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Journal Articles

Abstract 1803: Lethal synthesis: Potent anticancer activity of a glycine uptake inhibitor in tumor cells with mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) knocked down

Gulam Mohmad Rather, Joseph R. Bertino

Cancer Res (2022) 82 (12_Supplement): 1803.

https://doi.org/10.1158/1538-7445.AM2022-1803

Published: 15 June 2022

View article titled, Abstract 1803: Lethal synthesis: Potent anticancer activity of a glycine uptake inhibitor in tumor cells with mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) knocked down

Journal Articles

Abstract 2212: An antibody drug conjugate targeting activated matriptase, exhibits synergistic cytotoxicity with a PARP inhibitor, olaparib in triple negative breast cancer

Gulam M. Rather, Zoltan Szekely, Joseph R. Bertino

Cancer Res (2020) 80 (16_Supplement): 2212.

https://doi.org/10.1158/1538-7445.AM2020-2212

Published: 15 August 2020

View article titled, Abstract 2212: An antibody drug conjugate targeting activated matriptase, exhibits synergistic cytotoxicity with a PARP inhibitor, olaparib in triple negative breast cancer

Journal Articles

Abstract 5213: A modified L-penetratin peptide targeting e2f-1, 2 and 3 is effective in combination with cisplatin or pemetrexed against prostate and lung cancer cell lines

Gulam M. Rather, Michael Anyanwu, John E. Kerrigan, Kathleen W. Scotto, Olga Garbuzenko, Tamara Minko, Zoltan Szekely, Joseph R. Bertino

Cancer Res (2019) 79 (13_Supplement): 5213.

https://doi.org/10.1158/1538-7445.AM2019-5213

Published: 01 July 2019

View article titled, Abstract 5213: A modified L-penetratin peptide targeting e2f-1, 2 and 3 is effective in combination with cisplatin or pemetrexed against prostate and lung cancer cell lines

Journal Articles

Abstract 3981: Enhancement of the anticancer activity of methylenetetrahydrofolate dehydrogenase knockdown by folate depletion with carboxypeptidase G2

Gulam M. Rather, John E. Kerrigan, Kathleen W. Scotto, Joseph R. Bertino

Cancer Res (2018) 78 (13_Supplement): 3981.

https://doi.org/10.1158/1538-7445.AM2018-3981

Published: 01 July 2018

View article titled, Abstract 3981: Enhancement of the anticancer activity of methylenetetrahydrofolate dehydrogenase knockdown by folate depletion with carboxypeptidase G2

Journal Articles

Abstract 4615: Development of an antibody-drug conjugate with broad anticancer activity

Siang-Yo Lin, Zoltan Szekely, Chen-Yong Lin, Joseph R. Bertino, Gulam Mohmad Rather

Cancer Res (2017) 77 (13_Supplement): 4615.

https://doi.org/10.1158/1538-7445.AM2017-4615

Published: 01 July 2017

View article titled, Abstract 4615: Development of an antibody-drug conjugate with broad anticancer activity

Journal Articles

Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies

Neel S. Madhukar, Olivier Elemento, Cyril H. Benes, Mathew J. Garnett, Mark Stein, Joseph R. Bertino, Howard L. Kaufman, Isabel Arrillaga-Romany, Tracy T. Batchelor, Lee Schalop, Wolfgang Oster, Martin Stogniew, Michael Andreeff, Wafik S. El-Deiry, Joshua E. Allen

Cancer Res (2016) 76 (14_Supplement): LB-209.

https://doi.org/10.1158/1538-7445.AM2016-LB-209

Published: 15 July 2016

View article titled, Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies

Journal Articles

Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America

Joseph R. Bertino

Cancer Res (2016) 76 (2): 185.

https://doi.org/10.1158/0008-5472.CAN-15-3169

Published: 14 January 2016

View article titled, Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America

Journal Articles

Abstract 2535: Synergistic anti-tumor activity of the Notch gamma secretase inhibitor BMS-906024 and paclitaxel in the treatment of lung adenocarcinoma

Katherine M. Morgan, Francis Lee, Erin Michaud, Joseph R. Bertino, Bruce S. Fischer, Sharon R. Pine

Cancer Res (2015) 75 (15_Supplement): 2535.

