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Journal Articles

Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signaling

Zhen Li, Kang Ning, Diwei Zhao, Zhaohui Zhou, Junliang Zhao, Xingbo Long, Zhenyu Yang, Dong Chen, Xinyang Cai, Lexuan Hong, Luyao Zhang, Fangjian Zhou, Jun Wang, Yonghong Li
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0308
Published: 07 September 2023
View article titled, Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signaling
Open the PDF for Targeting the metabolic enzyme PGAM2 overcomes enzalutamide resistance in castration-resistant prostate cancer by inhibiting BCL2 signaling in another window
Includes: Supplementary data
Journal Articles

Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2+ Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma

Fanfan Fan, Jian Gao, Yue Zhao, Jun Wang, Lu Meng, Jiaqiang Ma, Teng Li, Han Han, Jinglei Lai, Zhendong Gao, Xiongfei Li, Ran Guo, Zhiwei Cao, Yang Zhang, Xiaoming Zhang, Haiquan Chen
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2690–2703.
https://doi.org/10.1158/0008-5472.CAN-22-3140
Published: 15 August 2023
View article titled, Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2<sup>+</sup> Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma
Open the PDF for Elevated Mast Cell Abundance Is Associated with Enrichment of CCR2<sup>+</sup> Cytotoxic T Cells and Favorable Prognosis in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk

Elom K. Aglago, Andre Kim, Yi Lin, Conghui Qu, Marina Evangelou, Yu Ren, John Morrison, Demetrius Albanes, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephanie A. Bien, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D. Buchanan, Arif Budiarto, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew T. Chan, Jenny Chang-Claude, Xuechen Chen, David V. Conti, Matthew Devall, Virginia Diez-Obrero, Niki Dimou, David Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Heather Hampel, Sophia Harlid, Akihisa Hidaka, Tabitha A. Harrison, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Kristina Jordahl, Amit D. Joshi, Eric S. Kawaguchi, Temitope O. Keku, Anshul Kundaje, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Brigid M. Lynch, Bharuno Mahesworo, Marko Mandic, Mireia Obón-Santacana, Victor Moreno, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A. Newcomb, Shuji Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoen, Anna Shcherbina, Martha L. Slattery, Mariana C. Stern, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Yu Tian, Cornelia M. Ulrich, Franzel JB van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Jun Wang, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Natalia Zemlianskaia, Li Hsu, W. James Gauderman, Ulrike Peters, Konstantinos K. Tsilidis, Peter T. Campbell
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2572–2583.
https://doi.org/10.1158/0008-5472.CAN-22-3713
Published: 01 August 2023
View article titled, A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Open the PDF for A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk in another window
Includes: Supplementary data
Journal Articles

Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer

Samar Elorbany, Chiara Berlato, Larissa Carnevalli, Eleni Maniati, Jun Wang, Simon Barry, Ranjit Manchanda, Julia Kzhyshkowska, Frances Balkwill
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB195.
https://doi.org/10.1158/1538-7445.AM2023-LB195
Published: 14 April 2023
View article titled, Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer
Journal Articles

Abstract 3274: Novel cell-based bioassays for mono- and multi-specific antibodies targeting PD-1/PD-L1 for combination immunotherapy

Jun Wang, Julia Gilden, Denise Garvin, Pete Stecha, Jim Hartnett, Frank Fan, Mei Cong, Jamison Grailer
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3274.
https://doi.org/10.1158/1538-7445.AM2023-3274
Published: 04 April 2023
View article titled, Abstract 3274: Novel cell-based bioassays for mono- and multi-specific antibodies targeting PD-1/PD-L1 for combination immunotherapy
Journal Articles

Abstract 1799: BH3120, a bispecific antibody targeting 4-1BB and PD-L1 simultaneously, stimulates T cells in tumor tissue preferred manner

Jing Wang, Jun Wang, Yang Liu, Yan Pang, Aihong Zhang, Jie Feng, Aibo Sun, Xiao Ma, Jingmei Cai, Jiangcheng Xu, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1799.
https://doi.org/10.1158/1538-7445.AM2023-1799
Published: 04 April 2023
View article titled, Abstract 1799: BH3120, a bispecific antibody targeting 4-1BB and PD-L1 simultaneously, stimulates T cells in tumor tissue preferred manner
Journal Articles

Abstract 5629: Spatial genomics and proteomics enable multimodal analyses of oral SCC clonal heterogeneity and interactions with tumor microenvironment

