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Joshua D. Rabinowitz
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Journal Articles

Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

Akshada Sawant, Fuqian Shi, Eduardo Cararo Lopes, Zhixian Hu, Somer Abdelfattah, Jennele Baul, Jesse R. Powers, Christian S. Hinrichs, Joshua D. Rabinowitz, Chang S. Chan, Edmund C. Lattime, Shridar Ganesan, Eileen P. White
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1130–1144.
https://doi.org/10.1158/0008-5472.CAN-24-2589
Published: 14 March 2025
View article titled, Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes
Open the PDF for Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes in another window
Includes: Supplementary data
Journal Articles

Abstract B012: Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer: initial results of safety and feasibility of the medically supervised ketogenic diet

Gayle S Jameson, Erkut Borazanci, Diana L Hanna, Caroline GP Roberts, Meredith S Pelster, Richard C Frank, Angela T Alistar, Julia E Wiedmeier-Nutor, Sandra D Algaze, Brandon Fell, Sarah J Hallberg, Denise J Roe, Betsy C Wertheim, Derek Cridebring, Joshua D Rabinowitz, Stephen Gately, Daniel D Von Hoff, Drew W Rasco
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B012.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B012
Published: 15 September 2024
View article titled, Abstract B012: Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer: initial results of safety and feasibility of the medically supervised ketogenic diet
Journal Articles

Abstract 285: Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma

xinyi zhang, Won D. Lee, Brooks P. Leitner, Wanling Zhu, Zongyu Li, Rafael C. Gaspar, Alexandra A. Halberstam, Briana Robles, Joshua D. Rabinowitz, Rachel J. Perry
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 285.
https://doi.org/10.1158/1538-7445.AM2023-285
Published: 04 April 2023
View article titled, Abstract 285: Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma
Journal Articles

Abstract IA018: ATP production in pancreas cancer and tumor infiltrating lymphocytes

Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): IA018.
https://doi.org/10.1158/1538-7445.PANCA22-IA018
Published: 15 November 2022
View article titled, Abstract IA018: ATP production in pancreas cancer and tumor infiltrating lymphocytes
Journal Articles

Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate

Connor S.R. Jankowski, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3486–3498.
https://doi.org/10.1158/0008-5472.CAN-22-0408
Published: 04 October 2022
View article titled, Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate
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Includes: Supplementary data
Journal Articles

Abstract PO-015: A phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with previously untreated metastatic pancreatic cancer (MPC)

Gayle S. Jameson, Erkut H. Borazanci, Daniel D. Von Hoff, Joshua D. Rabinowitz, Michael S. Gordon, Sarah D. LeGrand, Courtney Snyder, Karen Ansaldo, Denise J. Roe, Haiyong Han
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PO-015.
https://doi.org/10.1158/1538-7445.PANCA21-PO-015
Published: 15 November 2021
View article titled, Abstract PO-015: A phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with previously untreated metastatic pancreatic cancer (MPC)
Journal Articles

Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis

Jonathan M. Ghergurovich, Mark Esposito, Zihong Chen, Joshua Z. Wang, Vrushank Bhatt, Taijin Lan, Eileen White, Yibin Kang, Jessie Yanxiang Guo, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3820–3829.
https://doi.org/10.1158/0008-5472.CAN-19-2486
Published: 15 September 2020
View article titled, Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis
Open the PDF for Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras–Driven Tumor Growth or Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 5713: Reprogramming of serine metabolism during breast cancer progression

Albert Mao Li, Gregory S. Ducker, Yang Li, Jose A. Seoane, Yiren Xiao, Stavros Melemenidis, Yiren Zhou, Ling Liu, Sakari Vanharanta, Edward E. Graves, Erinn B. Rankin, Christina Curtis, Joan Massague, Joshua D. Rabinowitz, Craig B. Thompson, Jiangbin Ye
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5713.
https://doi.org/10.1158/1538-7445.AM2020-5713
Published: 15 August 2020
View article titled, Abstract 5713: Reprogramming of serine metabolism during breast cancer progression
Journal Articles

Abstract P3-02-06: Tracing glucose catabolism in human triple negative breast cancer tumors

Jonathan Michael Ghergurovich, Joyce O’Shaughnessy, Maren K Levin, Aaron Killian, William Hendricks, Virginia Espina, Joshua D Rabinowitz
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-02-06.
https://doi.org/10.1158/1538-7445.SABCS19-P3-02-06
Published: 15 February 2020
View article titled, Abstract P3-02-06: Tracing glucose catabolism in human triple negative breast cancer tumors
Journal Articles

Abstract CT163: A Phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC)

Gayle S. Jameson, Erkut H. Borazanci, Joshua D. Rabinowitz, David Propper, Karen Ansaldo, Denise J. Roe, Daniel D. Von Hoff
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT163.
https://doi.org/10.1158/1538-7445.AM2019-CT163
Published: 01 July 2019
View article titled, Abstract CT163: A Phase Ib/II trial of high dose ascorbic acid (AA) + paclitaxel protein bound (PP) + cisplatin (C) + gemcitabine (G) in patients (pts) with metastatic pancreatic cancer (MPC)
Journal Articles

