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Journal Articles

Abstract LB227: ALK201, a first-in-class FGFR2b-targeting antibody-drug conjugate for patients with FGFR2b+ gastric cancer and other solid tumors

Jiajia Pan, Hongwang He, Li Li, Jun Wang, Xiaolin Wang, Kehua Fan, Hui Feng
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB227.
https://doi.org/10.1158/1538-7445.AM2025-LB227
Published: 25 April 2025
View articletitled, Abstract LB227: ALK201, a first-in-class FGFR2b-targeting antibody-drug conjugate for patients with FGFR2b+ gastric cancer and other solid tumors
Journal Articles

Abstract 3411: Transcriptional modulations of tumor microenvironment by BH3120, a PD-L1x4-1BB bispecific antibody, in patient-derived organotypic tumor spheroids (PDOTS) model

Jun Wang, Jiangcheng Xu, Jing Wang, Jiawang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3411.
https://doi.org/10.1158/1538-7445.AM2025-3411
Published: 21 April 2025
View articletitled, Abstract 3411: Transcriptional modulations of tumor microenvironment by BH3120, a PD-L1x4-1BB bispecific antibody, in patient-derived organotypic tumor spheroids (PDOTS) model
Journal Articles

Abstract 3930: Preclinical models of cancer cachexia: Bridging the gap to clinical applications

Hongyan Sun, Dan Zhou, Yunlong Jiang, Jianming Xu, Jing Zhao, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3930.
https://doi.org/10.1158/1538-7445.AM2025-3930
Published: 21 April 2025
View articletitled, Abstract 3930: Preclinical models of cancer cachexia: Bridging the gap to clinical applications
Journal Articles

Abstract 6117: Development of preclinical models for the evaluation of conventional and in vivo CAR-T therapies

Hongyan Sun, Xiaoliu Yang, Shiying Guo, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6117.
https://doi.org/10.1158/1538-7445.AM2025-6117
Published: 21 April 2025
View articletitled, Abstract 6117: Development of preclinical models for the evaluation of conventional and in vivo CAR-T therapies
Journal Articles

Abstract 3532: Development of mouse models for preclinical evaluation of cancer mRNA vaccines

Hongyan Sun, Jialu Fan, Yunlong Jiang, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3532.
https://doi.org/10.1158/1538-7445.AM2025-3532
Published: 21 April 2025
View articletitled, Abstract 3532: Development of mouse models for preclinical evaluation of cancer mRNA vaccines
Journal Articles

Abstract 2192: Enhancing veterinary cancer drug development with innovative bioanalytical assays

Jun Wang, Ildiko Kasza, Denise Garvin, Trish Trish, Rod Flemming, Jeff Nelson, Ngan Lam, Marjeta Urh, Mei Cong, Jamison Grailer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2192.
https://doi.org/10.1158/1538-7445.AM2025-2192
Published: 21 April 2025
View articletitled, Abstract 2192: Enhancing veterinary cancer drug development with innovative bioanalytical assays
Journal Articles

Abstract 5215: IL-17RA expression by NSCLC is vital for restraining homeostatic tumor cell proliferation and baseline cytokine production

Dongpu Li, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5215.
https://doi.org/10.1158/1538-7445.AM2025-5215
Published: 21 April 2025
View articletitled, Abstract 5215: IL-17RA expression by NSCLC is vital for restraining homeostatic tumor cell proliferation and baseline cytokine production
Journal Articles

Abstract 1714: Understanding ADC resistance using preclinical enhertu-induced resistant models

Hongyan Sun, Yuan Fang, Fang Zhu, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1714.
https://doi.org/10.1158/1538-7445.AM2025-1714
Published: 21 April 2025
View articletitled, Abstract 1714: Understanding ADC resistance using preclinical enhertu-induced resistant models
Journal Articles

Abstract 4345: BH3120, a PD-L1x4-1BB bispecific antibody, exhibits favorable safety profiles in distinct in vivo and ex vivo liver toxicity evaluations

Jing Wang, Jiangcheng Xu, Jun Wang, Jiangwang Liu, Kyoungwoo Lee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4345.
https://doi.org/10.1158/1538-7445.AM2025-4345
Published: 21 April 2025
View articletitled, Abstract 4345: BH3120, a PD-L1x4-1BB bispecific antibody, exhibits favorable safety profiles in distinct in vivo and ex vivo liver toxicity evaluations
Journal Articles

Abstract 1297: Novel mouse models to study bone and brain metastasis

Hongyan Sun, Xue Wu, Fang Zhu, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1297.
https://doi.org/10.1158/1538-7445.AM2025-1297
Published: 21 April 2025
View articletitled, Abstract 1297: Novel mouse models to study bone and brain metastasis
Journal Articles

Abstract 5479: Development of novel luminescent assays for sensitive and specific quantitation of double-stranded RNA in mRNA vaccines

