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Joseph D. Mancias
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Journal Articles

Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer

Available to Purchase
Stephen L. DeAngelo, Liang Zhao, Sofia Dziechciarz, Myungsun Shin, Sumeet Solanki, Andrii Balia, Marwa O. El-Derany, Cristina Castillo, Yao Qin, Nupur K. Das, Hannah N. Bell, Joao A. Paulo, Yuezhong Zhang, Nicholas J. Rossiter, Elizabeth C. McCulla, Jianping He, Indrani Talukder, Billy Wai-Lung Ng, Zachary T. Schafer, Nouri Neamati, Joseph D. Mancias, Markos Koutmos, Yatrik M. Shah
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-3478
Published: 20 May 2025
View articletitled, Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer
Open the PDF for Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5507: Mechanisms of resistance to RAS-GTP inhibition in pancreatic cancer

Free
Joshua H. Choe, Julien Dilly, Eejung Kim, Lick P. Lai, Nicole Sindoni, Fan Yi Kong, Dennis Gong, Jaclyn Varga-Wiles, Brendan Parent, Junning Wang, Kyle Seamon, Jennifer A. Chan, Clint A. Stalnecker, Channing J. Der, William L. Hwang, Brian M. Wolpin, David Wildes, Joseph D. Mancias, Lewis C. Cantley, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5507.
https://doi.org/10.1158/1538-7445.AM2025-5507
Published: 21 April 2025
View articletitled, Abstract 5507: Mechanisms of resistance to RAS-GTP inhibition in pancreatic cancer
Journal Articles

Abstract A001: An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer

Free
Rishi Surana, Hui Zheng, Junning Wang, Micaela Morgado, Lauren K Brais, Kirsten L Bryant, Ashwin Somasundaram, Colin D Weekes, Bruno Bockorny, Mary Linton B Peters, Andrea J Bullock, Jessica A Zerillo, Ahmed A Rattani, Hanna K Sanoff, Jeffrey W Clark, Aparna R Parikh, Matthew B Yurgelun, Anuj Patel, Robert J Mayer, James M Cleary, Peter C Enzinger, Douglas A Rubinson, Nadine J McCleary, Andrea C Enzinger, Sarah E Slater, Kimmie Ng, Thomas A Abrams, Leah Biller, Srivatsan Raghavan, Joseph D Mancias, Jonathan O Nowak, Andrew J Aguirre, Channing J Der, Brian M Wolpin, Kimberley Perez
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A001.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A001
Published: 15 September 2024
View articletitled, Abstract A001: An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer
Journal Articles

Abstract A082: Defining the lysosome proteome during pancreatic cancer tumor evolution and metastasis

Free
Thuy T.P Nguyen, Grace A. Hernandez, Gilles Rademaker, Matthew Luy, Alexander Li, Longhui Qiu, Joao A. Paulo, Rushika M. Perera, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A082.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A082
Published: 15 September 2024
View articletitled, Abstract A082: Defining the lysosome proteome during pancreatic cancer tumor evolution and metastasis
Journal Articles

Abstract C024: Quantitative mass spectrometry-based multi-omic profiling to overcome drug resistance in pancreatic cancer post KRAS G12D inhibition

Free
Qijia Yu, Nicole Sindoni, Huan Zhang, Ziyue Li, Joao A. Paulo, Andrew J. Aguirre, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C024.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C024
Published: 15 September 2024
View articletitled, Abstract C024: Quantitative mass spectrometry-based multi-omic profiling to overcome drug resistance in pancreatic cancer post KRAS G12D inhibition
Journal Articles

Abstract C032: De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

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huan zhang, Qijia yu, Naiara Santana-Codina, Clara Poupault, Claudia Campos, Xingping Qin, Aparna Padhye, Nicole Sindoni, Miljan Kuljanin, Junning Wang, Matthew J. Dorman, Andrew J. Aguirre, Stephanie K. Dougan, Kristopher A. Sarosiek, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C032.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C032
Published: 15 September 2024
View articletitled, Abstract C032: De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
Journal Articles

Abstract IA-01: Targeting autophagy in pancreatic cancer

Free
Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): IA-01.
https://doi.org/10.1158/1538-7445.PANCREATIC24-IA-01
Published: 15 September 2024
View articletitled, Abstract IA-01: Targeting autophagy in pancreatic cancer
Journal Articles

Abstract C053: Autophagy regulates MAT2A in response to hypoxia in pancreatic cancer cells

Free
Yang Yang, Wenping Wang, Gilles Rademaker, Mirunalini Ravichandran, Jingjie Hu, Alexander Li, Joseph D. Mancias, Jessie Yanxiang Guo, Rushika M. Perera
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C053.
https://doi.org/10.1158/1538-7445.PANCA2023-C053
Published: 16 January 2024
View articletitled, Abstract C053: Autophagy regulates MAT2A in response to hypoxia in pancreatic cancer cells
Journal Articles

Abstract B052: Defining the lysosome proteome during tumor evolution

Free
Grace A. Hernandez, Thuy Nguyen, Matthew Luy, Alexander Li, Longhui Qiu, Joseph D. Mancias, Rushika M. Perera
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B052.
https://doi.org/10.1158/1538-7445.PANCA2023-B052
Published: 16 January 2024
View articletitled, Abstract B052: Defining the lysosome proteome during tumor evolution
Journal Articles