https://doi.org/10.1158/1538-7445.AM2015-2535

Published: 01 August 2015

View article titled, Abstract 2535: Synergistic anti-tumor activity of the Notch gamma secretase inhibitor BMS-906024 and paclitaxel in the treatment of lung adenocarcinoma

Journal Articles

Abstract 4208: The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to antimetabolites

Nitu Bansal, Lisa Wu, Nadine Johnson Farley, Philip Tedeschi, Joseph R. Bertino

Cancer Res (2015) 75 (15_Supplement): 4208.

https://doi.org/10.1158/1538-7445.AM2015-4208

Published: 01 August 2015

View article titled, Abstract 4208: The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to antimetabolites

Journal Articles

Abstract 214: Androgen resistance in prostate cancer is associated with an enrichment of stem-like cells

Lisa Y. Wu, Nitu Bansal, Tiancheng Liu, Clifford E. Berkman, Joseph R. Bertino

Cancer Res (2014) 74 (19_Supplement): 214.

https://doi.org/10.1158/1538-7445.AM2014-214

Published: 01 October 2014

View article titled, Abstract 214: Androgen resistance in prostate cancer is associated with an enrichment of stem-like cells

Journal Articles

Abstract 843: Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

Philip M. Tedeschi, Yamini K. Kathari, Iqra Farooqi, Joseph R. Bertino

Cancer Res (2014) 74 (19_Supplement): 843.

https://doi.org/10.1158/1538-7445.AM2014-843

Published: 01 October 2014

View article titled, Abstract 843: Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

Journal Articles

Abstract 5536: NAD+ Kinase inhibition synergizes with ROS-inducing chemotherapies.

Philip M. Tedeschi, John Kerrigan, Debabrata Banerjee, Joseph R. Bertino, Emine E. Abali

Cancer Res (2013) 73 (8_Supplement): 5536.

https://doi.org/10.1158/1538-7445.AM2013-5536

Published: 15 April 2013

View article titled, Abstract 5536: NAD+ Kinase inhibition synergizes with ROS-inducing chemotherapies.

Journal Articles

Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

Alexei Vazquez, Philip M. Tedeschi, Joseph R. Bertino

Cancer Res (2013) 73 (2): 478–482.

https://doi.org/10.1158/0008-5472.CAN-12-3709

Published: 16 January 2013

View article titled, Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

Journal Articles

Abstract 5689: Anti-E2F-1 PEGylated liposomal encapsulated peptide regresses human small cell lung cancer & lymphoma xenografts

Xiaoqi Xie, Debabrata Banerjee, Tamara Minko, Nadine Johnson-Farley, John E. Kerrigan, Emine Ercikan-Abali, Kathleen W. Scotto, Joseph R. Bertino

Cancer Res (2012) 72 (8_Supplement): 5689.

https://doi.org/10.1158/1538-7445.AM2012-5689

Published: 15 April 2012

View article titled, Abstract 5689: Anti-E2F-1 PEGylated liposomal encapsulated peptide regresses human small cell lung cancer & lymphoma xenografts

Journal Articles

Abstract 3548: Selective targeting of pancreatic tumors lacking methylthioadenosine phosphorylase (MTAP)

Joseph R. Bertino, Kuo-Chi Lee, Nadine Johnson-Farley, Martin Lubin

Cancer Res (2011) 71 (8_Supplement): 3548.

https://doi.org/10.1158/1538-7445.AM2011-3548

Published: 15 April 2011

View article titled, Abstract 3548: Selective targeting of pancreatic tumors lacking methylthioadenosine phosphorylase (MTAP)

Journal Articles

Abstract 2596: Targeted delivery of doxorubicin conjugated with anti-matriptase antibody to treat multiple myeloma

Joseph R. Bertino, Siang-Yo Lin, Chen-Yong Lin

Cancer Res (2010) 70 (8_Supplement): 2596.

https://doi.org/10.1158/1538-7445.AM10-2596

Published: 15 April 2010

View article titled, Abstract 2596: Targeted delivery of doxorubicin conjugated with anti-matriptase antibody to treat multiple myeloma

Journal Articles

Abstract 4279: Targeting Bmi1 in human prostate tumor initiating cells

Nitu Bansal, Neil Campbell, Daniel Medina, Robert DiPaola, Joseph R. Bertino, Hatem E. Sabaawy