The Tumor Metabolic Microenvironment: Lessons from Lactate

Juan C. García-Cañaveras, Li Chen, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3155–3162.
https://doi.org/10.1158/0008-5472.CAN-18-3726
Published: 01 July 2019
View article titled, The Tumor Metabolic Microenvironment: Lessons from Lactate
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Journal Articles

Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-d]pyrimidine antifolates

Aamod Dekhne, Khushbu Shah, Gregory S. Ducker, Md. Junayed Nayeen, Jade M. Katinas, Jennifer Wong, Arpit Doshi, Xun Bao, Hasini Kalpage, Jenney Liu, Seongho Kim, Adrianne Wallace-Povirk, Changwen Ning, Carrie O'Connor, Zhanjun Hou, Lisa Polin, Jing Li, Maik Hüttemann, Joshua D. Rabinowitz, Charles E. Dann, Aleem Gangjee, Larry Matherly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2992.
https://doi.org/10.1158/1538-7445.AM2019-2992
Published: 01 July 2019
View article titled, Abstract 2992: Cellular pharmacodynamics of mitochondrial one-carbon metabolism-targeting 5-substituted pyrrolo[3,2-<em>d</em>]pyrimidine antifolates
Journal Articles

Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine antifolates

Aamod S. Dekhne, Gregory S. Ducker, Josephine Frühauf, Khushbu Shah, Md. Junayed Nayeen, Adrianne Wallace-Povirk, Carrie O'Connor, Zhanjun Hou, Lisa Polin, Aleem Gangjee, Joshua D. Rabinowitz, Larry H. Matherly
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3980.
https://doi.org/10.1158/1538-7445.AM2018-3980
Published: 01 July 2018
View article titled, Abstract 3980: Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-<em>d</em>]pyrimidine antifolates
Journal Articles

Abstract 232: Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units

Vipin Suri, Nello Mainolfi, Adam Friedman, Mikel P. Moyer, Greg Ducker, Joshua D. Rabinowitz, Mark Manfredi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 232.
https://doi.org/10.1158/1538-7445.AM2016-232
Published: 15 July 2016
View article titled, Abstract 232: Pharmacological and genetic dissection of one carbon pathway provides novel insights into generation, transformation and utilization of one carbon units
Journal Articles

Abstract 1013: Quantification of NADPH balance in cancer

Ling Liu, Li Chen, Greg Ducker, Junyoung Park, Supriya Shah, Kathryn E. Wellen, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1013.
https://doi.org/10.1158/1538-7445.AM2016-1013
Published: 15 July 2016
View article titled, Abstract 1013: Quantification of NADPH balance in cancer
Journal Articles

Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels

Estela Jacinto, Joseph Moloughney, Peter K. Kim, Nicole M. Vega-Cotto, Chang-Chih Wu, Thomas Lynch, Sisi Zhang, Matthew Adlam, Sai Guntaka, Po-Chien Chou, Joshua D. Rabinowitz, Guy Werlen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 21.
https://doi.org/10.1158/1538-7445.AM2016-21
Published: 15 July 2016
View article titled, Abstract 21: The mTORC2 target Akt is regulated in response to glutamine metabolite levels
Journal Articles

Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function

N.V. Rajeshkumar, Prasanta Dutta, Shinichi Yabuuchi, Roeland F. de Wilde, Gary V. Martinez, Anne Le, Jurre J. Kamphorst, Joshua D. Rabinowitz, Sanjay K. Jain, Manuel Hidalgo, Chi V. Dang, Robert J. Gillies, Anirban Maitra
Journal: Cancer Research
Cancer Res (2015) 75 (16): 3355–3364.
https://doi.org/10.1158/0008-5472.CAN-15-0108
Published: 13 August 2015
View article titled, Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function
Open the PDF for Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function in another window
Includes: Supplementary data
Journal Articles

Abstract 4709: Compartmental flexibility in mammalian folate metabolism

Gregory S. Ducker, Li Chen, Xin Teng, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4709.
https://doi.org/10.1158/1538-7445.AM2015-4709
Published: 01 August 2015
View article titled, Abstract 4709: Compartmental flexibility in mammalian folate metabolism
Journal Articles

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Jurre J. Kamphorst, Michel Nofal, Cosimo Commisso, Sean R. Hackett, Wenyun Lu, Elda Grabocka, Matthew G. Vander Heiden, George Miller, Jeffrey A. Drebin, Dafna Bar-Sagi, Craig B. Thompson, Joshua D. Rabinowitz
Journal: Cancer Research
Cancer Res (2015) 75 (3): 544–553.
https://doi.org/10.1158/0008-5472.CAN-14-2211
Published: 01 February 2015
View article titled, Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein
Open the PDF for Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein in another window
Includes: Supplementary data
Journal Articles

Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism

Brian J. Altman, Annie Hsieh, Arvin M. Gouw, Zachary E. Stine, Anand Venkataraman, David I. Bellovin, Sharon J. Diskin, Wenyun Lu, Sisi Zhang, Dean W. Felsher, John M. Maris, Mitchell A. Lazar, Joshua D. Rabinowitz, John B. Hogenesch, Chi V. Dang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2953.
https://doi.org/10.1158/1538-7445.AM2014-2953
Published: 01 October 2014
View article titled, Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism