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Journal Articles

Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia

Joshua P. Plotnik, Raghuveer S. Mali, Velitchka Bontcheva, Colleen Dowell, Jun Chen, Adam E. Richardson, Ryan A. McClure, Paul Jung, Lan Pham, Andrew J. Souers, Jonathan A. Meulbroek, William N. Pappano
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6156.
https://doi.org/10.1158/1538-7445.AM2023-6156
Published: 04 April 2023
View article titled, Abstract 6156: MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia
Journal Articles

Abstract 5779: A platform utilizing high-grade serous ovarian cancer organoids for prospective patient stratification in functional precision medicine

Wojciech Senkowski, Laura Gall-Mas, Matias M. Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria Bulanova, Elin J. Pietras, Karolin Voßgröne, Yan-Jun Chen, Erdogan P. Erkan, Mia K. Høg, Ida M. Larsen, Tarja Lamminen, Katja Kaipio, Jutta Huvila, Anni Virtanen, Lars H. Engelholm, Pernille Christiansen, Eric Santoni Rugiu, Kaisa Huhtinen, Olli Carpén, Johanna Hynninen, Sampsa Hautaniemi, Anna Vähärautio, Krister Wennerberg
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5779.
https://doi.org/10.1158/1538-7445.AM2023-5779
Published: 04 April 2023
View article titled, Abstract 5779: A platform utilizing high-grade serous ovarian cancer organoids for prospective patient stratification in functional precision medicine
Journal Articles

Abstract 3584: Early and non-invasive detection of radiation-induced cardiotoxicity in pre-clinical and clinical models

Taylor-Jade Higgins, Jayesh Sharma, Elizabeth R. Zhang-Velten, Sarah Elliott, Junjie Ma, Jun Chen, Gabriele Schiattarella, Chantal Vidal, Nan Jiang, Daniel Daou, Joseph Hill, Thomas Gillette, Craig Malloy, Vlad Zaha, Jae Mo Park, Prasanna Alluri
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3584.
https://doi.org/10.1158/1538-7445.AM2023-3584
Published: 04 April 2023
View article titled, Abstract 3584: Early and non-invasive detection of radiation-induced cardiotoxicity in pre-clinical and clinical models
Journal Articles

Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3

Xingxin Zhu, Guangyuan Song, Shiyu Zhang, Jun Chen, Xiaoyi Hu, Hai Zhu, Xing Jia, Zequn Li, Wenfeng Song, Jian Chen, Cheng Jin, Mengqiao Zhou, Yongchao Zhao, Haiyang Xie, Shusen Zheng, Penghong Song
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3987–4000.
https://doi.org/10.1158/0008-5472.CAN-21-4337
Published: 02 November 2022
View article titled, Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3
Open the PDF for Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3 in another window
Includes: Supplementary data
Journal Articles

Abstract 3659: Early in vivo detection of radiation-induced cardiotoxicity

Jayesh Sharma, Elizabeth Zhang, Xuliang Wang, Junjie Ma, Jun Chen, Gabriele Schiattarella, Joseph Hill, Jaemo Park, Craig Malloy, Vlad Zaha, Prasanna Alluri
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3659.
https://doi.org/10.1158/1538-7445.AM2022-3659
Published: 15 June 2022
View article titled, Abstract 3659: Early <em>in vivo</em> detection of radiation-induced cardiotoxicity
Journal Articles

Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)

Shun Lu, Yiping Zhang, Guojun Zhang, Jianying Zhou, Shundong Cang, Ying Cheng, Gang Wu, Peiguo Cao, Dongqing Lv, Xiangming Jin, Hong Jian, Chengshui Chen, Guanming Jiang, Panwen Tian, Kai Wang, Hui Zhao, Gongyan Chen, Qun Chen, Cuimin Ding, Junquan Yang, Renhua Guo, Guoping Sun, Bin Wang, Liyan Jiang, Wu Zhuang, Zhe Liu, Jian Fang, Yunpeng Liu, Jian Zhang, Jun Chen, Yueyin Pan, Qitao Yu, Min Zhao, Jiuwei Cui, Dianming Li, Tienan Yi, Zhuang Yu, Yan Yang, Yan Zhang, Xiuyi Zhi, Yunchao Huang, Rong Wu, Liangan Chen, Aimin Zang, Lejie Cao, Qingshan Li, Xiaoling Li, Yong Song, Donglin Wang, Shucai Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT170.
https://doi.org/10.1158/1538-7445.AM2021-CT170
Published: 01 July 2021
View article titled, Abstract CT170: D-0316 in patients with advanced T790M-positive EGFR-mutant non-small cell lung cancer who progressed on prior EGFR-TKI therapy: results from a phase II study (NCT03861156)
Journal Articles

Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death

Nagarajan Kannan, Syed Mohammed Musheer Aalam, Xiaojia Tang, Krishna Kalari, Purna Kashyap, Jun Chen, Stephen Johnson, Anguraj Sadanandam, Mark Sherman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB226.
https://doi.org/10.1158/1538-7445.AM2021-LB226
Published: 01 July 2021
View article titled, Abstract LB226: Maternal microbiome protects host against clonal de novo transformation, early onset systemic metastasis, and sudden death
Journal Articles

Abstract 2000: Systemic and tumor associated IL-8 correlates with resistance to PD-L1 blockade

Kobe Yuen, Lifen Liu, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward Kadel, Hartmut Koeppen, Shravan Madireddi, Shilpa Keerthivasan, Ying-Jun Chen, Zora Modrusen, Romain Banchereau, Ning Leng, Priti Hegde, Mahrukh Huseni, Sanjeev Mariathasan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2000.
https://doi.org/10.1158/1538-7445.AM2020-2000
Published: 15 August 2020
View article titled, Abstract 2000: Systemic and tumor associated IL-8 correlates with resistance to PD-L1 blockade
Journal Articles

Abstract PR09: Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome): Putative role of Porphyromonas somerae in the disease

Marina Walther-Antonio, Dana Walsh, Alexis Hokenstad, Jun Chen, Jayeun Sung, Gregory Jenkins, Nicholas Chia, Heidi Nelson, Andrea Mariani
Journal: Cancer Research
Cancer Res (2020) 80 (8_Supplement): PR09.
https://doi.org/10.1158/1538-7445.MVC2020-PR09
Published: 15 April 2020
View article titled, Abstract PR09: Postmenopause as a key factor in the composition of the Endometrial Cancer Microbiome (ECbiome): Putative role of <em>Porphyromonas somerae</em> in the disease
Journal Articles

Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis

Shenglan Shang, Xinran Ji, Lili Zhang, Jun Chen, Chuan Li, Rongchen Shi, Wei Xiang, Xia Kang, Dapeng Zhang, Fan Yang, Rongyang Dai, Peng Chen, Shan Chen, Yongchuan Chen, Yongsheng Li, Hongming Miao
Journal: Cancer Research
Cancer Res (2019) 79 (21): 5513–5526.
https://doi.org/10.1158/0008-5472.CAN-19-1059
Published: 01 November 2019
View article titled, Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis
Open the PDF for Macrophage ABHD5 Suppresses NFκB-Dependent Matrix Metalloproteinase Expression and Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 4420: MiR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin

Yongwen Li, Hongbing Zhang, Hongyu Liu, Jun Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4420.
https://doi.org/10.1158/1538-7445.AM2018-4420
Published: 01 July 2018
View article titled, Abstract 4420: MiR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin
Journal Articles

Abstract 167: Ibrutinib regulates tumor microenvironment and enhances response to everolimus in renal cell carcinoma mouse models

Jun Chen, Chun-Te Chen, Jing Liu, Jeff Hsu, Taisei Kinoshita, Betty Y. Chang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 167.
https://doi.org/10.1158/1538-7445.AM2017-167
Published: 01 July 2017
View article titled, Abstract 167: Ibrutinib regulates tumor microenvironment and enhances response to everolimus in renal cell carcinoma mouse models
Journal Articles

MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

Li Su, Yongli Luo, Zhi Yang, Jing Yang, Chao Yao, Feifei Cheng, Juanjuan Shan, Jun Chen, Fangfang Li, Limei Liu, Chungang Liu, Yanmin Xu, Lupin Jiang, Deyu Guo, Jesus Prieto, Matías A. Ávila, Junjie Shen, Cheng Qian
Journal: Cancer Research
Cancer Res (2016) 76 (17): 5054–5067.
https://doi.org/10.1158/0008-5472.CAN-16-0246
Published: 31 August 2016
View article titled, MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Open the PDF for MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2321: Ibrutinib enhances antitumor activity in solid tumors when combined with checkpoint inhibitors

