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Journal Articles

CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer

Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Phil East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2231–2246.
https://doi.org/10.1158/0008-5472.CAN-23-2627
Published: 15 July 2024
View article titled, CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer
Open the PDF for CRISPR–Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1214: Investigating therapeutic strategies to promote immune rejection of KRASG12C inhibitor-resistant subpopulations in lung cancer

Mona Tomaschko, Christopher Moore, Claire E. Pillsbury, Kangbo Ng, Sophie de Carne, Sareena Rana, Andrea de Castro, Panayiotis Anastasiou, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1214.
https://doi.org/10.1158/1538-7445.AM2024-1214
Published: 22 March 2024
View article titled, Abstract 1214: Investigating therapeutic strategies to promote immune rejection of KRAS<sup>G12C</sup> inhibitor-resistant subpopulations in lung cancer
Journal Articles

Abstract 5733: Combining KRASG12C(ON) inhibition with SHP2 and immune checkpoint blockade to enhance anti-tumor immunity and overcome development of resistance in lung cancer

Panayiotis Anastasiou, Mona Tomaschko, Jesse Boumelha, Sareena Rana, Christopher Moore, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5733.
https://doi.org/10.1158/1538-7445.AM2023-5733
Published: 04 April 2023
View article titled, Abstract 5733: Combining KRAS<sup>G12C</sup>(ON) inhibition with SHP2 and immune checkpoint blockade to enhance anti-tumor immunity and overcome development of resistance in lung cancer
Journal Articles

Abstract 4155: The RAF/MEK clamp avutometinib (VS-6766) induces an immunogenic tumor microenvironment and potentiates the efficacy of anti-PD-1

Silvia Coma, Miriam Molina Arcas, Julian Downward, Jonathan A. Pachter
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4155.
https://doi.org/10.1158/1538-7445.AM2023-4155
Published: 04 April 2023
View article titled, Abstract 4155: The RAF/MEK clamp avutometinib (VS-6766) induces an immunogenic tumor microenvironment and potentiates the efficacy of anti-PD-1
Journal Articles

An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations

Jesse Boumelha, Sophie de Carné Trécesson, Emily K. Law, Pablo Romero-Clavijo, Matthew A. Coelho, Kevin W. Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R. Caswell, Miguel Murillo, David C. Hancock, Prokopios P. Argyris, William L. Brown, Cameron Durfee, Lindsay K. Larson, Rachel I. Vogel, Alejandro Suárez-Bonnet, Simon L. Priestnall, Philip East, Sarah J. Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Harris, Julian Downward
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3435–3448.
https://doi.org/10.1158/0008-5472.CAN-22-0325
Published: 04 October 2022
View article titled, An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations
Open the PDF for An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations in another window
Includes: Supplementary data
Journal Articles

Abstract 4029: Combination of KRASG12C(ON) and SHP2 inhibitors overcomes adaptive resistance and enhances anti-tumor immunity

Panayiotis Anastasiou, Edurne Mugarza, Jesse Boumelha, Sareena Rana, Christopher Moore, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4029.
https://doi.org/10.1158/1538-7445.AM2022-4029
Published: 15 June 2022
View article titled, Abstract 4029: Combination of KRAS<sup>G12C</sup>(ON) and SHP2 inhibitors overcomes adaptive resistance and enhances anti-tumor immunity
Journal Articles

Abstract 3609: Defining extrinsic and intrinsic mechanisms of immune evasion in TRACERx using imaging mass cytometry

Katey Enfield, Emma Colliver, Mihaela Angelova, Alastair Magness, Claudia Lee, Kristiana Grigoriadis, Oriol Pich, Clare Puttick, Dina Levi, Philip Hobson, David Moore, Takahiro Karasaki, Selvaraju Veeriah, TRACERx Consortium, Mariam Jamal-Hanjani, Nicholas McGranahan, Erik Sahai, Julian Downward, Crispin Hiley, Charles Swanton
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3609.
https://doi.org/10.1158/1538-7445.AM2022-3609
Published: 15 June 2022
View article titled, Abstract 3609: Defining extrinsic and intrinsic mechanisms of immune evasion in TRACERx using imaging mass cytometry
Journal Articles

