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Journal Articles

Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma

Tingting Wang, Lingling Liu, Jie Fang, Hongjian Jin, Sivaraman Natarajan, Heather Sheppard, Meifen Lu, Gregory Turner, Thomas Confer, Melissa Johnson, Jeffrey Steinberg, Larry Ha, Nour Yadak, Richa Jain, David J. Picketts, Xiaotu Ma, Andrew Murphy, Andrew M. Davidoff, Evan S. Glazer, John Easton, Xiang Chen, Ruoning Wang, Jun Yang
Journal: Cancer Research
Cancer Res (2025) 85 (3): 424–441.
https://doi.org/10.1158/0008-5472.CAN-24-1142
Published: 01 February 2025
View articletitled, Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma
Open the PDF for Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma in another window
Includes: Supplementary data
Journal Articles

Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance

Noha AM Shendy, Yang Zhang, Ha-Won Lee, Stephanie Nance, Yousef Khashana, Mohammad AM Nezhady, Elaine Ritter, Shivendra Singh, Qi Liu, Yiping Fan, Jun Yang, Anand G. Patel, Jun Qi, Taosheng Chen, Brian J. Abraham, Adam D. Durbin
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A054.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A054
Published: 05 September 2024
View articletitled, Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance
Journal Articles

Abstract 6618: Pleiotropic GATA3 locus is associated with multiple childhood cancers: harnessing the existing data from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study for genetic etiology research

Cheng Chen, Xijun Zhang, Qian Dong, Heather L. Mulder, John Easton, Xiaotu Ma, Jinghui Zhang, Jun Yang, Kim E. Nichols, Gregory T. Armstong, Kirsten K. Ness, Melissa M. Hudson, Hui Wang, Nilanjan Chatterjee, Cindy Im, Zhaoming Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6618.
https://doi.org/10.1158/1538-7445.AM2024-6618
Published: 22 March 2024
View articletitled, Abstract 6618: Pleiotropic GATA3 locus is associated with multiple childhood cancers: harnessing the existing data from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study for genetic etiology research
Journal Articles

Abstract 6816: Prevention of cancer cachexia by inhibition of soluble epoxide hydrolase

Rachel L. Bayer, Sarina Virani, Michael Gillespie, Jacqueline Capuano, Keira Smith, Katherine Quinlivan, Kimberly Vasquez, Jun Yang, Haixia Yang, Nicholas Mitsiades, Bruce D. Hammock, Dipak Panigrahy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6816.
https://doi.org/10.1158/1538-7445.AM2024-6816
Published: 22 March 2024
View articletitled, Abstract 6816: Prevention of cancer cachexia by inhibition of soluble epoxide hydrolase
Journal Articles

Abstract 4923: Prostaglandin E2 receptor EP2: A novel target for high-risk neuroblastoma

Ruida Hou, Ying Yu, Jun Yang, Jianxiong Jiang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4923.
https://doi.org/10.1158/1538-7445.AM2023-4923
Published: 04 April 2023
View articletitled, Abstract 4923: Prostaglandin E2 receptor EP2: A novel target for high-risk neuroblastoma
Journal Articles

Abstract 2702: GQ1001 is a next generation HER2-targeting ADC with excellent druggability, safety and potency

Lei Huang, Lili Shi, Yajun Sun, Cao Lv, Chengcheng Gong, Chong Liu, Jun Yang, Lu Jiang, Jinduo Yuan, Xuesong Li, Mingyu Hu, Xinju Gao, Yu Si, Hui Yang, Yan Shi, Bo Yang, Paul H. Song, Gang Qin, Biyun Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2702.
https://doi.org/10.1158/1538-7445.AM2023-2702
Published: 04 April 2023
View articletitled, Abstract 2702: GQ1001 is a next generation HER2-targeting ADC with excellent druggability, safety and potency
Journal Articles

Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors

Karissa Dieseldorff Jones, Waise Quarni, Daniel Putnam, Shivendra Singh, Qiong Wu, Jun Yang, Xiang Chen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5363.
https://doi.org/10.1158/1538-7445.AM2023-5363
Published: 04 April 2023
View articletitled, Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors
Journal Articles

Abstract B044: Bromodomain and Extra-Terminal Protein inhibition decreases pancreatic cancer proliferation via MYC-independent pathways