Rich Moravec, Jun Wang, Jim Hartnett, Mei Cong, Jamison Grailer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5479.
https://doi.org/10.1158/1538-7445.AM2025-5479
Published: 21 April 2025
View articletitled, Abstract 5479: Development of novel luminescent assays for sensitive and specific quantitation of double-stranded RNA in mRNA vaccines
Journal Articles

Abstract 1296: Development of a novel NCG-hIL15-FcγR-KO model for precise drug efficacy evaluation

Hongyan Sun, Jun Xing, Jianming Xu, Shiying Guo, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1296.
https://doi.org/10.1158/1538-7445.AM2025-1296
Published: 21 April 2025
View articletitled, Abstract 1296: Development of a novel NCG-hIL15-FcγR-KO model for precise drug efficacy evaluation
Journal Articles

Abstract 5737: Preclinical study of a novel long-acting receptor-biased rhIL-2 drug with sustained activation of cytotoxic T cells

Peipei Cao, Biaxue Zhao, Jun Wang, Chenyang Jiang, Yu Zhuang, Bruce Y. Ma
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5737.
https://doi.org/10.1158/1538-7445.AM2025-5737
Published: 21 April 2025
View articletitled, Abstract 5737: Preclinical study of a novel long-acting receptor-biased rhIL-2 drug with sustained activation of cytotoxic T cells
Journal Articles

Abstract 4110: Non-classical HLA epigenetic biomarkers associated with concordant cervical and oral HPV infection

Yinan Zheng, Imran Morhason-Bello, Yishu Qu, Jun Wang, Adeola Fowotade, Adekunle Daniel, Akinyele Adisa, Olutosin Awolude, John Ogunbiyi, Miquel Pavon, Robert Murphy, Isaac Adewole, Deborah Watson-Jones, Lifang Hou
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4110.
https://doi.org/10.1158/1538-7445.AM2025-4110
Published: 21 April 2025
View articletitled, Abstract 4110: Non-classical HLA epigenetic biomarkers associated with concordant cervical and oral HPV infection
Journal Articles

Abstract 5556: Development of osimertinib resistant mouse models for preclinical evaluation of third-generation EFGR-TKI therapies

Hongyan Sun, Yinuo Wang, Shiying Guo, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5556.
https://doi.org/10.1158/1538-7445.AM2025-5556
Published: 21 April 2025
View articletitled, Abstract 5556: Development of osimertinib resistant mouse models for preclinical evaluation of third-generation EFGR-TKI therapies
Journal Articles

Abstract 7291: Advancing cancer immunotherapy: characterizing and leveraging bispecific antibodies targeting immune checkpoints

Jun Wang, Denise Garvin, Jonathan Mitchell, Pete Stecha, Michael Beck, Jim Hartnett, Kai Hillman, Gopal Krishnan, Frank Fan, Julia Gilden, Mei Cong, Jamison Grailer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7291.
https://doi.org/10.1158/1538-7445.AM2025-7291
Published: 21 April 2025
View articletitled, Abstract 7291: Advancing cancer immunotherapy: characterizing and leveraging bispecific antibodies targeting immune checkpoints
Journal Articles

Abstract 4665: Real-world data of resected early-stage non-small cell lung cancer (NSCLC) harboring copy number variations

Jun Wang, Ning Gao, Ding Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4665.
https://doi.org/10.1158/1538-7445.AM2025-4665
Published: 21 April 2025
View articletitled, Abstract 4665: Real-world data of resected early-stage non-small cell lung cancer (NSCLC) harboring copy number variations
Journal Articles

Abstract 7255: Novel anti-PD(L)1 resistance models for post-anti-PD(L)1 drug development

Hongyan Sun, Yan Wang, Zhu Fang, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7255.
https://doi.org/10.1158/1538-7445.AM2025-7255
Published: 21 April 2025
View articletitled, Abstract 7255: Novel anti-PD(L)1 resistance models for post-anti-PD(L)1 drug development
Journal Articles

Abstract 7254: Mouse models for alleviating GvHD and assessing on-target off-tumor toxicity of bispecific T-cell engagers

Hongyan Sun, Bei Zhang, Yunlong Jiang, Jianming Xu, Xiang Gao, Jun Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7254.
https://doi.org/10.1158/1538-7445.AM2025-7254
Published: 21 April 2025
View articletitled, Abstract 7254: Mouse models for alleviating GvHD and assessing on-target off-tumor toxicity of bispecific T-cell engagers
Journal Articles

Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer

Shenghe Deng, Jun Wang, Falong Zou, Denglong Cheng, Mian Chen, Junnan Gu, Jianguo Shi, Jia Yang, Yifan Xue, Zhengxin Jiang, Le Qin, Fuwei Mao, Xiaona Chang, Xiu Nie, Li Liu, Yinghao Cao, Kailin Cai
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-2892
Published: 24 February 2025
View articletitled, Palmitic Acid Accumulation Activates Fibroblasts and Promotes Matrix Stiffness in Colorectal Cancer
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Includes: Supplementary data