Abstract 1926: Machine learning-enhanced image and spatial analytic pipelines for imaging mass cytometry applied to the TRACERx non-small cell lung cancer study

Alastair Magness, Katey Enfield, Mihaela Angelova, Emma Colliver, Emer Daly, Kristiana Grigoriadis, Claudia Lee, Oriol Pich, Philip Hobson, Dina Levi, Takahiro Karasaki, David Moore, Julian Downward, Erik Sahai, Mariam Jamal-Hanjani, Charles Swanton, TRACERx Consortium
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1926.
https://doi.org/10.1158/1538-7445.AM2022-1926
Published: 15 June 2022
View article titled, Abstract 1926: Machine learning-enhanced image and spatial analytic pipelines for imaging mass cytometry applied to the TRACERx non-small cell lung cancer study
Journal Articles

Abstract 1352: In vivo CRISPR screening identifies mediators of immune evasion in KRAS-mutant lung cancer

Jesse Boumelha, Pablo Romero-Clavijo, Sophie de Carné, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1352.
https://doi.org/10.1158/1538-7445.AM2022-1352
Published: 15 June 2022
View article titled, Abstract 1352: <em>In vivo</em> CRISPR screening identifies mediators of immune evasion in KRAS-mutant lung cancer
Journal Articles

Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance

Manasi Mayekar, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, Andrew Rowan, Maise Al Bakir, Clare Weeden, Caroline E. McCoach, Collin M. Blakely, Nuri Alpay Temiz, Ai Nagano, Daniel L. Kerr, Julia K. Rotow, Oriol Pich, Franziska Haderk, Michelle Dietzen, Carlos Martinez Ruiz, Bruna Almeida, Lauren Cech, Beatrice Gini, Joanna Przewrocka, Chris Moore, Miguel Murillo, Bjorn Bakker, Brandon Rule, Cameron Durfee, Shigeki Nanj, Lisa Tan, Lindsay K. Larson, Prokopios P. Argyris, William L. Brown, Johnny Yu, Carlos Gomez, Philippe Gui, Rachel I. Vogel, Elizabeth A. Yu, Nicholas J. Thomas, Subramanian Venkatesan, Sebastijan Hobor, Su Kit Chew, Nicholas McGranahan, Nnennaya Kanu, Eliezer M. Van Allen, Julian Downward, Reuben S. Harris, Trever Bivona, Charles Swanton
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2197.
https://doi.org/10.1158/1538-7445.AM2022-2197
Published: 15 June 2022
View article titled, Abstract 2197: Targeted cancer therapy induces APOBEC fueling the evolution of drug resistance
Journal Articles

Abstract 1390: Immunotherapy boosts B cell responses in lung adenocarcinoma

Katey Enfield, Kevin Ng, Jesse Boumelha, Kevin Litchfield, Oriol Pich, TRACERx Consortium, Charles Swanton, George Kassiotis, Julian Downward
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1390.
https://doi.org/10.1158/1538-7445.AM2022-1390
Published: 15 June 2022
View article titled, Abstract 1390: Immunotherapy boosts B cell responses in lung adenocarcinoma
Journal Articles

Abstract 6113: Spatially resolved biomarker detection on single cells in TRACERx using multiplex imaging

Mihaela Angelova, Katey Enfield, Alastair Magness, Emma Colliver, Masako Shimato, Claudia Lee, David A. Moore, Febe Van Maldegem, Philip Hobson, Dina Levi, James L. Reading, Crispin T. Hiley, Julian Downward, Erik Sahai, Charles Swanton
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6113.
https://doi.org/10.1158/1538-7445.AM2022-6113
Published: 15 June 2022
View article titled, Abstract 6113: Spatially resolved biomarker detection on single cells in TRACERx using multiplex imaging
Journal Articles

Abstract LB124: APOBEC3B fuels evolution of resistance during targeted cancer therapy

