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Jürgen Mestan
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Journal Articles

AMN107: Efficacy of the selective Bcr-Abl tyrosine kinase inhibitor in a murine model of chronic myelogenous leukemia

Michael R. Jensen, Josef Brüggen, Clifford Dilea, Jürgen Mestan, Paul W. Manley
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 61–62.
Published: 15 April 2006
View article titled, AMN107: Efficacy of the selective Bcr-Abl tyrosine kinase inhibitor in a murine model of chronic myelogenous leukemia
Journal Articles

In vitro Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants

Thomas O'Hare, Denise K. Walters, Eric P. Stoffregen, Taiping Jia, Paul W. Manley, Jürgen Mestan, Sandra W. Cowan-Jacob, Francis Y. Lee, Michael C. Heinrich, Michael W.N. Deininger, Brian J. Druker
Journal: Cancer Research
Cancer Res (2005) 65 (11): 4500–4505.
https://doi.org/10.1158/0008-5472.CAN-05-0259
Published: 01 June 2005
View article titled, <em>In vitro</em> Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants
Open the PDF for <em>In vitro</em> Activity of Bcr-Abl Inhibitors AMN107 and BMS-354825 against Clinically Relevant Imatinib-Resistant Abl Kinase Domain Mutants in another window
Includes: Supplementary data
Journal Articles

AMN107: Inhibitory profile against non-mutated and mutated forms of the Bcr-Abl tyrosine kinase

Paul W. Manley, Jürgen Mestan, Sandra Cowan-Jacob, Markus Wartmann, Ellen Weisberg, Doriano Fabbro, D. Gary Gilliland, James D. Griffin
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1408.
Published: 01 May 2005
View article titled, AMN107: Inhibitory profile against non-mutated and mutated forms of the Bcr-Abl tyrosine kinase
Journal Articles

Activity and induction of apoptosis of the tyrosine kinase inhibitor AMN107 in bcr-abl + cell lines and in imatinib resistant primary cells from CML patients

Philipp Le Coutre, Gökben Baskaynak, Ingo Tamm, Jörg Westermann, Justus Duyster, Malte Von Bonin, Stefan Pursche, Petra Mayer, Paul Manley, Jürgen Mestan, Eberhard Schleyer, Bernd Dörken
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1408–1409.
Published: 01 May 2005
View article titled, Activity and induction of apoptosis of the tyrosine kinase inhibitor AMN107 in bcr-abl + cell lines and in imatinib resistant primary cells from CML patients
Journal Articles

AEE788: A Dual Family Epidermal Growth Factor Receptor/ErbB2 and Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor with Antitumor and Antiangiogenic Activity

Peter Traxler, Peter R. Allegrini, Ralf Brandt, Josef Brueggen, Robert Cozens, Doriano Fabbro, Konstantina Grosios, Heidi A. Lane, Paul McSheehy, Jürgen Mestan, Thomas Meyer, Careen Tang, Markus Wartmann, Jeanette Wood, Giorgio Caravatti
Journal: Cancer Research
Cancer Res (2004) 64 (14): 4931–4941.
https://doi.org/10.1158/0008-5472.CAN-03-3681
Published: 15 July 2004
View article titled, AEE788: <subtitle>A Dual Family Epidermal Growth Factor Receptor/ErbB2 and Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor with Antitumor and Antiangiogenic Activity</subtitle>
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Journal Articles

PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration

Jeanette M. Wood, Guido Bold, Elizabeth Buchdunger, Robert Cozens, Stefano Ferrari, Jörg Frei, Francesco Hofmann, Jürgen Mestan, Helmut Mett, Terence O’Reilly, Elke Persohn, Johannes Rösel, Christian Schnell, David Stover, Andreas Theuer, Harry Towbin, Fritz Wenger, Kathie Woods-Cook, Andreas Menrad, Gerhard Siemeister, Michael Schirner, Karl-Heinz Thierauch, Martin R. Schneider, Joachim Drevs, Georg Martiny-Baron, Frank Totzke, Dieter Marmé
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2178–2189.
Published: 01 April 2000
View article titled, PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration
Open the PDF for PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration in another window