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Journal Articles

Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy

Sean Murphy, Sharif Rahmy, Dailin Gan, Guoqiang Liu, Yini Zhu, Maxim Manyak, Loan Duong, Jianping He, James H. Schofield, Zachary T. Schafer, Jun Li, Xuemin Lu, Xin Lu
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1597–1612.
https://doi.org/10.1158/0008-5472.CAN-23-2742
Published: 15 May 2024
View article titled, Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy
Open the PDF for Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract LB065: Tumor-infiltrating lymphocytes (TIL) engineered with regulatable membrane-bound IL15 (mbIL15) and LIGHT (TNFSF14) show enhanced efficacy in fibroblast-containing cold tumors

Balazs Koscso, Zheng Ao, Carmela Passaro, Nirzari Shah, Ngoc Ly, Patricia Timpug, Bulent A. Aksoy, Dexue Sun, Dan Jun Li, Kerri-Lynn Sheahan, Violet Young, Theresa Ross, Benjamin Primack, Meghan Langley, Jeremy Tchaicha, Dhruv K. Sethi, Jan ter Meulen, Michelle Ols
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB065.
https://doi.org/10.1158/1538-7445.AM2024-LB065
Published: 05 April 2024
View article titled, Abstract LB065: Tumor-infiltrating lymphocytes (TIL) engineered with regulatable membrane-bound IL15 (mbIL15) and LIGHT (TNFSF14) show enhanced efficacy in fibroblast-containing cold tumors
Journal Articles

Abstract LB003: Comprehensive multi-omics analysis unveils NFE2L2/KEAP1 mutations as key drivers of treatment resistance in esophageal squamous cell carcinoma during chemoradiotherapy

Kuaile Zhao, Hu Chen, Zhenzhen Xun, Jiaying Deng, Yikai Luo, Jinjun Ye, Junqiang Chen, Weiwei Chen, Jun Li, Han Liang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB003.
https://doi.org/10.1158/1538-7445.AM2024-LB003
Published: 05 April 2024
View article titled, Abstract LB003: Comprehensive multi-omics analysis unveils NFE2L2/KEAP1 mutations as key drivers of treatment resistance in esophageal squamous cell carcinoma during chemoradiotherapy
Journal Articles

Abstract LB341: Clinical validation and mechanistic insights of ThisCART: A novel allogeneic platform enhancing CAR-T signaling via intracellular TCRαβ/CD3 retention

Jun Li, Lei Xue, Sujun Li, Ling He, Kaichun Liu, Rong Jin, Tao Wang, Yinhang Zhang, Shanshan Chen, Yulian Gao, Dan Liu, Liyun Yang, Xingbing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB341.
https://doi.org/10.1158/1538-7445.AM2024-LB341
Published: 05 April 2024
View article titled, Abstract LB341: Clinical validation and mechanistic insights of ThisCART: A novel allogeneic platform enhancing CAR-T signaling via intracellular TCRαβ/CD3 retention
Journal Articles

Abstract 6630: Non-cell-autonomous cancer progression from chromosomal instability

Jun Li, Melissa Hubisz, Ethan Earlie, Mercedes Duran, Christy Hong, Austin Varela, Emanuele Lettera, Matthew Deyell, Bernardo Tavora, Jonathan Havel, Phyu Su, Amit Dipak Amin, Karolina Budre, Erina Kamiya, Julie-Ann Cavallo, Christopher Garris, Simon Powell, Jorge Reis-Filho, Hannah Wen, Sarah Bettigole, Atif Khan, Benjamin Izar, Eileen Parkes, Ashley Laughney, Samuel Bakhoum
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6630.
https://doi.org/10.1158/1538-7445.AM2024-6630
Published: 22 March 2024
View article titled, Abstract 6630: Non-cell-autonomous cancer progression from chromosomal instability
Journal Articles

Abstract 3135: BSI-730, a bispecific antibody targeting HER2 and PD-L1 for the development of a first-in-class bispecific ADC

Xiaoyao Hao, Hongyan Li, Xiaodong F. Liu, Jinyu Liu, Wenwen Dai, Ying Pan, Hui-Han Hu, Jun Li, Shukai Xia, Qun Lyu, Hugh M. Davis, Mingjiu Chen, Zeyu Peng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3135.
https://doi.org/10.1158/1538-7445.AM2024-3135
Published: 22 March 2024
View article titled, Abstract 3135: BSI-730, a bispecific antibody targeting HER2 and PD-L1 for the development of a first-in-class bispecific ADC
Journal Articles

Abstract 5331: Spatial resolution of immune cell lineages in the tumor microenvironment of plasma cell dyscrasias