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

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Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S. Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2023) 83 (3): 441–455.
https://doi.org/10.1158/0008-5472.CAN-22-3050
Published: 03 February 2023
View articletitled, Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Open the PDF for Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer

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Jimmy A. Guo, Jennifer Su, Ananya Jambhale, Julien Dilly, Connor J. Hennessey, Carina Shiau, Patrick Yu, Steven Wang, Junning Wang, Laleh Abbassi, James Neiswender, Tate Bertea, Annan Yang, Qijia Yu, Peter Westcott, Jason Schenkel, Daniel Y. Kim, Hannah I. Hoffman, Grissel Cervantes Jaramillo, Giselle A. Uribe, Westley W. Wu, Arnav Mehta, David Ting, Julian A. Pacheco, Amy Deik, Clary Clish, Francisca Vazquez, Brian Wolpin, Aviv Regev, William A. Freed-Pastor, Joseph D. Mancias, Tyler Jacks, William L. Hwang, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A052.
https://doi.org/10.1158/1538-7445.PANCA22-A052
Published: 15 November 2022
View articletitled, Abstract A052: Systematic dissection of transcriptional states in pancreatic cancer
Journal Articles

Abstract A075: NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins

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Naiara Santana-Codina, Huan Zhang, Maria Quiles del Rey, Kevin S. Kapner, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen John, Douglas E. Biancur, Brandon Chen, Nupur Das, Kristen Lowder, Connor J. Hennessey, Wesley Huang, Annan Yang, Yatrik M. Shah, Jonathan A. Nowak, Andrew J. Aguirre, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A075.
https://doi.org/10.1158/1538-7445.PANCA22-A075
Published: 15 November 2022
View articletitled, Abstract A075: NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
Journal Articles

Abstract A057: Therapeutic efficacy of selective CDK7 inhibition in pancreatic cancer mediated by induction of R-loop formation, DNA replication stress and genomic instability

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Annan Yang, Jie Jiang, Ziyue Li, Kevin S. Kapner, Hanrong Feng, Kristen E. Lowder, Miljan Kuljanin, Whiteny Johnson, Giselle Uribe, Jasper E. Neggers, Shengwu Liu, Tinghu Zhang, James Decaprio, Ewa Sicinska, Brian M. Wolpin, Nicholas P. Kwiatkowski, Stephanie K. Dougan, Joseph D. Mancias, Nathanael S. Gray, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A057.
https://doi.org/10.1158/1538-7445.PANCA22-A057
Published: 15 November 2022
View articletitled, Abstract A057: Therapeutic efficacy of selective CDK7 inhibition in pancreatic cancer mediated by induction of R-loop formation, DNA replication stress and genomic instability
Journal Articles

Abstract C48: Defining mechanisms of adaptation to KRAS G12C inhibitors: Using quantitative proteomics to design combinatorial strategies in pancreatic cancer

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Naiara Santana-Codina, Amrita Singh Chandhoke, Qijia Yu, Beata Malachowska, Miljan Kuljanin, Mark P. Jedrychowski, Ajami Gikandi, Marcin Stanczak, David A. Scott, Wojciech Fendler, Nathanael S. Gray, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C48.
https://doi.org/10.1158/1538-7445.PANCA19-C48
Published: 13 December 2019
View articletitled, Abstract C48: Defining mechanisms of adaptation to KRAS G12C inhibitors: Using quantitative proteomics to design combinatorial strategies in pancreatic cancer
Journal Articles

Abstract 4272: Mutations in RABL3 alter RAS prenylation and are associated with hereditary pancreatic cancer

Free
Sahar Nissim, Ignaty Leshchiner, Joseph D. Mancias, Matthew B. Greenblatt, Ophélia Maertens, Christopher A. Cassa, Jill A. Rosenfeld, Andrew G. Cox, John Hedgepeth, Julia Wücherpfennig, Andrew J. Kim, Jake E. Henderson, Patrick Gonyo, Anthony Brandt, Ellen Lorimer, Bethany Unger, Jeremy W. Prokop, Jeremy W. Heidel, Xiao-Xu Wang, Chinedu I. Ukaegbu, Gad Getz, Shamil R. Sunyaev, J. Wade Harper, Karen Cichowski, Alec C. Kimmelman, Yariv Houvras, Sapna Syngal, Carol Williams, Wolfram Goessling
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4272.
https://doi.org/10.1158/1538-7445.AM2017-4272
Published: 01 July 2017
View articletitled, Abstract 4272: Mutations in RABL3 alter RAS prenylation and are associated with hereditary pancreatic cancer
Journal Articles

Abstract 4986: Pancreatic cancers develop metabolic resistance pathways to glutaminase inhibition

Free
Joseph D. Mancias, Douglas E. Biancur, Joao A. Paulo, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Alec C. Kimmelman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4986.
https://doi.org/10.1158/1538-7445.AM2017-4986
Published: 01 July 2017
View articletitled, Abstract 4986: Pancreatic cancers develop metabolic resistance pathways to glutaminase inhibition