599.
https://doi.org/10.1158/1538-7445.AM2024-2599
Published: 22 March 2024
View article titled, Abstract 2599: Trastuzumab deruxtecan reprograms immune response by stimulating cGAS-STING pathway in gastric cancer cells