Raju Kumar, Rana Ibrahim, Bassem Ben Cheikh, Emma Bailey, Hannah Cottom, Oliver Braubach, Trevor Graham, Jun Wang, Ines Sequeira
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5629.
https://doi.org/10.1158/1538-7445.AM2023-5629
Published: 04 April 2023
View article titled, Abstract 5629: Spatial genomics and proteomics enable multimodal analyses of oral SCC clonal heterogeneity and interactions with tumor microenvironment
Journal Articles

Abstract 3021: Epigenetic signatures of virus-associated cervical cancer in women living with HIV

Yinan Zheng, Olugbenga Silas, Jonah Musa, Yishu Qu, Tao Gao, Kyeezu Kim, Brian Joyce, Jun Wang, Demirkan Gursel, Abdulkareem Fatimah, Godwin Imade, Alani Akanmu, Jian-Jun Wei, Masha Kocherginsky, Kwang-Youn Kim, Firas Wehbe, Chad Achenbach, Rose Anorlu, Melissa Simon, Atiene Sagay, Folasade Ogunsola, Robert Murphy, Lifang Hou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3021.
https://doi.org/10.1158/1538-7445.AM2023-3021
Published: 04 April 2023
View article titled, Abstract 3021: Epigenetic signatures of virus-associated cervical cancer in women living with HIV
Journal Articles

Abstract P1-05-11: Improving the Performance of Early Breast Cancer Diagnosis by a Model Combining Breast Ultrasound with Methylation Markers in Non-Invasive Circulating Tumor DNA

Xianyu Zhang, Zhujia Ye, Yanling Yin, Liuhong Zeng, Jun Wang, Shan Lei, Marina Bibikova, Zhiwei Chen, Jian-Bing Fan, Da Pang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-05-11.
https://doi.org/10.1158/1538-7445.SABCS22-P1-05-11
Published: 01 March 2023
View article titled, Abstract P1-05-11: Improving the Performance of Early Breast Cancer Diagnosis by a Model Combining Breast Ultrasound with Methylation Markers in Non-Invasive Circulating Tumor DNA
Journal Articles

Abstract P1-05-27: Liquid Biopsy for HER2 Status Assessment in Breast Cancer Using Surrogate DNA Methylation Markers

Xianyu Zhang, Shiyao Lu, Hui Li, Xin Liu, Jun Wang, Liuhong Zeng, Zhipeng Lu, Siyu Liu, Yanling Yin, Marina Bibikova, Zhiwei Chen, Jian-Bing Fan, Da Pang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P1-05-27.
https://doi.org/10.1158/1538-7445.SABCS22-P1-05-27
Published: 01 March 2023
View article titled, Abstract P1-05-27: Liquid Biopsy for HER2 Status Assessment in Breast Cancer Using Surrogate DNA Methylation Markers
Journal Articles

Abstract 5605: BH3120: A novel bispecific antibody targeting 4-1BB and PD-L1 with well balanced efficacy and safety profiles

Jiangcheng Xu, Yang Liu, Jing Wang, Fei Fan, Haitao Gu, Lanxin Zhang, Jun Wang, Ding Song, Ailong Guo, Hongjuan Zhang, Kaixuan Su, Jiaojiao Su, Lijuan Li, Jingmei Cai, Aihong Zhang, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5605.
https://doi.org/10.1158/1538-7445.AM2022-5605
Published: 15 June 2022
View article titled, Abstract 5605: BH3120: A novel bispecific antibody targeting 4-1BB and PD-L1 with well balanced efficacy and safety profiles
Journal Articles

Abstract 4249: Quantitative PBMC ADCC bioassay and ADCC reporter bioassays for immunotherapy and SARS-CoV-2 monoclonal antibody development

Pete Stecha, Jun Wang, Denise Garvin, Julia Gilden, Jamison Grailer, Jim Hartnett, Frank Fan, Mei Cong, Zhi-jie Jey Cheng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4249.
https://doi.org/10.1158/1538-7445.AM2022-4249
Published: 15 June 2022
View article titled, Abstract 4249: Quantitative PBMC ADCC bioassay and ADCC reporter bioassays for immunotherapy and SARS-CoV-2 monoclonal antibody development
Journal Articles

Abstract 1875: Novel cell-based bioassays for monoclonal antibody and bispecific molecules in PD-1 blockade monotherapy and combination therapy

