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Journal Articles

Abstract C051: Epigenetic reprogramming of brain-infiltrating myeloid cells deters brain metastasis outgrowth

Shao-Ping Yang, Yimin Duan, Xiangliang Yuan, Lin Zhang, Wendao Liu, Jun Yao, Patrick Zhang, Jason T Huse, Zhongming Zhao, Dihua Yu
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): C051.
https://doi.org/10.1158/1538-7445.TUMBODY-C051
Published: 17 November 2024
View article titled, Abstract C051: Epigenetic reprogramming of brain-infiltrating myeloid cells deters brain metastasis outgrowth
Journal Articles

Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer

Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Xiaofei Wang, Jun Yao, Jennifer Li, Jangho Park, Yangxi Zheng, Long T Vien, Laura Bover, Haoqiang Ying, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C019.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C019
Published: 15 September 2024
View article titled, Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer
Journal Articles

Abstract 3009: ATRX loss blocks the differentiation of mesenchymal stem cells and promotes undifferentiated sarcoma development

Yiming Cai, Jun Yao, Dean N. Pan, Yanqiang Jin, James M. You, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3009.
https://doi.org/10.1158/1538-7445.AM2024-3009
Published: 22 March 2024
View article titled, Abstract 3009: ATRX loss blocks the differentiation of mesenchymal stem cells and promotes undifferentiated sarcoma development
Journal Articles

Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Abdelrahman Yousef, Dean Pan, Yanqing Jin, Madelaine S. Theady, Jangho Park, Yiming Cai, Mitsunobu Takeda, Matthew Vasquez, Yong Zhou, Hong Zhao, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6532.
https://doi.org/10.1158/1538-7445.AM2024-6532
Published: 22 March 2024
View article titled, Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors
Journal Articles

Abstract 5070: Landscape of clonal hematopoiesis prior to PARP inhibitor treatment in patients with ovarian cancer

Amma Asare, Sara Corvigno, Jun Yao, Li Zhao, Nicole D. Fleming, Joseph Celestino, Richard A. Hajek, Mark S. Kim, Alejandra Flores Legarreta, Karen H. Lu, Koichi Takahashi, P Andrew Futreal, Amir A. Jazaeri, Shannon N. Westin, Anil K. Sood, Sanghoon Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5070.
https://doi.org/10.1158/1538-7445.AM2024-5070
Published: 22 March 2024
View article titled, Abstract 5070: Landscape of clonal hematopoiesis prior to PARP inhibitor treatment in patients with ovarian cancer
Journal Articles

Abstract 6407: Identification of novel chemotherapy-related CHIP variations in patients with high-grade serous ovarian cancer

Sara Corvigno, Amma Asare, Jun Yao, Li Zhao, Nicole Fleming, Joseph Celestino, Richard A. Hajek, Ency A. Arboleda Goette, Ridge T. Rogers, Tri V. Nguyen, Raymond N. Montoya, Karen H. Lu, Amir A. Jazaeri, Shannon N. Westin, Anil K. Sood, Sanghoon Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6407.
https://doi.org/10.1158/1538-7445.AM2024-6407
Published: 22 March 2024
View article titled, Abstract 6407: Identification of novel chemotherapy-related CHIP variations in patients with high-grade serous ovarian cancer
Journal Articles

Abstract 5473: Genomic profiling of chemotherapy-related clonal hematopoiesis in patients with high-grade serous ovarian cancer

Sara Corvigno, Jun Yao, Li Zhao, Amma Asare, Joseph Celestino, Richard Hajek, Ency Arboleda Goette, Elaine Stur, Emine Bayraktar, Mark S Kim, Ping Song, Qingxiu Zhang, Xingzhi Song, Mohammad Mohammad, Kenna Shaw, Jianhua Zhang, Karen Lu, Amir Jazaeri, Shannon Westin, Anil Sood, Sanghoon Lee
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5473.
https://doi.org/10.1158/1538-7445.AM2023-5473
Published: 04 April 2023
View article titled, Abstract 5473: Genomic profiling of chemotherapy-related clonal hematopoiesis in patients with high-grade serous ovarian cancer
Journal Articles

Abstract 2967: Preclinical development of a B7-H3-targeting ADC with a novel DNA topoisomerase I inhibitor for solid tumors

Chenggang Li, Jun Yao, Chen Qu, Bing Li, Yu Zhang, Rong Shi, Yang Qiu, Haiqing Hua
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2967.
https://doi.org/10.1158/1538-7445.AM2023-2967
Published: 04 April 2023
View article titled, Abstract 2967: Preclinical development of a B7-H3-targeting ADC with a novel DNA topoisomerase I inhibitor for solid tumors
Journal Articles

Abstract 1884: DB-1310, a novel Her3 targeting antibody-drug conjugate, exhibits therapeutic efficacy for solid tumors

Xi Li, Jun Yao, Chen Qu, Luo Lan, Bing Li, Yu Zhang, Rong Shi, Haiqing Hua, Yang Qiu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1884.
https://doi.org/10.1158/1538-7445.AM2023-1884
Published: 04 April 2023
View article titled, Abstract 1884: DB-1310, a novel Her3 targeting antibody-drug conjugate, exhibits therapeutic efficacy for solid tumors
Journal Articles

Abstract 2435: EZH2 engages TGFb signaling to promote breast cancer bone metastasis via Integrin b1-FAK activation

