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Joseph R. Testa
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Journal Articles

AKT and the Hallmarks of Cancer

Eleonora Sementino, Dalal Hassan, Alfonso Bellacosa, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4126–4139.
https://doi.org/10.1158/0008-5472.CAN-24-1846
Published: 16 December 2024
View article titled, AKT and the Hallmarks of Cancer
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Journal Articles

Abstract 1468: Low exposures to amphibole or serpentine asbestos in germline Bap1-mutant mice induce mesotheliomacharacterized by an immunosuppressive tumor microenvironment

Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Andres J. Klein-Szanto, Kathy Cai, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1468.
https://doi.org/10.1158/1538-7445.AM2024-1468
Published: 22 March 2024
View article titled, Abstract 1468: Low exposures to amphibole or serpentine asbestos in germline <em>Bap1</em>-mutant mice induce mesotheliomacharacterized by an immunosuppressive tumor microenvironment
Journal Articles

Abstract 1467: Contribution of estrogen metabolites to never-smoking lung cancer

Mitchell Cheung, Lisa A. Vanderveer, Daniel Krzizike, J. Nicholas Bodor, Joseph Treat, Joseph R. Testa, Margie L. Clapper
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1467.
https://doi.org/10.1158/1538-7445.AM2024-1467
Published: 22 March 2024
View article titled, Abstract 1467: Contribution of estrogen metabolites to never-smoking lung cancer
Journal Articles

Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models

Anna-Mariya Kukuyan, Eleonora Sementino, Yuwaraj Kadariya, Craig W. Menges, Mitchell Cheung, Yinfei Tan, Kathy Q. Cai, Michael J. Slifker, Suraj Peri, Andres J. Klein-Szanto, Frank J. Rauscher, III, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2019) 79 (16): 4113–4123.
https://doi.org/10.1158/0008-5472.CAN-18-4093
Published: 15 August 2019
View article titled, Inactivation of <em>Bap1</em> Cooperates with Losses of <em>Nf2</em> and <em>Cdkn2a</em> to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models
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Includes: Supplementary data
Journal Articles

Abstract 1232: Familial mesothelioma: Beyond BAP1

Mitchell Cheung, Jill A. Ohar, Suzanne E. Howard, Timothy D. Howard, Mary Hesdorffer, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1232.
https://doi.org/10.1158/1538-7445.AM2018-1232
Published: 01 July 2018
View article titled, Abstract 1232: Familial mesothelioma: Beyond <em>BAP1</em>
Journal Articles

Abstract 1940: Thymine DNA glycosylase (TDG) as a novel target for melanoma

Rossella Tricarico, Pietro Mancuso, Vikram Bhattacharjee, Laura Cosentino, Emmanuelle Nicolas, Margret Einarson, Neil Beeharry, Karthik Devarajan, Rich Katz, Dorjbal G. Dorjsuren, Anton Simeonov, Yuwaraj Kadariya, Guillaume Davidson, Joseph R. Testa, Irwin Davidson, Lionel Larue, Robert W. Sobol, Timothy Yen, Alfonso Bellacosa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1940.
https://doi.org/10.1158/1538-7445.AM2018-1940
Published: 01 July 2018
View article titled, Abstract 1940: Thymine DNA glycosylase (TDG) as a novel target for melanoma
Journal Articles

Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains

Hongzhuang Peng, Jeremy Prokop, Jayashree Karar, Kyewon Park, Li Cao, J. William Harbour, Anne M. Bowcock, S. Bruce Malkowicz, Mitchell Cheung, Joseph R. Testa, Frank J. Rauscher, III
Journal: Cancer Research
Cancer Res (2018) 78 (5): 1200–1213.
https://doi.org/10.1158/0008-5472.CAN-17-2876
Published: 28 February 2018
View article titled, Familial and Somatic <em>BAP1</em> Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains
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Includes: Supplementary data
Journal Articles

Abstract 2833: Genetic and pharmacologic inhibition of mTOR delays mortality due to thymc lymphoma formation in mice and is associated with decreases in cell cycle proteins

Shuling Zhang, Joy M. Gary, John K. Simmons, Jinfei Xu, Benjamin J. Gamache, Ke Zhang, Nicholas Watson, Alexander L. Kovalchuk, Aleksandra M. Michalowski, Jin-Qiu Chen, Michelle A. Herrmann, Tuddow Thaiwong, Matti Kiupel, Wendy Dubois, Joseph R. Testa, Beverly A. Mock
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2833.
https://doi.org/10.1158/1538-7445.AM2016-2833
Published: 15 July 2016
View article titled, Abstract 2833: Genetic and pharmacologic inhibition of mTOR delays mortality due to thymc lymphoma formation in mice and is associated with decreases in cell cycle proteins
Journal Articles

Abstract 842: The NALP3 inflammasome and IL-1â signaling link asbestos-induced inflammation with the development of malignant mesothelioma

Yuwaraj Kadariya, Craig W. Menges, Jacqueline Talarchek, Qi Cai, Andres J. Klein-Szanto, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou, Brooke T. Mossman, Arti Shukla, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 842.
https://doi.org/10.1158/1538-7445.AM2016-842
Published: 15 July 2016
View article titled, Abstract 842: The NALP3 inflammasome and IL-1â signaling link asbestos-induced inflammation with the development of malignant mesothelioma
Journal Articles

Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma

Shuyun Rao, Kathy Q. Cai, Jason E. Stadanlick, Noa Greenberg-Kushnir, Nehal Solanki-Patel, Sang-Yun Lee, Shawn P. Fahl, Joseph R. Testa, David L. Wiest
Journal: Cancer Research
Cancer Res (2016) 76 (11): 3387–3396.
https://doi.org/10.1158/0008-5472.CAN-15-2698
Published: 31 May 2016
View article titled, Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma
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Includes: Supplementary data
Journal Articles