Manjul Rana, Rita G. Kansal, Jie Fang, Benjamin T. Allen, Jun Yang, Evan S. Glazer
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B044.
https://doi.org/10.1158/1538-7445.PANCA22-B044
Published: 15 November 2022
View articletitled, Abstract B044: Bromodomain and Extra-Terminal Protein inhibition decreases pancreatic cancer proliferation via MYC-independent pathways
Journal Articles

Abstract 5191: BCL-2 inhibitor APG-2575 promotes anti-tumor immunity through converting tumor-associated macrophages into M1 phenotype in non-small cell lung cancer

Fan Luo, Fei-teng Lu, Miao-zhen Qiu, Wen-tao Pan, Lin Zhang, Hong-yun Zhao, Li Zhang, Da-jun Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5191.
https://doi.org/10.1158/1538-7445.AM2022-5191
Published: 15 June 2022
View articletitled, Abstract 5191: BCL-2 inhibitor APG-2575 promotes anti-tumor immunity through converting tumor-associated macrophages into M1 phenotype in non-small cell lung cancer
Journal Articles

Abstract 6094: SRC inhibitor saracatinib enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer

Fei-Teng Lu, Fan Luo, Miao-Zhen Qiu, Jia-Xin Cao, Qiu-Yun Luo, Da-Jun Yang, Hong-Yun Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6094.
https://doi.org/10.1158/1538-7445.AM2022-6094
Published: 15 June 2022
View articletitled, Abstract 6094: SRC inhibitor saracatinib enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer
Journal Articles

Abstract 439: BCL-2 inhibitor APG-2575 promotes anti-tumor efficacy of immune checkpoint blockade through converting tumor-associated macrophages into M1 phenotype in non-small cell lung cancer

Fan Luo, Fei Teng Lu, Miao Zhen Qiu, Wen Tao Pan, Lin Zhang, Hong Yun Zhao, Li Zhang, Da Jun yang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 439.
https://doi.org/10.1158/1538-7445.AM2021-439
Published: 01 July 2021
View articletitled, Abstract 439: BCL-2 inhibitor APG-2575 promotes anti-tumor efficacy of immune checkpoint blockade through converting tumor-associated macrophages into M1 phenotype in non-small cell lung cancer
Journal Articles

Abstract 2118: Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia

Hongbo Yang, Hui Zhang, Yu Luan, Tingting Liu, Kathryn Roberts, Mao-xiang Qian, Bo Zhang, Wenjian Yang, Virginia Perez-Andreu, Jie Xu, Sriranga lyyanki, Da Kuang, Shalini Reshmi, Julie Gastier-Foster, Colton Smith, Ching-Hon Pui, William Evans, Stephen Hunger, Stephen Hunger, Leonidas Platanias, Mary Relling, Charles Mullighan, Mignon Loh, Feng Yue, Jun Yang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2118.
https://doi.org/10.1158/1538-7445.AM2021-2118
Published: 01 July 2021
View articletitled, Abstract 2118: Non-coding germline GATA3 variants alter chromatin topology and contribute to pathogenesis of acute lymphoblastic leukemia
Journal Articles

Abstract 2346: Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel

Estefania Labanca, Juan Bizzotto, Jun Yang, Pablo Sanchis, Peter Shepherd, Alejandra Paez, Valeria Antico-Arciuch, Nicolas Anselmino, Sofia Lage-Vickers, Anh Hoang, Mark Tituts, Eleni Efstathiou, Javier Cotignola, Christopher Logothetis, Elba Vazquez, Nora Navone, Geraldine Gueron
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2346.
https://doi.org/10.1158/1538-7445.AM2021-2346
Published: 01 July 2021
View articletitled, Abstract 2346: Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuel
Journal Articles

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

P. Jake Slavish, Liying Chi, Mi-Kyung Yun, Lyudmila Tsurkan, Nancy E. Martinez, Barbara Jonchere, Sergio C. Chai, Michele Connelly, M. Brett Waddell, Sourav Das, Geoffrey Neale, Zhenmei Li, William R. Shadrick, Rachelle R. Olsen, Kevin W. Freeman, Jonathan A. Low, Jeanine E. Price, Brandon M. Young, Nagakumar Bharatham, Vincent A. Boyd, Jun Yang, Richard E. Lee, Marie Morfouace, Martine F. Roussel, Taosheng Chen, Daniel Savic, R. Kiplin Guy, Stephen W. White, Anang A. Shelat, Philip M. Potter
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3507–3518.
https://doi.org/10.1158/0008-5472.CAN-19-3934
Published: 02 September 2020
View articletitled, Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
Open the PDF for Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3871: Infiltration of CD56dim NK cells regulated by MLH1 into tumor tissue of FAP patients predict better prognosis