Jamison Grailer, Julia Gilden, Jun Wang, Denise Garvin, Pete Stecha, Jim Hartnett, Steven Edenson, Frank Fan, Mei Cong, Zhi-jie Jey Cheng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1875.
https://doi.org/10.1158/1538-7445.AM2022-1875
Published: 15 June 2022
View article titled, Abstract 1875: Novel cell-based bioassays for monoclonal antibody and bispecific molecules in PD-1 blockade monotherapy and combination therapy
Journal Articles

Abstract P2-11-03: Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology

Omid Hosseini, Irene Helenowski, Oukseub Lee, Hui Zhang, Jun Wang, Luis Blanco, Seema A Khan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-11-03.
https://doi.org/10.1158/1538-7445.SABCS21-P2-11-03
Published: 15 February 2022
View article titled, Abstract P2-11-03: Menstrual phase classification of benign breast tissue using hormone-regulated gene expression and morphology
Journal Articles

Abstract 506: A homogenous PBMC ADCC bioassay enables bridging studies with ADCC reporter bioassays in immunotherapy monoclonal antibody development

Pete Stecha, Denise Garvin, Julia Gilden, Jun Wang, Jamison Grailer, Jim Hartnett, Gopal B. Krishnan, Frank Fan, Mei Cong, Zhijie Jey Cheng
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 506.
https://doi.org/10.1158/1538-7445.AM2021-506
Published: 01 July 2021
View article titled, Abstract 506: A homogenous PBMC ADCC bioassay enables bridging studies with ADCC reporter bioassays in immunotherapy monoclonal antibody development
Journal Articles

Abstract 618: Spatio-temporal multiomics analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers after R0 tumor resection

Kezhong Chen, Airong Yang, Shuangxiu Wu, Yuntao Nie, Haifeng Shen, Jian Bai, Lin Wu, Fan Yang, Jun Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 618.
https://doi.org/10.1158/1538-7445.AM2021-618
Published: 01 July 2021
View article titled, Abstract 618: Spatio-temporal multiomics analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers after R0 tumor resection
Journal Articles

Abstract 2610: A high performance blood test for multiple cancer early screening

Linhao Xu, Jun Wang, Weifeng Ma, Xin Liu, Ting Yang, Sihui Li, Qian Hu, Jinsheng Tao, Zhujia Ye, Zhiwei Chen, Jian-Bing Fan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2610.
https://doi.org/10.1158/1538-7445.AM2021-2610
Published: 01 July 2021
View article titled, Abstract 2610: A high performance blood test for multiple cancer early screening
Journal Articles

Abstract 1650: MoA-based reporter bioassays enable quantitative potency determination for therapeutic biologics targeting co-stimulatory and co-inhibitory immune checkpoint receptors

Jamison Grailer, Julia Gilden, Pete Stecha, Denise Garvin, Jun Wang, michael Beck, Jim Hartnett, Frank Fan, mei cong, Zhi-Jie Jey Cheng
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1650.
https://doi.org/10.1158/1538-7445.AM2021-1650
Published: 01 July 2021
View article titled, Abstract 1650: MoA-based reporter bioassays enable quantitative potency determination for therapeutic biologics targeting co-stimulatory and co-inhibitory immune checkpoint receptors
Journal Articles

Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages

Qingguo Zhao, Linying Zhang, Bo Hai, Jun Wang, Courtney L. Baetge, Michael A. Deveau, Geoffrey M. Kapler, Jian Q. Feng, Fei Liu
Journal: Cancer Research
Cancer Res (2020) 80 (24): 5531–5542.
https://doi.org/10.1158/0008-5472.CAN-20-0503
Published: 15 December 2020
View article titled, Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages
Open the PDF for Transient Activation of the Hedgehog-Gli Pathway Rescues Radiotherapy-Induced Dry Mouth via Recovering Salivary Gland Resident Macrophages in another window
Includes: Supplementary data
Journal Articles

Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma

Naoka Tamura, Nadeem Shaikh, Daniel Muliaditan, Tanya N. Soliman, Jennifer R. McGuinness, Eleni Maniati, Daniela Moralli, Mary-Anne Durin, Catherine M. Green, Frances R. Balkwill, Jun Wang, Kit Curtius, Sarah E. McClelland
Journal: Cancer Research
Cancer Res (2020) 80 (22): 4946–4959.
https://doi.org/10.1158/0008-5472.CAN-19-0852
Published: 13 November 2020
View article titled, Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma
Open the PDF for Specific Mechanisms of Chromosomal Instability Indicate Therapeutic Sensitivities in High-Grade Serous Ovarian Carcinoma in another window
Includes: Multimedia, Supplementary data