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations

Yuwaraj Kadariya, Mitchell Cheung, Jinfei Xu, Jianming Pei, Eleonora Sementino, Craig W. Menges, Kathy Q. Cai, Frank J. Rauscher, Andres J. Klein-Szanto, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2836–2844.
https://doi.org/10.1158/0008-5472.CAN-15-3371
Published: 01 May 2016
View article titled, Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline <em>Bap1</em> Mutations
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Includes: Supplementary data
Journal Articles

Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer

Jill A. Ohar, Mitchell Cheung, Jacqueline Talarchek, Suzanne E. Howard, Timothy D. Howard, Mary Hesdorffer, Hongzhuang Peng, Frank J. Rauscher, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2016) 76 (2): 206–215.
https://doi.org/10.1158/0008-5472.CAN-15-0295
Published: 14 January 2016
View article titled, Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer
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Journal Articles

Abstract 5542: Flaxseed and its lignan component protect from asbestos-induced inflammation in mice

Steven M. Albelda, Ralph A. Pietrofesa, Craig W. Menges, Joseph R. Testa, Melpo Christofidou-Solomidou
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5542.
https://doi.org/10.1158/1538-7445.AM2015-5542
Published: 01 August 2015
View article titled, Abstract 5542: Flaxseed and its lignan component protect from asbestos-induced inflammation in mice
Journal Articles

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Jinfei Xu, Yuwaraj Kadariya, Mitchell Cheung, Jianming Pei, Jacqueline Talarchek, Eleonora Sementino, Yinfei Tan, Craig W. Menges, Kathy Q. Cai, Samuel Litwin, Hongzhuang Peng, Jayashree Karar, Frank J. Rauscher, Joseph R. Testa
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (16): 4388–4397.
https://doi.org/10.1158/0008-5472.CAN-14-1328
Published: 13 August 2014
View article titled, Germline Mutation of <em>Bap1</em> Accelerates Development of Asbestos-Induced Malignant Mesothelioma
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Includes: Supplementary data
Journal Articles

Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53–miR-34a–c-Met Axis

Craig W. Menges, Yuwaraj Kadariya, Deborah Altomare, Jacqueline Talarchek, Erin Neumann-Domer, Yue Wu, Guang-Hui Xiao, Irina M. Shapiro, Vihren N. Kolev, Jonathan A. Pachter, Andres J. Klein-Szanto, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2014) 74 (4): 1261–1271.
https://doi.org/10.1158/0008-5472.CAN-13-2062
Published: 16 February 2014
View article titled, Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53–miR-34a–c-Met Axis
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Includes: Supplementary data
Journal Articles

Abstract 924: FAK inhibition preferentially attenuates growth of Merlin-negative malignant mesotheliomas: role of cancer stem cells.

Irina M. Shapiro, Vihren N. Kolev, Christian M. Vidal, Jennifer E. Ring, Mitchell Keegan, Qunli Xu, Craig W. Menges, Joseph R. Testa, Jonathan A. Pachter
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 924.
https://doi.org/10.1158/1538-7445.AM2013-924
Published: 15 April 2013
View article titled, Abstract 924: FAK inhibition preferentially attenuates growth of Merlin-negative malignant mesotheliomas: role of cancer stem cells.
Journal Articles

Abstract 4312: Loss of Ink4a and Arf each contributes to increased susceptibility to asbestos-induced malignant mesothelioma development

Deborah A. Altomare, Craig W. Menges, Jinfei Xu, Jianming Pei, Lili Zhang, Ara Tadevosyan, Erin Neumann-Domer, Zemin Liu, Michele Carbone, Ilse Chudoba, Andres J. Klein-Szanto, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4312.
https://doi.org/10.1158/1538-7445.AM2011-4312
Published: 15 April 2011
View article titled, Abstract 4312: Loss of Ink4a and Arf each contributes to increased susceptibility to asbestos-induced malignant mesothelioma development
Journal Articles

Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling

Yinfei Tan, Mitchell Cheung, Jianming Pei, Craig W. Menges, Andrew K. Godwin, Joseph R. Testa
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9197–9206.
https://doi.org/10.1158/0008-5472.CAN-10-1568
Published: 14 November 2010
View article titled, Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling
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Includes: Supplementary data
Journal Articles

Abstract 347: Inhibition of ERK1/2 can sensitize human malignant mesothelioma cells and tumors to doxorubicin

Arti Shukla, Jedd M. Hillegass, Maximilian B. MacPherson, Stacie L. Beuschel, Nicholas H. Heintz, Pamela M. Vacek, Harvey I. Pass, Michele Carbone, Joseph R. Testa, Brooke T. Mossman
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 347.
https://doi.org/10.1158/1538-7445.AM10-347
Published: 15 April 2010
View article titled, Abstract 347: Inhibition of ERK1/2 can sensitize human malignant mesothelioma cells and tumors to doxorubicin
Journal Articles

A Novel Mechanism of Late Gene Silencing Drives SV40 Transformation of Human Mesothelial Cells

Michele Carbone, Antonio Pannuti, Lei Zhang, Joseph R. Testa, Maurizio Bocchetta
Journal: Cancer Research
Cancer Res (2008) 68 (22): 9488–9496.
https://doi.org/10.1158/0008-5472.CAN-08-2332
Published: 14 November 2008
View article titled, A Novel Mechanism of Late Gene Silencing Drives SV40 Transformation of Human Mesothelial Cells
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Includes: Supplementary data