Jun Yang, Hushan Zhang, Wei Qing Liu, Wenliang Li, Shumin Ma, Lei Liang, Zhiyong Kou, Depei Huang, Xudong Shen, Jian Dong
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3871.
https://doi.org/10.1158/1538-7445.AM2020-3871
Published: 15 August 2020
View articletitled, Abstract 3871: Infiltration of CD56dim NK cells regulated by MLH1 into tumor tissue of FAP patients predict better prognosis
Journal Articles

SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence

Sen Ye, Yan-Fu Ding, Wen-Huan Jia, Xiao-Li Liu, Jing-Yi Feng, Qian Zhu, Sun-Li Cai, Yao-Shun Yang, Qian-Yun Lu, Xue-Ting Huang, Jin-Shu Yang, Sheng-Nan Jia, Guo-Ping Ding, Yue-Hong Wang, Jiao-Jiao Zhou, Yi-Ding Chen, Wei-Jun Yang
Journal: Cancer Research
Cancer Res (2019) 79 (18): 4729–4743.
https://doi.org/10.1158/0008-5472.CAN-19-1084
Published: 13 September 2019
View articletitled, SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence
Open the PDF for SET Domain–Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence in another window
Includes: Supplementary data
Journal Articles

Abstract 309: FAK blockade enhances antitumor effect of BTK inhibitor in esophageal squamous cell carcinoma via EGFR-ERK-Akt pathway inhibition

Qiu-Yun Luo, Su-Na Zhou, Wen-Tao Pan, Meng-xian Pan, Lu-ping Yuan, Lin Zhang, Xiang-Lei Yan, Yu-xin Zhang, Jian Sun, Miaozhen Qiu, Da-Jun Yang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 309.
https://doi.org/10.1158/1538-7445.AM2019-309
Published: 01 July 2019
View articletitled, Abstract 309: FAK blockade enhances antitumor effect of BTK inhibitor in esophageal squamous cell carcinoma via EGFR-ERK-Akt pathway inhibition
Journal Articles

Abstract 2872: Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia

Benshang Li, Samuel W. Brady, Xiaotu Ma, Shuhong Shen, Yingchi Zhang, Yongjin Li, Yu Liu, Ningling Wang, Diane Flasch, Matthew Myers, Heather Mulder, Lixia Ding, Yanling Lu, Liqing Tian, Kohei Hagiwara, Ke Xu, Edgar Sioson, Tianyi Wang, Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Jiaoyang Cai, Ting-Nien Lin, Lijuan Du, Fan Yang, Michael Rusch, Michael Edmonson, John Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin Raphael, Jingyan Tang, James Downing, Bin-Bing Zhou, Ching-Hon Pui, Jun Yang, Jinghui Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2872.
https://doi.org/10.1158/1538-7445.AM2019-2872
Published: 01 July 2019
View articletitled, Abstract 2872: Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia
Journal Articles

Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis

Weicang Wang, Jun Yang, Matthew L. Edin, Yuxin Wang, Ying Luo, Debin Wan, Haixia Yang, Chun-Qing Song, Wen Xue, Katherine Z. Sanidad, Mingyue Song, Heather A. Bisbee, Jennifer A. Bradbury, Guanjun Nan, Jianan Zhang, Pei-an Betty Shih, Kin Sing Stephen Lee, Lisa M. Minter, Daeyoung Kim, Hang Xiao, Jun-Yan Liu, Bruce D. Hammock, Darryl C. Zeldin, Guodong Zhang
Journal: Cancer Research
Cancer Res (2019) 79 (8): 1822–1830.
https://doi.org/10.1158/0008-5472.CAN-18-3221
Published: 15 April 2019
View articletitled, Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis
Open the PDF for Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract B050: The role of activated beta-catenin/Wnt signaling in the progression of castration resistance of prostate cancer in bone

Justin M. Roberts, Estefania Labanca, Peter Shepherd, Jun Yang, Michael W. Starbuck, Nora M. Navone
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): B050.
https://doi.org/10.1158/1538-7445.PRCA2017-B050
Published: 14 August 2018
View articletitled, Abstract B050: The role of activated beta-catenin/Wnt signaling in the progression of castration resistance of prostate cancer in bone