Medbh A. Dillon, Lisa Arvidson, Cole G. Phalen, Julian R. Ishibashi, John B. Johanneson, Zachary J. Thomson, Peiyao A. Zhao, Jocelin Malone, Mackenzie S. Kopp, Matthew Norton, Gabriella Spang, Susan A. Ludmann, Adam K. Savage, Claire E. Gustafson, Marla Glass, Emma L. Kuan, Tao Peng, Lucas T. Graybuck, Xiao-jun Li, Troy R. Torgerson, Peter J. Skene, Ananda W. Goldrath, Samuel Jensen, Stephanie Anover-Sombke, Melinda L. Angus-Hill
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5331.
https://doi.org/10.1158/1538-7445.AM2024-5331
Published: 22 March 2024
View article titled, Abstract 5331: Spatial resolution of immune cell lineages in the tumor microenvironment of plasma cell dyscrasias
Journal Articles

Abstract 4931: The Cancer Proteome Atlas: Expanded datasets and empowered with an AI-driven chatbot

Han Liang, Wei Liu, Jun Li, Yitao Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4931.
https://doi.org/10.1158/1538-7445.AM2024-4931
Published: 22 March 2024
View article titled, Abstract 4931: The Cancer Proteome Atlas: Expanded datasets and empowered with an AI-driven chatbot
Journal Articles

Abstract 2638: Sensitizing immunotherapy-refractory prostate cancer to immune checkpoint blockade therapy with optimized ketogenic diet regimens

Sean Murphy, Sharif Rahmy, Dailin Gan, Jun Li, Xuemin Lu, Xin Lu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2638.
https://doi.org/10.1158/1538-7445.AM2024-2638
Published: 22 March 2024
View article titled, Abstract 2638: Sensitizing immunotherapy-refractory prostate cancer to immune checkpoint blockade therapy with optimized ketogenic diet regimens
Journal Articles

Abstract 1343: BSI-111, a highly selective anti-CD16a monoclonal antibody with potent agonist activity for building a NK cell engager platform

Jinyu Liu, Wenwen Dai, Hongyan Li, Xiaodong F. Liu, Jun Li, Shukai Xia, Qun Lyu, Hugh M. Davis, Mingjiu Chen, Zeyu Peng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1343.
https://doi.org/10.1158/1538-7445.AM2024-1343
Published: 22 March 2024
View article titled, Abstract 1343: BSI-111, a highly selective anti-CD16a monoclonal antibody with potent agonist activity for building a NK cell engager platform
Journal Articles

Abstract 5151: High serum kidney injury marker-1 and high baseline tumor PD-L1 protein expression levels are independently associated with treatment effect in adjuvant nivolumab plus ipilimumab vs placebo in localized clear cell renal cell carcinoma

Sai Vikram Vemula, Wenxin Xu, Yu Wang, Xiaowen Liu, Jorge Ruiz de Somocurcio, David McDermott, Jun Li, Rupal Bhatt, Chung-Wei Lee, Burcin Simsek, Saurabh Gupta, Robert Motzer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5151.
https://doi.org/10.1158/1538-7445.AM2024-5151
Published: 22 March 2024
View article titled, Abstract 5151: High serum kidney injury marker-1 and high baseline tumor PD-L1 protein expression levels are independently associated with treatment effect in adjuvant nivolumab plus ipilimumab vs placebo in localized clear cell renal cell carcinoma
Journal Articles

Abstract 3328: Oridonin derivative compounds target STATs to inhibit triple-negative breast cancer

Gabrielle Vontz, Jun Li, Zhipin Liang, Ruixia Ma, Pingyuan Wang, Haiying Chen, Jia Zhou, Qiang Shen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3328.
https://doi.org/10.1158/1538-7445.AM2024-3328
Published: 22 March 2024
View article titled, Abstract 3328: Oridonin derivative compounds target STATs to inhibit triple-negative breast cancer
Journal Articles

Abstract 5298: BSI-093, a best-in-class anti-BTN3A monoclonal antibody for cancer immunotherapy by activation of Vg9Vd2 T cells

Wenwen Dai, Jun Li, Jinyu Liu, Hongyan Li, Xiaodong F. Liu, Shukai Xia, Qun Lyu, Hugh M. Davis, Mingjiu Chen, Zeyu Peng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5298.
https://doi.org/10.1158/1538-7445.AM2024-5298
Published: 22 March 2024
View article titled, Abstract 5298: BSI-093, a best-in-class anti-BTN3A monoclonal antibody for cancer immunotherapy by activation of Vg9Vd2 T cells
Journal Articles