Jeff Hsu, Yujun Huang, Chun-Te Chen, Jun Chen, Mint Sirisawad, Betty Y. Chang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2321.
https://doi.org/10.1158/1538-7445.AM2016-2321
Published: 15 July 2016
View article titled, Abstract 2321: Ibrutinib enhances antitumor activity in solid tumors when combined with checkpoint inhibitors
Journal Articles

Abstract 6: Quantitative assessment of BCL-2:BIM complexes as a pharmacodynamic marker for venetoclax (ABT-199)

Sha Jin, Paul Tapang, Donald J. Osterling, Wenqing Gao, Daniel H. Albert, Andrew J. Souers, Joel D. Leverson, Darren C. Phillips, Jun Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 6.
https://doi.org/10.1158/1538-7445.AM2015-6
Published: 01 August 2015
View article titled, Abstract 6: Quantitative assessment of BCL-2:BIM complexes as a pharmacodynamic marker for venetoclax (ABT-199)
Journal Articles

Abstract 2759: Colorectal cancer cell lines with high BCL-XL and low MCL-1 expression are sensitive to a potent and selective BCL-XL inhibitor

Lloyd T. Lam, Haichao Zhang, John Xue, Paul Hessler, Stephen K. Tahir, Jun Chen, Sha Jin, Andrew J. Souers, Joel D. Leverson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2759.
https://doi.org/10.1158/1538-7445.AM2014-2759
Published: 01 October 2014
View article titled, Abstract 2759: Colorectal cancer cell lines with high BCL-XL and low MCL-1 expression are sensitive to a potent and selective BCL-XL inhibitor
Journal Articles

Abstract 4564: Inhibitory effects of the BTK inhibitor, ibrutinib, on Her2 amplified breast cancer growth, cell cycle progression and clonogenicity

Jun Chen, Betty Y. Chang, Laurence Elias
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4564.
https://doi.org/10.1158/1538-7445.AM2014-4564
Published: 01 October 2014
View article titled, Abstract 4564: Inhibitory effects of the BTK inhibitor, ibrutinib, on Her2 amplified breast cancer growth, cell cycle progression and clonogenicity
Journal Articles

Abstract LB-72: An immunoassay detecting Bcl-2:Bim and Mcl-1:Bim complexes in the phase 1 monotherapy study of the Bcl-2 inhibitor, ABT-199/GDC-0199, in chronic lymphocytic leukemia patients

Jessica Li, Jun Chen, Ward Kadel, Brenda Chyla, evelyn McKeegan, Elizabeth Punnoose, Walter Darbonne
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-72.
https://doi.org/10.1158/1538-7445.AM2014-LB-72
Published: 01 October 2014
View article titled, Abstract LB-72: An immunoassay detecting Bcl-2:Bim and Mcl-1:Bim complexes in the phase 1 monotherapy study of the Bcl-2 inhibitor, ABT-199/GDC-0199, in chronic lymphocytic leukemia patients
Journal Articles

Abstract 4966: Establishment and characterization of a paired human non-small cell lung cancer cell lines from primary cancer and metastasis lymph node

Jun Chen, Min Wang, Lingling Zu, Yongwen Li, Weiqiang Wang, Ying Li, Hongyu Liu
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4966.
https://doi.org/10.1158/1538-7445.AM2014-4966
Published: 01 October 2014
View article titled, Abstract 4966: Establishment and characterization of a paired human non-small cell lung cancer cell lines from primary cancer and metastasis lymph node
Journal Articles

Abstract 4607: Expression of Bcl-2 pro-survival family proteins predicts pharmacological responses to ABT-199, a novel and selective Bcl-2 antagonist, in multiple myeloma models.

Deepak Sampath, Elizabeth Punnoose, Erwin Boghaert, Lisa Belmont, Franklin Peale, Nguyen Tan, Jun Chen, Walter Darbonne, Peng Yue, Jason Oeh, Leslie Lee, Wayne J. Fairbrother, Andrew J. Souers, Steven W. Elmore, Joel D. Leverson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4607.
https://doi.org/10.1158/1538-7445.AM2013-4607
Published: 15 April 2013
View article titled, Abstract 4607: Expression of Bcl-2 pro-survival family proteins predicts pharmacological responses to ABT-199, a novel and selective Bcl-2 antagonist, in multiple myeloma models.