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Journal Articles

Abstract 2213: Obesity alters cancer-related microbial pathways in women with benign and malignant breast disease

Jack W. Sample, Matteo Redaelli, Stephen Johnson, Tanya L. Hoskin, Marina R. Walther-Antonio, Jun Chen, Tina J. Hieken
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2213.
https://doi.org/10.1158/1538-7445.AM2025-2213
Published: 21 April 2025
View articletitled, Abstract 2213: Obesity alters cancer-related microbial pathways in women with benign and malignant breast disease
Journal Articles

Abstract 5207: Organoid-based drug screening identifies CDK9 as a target for stratified treatment of high-grade serous ovarian cancer

Wojciech Senkowski, David Fontaneda-Arenas, Yilin Li, Kari A. Lavikka, Aura Crispino, Jakub Červinka, Francesca Gorini, Kyriaki Driva, Laura Gall-Mas, Lidia Moyano-Galceran, Jaana Oikkonen, Yan-Jun Chen, Karolin Voßgröne, Elin Pietras, Jutta Huvila, Kaisa Huhtinen, Johanna Hynninen, Sampsa Hautaniemi, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5207.
https://doi.org/10.1158/1538-7445.AM2025-5207
Published: 21 April 2025
View articletitled, Abstract 5207: Organoid-based drug screening identifies CDK9 as a target for stratified treatment of high-grade serous ovarian cancer
Journal Articles

SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T cell Activity in Hepatocellular Carcinoma

Yating Chang, Naizhen Wang, Shaopeng Li, Jiaqi Zhang, Yipeng Rao, Zilong Xu, Lu Li, Hongning Wu, Jun Chen, Yanhua Lin, Xiaoxuan Huang, Pingguo Liu, Jun Zhang, Yueting Liao, Chaolong Lin, Chenghao Huang, Ningshao Xia
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3180
Published: 24 March 2025
View articletitled, SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T cell Activity in Hepatocellular Carcinoma
Open the PDF for SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T cell Activity in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT213: Anlotinib plus chemotherapy as first-line therapy for gastrointestinal tumor patients with unresectable liver metastasis: Updated results from a multi-cohort, multi-center phase II trial ALTER-G-001-cohort C

Junwei Wu, Chenfei Zhou, Jun Yan, Zhengxiang Han, Chun Wang, Zhiquan Qin, Jinling Jiang, Chunbin Wang, Xinyu Tang, Lingjun Zhu, Jun Chen, Yong Mao, Xiaowei Wei, Chengfang Shangguan, Jun Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT213.
https://doi.org/10.1158/1538-7445.AM2024-CT213
Published: 05 April 2024
View articletitled, Abstract CT213: Anlotinib plus chemotherapy as first-line therapy for gastrointestinal tumor patients with unresectable liver metastasis: Updated results from a multi-cohort, multi-center phase II trial ALTER-G-001-cohort C
Journal Articles

Abstract 383: Mic19 regulates mitophagy in non-small cell lung cancer under hypoxic microenvironment

Hua Huang, Chen Ding, Zhanrui Zhang, Di Wu, Chen Chen, Yongwen Li, Hongyu Liu, Jun Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 383.
https://doi.org/10.1158/1538-7445.AM2024-383
Published: 22 March 2024
View articletitled, Abstract 383: Mic19 regulates mitophagy in non-small cell lung cancer under hypoxic microenvironment
Journal Articles

Abstract 7581: Nicotine promotes the proliferation and metastasis of non-small cell lung cancer through c-Myc/EZH2 pathway

Chen Ding, Hua Huang, Chen Chen, Yongwen Li, Hongyu Liu, Jun Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7581.
https://doi.org/10.1158/1538-7445.AM2024-7581
Published: 22 March 2024
View articletitled, Abstract 7581: Nicotine promotes the proliferation and metastasis of non-small cell lung cancer through c-Myc/EZH2 pathway
Journal Articles

Abstract 6390: Exploratory biomarker analysis of phase 3 ASTRUM-005 study: Serplulimab versus placebo plus chemotherapy for extensive-stage small cell lung cancer

Ying Cheng, Liang Han, Lin Wu, Jun Chen, Hongmei Sun, Guilan Wen, Yinghua Ji, Anastasia Zimina, Jianhua Shi, Zhijie Pan, Jinsheng Shi, Xicheng Wang, Fang Yang, Xinyi Yang, Mengkai Chen, Shiqi Zhong, Qingyu Wang, Jing Li, Jiancheng Cheng, Chen Ling, Yongqiang Shan, Jun Zhu, The ASTRUM-005 Study Group
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6390.
https://doi.org/10.1158/1538-7445.AM2024-6390
Published: 22 March 2024
View articletitled, Abstract 6390: Exploratory biomarker analysis of phase 3 ASTRUM-005 study: Serplulimab versus placebo plus chemotherapy for extensive-stage small cell lung cancer
Journal Articles