Abstract 27: A single amino acid mutated AFP specific T cell receptor uniting synergistic functionalities of CD4 and CD8 T Cells with no cross-activity

Chen-Song Huang, shudan Ou, Jun Li, Junjun Chu, Yanyan Han
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 27.
https://doi.org/10.1158/1538-7445.AM2024-27
Published: 22 March 2024
View article titled, Abstract 27: A single amino acid mutated AFP specific T cell receptor uniting synergistic functionalities of CD4 and CD8 T Cells with no cross-activity
Journal Articles

Abstract 5962: Novel xCT-targeted biologics significantly suppress metastasis, improve survival, and sensitize primary tumors to chemotherapy in TNBC xenograft models

He Gong, Jun Li, Cyrus Becker, Luika Timmerman, Shaheen Sikandar, Yong Huang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5962.
https://doi.org/10.1158/1538-7445.AM2024-5962
Published: 22 March 2024
View article titled, Abstract 5962: Novel xCT-targeted biologics significantly suppress metastasis, improve survival, and sensitize primary tumors to chemotherapy in TNBC xenograft models
Journal Articles

Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition

Liang Fang, Li Zhang, Mengran Wang, Yuhao He, Jiao Yang, Zengjin Huang, Ying Tan, Ke Fang, Jun Li, Zhiyuan Sun, Yanping Li, Yisen Tang, Weizheng Liang, Huanhuan Cui, Qionghua Zhu, Zhe Wu, Yiming Li, Yuhui Hu, Wei Chen
Journal: Cancer Research
Cancer Res (2024) 84 (5): 659–674.
https://doi.org/10.1158/0008-5472.CAN-23-1693
Published: 04 March 2024
View article titled, Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition
Open the PDF for Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial–Mesenchymal Transition in another window
Includes: Supplementary data
Journal Articles

Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer

Ignacio Vázquez-García, Matthew Myers, Marc J. Williams, Samuel S. Freeman, Jun Li, Hongyu Shi, Gryte Satas, Nicholas Ceglia, Florian Uhlitz, MSK SPECTRUM Consortium, Britta Weigelt, Dmitriy Zamarin, Andrew McPherson, Samuel F. Bakhoum, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_2): PR012.
https://doi.org/10.1158/1538-7445.CANEVOL23-PR012
Published: 01 February 2024
View article titled, Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer
Journal Articles

CircMMP2(6,7) Cooperates with β-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis

Yingru Xu, Xincheng Li, Shuxia Zhang, Miaoling Tang, Ruyuan Yu, Xinyi Liao, Ziwen Li, Man Li, Suwen Chen, Wanying Qian, Libing Song, Zunfu Ke, Jun Li
Journal: Cancer Research
Cancer Res (2024) 84 (2): 328–343.
https://doi.org/10.1158/0008-5472.CAN-23-1899
Published: 16 January 2024
View article titled, CircMMP2(6,7) Cooperates with β-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis
Open the PDF for CircMMP2(6,7) Cooperates with β-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 102: Transient chromosomal instability as a driver of ovarian cancer genome evolution

Ignacio Vazquez-Garcia, Florian Uhlitz, Marc J. Williams, Jun Li, Hongyu Shi, Samuel Freeman, Matthew Myers, MSK SPECTRUM Consortium, Britta Weigelt, Dmitriy Zamarin, Andrew McPherson, Samuel F. Bakhoum, Sohrab P. Shah
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 102.
https://doi.org/10.1158/1538-7445.AM2023-102
Published: 29 May 2023
View article titled, Abstract 102: Transient chromosomal instability as a driver of ovarian cancer genome evolution
Journal Articles

The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer

Jia Liu, Ze-Xian Liu, Jia-Jun Li, Zhao-Lei Zeng, Jin-Hong Wang, Xiao-Jing Luo, Chau-Wei Wong, Jia-Bo Zheng, Heng-Ying Pu, Hai-Yu Mo, Hui Sheng, Qi-Nian Wu, Hao Li, Gang Wan, Bo Li, De-shen Wang, Rui-Hua Xu, Huai-Qiang Ju
Journal: Cancer Research
Cancer Res (2023) 83 (9): 1476–1489.
https://doi.org/10.1158/0008-5472.CAN-22-1922
Published: 02 May 2023
View article titled, The Macrophage-Associated LncRNA <em>MALR</em> Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer
Open the PDF for The Macrophage-Associated LncRNA <em>MALR</em> Facilitates ILF3 Liquid–Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer in another window
Includes: Multimedia, Supplementary data