Manasi K. Mayekar, Deborah Caswell, Natalie Vokes, Wei Wu, Caroline McCoach, Collin Blakely, Nuri Alpay Temiz, Daniel Lucas Kerr, Julia Rotow, Franziska Haderk, Lauren Cech, Beatrice Gini, Shigeki Nanjo, Lisa Tan, Johnny Yu, Carlos Gomez, Philippe Gui, Elizabeth Yu, Nicholas Thomas, Julian Downward, Reuben Harris, Eliezer Van Allen, Charles Swanton, Trever Bivona
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB124.
https://doi.org/10.1158/1538-7445.AM2021-LB124
Published: 01 July 2021
View article titled, Abstract LB124: APOBEC3B fuels evolution of resistance during targeted cancer therapy
Journal Articles

Abstract 1820: Uncovering mechanisms of immune evasion in a novel immunogenic model of KRAS-mutant lung cancer

Jesse Boumelha, Sophie de Carné, Edurne Mugarza, Pablo Romero-Clavijo, Miriam Molina-Arcas, Julian Downward
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1820.
https://doi.org/10.1158/1538-7445.AM2021-1820
Published: 01 July 2021
View article titled, Abstract 1820: Uncovering mechanisms of immune evasion in a novel immunogenic model of KRAS-mutant lung cancer
Journal Articles

ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma

Hanna Foster, E. Josue Ruiz, Christopher Moore, Gordon W. H. Stamp, Emma L. Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens
Journal: Cancer Research
Cancer Res (2019) 79 (20): 5159–5166.
https://doi.org/10.1158/0008-5472.CAN-19-0647
Published: 15 October 2019
View article titled, <em>ATMIN</em> Is a Tumor Suppressor Gene in Lung Adenocarcinoma
Open the PDF for <em>ATMIN</em> Is a Tumor Suppressor Gene in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2987: Identification of new combination therapies for lung tumors harboring KRAS mutations

Miriam Molina-Arcas, Christopher Moore, Sareena Rana, Febe van Maldegem, Stuart Horswell, David Hancock, Julian Downward
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2987.
https://doi.org/10.1158/1538-7445.AM2018-2987
Published: 01 July 2018
View article titled, Abstract 2987: Identification of new combination therapies for lung tumors harboring KRAS mutations
Journal Articles

Abstract 2408: A novel multiplex droplet digital PCR approach to KRAS mutation detection in circulating tumor DNA

Alexandra Pender, Isaac Garcia-Murillas, Sareena Rana, David Gonzalez de Castro, Nicholas Turner, Sanjay Popat, Julian Downward
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2408.
https://doi.org/10.1158/1538-7445.AM2015-2408
Published: 01 August 2015
View article titled, Abstract 2408: A novel multiplex droplet digital PCR approach to KRAS mutation detection in circulating tumor DNA
Journal Articles

Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer

David Endesfelder, Rebecca A. Burrell, Nnennaya Kanu, Nicholas McGranahan, Mike Howell, Peter J. Parker, Julian Downward, Charles Swanton, Maik Kschischo
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (17): 4853–4863.
https://doi.org/10.1158/0008-5472.CAN-13-2664
Published: 01 September 2014
View article titled, Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER<sup>+</sup> Breast Cancer
Open the PDF for Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER<sup>+</sup> Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A54: Requirement for interaction of PI 3-kinase p110alpha with Ras in lung tumor maintenance

Clare Sheridan, Esther Castellano, May Zaw Thin, Miguel Murillo, Francois Lassailly, Gordon Stamp, Julian Downward
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): A54.
https://doi.org/10.1158/1538-7445.FBCR13-A54
Published: 15 May 2014
View article titled, Abstract A54: Requirement for interaction of PI 3-kinase p110alpha with Ras in lung tumor maintenance
Journal Articles

Abstract IA12: Targeting unique dependencies of RAS mutant tumors.

Julian Downward
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): IA12.
https://doi.org/10.1158/1538-7445.PANCA2012-IA12
Published: 03 April 2014
View article titled, Abstract IA12: Targeting unique dependencies of RAS mutant tumors.