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Journal Articles

RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis

Danyu Chen, Fenfen Ji, Qiming Zhou, Henley Cheung, Yasi Pan, Harry C.-H. Lau, Cong Liang, Zhenjie Yang, Pingmei Huang, Qinyao Wei, Alvin H.-K. Cheung, Wei Kang, Huarong Chen, Jun Yu, Chi Chun Wong
Journal: Cancer Research
Cancer Res (2024) 84 (17): 2856–2872.
https://doi.org/10.1158/0008-5472.CAN-23-2081
Published: 04 September 2024
View article titled, RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m<sup>6</sup>A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
Open the PDF for RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m<sup>6</sup>A-Dependent Oncogenic Translation and Colorectal Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

FOXP4 is a Direct YAP1 Target that Promotes Gastric Cancer Stemness and Drives Metastasis

Xiaoli Liu, Bonan Chen, Fuda Xie, Kit Yee. Wong, Alvin Ho-Kwan. Cheung, Jinglin Zhang, Qian Wu, Canbin Fang, Jintao Hu, Shouyu Wang, Dazhi Xu, Jianwu Chen, Yuzhi Wang, Chi Chun. Wong, Huarong Chen, William Ka Kei. Wu, Jun Yu, Michael W.Y. Chan, Chi Man. Tsang, Kwok Wai. Lo, Gary M.K. Tse, Ka-Fai To, Wei Kang
Journal: Cancer Research
Cancer Res (2024)
https://doi.org/10.1158/0008-5472.CAN-23-3074
Published: 24 July 2024
View article titled, FOXP4 is a Direct YAP1 Target that Promotes Gastric Cancer Stemness and Drives Metastasis
Open the PDF for FOXP4 is a Direct YAP1 Target that Promotes Gastric Cancer Stemness and Drives Metastasis in another window
Includes: Supplementary data
Journal Articles

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma

Samantha Guinn, Benedict Kinny-Köster, Joseph A. Tandurella, Jacob T. Mitchell, Dimitrios N. Sidiropoulos, Melanie Loth, Melissa R. Lyman, Alexandra B. Pucsek, Daniel J. Zabransky, Jae W. Lee, Emma Kartalia, Mili Ramani, Toni T. Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L. Wolfgang, Jun Yu, Lei Zheng, David P. Ryan, David T. Ting, Alec Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H. Elisseeff, Laura D. Wood, Genevieve Stein-O'Brien, Luciane T. Kagohara, Elizabeth M. Jaffee, Richard A. Burkhart, Elana J. Fertig, Jacquelyn W. Zimmerman
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1517–1533.
https://doi.org/10.1158/0008-5472.CAN-23-1660
Published: 02 May 2024
View article titled, Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
Open the PDF for Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis

Xin Liu, Xin Wang, Qingxia Yang, Li Luo, Ziqin Liu, Xiaoxue Ren, Kai Lei, Shangru Li, Zonglin Xie, Gaomin Zheng, Yifan Zhang, Yijie Hao, Qianying Zhou, Yingdong Hou, Fei Fang, Wu Song, Ji Cui, Jinping Ma, Wenxuan Xie, Shunli Shen, Ce Tang, Sui Peng, Jun Yu, Ming Kuang, Xinming Song, Fang Wang, Lixia Xu
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1352–1371.
https://doi.org/10.1158/0008-5472.CAN-23-2123
Published: 15 April 2024
View article titled, Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis
Open the PDF for Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 2802: Enterococcus faecalis-derived X facilitates pancreatic tumor by regulating immune microenvironment

Bin Wang, Chao Yang, Yongjie Xie, Tianxing Zhou, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2802.
https://doi.org/10.1158/1538-7445.AM2024-2802
Published: 22 March 2024
View article titled, Abstract 2802: <em>Enterococcus faecalis</em>-derived X facilitates pancreatic tumor by regulating immune microenvironment
Journal Articles

Abstract 2128: Surufatinib treatment in pancreatic cancer: unveiling the role of GPR34 in TAMs and enhancing immunotherapy efficacy

Xiaofan Guo, Yuxiao Liu, Yuning Song, Jing Huang, Wenbo Zhu, Peijun Xu, Jun Yu, Song Gao, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2128.
https://doi.org/10.1158/1538-7445.AM2024-2128
Published: 22 March 2024
View article titled, Abstract 2128: Surufatinib treatment in pancreatic cancer: unveiling the role of GPR34 in TAMs and enhancing immunotherapy efficacy
Journal Articles

Abstract 1576: The heterogeneity between pancreatic ductal adenocarcinoma with & without lymphovascular invasion

Yiping Zou, Yongjie Xie, Song Gao, Tianxing Zhou, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1576.
https://doi.org/10.1158/1538-7445.AM2024-1576
Published: 22 March 2024
View article titled, Abstract 1576: The heterogeneity between pancreatic ductal adenocarcinoma with &amp; without lymphovascular invasion
Journal Articles

Abstract 6493: CRISPR-directed prime editing sensitizes EGFR inhibitor by correcting oncogenic KRAS mutants In NSCLC

Qingxiao Fang, Chao Yang, Chongbiao Huang, Hongwei Wang, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6493.
https://doi.org/10.1158/1538-7445.AM2024-6493
Published: 22 March 2024
View article titled, Abstract 6493: CRISPR-directed prime editing sensitizes EGFR inhibitor by correcting oncogenic KRAS mutants In NSCLC
Journal Articles

Abstract 6433: Anti-CD36 monoclonal antibody can sensitize the neoadjuvant chemotherapy response in PDAC by eliminating the senescent tertiary lymphatic structure

