1-20 of 28
Judy Lucas
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 818: NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trial

Matthew S. Sung, Christine Hopf, Erik Upeslacis, Jonathon Golas, Mark Kaplan, Kiran Khandke, Manoj Charati, Frank Kotch, Frank Loganzo, Ken Geles, Judy Lucas, Hans-Peter Gerber, Puja Sapra, Edward Rosfjord
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 818.
https://doi.org/10.1158/1538-7445.AM2018-818
Published: 01 July 2018
View article titled, Abstract 818: NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trial
Journal Articles

Abstract 868: Creating a superior, site-specific anti-HER2 antibody-drug conjugate (NG-HER2 ADC) for treatment of solid tumors

Dangshe Ma, Bitha Narayanan, Kim Marquette, Edmund Graziani, Frank Loganzo, Manoj Charati, Nadira Prashad, Nathan Tumey, Jon Golas, Christine Hosselet, George Hu, Frank Barletta, Alison Betts, Judy Lucas, Chris O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 868.
https://doi.org/10.1158/1538-7445.AM2016-868
Published: 15 July 2016
View article titled, Abstract 868: Creating a superior, site-specific anti-HER2 antibody-drug conjugate (NG-HER2 ADC) for treatment of solid tumors
Journal Articles

Abstract 2113: Caveolae-mediated endocytosis as a novel mechanism of resistance to T-DM1 ADC

Matthew S. Sung, Xingzhi Tan, Christine Hosselet, Michael Cinque, Erik Upeslacis, Jonathon Golas, Fang Wang, Bingwen Lu, Laurie Tylaska, Lindsay King, Jeremy Myers, Edward Rosfjord, Judy Lucas, Hans-Peter Gerber, Frank Loganzo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2113.
https://doi.org/10.1158/1538-7445.AM2016-2113
Published: 15 July 2016
View article titled, Abstract 2113: Caveolae-mediated endocytosis as a novel mechanism of resistance to T-DM1 ADC
Journal Articles

Abstract A2-33: Molecular profiling of patient-derived xenograft models across cancers

Zhengyan Kan, Edward Rosfjord, James Hardwick, Ying Ding, Xianxian Zheng, Julio Fernandez, Stephanie Shi, Mark Ozeck, Hui Wang, Gabriel Troche, Eric Upeslacis, Amy Jackson-Fisher, Keith Ching, Shibing Deng, Xie Tao, John Chionis, Maruja Lira, Xiaorong Li, Konstantinos Tsaparikos, Patrick Lappin, Pamela Vizcarra, David Shields, Judy Lucas, Paul Rejto
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-33.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-33
Published: 15 November 2015
View article titled, Abstract A2-33: Molecular profiling of patient-derived xenograft models across cancers
Journal Articles

Abstract 1697: Therapeutic targeting the NOTCH3 receptor with antibody drug conjugates

Kenneth G. Geles, Yijie Gao, Latha Sridharan, Andreas Giannakou, Ting-Ting Yamin, Jonathan Golas, Judy Lucas, Manoj Charati, Xiantang Li, Magali Guffroy, Tim Nichols, Kai Wang, Max Follettie, Andreas Maderna, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1697.
https://doi.org/10.1158/1538-7445.AM2015-1697
Published: 01 August 2015
View article titled, Abstract 1697: Therapeutic targeting the NOTCH3 receptor with antibody drug conjugates
Journal Articles

Abstract 644: Impact of conjugation site on pharmacokinetics and off-target toxicity of site-specific antibody drug conjugates

Dangshe Ma, Fang Jin, Frank Barletta, George Hu, Nathan Tumey, Haige Zhang, Tao He, Eric Sousa, Manoj Charti, Kiran Khadke, Judy Lucas, Darren Ferguson, Christoper Brown, Weijun Ma, Scott Gatto, William Brady, Edmund Graziani, Hans-Peter Gerber, Puja Sapra, Lioudmila Tchistikova
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 644.
https://doi.org/10.1158/1538-7445.AM2015-644
Published: 01 August 2015
View article titled, Abstract 644: Impact of conjugation site on pharmacokinetics and off-target toxicity of site-specific antibody drug conjugates
Journal Articles

Abstract 1469: Patient derived xenograft (PDX) models: improving predictability of experimental cancer therapies

Edward Rosfjord, Xin Han, Danielle Leahy, Erik Upeslacis, Justin Lucas, Jonathon Golas, Andrea Hooper, Fred Immermann, Bingwen Lu, Jeremy Myers, Zhengyan Kan, James Hardwick, Eric Powell, Puja Sapra, Paul Rejto, Hans-Peter Gerber, Judy Lucas
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1469.
https://doi.org/10.1158/1538-7445.AM2015-1469
Published: 01 August 2015
View article titled, Abstract 1469: Patient derived xenograft (PDX) models: improving predictability of experimental cancer therapies
Journal Articles