Cancer Res (2010) 70 (8_Supplement): 4279.

https://doi.org/10.1158/1538-7445.AM10-4279

Published: 15 April 2010

View article titled, Abstract 4279: Targeting Bmi1 in human prostate tumor initiating cells

Journal Articles

Abstract 4543: Targeting the NADPH binding site of dihydrofolate reductase for cancer therapy

Yi-Ching Hsieh, Rialnat AdeBisi Lawal, Kathleen Scotto, Debabrata Banerjee, Emine Ercikan Abali, Joseph R. Bertino

Cancer Res (2010) 70 (8_Supplement): 4543.

https://doi.org/10.1158/1538-7445.AM10-4543

Published: 15 April 2010

View article titled, Abstract 4543: Targeting the NADPH binding site of dihydrofolate reductase for cancer therapy

Journal Articles

Abstract 2759: Validated liquid chromatography-mass spectrometry assay for determination of busulfan: Application to clinical pharmacokinetics studies

Hongxia Lin, Murugesan K. Gounder, Susan Goodin, Joseph R. Bertino, Robert S. DiPaola, Roger K. Strair

Cancer Res (2010) 70 (8_Supplement): 2759.

https://doi.org/10.1158/1538-7445.AM10-2759

Published: 15 April 2010

View article titled, Abstract 2759: Validated liquid chromatography-mass spectrometry assay for determination of busulfan: Application to clinical pharmacokinetics studies

Journal Articles

Abstract 2673: In silico design of E2F1 mimics as potential anticancer agents

John E. Kerrigan, Emine E. Abali, Debabrata Banerjee, Yi-Ching Hsieh, Xiaoqi Xie, Joseph R. Bertino

Cancer Res (2010) 70 (8_Supplement): 2673.

https://doi.org/10.1158/1538-7445.AM10-2673

Published: 15 April 2010

View article titled, Abstract 2673: In silico design of E2F1 mimics as potential anticancer agents

NARROW

Abstract 1803: Lethal synthesis: Potent anticancer activity of a glycine uptake inhibitor in tumor cells with mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) knocked down

Abstract 2212: An antibody drug conjugate targeting activated matriptase, exhibits synergistic cytotoxicity with a PARP inhibitor, olaparib in triple negative breast cancer

Abstract 5213: A modified L-penetratin peptide targeting e2f-1, 2 and 3 is effective in combination with cisplatin or pemetrexed against prostate and lung cancer cell lines

Abstract 3981: Enhancement of the anticancer activity of methylenetetrahydrofolate dehydrogenase knockdown by folate depletion with carboxypeptidase G2

Abstract 4615: Development of an antibody-drug conjugate with broad anticancer activity

Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies

Landmark Study: The Relation of Solar Radiation to Cancer Mortality in North America

Abstract 2535: Synergistic anti-tumor activity of the Notch gamma secretase inhibitor BMS-906024 and paclitaxel in the treatment of lung adenocarcinoma

Abstract 4208: The castrate resistant PC-3 cell line with neuroendocrine features is enriched in tumor initiating cells and is resistant to enzalutamide and abiraterone but sensitive to antimetabolites

Abstract 214: Androgen resistance in prostate cancer is associated with an enrichment of stem-like cells

Abstract 843: Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

Abstract 5536: NAD+ Kinase inhibition synergizes with ROS-inducing chemotherapies.

Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors

Abstract 5689: Anti-E2F-1 PEGylated liposomal encapsulated peptide regresses human small cell lung cancer & lymphoma xenografts

Abstract 3548: Selective targeting of pancreatic tumors lacking methylthioadenosine phosphorylase (MTAP)

Abstract 2596: Targeted delivery of doxorubicin conjugated with anti-matriptase antibody to treat multiple myeloma

Abstract 4279: Targeting Bmi1 in human prostate tumor initiating cells

Abstract 4543: Targeting the NADPH binding site of dihydrofolate reductase for cancer therapy

Abstract 2759: Validated liquid chromatography-mass spectrometry assay for determination of busulfan: Application to clinical pharmacokinetics studies

Abstract 2673: In silico design of E2F1 mimics as potential anticancer agents

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