Jingrui Yan, Tianxing Zhou, Chao Yang, Yongjie Xie, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6433.
https://doi.org/10.1158/1538-7445.AM2024-6433
Published: 22 March 2024
View article titled, Abstract 6433: Anti-CD36 monoclonal antibody can sensitize the neoadjuvant chemotherapy response in PDAC by eliminating the senescent tertiary lymphatic structure
Journal Articles

Abstract 1597: CD144+cancer-associated fibroblasts drive the malignancy of pancreatic cancer via stimulating inflammatory paracrine

Xugang Sun, Jun Yu, Tiansuo Zhao, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1597.
https://doi.org/10.1158/1538-7445.AM2024-1597
Published: 22 March 2024
View article titled, Abstract 1597: CD144<sup>+</sup>cancer-associated fibroblasts drive the malignancy of pancreatic cancer via stimulating inflammatory paracrine
Journal Articles

Abstract 2367: STING agonist ADU-S100 improves the antitumor response of CLDN18.2/CD3 BiTEs by enhancing stem-like tumor-reactive CD8+ T cells in pancreatic adenocarcinoma

Tianxing Zhou, Jingrui Yan, Bin Wang, Yongjie Xie, Chao Yang, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2367.
https://doi.org/10.1158/1538-7445.AM2024-2367
Published: 22 March 2024
View article titled, Abstract 2367: STING agonist ADU-S100 improves the antitumor response of CLDN18.2/CD3 BiTEs by enhancing stem-like tumor-reactive CD8<sup>+</sup> T cells in pancreatic adenocarcinoma
Journal Articles

Abstract 7246: Enhancing PDAC therapy through in vivo correction of KRASG12D using enIscB-directed base editor combined with ICB

Chao Yang, Qingxiao Fang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7246.
https://doi.org/10.1158/1538-7445.AM2024-7246
Published: 22 March 2024
View article titled, Abstract 7246: Enhancing PDAC therapy through <em>in vivo</em> correction of <em>KRAS</em><sup>G12D</sup> using enIscB-directed base editor combined with ICB
Journal Articles

N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression

Xinyue Zhang, Tianhong Su, Yifan Wu, Yuhong Cai, Lina Wang, Cong Liang, Lei Zhou, Shiyan Wang, Xiao-Xing Li, Sui Peng, Ming Kuang, Jun Yu, Lixia Xu
Journal: Cancer Research
Cancer Res (2024) 84 (6): 827–840.
https://doi.org/10.1158/0008-5472.CAN-23-1916
Published: 15 March 2024
View article titled, <em>N<sup>6</sup></em>-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Open the PDF for <em>N<sup>6</sup></em>-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression in another window
Includes: Supplementary data
Journal Articles

Faecalibacterium prausnitzii Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade

Yaqi Gao, Pingping Xu, Danfeng Sun, Yi Jiang, Xiao-Lin Lin, Ting Han, Jun Yu, Chunquan Sheng, Haoyan Chen, Jie Hong, Yingxuan Chen, Xiu-Ying Xiao, Jing-Yuan Fang
Journal: Cancer Research
Cancer Res (2023) 83 (22): 3710–3725.
https://doi.org/10.1158/0008-5472.CAN-23-0605
Published: 15 November 2023
View article titled, <em>Faecalibacterium prausnitzii</em> Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade
Open the PDF for <em>Faecalibacterium prausnitzii</em> Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma

Ki-Fong Man, Lei Zhou, Ying-Tung Lam, Jun Yu, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5799.
https://doi.org/10.1158/1538-7445.AM2023-5799
Published: 04 April 2023
View article titled, Abstract 5799: SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma
Journal Articles

Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling

Huajian Yu, Lei Zhou, Jane Ho-Chun Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor WS Ma, Yanyan Wang, Xiang Zhang, Terence K Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2023-2433
Published: 04 April 2023
View article titled, Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling
Journal Articles

Abstract 2332: VSTM2A modulation of immune response in colorectal cancer through abrogating PD-L1 and PD-1 interaction

Yujuan Dong, Yunfei Zhou, Nathalie Wong, Jun Yu, Siu Man Simon Ng
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2332.
https://doi.org/10.1158/1538-7445.AM2023-2332
Published: 04 April 2023
View article titled, Abstract 2332: VSTM2A modulation of immune response in colorectal cancer through abrogating PD-L1 and PD-1 interaction
Journal Articles

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie Ma, Terence Kin Wah Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3102–3115.
https://doi.org/10.1158/0008-5472.CAN-21-2934
Published: 02 September 2022
View article titled, Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma
Open the PDF for Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB099: Direct identification of MHC class I and class II epitopes for TCR-based T cell therapy for pancreatic cancer

Tengyi Zhang, Jianxin Wang, Yingkuan Shao, Pan Li, Nan Niu, Brian Herbst, Jessica Gai, Juan Fu, Pingbo Zhang, Jun Yu, Kenji Fujiwara, Lei Zheng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB099.
https://doi.org/10.1158/1538-7445.AM2022-LB099
Published: 15 June 2022
View article titled, Abstract LB099: Direct identification of MHC class I and class II epitopes for TCR-based T cell therapy for pancreatic cancer
Journal Articles

Abstract 5436: HH2853 is a selective small molecular dual inhibitor of EZH1/2 with potent anti-tumor activities

Xu-Xing Chen, Qian-Qian Shen, Zhao Zhao, Yan-Fen Fang, Jun-Yu Yang, Ying-Lei Gao, Lei Liu, Yixiang Zhang, Yi Chen, Leping Li
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5436.
https://doi.org/10.1158/1538-7445.AM2022-5436
Published: 15 June 2022
View article titled, Abstract 5436: HH2853 is a selective small molecular dual inhibitor of EZH1/2 with potent anti-tumor activities