Abstract 6219: Type V collagen promotes lung adenocarcinoma metastasis by regulating tumor mechanical stress and the implication for prognosis and therapeutic strategies

Guangsheng Zhu, Yanan Wang, Yingjie Wang, Chen, Yongwen Li, Hongyu Liu, Jun Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6219.
https://doi.org/10.1158/1538-7445.AM2024-6219
Published: 22 March 2024
View articletitled, Abstract 6219: Type V collagen promotes lung adenocarcinoma metastasis by regulating tumor mechanical stress and the implication for prognosis and therapeutic strategies
Journal Articles

Abstract 235: Application of high-grade serous ovarian cancer organoids in functional precision medicine

Wojciech Senkowski, Laura Gall-Mas, Matias M. Falco, Yilin Li, Kari Lavikka, Aura Crispino, Jaana Oikkonen, Daria Bulanova, Yan-Jun Chen, Elena M. Doncel, Karolin Voßgröne, Erdogan P. Erkan, Jun Dai, Anastasia Lundgren, Jutta Huvila, Kaisa Huhtinen, Johanna Hynninen, Sampsa Hautaniemi, Anna Vähärautio, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 235.
https://doi.org/10.1158/1538-7445.AM2024-235
Published: 22 March 2024
View articletitled, Abstract 235: Application of high-grade serous ovarian cancer organoids in functional precision medicine
Journal Articles

Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors

Xiuxiu Zhu, Jun Chen, Wuling Li, Yanmin Xu, Juanjuan Shan, Juan Hong, Yongchun Zhao, Huailong Xu, Jiabin Ma, Junjie Shen, Cheng Qian
Journal: Cancer Research
Cancer Res (2024) 84 (1): 84–100.
https://doi.org/10.1158/0008-5472.CAN-23-1038
Published: 02 January 2024
View articletitled, Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors
Open the PDF for Hypoxia-Responsive CAR-T Cells Exhibit Reduced Exhaustion and Enhanced Efficacy in Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 3584: Early and non-invasive detection of radiation-induced cardiotoxicity in pre-clinical and clinical models

Taylor-Jade Higgins, Jayesh Sharma, Elizabeth R. Zhang-Velten, Sarah Elliott, Junjie Ma, Jun Chen, Gabriele Schiattarella, Chantal Vidal, Nan Jiang, Daniel Daou, Joseph Hill, Thomas Gillette, Craig Malloy, Vlad Zaha, Jae Mo Park, Prasanna Alluri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3584.
https://doi.org/10.1158/1538-7445.AM2023-3584
Published: 04 April 2023
View articletitled, Abstract 3584: Early and non-invasive detection of radiation-induced cardiotoxicity in pre-clinical and clinical models
Journal Articles

Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia

Joshua P. Plotnik, Raghuveer S. Mali, Velitchka Bontcheva, Colleen Dowell, Jun Chen, Adam E. Richardson, Ryan A. McClure, Paul Jung, Lan Pham, Andrew J. Souers, Jonathan A. Meulbroek, William N. Pappano
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6156.
https://doi.org/10.1158/1538-7445.AM2023-6156
Published: 04 April 2023
View articletitled, Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia
Journal Articles

Abstract 5779: A platform utilizing high-grade serous ovarian cancer organoids for prospective patient stratification in functional precision medicine

Wojciech Senkowski, Laura Gall-Mas, Matias M. Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria Bulanova, Elin J. Pietras, Karolin Voßgröne, Yan-Jun Chen, Erdogan P. Erkan, Mia K. Høg, Ida M. Larsen, Tarja Lamminen, Katja Kaipio, Jutta Huvila, Anni Virtanen, Lars H. Engelholm, Pernille Christiansen, Eric Santoni Rugiu, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Sampsa Hautaniemi, Anna Vähärautio, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5779.
https://doi.org/10.1158/1538-7445.AM2023-5779
Published: 04 April 2023
View articletitled, Abstract 5779: A platform utilizing high-grade serous ovarian cancer organoids for prospective patient stratification in functional precision medicine
Journal Articles

Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3

Xingxin Zhu, Guangyuan Song, Shiyu Zhang, Jun Chen, Xiaoyi Hu, Hai Zhu, Xing Jia, Zequn Li, Wenfeng Song, Jian Chen, Cheng Jin, Mengqiao Zhou, Yongchao Zhao, Haiyang Xie, Shusen Zheng, Penghong Song
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3987–4000.
https://doi.org/10.1158/0008-5472.CAN-21-4337
Published: 02 November 2022
View articletitled, Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3
Open the PDF for Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3 in another window
Includes: Supplementary data
Journal Articles

Abstract 3659: Early in vivo detection of radiation-induced cardiotoxicity

Jayesh Sharma, Elizabeth Zhang, Xuliang Wang, Junjie Ma, Jun Chen, Gabriele Schiattarella, Joseph Hill, Jaemo Park, Craig Malloy, Vlad Zaha, Prasanna Alluri
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3659.
https://doi.org/10.1158/1538-7445.AM2022-3659
Published: 15 June 2022
View articletitled, Abstract 3659: Early in vivo detection of radiation-induced cardiotoxicity
Journal Articles

Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)

Shun Lu, Yiping Zhang, Guojun Zhang, Jianying Zhou, Shundong Cang, Ying Cheng, Gang Wu, Peiguo Cao, Dongqing Lv, Xiangming Jin, Hong Jian, Chengshui Chen, Guanming Jiang, Panwen Tian, Kai Wang, Hui Zhao, Gongyan Chen, Qun Chen, Cuimin Ding, Junquan Yang, Renhua Guo, Guoping Sun, Bin Wang, Liyan Jiang, Wu Zhuang, Zhe Liu, Jian Fang, Yunpeng Liu, Jian Zhang, Jun Chen, Yueyin Pan, Qitao Yu, Min Zhao, Jiuwei Cui, Dianming Li, Tienan Yi, Zhuang Yu, Yan Yang, Yan Zhang, Xiuyi Zhi, Yunchao Huang, Rong Wu, Liangan Chen, Aimin Zang, Lejie Cao, Qingshan Li, Xiaoling Li, Yong Song, Donglin Wang, Shucai Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT170.
https://doi.org/10.1158/1538-7445.AM2021-CT170
Published: 01 July 2021
View articletitled, Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)
Journal Articles

Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death

Nagarajan Kannan, Syed Mohammed Musheer Aalam, Xiaojia Tang, Krishna Kalari, Purna Kashyap, Jun Chen, Stephen Johnson, Anguraj Sadanandam, Mark Sherman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB226.
https://doi.org/10.1158/1538-7445.AM2021-LB226
Published: 01 July 2021
View articletitled, Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death
Journal Articles

Abstract 2000: Systemic and tumor associated IL-8 correlates with resistance to PD-L1 blockade

Kobe Yuen, Lifen Liu, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward Kadel, Hartmut Koeppen, Shravan Madireddi, Shilpa Keerthivasan, Ying-Jun Chen, Zora Modrusen, Romain Banchereau, Ning Leng, Priti Hegde, Mahrukh Huseni, Sanjeev Mariathasan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2000.
https://doi.org/10.1158/1538-7445.AM2020-2000
Published: 15 August 2020
View articletitled, Abstract 2000: Systemic and tumor associated IL-8 correlates with resistance to PD-L1 blockade
Journal Articles

Abstract PR09: Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome): Putative role of Porphyromonas somerae in the disease

Marina Walther-Antonio, Dana Walsh, Alexis Hokenstad, Jun Chen, Jayeun Sung, Gregory Jenkins, Nicholas Chia, Heidi Nelson, Andrea Mariani
Journal: Cancer Research
Cancer Res (2020) 80 (8_Supplement): PR09.
https://doi.org/10.1158/1538-7445.MVC2020-PR09
Published: 15 April 2020
View articletitled, Abstract PR09: Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome): Putative role of Porphyromonas somerae in the disease
Journal Articles

Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis

Shenglan Shang, Xinran Ji, Lili Zhang, Jun Chen, Chuan Li, Rongchen Shi, Wei Xiang, Xia Kang, Dapeng Zhang, Fan Yang, Rongyang Dai, Peng Chen, Shan Chen, Yongchuan Chen, Yongsheng Li, Hongming Miao
Journal: Cancer Research
Cancer Res (2019) 79 (21): 5513–5526.
https://doi.org/10.1158/0008-5472.CAN-19-1059
Published: 01 November 2019
View articletitled, Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis
Open the PDF for Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis in another window
Includes: Supplementary data