Lin Zhang, Jingkun Qu, Yutao Qi, Yimin Duan, Yu-Wen Huang, Zhifen Zhou, Ping Li, Jun Yao, Beibei Huang, Shuxing Zhang, Dihua Yu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2435.
https://doi.org/10.1158/1538-7445.AM2022-2435
Published: 15 June 2022
View article titled, Abstract 2435: EZH2 engages TGFb signaling to promote breast cancer bone metastasis via Integrin b1-FAK activation
Journal Articles

Abstract 3249: Targeting polyploid giant cancer cells to overcome resistance to PARP inhibitors in ovarian cancer

Xudong Zhang, Jun Yao, Xiaoran Li, Na Niu, Yan Liu, Anil K. Sood, Jinsong Liu
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3249.
https://doi.org/10.1158/1538-7445.AM2022-3249
Published: 15 June 2022
View article titled, Abstract 3249: Targeting polyploid giant cancer cells to overcome resistance to PARP inhibitors in ovarian cancer
Journal Articles

Abstract P5-07-03: Disease classification modeling of inflammatory breast cancer based on simultaneous profiling of coding and non-coding RNAs in tumor and blood samples by TGIRT-sequencing

Dennis C. Wylie, Xiaoping Wang, Jun Yao, Hengyi Xu, Toshiaki Iwase, Savitri Krishnamurthy, Naoto T. Ueno, Alan M. Lambowitz
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-07-03.
https://doi.org/10.1158/1538-7445.SABCS21-P5-07-03
Published: 15 February 2022
View article titled, Abstract P5-07-03: Disease classification modeling of inflammatory breast cancer based on simultaneous profiling of coding and non-coding RNAs in tumor and blood samples by TGIRT-sequencing
Journal Articles

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya'an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4054–4065.
https://doi.org/10.1158/0008-5472.CAN-20-3792
Published: 01 August 2021
View article titled, Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Open the PDF for Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 2794: Blocking histamine receptor H1 on macrophages with anti-allergy drugs restores T-cell anti-tumor immunity

Hongzhong Li, Yi Xiao, Jun Yao, Xiangliang Yuan, Xuedong Yin, Yuan Zhang, Yohei Saito, Hideo Yagita, Don Gibbons, Dihua Yu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2794.
https://doi.org/10.1158/1538-7445.AM2021-2794
Published: 01 July 2021
View article titled, Abstract 2794: Blocking histamine receptor H1 on macrophages with anti-allergy drugs restores T-cell anti-tumor immunity
Journal Articles

Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling

Hwanhee Oh, Inah Hwang, Ja-Young Jang, Lingxiang Wu, Dongqing Cao, Jun Yao, Haoqiang Ying, Jian Yi Li, Yu Yao, Baoli Hu, Qianghu Wang, Hongwu Zheng, Jihye Paik
Journal: Cancer Research
Cancer Res (2021) 81 (6): 1528–1539.
https://doi.org/10.1158/0008-5472.CAN-20-1810
Published: 15 March 2021
View article titled, Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling
Open the PDF for Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract A17: Polyploid giant cancer cells lead to evolution of drug resistance in high-grade ovarian cancer

Na Niu, Xiaoran Li, Jun Yao, Anil Sood, Jinsong Liu
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): A17.
https://doi.org/10.1158/1538-7445.CAMODELS2020-A17
Published: 02 June 2020
View article titled, Abstract A17: Polyploid giant cancer cells lead to evolution of drug resistance in high-grade ovarian cancer
Journal Articles

Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity

Linlin Sun, Chia-Wei Li, Ezra M. Chung, Riyao Yang, Yong-Soo Kim, Andrew H. Park, Yun-Ju Lai, Yi Yang, Yu-Han Wang, Jielin Liu, Yufan Qiu, Kay-Hooi Khoo, Jun Yao, Jennifer L. Hsu, Jong-Ho Cha, Li-Chuan Chan, Jung-Mao Hsu, Heng-Huan Lee, Stephen S. Yoo, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (11): 2298–2310.
https://doi.org/10.1158/0008-5472.CAN-19-3133
Published: 02 June 2020
View article titled, Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
Open the PDF for Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer

Sunil Acharya, Jun Yao, Ping Li, Chenyu Zhang, Frank J. Lowery, Qingling Zhang, Hua Guo, Jingkun Qu, Fei Yang, Ignacio I. Wistuba, Helen Piwnica-Worms, Aysegul A. Sahin, Dihua Yu
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4211–4226.
https://doi.org/10.1158/0008-5472.CAN-18-3803
Published: 15 August 2019
View article titled, Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer
Open the PDF for Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1857: Proscillaridin A induces apoptosis and suppresses non-small cell lung cancer tumor growth via calcium-induced DR4 up-regulation

Run-Ze Li, Xing Xing Fan, Xiao- Jun Yao, Elaine L. Leung, Liang Liu
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1857.
https://doi.org/10.1158/1538-7445.AM2019-1857
Published: 01 July 2019
View article titled, Abstract 1857: Proscillaridin A induces apoptosis and suppresses non-small cell lung cancer tumor growth via calcium-induced DR4 up-regulation
Journal Articles

Abstract 1674: Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism

Xi Chen, Chun Xie, Xing Xing Fan, Ze Bo Jiang, Vincent Wong, Jia Hui Xu, Xiao Jun Yao, Liang Liu, Elaine L. Leung
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1674.
https://doi.org/10.1158/1538-7445.AM2018-1674
Published: 01 July 2018
View article titled, Abstract 1674: Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism