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Journal Articles

Abstract PO2-16-08: Adjuvant Treatment Selection for County-Level Patients with HR+/HER2- Early Breast Cancer in a Real-Life Setting in China

Yinghua Ji, Honglan Qu, Feidu Zhou, Juan Wang, Qianfu Wu, Guohua Dai, Mengyou Liu, Wenbo He, Wei Liang, Qiuli Meng, Yun Ren, Guoxiang Luo, Hongjian Wang, Hui Liu, Zien Qin, Yingguo Tian, Huali Tang, Hongmei Liu, Jun Luo, Zengfeng Yu, Guinv Hu, Jianzhi Gao, Xiang Tan, Yi Liu, Yuanjiang Zhang, Ming Wang, Min Zhang, Ping Lu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-16-08.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-16-08
Published: 02 May 2024
View article titled, Abstract PO2-16-08: Adjuvant Treatment Selection for County-Level Patients with HR+/HER2- Early Breast Cancer in a Real-Life Setting in China
Journal Articles

Abstract 5820: An antibody drug conjugate platform based on novel camptothecin payloads with branch hydrophilic linkers and site-specific conjugation

Yuanyuan Huang, Hangbo Ye, Qingliang Yang, Lingli Zhang, Huihui Guo, Xiaolei Liu, Wenjun Li, Lu Bai, Junxiang Jia, Juan Wang, Xiangfei Kong, Jun Zheng, Yifang Xu, Gengxiang Zhao, Linyao Zhao, Xiang Cai, Ziyu Zhao, Hui Xia, Xia Zhou, You Zhou, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5820.
https://doi.org/10.1158/1538-7445.AM2024-5820
Published: 22 March 2024
View article titled, Abstract 5820: An antibody drug conjugate platform based on novel camptothecin payloads with branch hydrophilic linkers and site-specific conjugation
Journal Articles

Abstract 5819: An anti-TROP2-CPT113 ADC, exhibits potent targeted antitumor activity and favorable pharmacokinetic properties

Huihui Guo, Xiangfei Kong, Yong Du, Zhicang Ye, Yongxiang Chen, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Juan Wang, Miaomiao Chen, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5819.
https://doi.org/10.1158/1538-7445.AM2024-5819
Published: 22 March 2024
View article titled, Abstract 5819: An anti-TROP2-CPT113 ADC, exhibits potent targeted antitumor activity and favorable pharmacokinetic properties
Journal Articles

Abstract 4401: GATA6 is a novel regulator of gene expression and 3D genome in colorectal cancer

Huijue Lyu, Xintong Chen, Yang Cheng, Te Zhang, Ping Wang, Josiah Hiu-yuen Wong, Juan Wang, Lena Stasiak, Leyu Sun, Guangyu Yang, Lu Wang, Feng Yue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4401.
https://doi.org/10.1158/1538-7445.AM2024-4401
Published: 22 March 2024
View article titled, Abstract 4401: GATA6 is a novel regulator of gene expression and 3D genome in colorectal cancer
Journal Articles

Abstract 3147: DXC025, a novel anti-MUC1/EGFR bispecific antibody-tubulysin conjugate with a function linker, exhibits potent anti-tumor efficacy

Xingyan Jiang, Junxiang Jia, Huihui Guo, Xiangfei Kong, Yongfang Xu, Sishi Ye, Yong Du, Zhicang Ye, Qikuang Cen, Lingli Zhang, Yongxiang Chen, Gaituo Chen, Lu Bai, Yunxia Zheng, Wei Zheng, Jun Zheng, Juan Wang, Wenjun Li, Yuanyuan Huang, Linyao Zhao, Yifang Xu, Mengmeng Liu, Binbin Chen, Meng Dai, Miaomiao Chen, Zhixiang Guo, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3147.
https://doi.org/10.1158/1538-7445.AM2024-3147
Published: 22 March 2024
View article titled, Abstract 3147: DXC025, a novel anti-MUC1/EGFR bispecific antibody-tubulysin conjugate with a function linker, exhibits potent anti-tumor efficacy
Journal Articles

Abstract 2461: Discovery of an orally available and liver-targeted ALPK1 agonist for cancer immunotherapy

Yupeng Wang, Nana Du, Xiaona Dong, Xuebing Sun, Yuan Hong, Xiaolong Yang, Zhijiang Ji, Qianyu Wang, Yun Lv, Zhichen Shi, Yajuan Gao, Xiaofu Hou, Yaxin Zhang, Juan Wang, Rui Mao, Yinxin Liu, Liang Li, Jingjin Ding, Hexiang Wang, Nan Hu, Counde O’Yang, Zhihong Li, Keith Bley, Feng Shao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2461.
https://doi.org/10.1158/1538-7445.AM2024-2461
Published: 22 March 2024
View article titled, Abstract 2461: Discovery of an orally available and liver-targeted ALPK1 agonist for cancer immunotherapy
Journal Articles

Abstract 1884: DXC006, Anti-CD56-CPT113 ADC displays favorable anti-tumor efficacy, pharmacokinetic and safety profiles in preclinical studies

Xiangfei Kong, Huihui Guo, Yong Du, Zhicang Ye, Yongxiang Chen, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Juan Wang, Fang Du, Miaomiao Chen, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1884.
https://doi.org/10.1158/1538-7445.AM2024-1884
Published: 22 March 2024
View article titled, Abstract 1884: DXC006, Anti-CD56-CPT113 ADC displays favorable anti-tumor efficacy, pharmacokinetic and safety profiles in preclinical studies
Journal Articles

Abstract 1882: DXC024, a novel anti-TROP2/EGFR bispecific antibody and tubulysin conjugate, for targeted treatment of highly TROP2- or EGFR-expressing tumors

Jingjing Zhu, Junxiang Jia, Huihui Guo, Xiangfei Kong, Yong Du, Zhicang Ye, Lingli Zhang, Yongxiang Chen, Lu Bai, Yunxia Zheng, Wei Zheng, Jun Zheng, Juan Wang, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Fang Du, Miaomiao Chen, Zhixiang Guo, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1882.
https://doi.org/10.1158/1538-7445.AM2024-1882
Published: 22 March 2024
View article titled, Abstract 1882: DXC024, a novel anti-TROP2/EGFR bispecific antibody and tubulysin conjugate, for targeted treatment of highly TROP2- or EGFR-expressing tumors
Journal Articles

Abstract 5676: Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples

Qixuan Wang, Juan Wang, Radhika Mathur, Mark W. Youngblood, Qiushi Jin, Ye Hou, Lena A. Stasiak, Yu Luan, Joseph F. Costello, Feng Yue
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5676.
https://doi.org/10.1158/1538-7445.AM2024-5676
Published: 22 March 2024
View article titled, Abstract 5676: Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples
Journal Articles

Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma

Tingting Liu, Juan Wang, Hongbo Yang, Qiushi Jin, Xiaotao Wang, Yihao Fu, Yu Luan, Qixuan Wang, Mark W. Youngblood, Xinyan Lu, Lucia Casadei, Raphael Pollock, Feng Yue
Journal: Cancer Research
Cancer Res (2023) 83 (9): 1517–1530.
https://doi.org/10.1158/0008-5472.CAN-22-1858
Published: 02 May 2023
View article titled, Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma
Open the PDF for Enhancer Coamplification and Hijacking Promote Oncogene Expression in Liposarcoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5611: LAG-3 PET imaging in patients with cancer before immune checkpoint inhibitor therapy

Pim P. van de Donk, Lotte M. Smit, Joyce van Sluis, Wim Timens, Adrienne H. Brouwers, Marjolijn N. Lub- de Hooge, Sjoerd G. Elias, Jourik A. Gietema, Claudia A. van Winkel, JuAn Wang, Jason Giurleo, Thomas Uldrick, Hung Kam Cheung, Hilde Jalving, Sjoukje F. Oosting, Daan G. Knapen, Derk-Jan A. de Groot, Elisabeth G. de Vries
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5611.
https://doi.org/10.1158/1538-7445.AM2023-5611
Published: 04 April 2023
View article titled, Abstract 5611: LAG-3 PET imaging in patients with cancer before immune checkpoint inhibitor therapy
Journal Articles

Abstract 1380: Blocking autophagy ameliorates the severity of ConA induced autoimmune hepatitis in mice

Juan Wang, Cheng Qian, Chuanzhi Yangmeng, Li Fang, Ruiqing Yan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1380.
https://doi.org/10.1158/1538-7445.AM2023-1380
Published: 04 April 2023
View article titled, Abstract 1380: Blocking autophagy ameliorates the severity of ConA induced autoimmune hepatitis in mice
Journal Articles

Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer

Yao Wang, Yang Zhang, Peng-Chao Li, Jiajie Guo, Fan Huo, Jintao Yang, Ru Jia, Juan Wang, Qiju Huang, Dan Theodorescu, Hanyang Yu, Chao Yan
Journal: Cancer Research
Cancer Res (2022) 82 (6): 1128–1139.
https://doi.org/10.1158/0008-5472.CAN-21-2691
Published: 15 March 2022
View article titled, Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer
Open the PDF for Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer

Antao Chang, Liang Liu, Justin M. Ashby, Dan Wu, Yanan Chen, Stacey S. O'Neill, Shan Huang, Juan Wang, Guanwen Wang, Dongmei Cheng, Xiaoming Tan, W.J. Petty, Boris C. Pasche, Rong Xiang, Wei Zhang, Peiqing Sun
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3358–3373.
https://doi.org/10.1158/0008-5472.CAN-21-0688
Published: 15 June 2021
View article titled, Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer
Open the PDF for Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5434: Insulinoma-associated protein 1 (INSM1) expression in small cell neuroendocrine carcinoma of the urinary tract

Isaac E. Kim, Ali Amin, Li Juan Wang, Liang Cheng, Carmen M. Perrino
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5434.
https://doi.org/10.1158/1538-7445.AM2020-5434
Published: 15 August 2020
View article titled, Abstract 5434: Insulinoma-associated protein 1 (INSM1) expression in small cell neuroendocrine carcinoma of the urinary tract
Journal Articles

LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion

Xiu-Hui Zhan, Ji-Wei Jiao, Hai-Feng Zhang, Xiu-E Xu, Jian-Zhong He, Run-Liu Li, Hai-Ying Zou, Zhi-Yong Wu, Shao-Hong Wang, Jian-Yi Wu, Lian-Di Liao, Juan-Juan Wang, Yin-Wei Cheng, Kai Zhang, Gera Neufeld, Li-Yan Xu, En-Min Li
Journal: Cancer Research
Cancer Res (2019) 79 (19): 4951–4964.
https://doi.org/10.1158/0008-5472.CAN-19-0860
Published: 01 October 2019
View article titled, LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion
Open the PDF for LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion in another window
Includes: Supplementary data
Journal Articles

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

Jing-jing Liu, Hui-ni Zeng, Lian-ru Zhang, Yan-yan Zhan, Yan Chen, Yuan Wang, Juan Wang, Shao-hua Xiang, Wen-jun Liu, Wei-jia Wang, Hang-zi Chen, Yue-mao Shen, Wen-jin Su, Pei-qiang Huang, Hong-kui Zhang, Qiao Wu
Journal: Cancer Research
Cancer Res (2010) 70 (9): 3628–3637.
https://doi.org/10.1158/0008-5472.CAN-09-3160
Published: 28 April 2010
View article titled, A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 <em>In vivo</em> and <em>In vitro</em>
Open the PDF for A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 <em>In vivo</em> and <em>In vitro</em> in another window
Includes: Supplementary data
Journal Articles

Bile Acid Reflux Contributes to Development of Esophageal Adenocarcinoma via Activation of Phosphatidylinositol-Specific Phospholipase Cγ2 and NADPH Oxidase NOX5-S

Jie Hong, Jose Behar, Jack Wands, Murray Resnick, Li Juan Wang, Ronald A. DeLellis, David Lambeth, Weibiao Cao
Journal: Cancer Research
Cancer Res (2010) 70 (3): 1247–1255.
https://doi.org/10.1158/0008-5472.CAN-09-2774
Published: 31 January 2010
View article titled, Bile Acid Reflux Contributes to Development of Esophageal Adenocarcinoma via Activation of Phosphatidylinositol-Specific Phospholipase Cγ2 and NADPH Oxidase NOX5-S
Open the PDF for Bile Acid Reflux Contributes to Development of Esophageal Adenocarcinoma via Activation of Phosphatidylinositol-Specific Phospholipase Cγ2 and NADPH Oxidase NOX5-S in another window
Includes: Supplementary data
Journal Articles

LY573636 Na+ promotes cell death by inducing reactive oxygen species (ROS) in tumor cells

Magda Gutowski, Robert Jolly, Michelle Swearingen, Juan Wang, Marcio Chedid
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3318.
Published: 01 May 2008
View article titled, LY573636 Na<sup>+ </sup>promotes cell death by inducing reactive oxygen species (ROS) in tumor cells
Journal Articles

ERK-Dependent MKP-1–Mediated Cisplatin Resistance in Human Ovarian Cancer Cells

Juan Wang, Jun-Ying Zhou, Gen Sheng Wu
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11933–11941.
https://doi.org/10.1158/0008-5472.CAN-07-5185
Published: 18 December 2007
View article titled, ERK-Dependent MKP-1–Mediated Cisplatin Resistance in Human Ovarian Cancer Cells
Open the PDF for ERK-Dependent MKP-1–Mediated Cisplatin Resistance in Human Ovarian Cancer Cells in another window