Abstract 5425: An anti-Ephrin-A4 calicheamicin conjugate effectively targets triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regression

Marc Damelin, Alex Bankovich, Albert Park, Jorge Aguilar, Wade Anderson, Marianne Santaguida, Sarah Fong, Monette Aujay, Kiran Khandke, Virginia Pulito, Elana Ernstoff, Paul Escarpe, Jeff Bernstein, Marybeth A. Pysz, Wenyan Zhong, Erik Upeslacis, Judy Lucas, Justin Lucas, Timothy Nichols, Kathryn Loving, Orit Foord, Johannes Hampl, Robert Stull, Frank Barletta, Hadi Falahatpisheh, Puja Sapra, Hans Peter Gerber, Scott J. Dylla
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5425.
https://doi.org/10.1158/1538-7445.AM2015-5425
Published: 01 August 2015
View article titled, Abstract 5425: An anti-Ephrin-A4 calicheamicin conjugate effectively targets triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regression
Journal Articles

Abstract 4837: Extracellular proteolytic cleavage of peptide-linked antibody-drug conjugates promotes bystander killing of cancer cells

My-Hanh Lam, Judy Lucas, Andreas Maderna, Hallie Wald, Megan Wojciechowicz, Russell Dushin, Bryan Peano, Fang Wang, Jeremy Myers, Xingzhi Tan, Sylvia Musto, Manoj Charati, Hans-Peter Gerber, Frank Loganzo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4837.
https://doi.org/10.1158/1538-7445.AM2014-4837
Published: 01 October 2014
View article titled, Abstract 4837: Extracellular proteolytic cleavage of peptide-linked antibody-drug conjugates promotes bystander killing of cancer cells
Journal Articles

Abstract 2669: Targeting the tumor vasculature with antibody drug conjugates

Andrea T. Hooper, Chao-Pei Betty Chang, Kimberly Marquette, Jonathon Golas, Justin Lucas, Timothy Nichols, Judy Lucas, Gavriil Maria, Edward Rosfjord, Anton Xavier, Nathan Scott, Sadhana Jain, Wei Cao, Mauricio Leal, Andreas Maderna, Magali Guffroy, Xiang Zheng, Lioudmila Tchistiakova, Frank Loganzo, Hans-Peter Gerber, Chad May
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2669.
https://doi.org/10.1158/1538-7445.AM2014-2669
Published: 01 October 2014
View article titled, Abstract 2669: Targeting the tumor vasculature with antibody drug conjugates
Journal Articles

Abstract 3487: CA9 expression highly correlates with cancer stem cell markers during passaging of PDX lines

Julia Friedman, Wenyan Zhong, Christine Loreth, Veronica Diesl, Xin Han, Justin Lucas, Andrea Hooper, Vlad Buklan, Edward Rosfjord, Danielle Leahy, Judy Lucas, Maximillian Follettie, Kim Arndt
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3487.
https://doi.org/10.1158/1538-7445.AM2014-3487
Published: 01 October 2014
View article titled, Abstract 3487: CA9 expression highly correlates with cancer stem cell markers during passaging of PDX lines
Journal Articles

Abstract 2059: In situ imaging of antibody drug conjugate (ADC) binding and pharmacodynamic biomarkers of response in models of human cancer

Jonathon Golas, Andrea T. Hooper, Justin Lucas, Heather Jones, Timothy Nichols, Kiran Khandke, Manoj Charati, Roger Conant, Michael Cinque, Judy Lucas, Marc Damelin, Ken Geles, Caiazzo Teresa, Frank Loganzo, Puja Sapra, Hans-Peter Gerber, Chad May
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2059.
https://doi.org/10.1158/1538-7445.AM2014-2059
Published: 01 October 2014
View article titled, Abstract 2059: In situ imaging of antibody drug conjugate (ADC) binding and pharmacodynamic biomarkers of response in models of human cancer
Journal Articles

Abstract 5471: Notch-antibody drug conjugates have a different mechanism of action than Notch signaling inhibitors and induce tumor regression.

Kenneth G. Geles, Yijie Gao, Latha Sridharan, Andreas Giannakou, Ting-Ting Yamin, Jonathan Golas, Manoj Charati, Kiran Khandke, Judy Lucas, Andreas Maderna, Christopher J. O'Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5471.
https://doi.org/10.1158/1538-7445.AM2013-5471
Published: 15 April 2013
View article titled, Abstract 5471: Notch-antibody drug conjugates have a different mechanism of action than Notch signaling inhibitors and induce tumor regression.
Journal Articles

Abstract 4752: Preclinical development and translational research on a novel antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells.

Puja Sapra, Marc Damelin, Kimberly Marquette, Kenneth G. Geles, Jonathon Golas, Maureen Dougher, Bitha Narayanan, Andreas Giannakou, Kiran Khandke, Russell Dushin, Elana Ernstoff, Judy Lucas, Mauricio Leal, George Hu, Alison Betts, Nahor Haddish-Berhane, Eric Powell, Steven Pirie-Shepherd, Christopher O'Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Dena Marrinucci, Eric Tucker
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4752.
https://doi.org/10.1158/1538-7445.AM2013-4752
Published: 15 April 2013
View article titled, Abstract 4752: Preclinical development and translational research on a novel antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells.
Journal Articles

Abstract 1241: Targeting the IL-13 receptor alpha 2 with novel antibody-drug conjugates for the treatment of cancer.

Dangshe Ma, Haige Zhang, Fang Jin, Manoj Charati, Kiran Khandke, Judy Lucas, Max Follettie, L. Nathan Tumey, Hans-Peter Gerber, Lioudmila Tchistiakova, Puja Sapra
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1241.
https://doi.org/10.1158/1538-7445.AM2013-1241
Published: 15 April 2013
View article titled, Abstract 1241: Targeting the IL-13 receptor alpha 2 with novel antibody-drug conjugates for the treatment of cancer.
Journal Articles

Abstract 2530: Long-term tumor regression induced by a novel antibody drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells

Puja Sapra, John DiJoseph, Marc Damelin, Maureen Dougher, Bitha Narayanan, Kiran Khandke, Judy Lucas, Jon Golas, Lioudmila Tchistiakova, Mauricio Leal, George Hu, Andreas Maderna, Kimberly Marquette, Frank Loganzo, Russell Dushin, Christopher J. O'Donnell, Robert Abraham, Hans-Peter Gerber
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2530.
https://doi.org/10.1158/1538-7445.AM2012-2530
Published: 15 April 2012
View article titled, Abstract 2530: Long-term tumor regression induced by a novel antibody drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
Journal Articles

Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor

Aranapakam M. Venkatesan, Christoph M. Dehnhardt, Efren Delos Santos, Zecheng Chen, Osvaldo Dos Santos, Semiramis Ayral-Kaloustian, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Natasja Brooijmans, Joel Bard, James Gibbons, Robert T. Abraham, Tarek S. Mansour
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 723.
https://doi.org/10.1158/1538-7445.AM10-723
Published: 15 April 2010
View article titled, Abstract 723: Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor
Journal Articles

Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2

Ker Yu, Celine Shi, Lourdes Toral-Barza, Judy Lucas, Boris Shor, Jae Eun Kim, Wei-Guo Zhang, Robert Mahoney, Christine Gaydos, LuAnna Tardio, Sung Kyoo Kim, Roger Conant, Kevin Curran, Joshua Kaplan, Jeroen Verheijen, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Robert T. Abraham, Arie Zask, James J. Gibbons
Journal: Cancer Research
Cancer Res (2010) 70 (2): 621–631.
https://doi.org/10.1158/0008-5472.CAN-09-2340
Published: 13 January 2010
View article titled, Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2
Open the PDF for Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2 in another window
Includes: Supplementary data
Journal Articles

Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin

Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Boris Shor, Jamie Kim, Jeroen Verheijen, Kevin Curran, David J. Malwitz, Derek C. Cole, John Ellingboe, Semiramis Ayral-Kaloustian, Tarek S. Mansour, James J. Gibbons, Robert T. Abraham, Pawel Nowak, Arie Zask
Journal: Cancer Research
Cancer Res (2009) 69 (15): 6232–6240.
https://doi.org/10.1158/0008-5472.CAN-09-0299
Published: 29 July 2009
View article titled, Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
Open the PDF for Biochemical, Cellular, and <em>In vivo</em> Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin in another window
Includes: Supplementary data
Journal Articles

Abstract #2017: Novel imidazolopyrimidines as dual PI3-kinase/ mTor inhibitors

Christoph Dehnhardt, Aranapakam Venkatesan, Zecheng Chen, Efren Delos Santos, Oswaldo Santos, Matthew Bursavich, Natasja Brooijmans, Robert Mallon, Irwin Hollander, Larry Feldberg, Judy Lucas, Ker Yu, Semiramis Ayral-Kaloustian, Jay Gibbons, Robert Abraham, Tarek Mansour
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2017.
Published: 01 May 2009
View article titled, Abstract #2017: Novel imidazolopyrimidines as dual PI3-kinase/ mTor inhibitors