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Journal Articles

Abstract 6624: MYC promotes lobuloalveologenesis and mammary tumorigenesis in male mice

Emilia M. Pulver, Eline van der Burg, Anne Paulien Drenth, Julia Yemelyanenko, Nils Ravensbergen, Roebi de Bruijn, Sjoerd Klarenbeek, Ji-Ying Song, Manon Boeije, Bjørn Siteur, Natalie Proost, Colinda Scheele, Peter Bouwman, Jos Jonkers
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6624.
https://doi.org/10.1158/1538-7445.AM2024-6624
Published: 22 March 2024
View article titled, Abstract 6624: MYC promotes lobuloalveologenesis and mammary tumorigenesis in male mice
Journal Articles

Abstract PR10: Mammary epithelial architecture modulates field cancerization

Hendrik A Messal, Cindy Cleyp0ol, Catrin Lutz, Stefan Hutten, Esther Lips, Jos Jonkers, Jelle Wesseling, Ronald Bleys, Ben Simons, Colinda Scheele, Jacco van Rheenen
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): PR10.
https://doi.org/10.1158/1538-7445.ADVBC23-PR10
Published: 01 February 2024
View article titled, Abstract PR10: Mammary epithelial architecture modulates field cancerization
Journal Articles

Abstract A052: Dissecting the immune regulatory mechanisms of distinct PI3K alterations in invasive lobular carcinoma

Antoinette van Weverwijk, Michael Schubert, Joseph Siefert, Martine van Miltenburg, Kim Vrijland, Julia Houthuijzen, Anne Stunnenberg, Cheei-Sing Hau, Lodewyk Wessels, Jos Jonkers, Karin E de Visser
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): A052.
https://doi.org/10.1158/1538-7445.ADVBC23-A052
Published: 01 February 2024
View article titled, Abstract A052: Dissecting the immune regulatory mechanisms of distinct PI3K alterations in invasive lobular carcinoma
Journal Articles

Abstract A062: Somatic engineering of rat models to recapitulate human breast cancer evolution and heterogeneity

Catrin Lutz, Ji-Ying Song, Hendrik A Messal, Madelon Badoux, Timo Eijkman, Bim de Klein, Jelle Wesseling, Jos Jonkers
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): A062.
https://doi.org/10.1158/1538-7445.ADVBC23-A062
Published: 01 February 2024
View article titled, Abstract A062: Somatic engineering of rat models to recapitulate human breast cancer evolution and heterogeneity
Journal Articles

Abstract 3488: Truncated FGFR2 - a clinically actionable oncogene in multiple cancers

Daniel Kaspar Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M. Kas, Catrin Lutz, Chi-Chuan Lin, Sjoerd Klarenbeek, Jessica K. Lee, Ian M. Silverman, Stefano Annunziato, Marieke van de Ven, Siraj M. Ali, Timothy C. Burn, Shridar Ganesan, Lodewyk F. Wessels, Jos Jonkers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3488.
https://doi.org/10.1158/1538-7445.AM2023-3488
Published: 04 April 2023
View article titled, Abstract 3488: Truncated FGFR2 - a clinically actionable oncogene in multiple cancers
Journal Articles

Abstract P5-01-01: Intraductal patient-derived xenograft models of ductal carcinoma in situ (DCIS) to distinguish indolent DCIS from aggressive DCIS

Jelle Wesseling, Stefan Hutten, Catrin Lutz, Colinda Scheele, Madelon Badoux, Timo Eijkman, Roebi de Bruijn, Mathilde Almekinders, Joyce Sanders, Esther Lips, Jacco van Rheenen, Jos Jonkers, Grand challenge PRECISION consortium
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P5-01-01.
https://doi.org/10.1158/1538-7445.SABCS21-P5-01-01
Published: 15 February 2022
View article titled, Abstract P5-01-01: Intraductal patient-derived xenograft models of ductal carcinoma in situ (DCIS) to distinguish indolent DCIS from aggressive DCIS
Journal Articles

A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture

Sanjiban Chakrabarty, William F. Quiros-Solano, Maayke M.P. Kuijten, Ben Haspels, Sandeep Mallya, Calvin Shun Yu Lo, Amr Othman, Cinzia Silvestri, Anja van de Stolpe, Nikolas Gaio, Hanny Odijk, Marieke van de Ven, Corrina M.A. de Ridder, Wytske M. van Weerden, Jos Jonkers, Ronald Dekker, Nitika Taneja, Roland Kanaar, Dik C. van Gent
Journal: Cancer Research
Cancer Res (2022) 82 (3): 510–520.
https://doi.org/10.1158/0008-5472.CAN-21-0799
Published: 01 February 2022
View article titled, A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture
Open the PDF for A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture in another window
Includes: Supplementary data
Journal Articles

A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair

Emilia M. Pulver, Chirantani Mukherjee, Gerarda van de Kamp, Stefan J. Roobol, Magdalena B. Rother, Hanneke van der Gulden, Roebi de Bruijn, Maria Valeria Lattanzio, Eline van der Burg, Anne Paulien Drenth, Nicole S. Verkaik, Kerstin Hahn, Sjoerd Klarenbeek, Renske de Korte-Grimmerink, Marieke van de Ven, Colin E.J. Pritchard, Ivo J. Huijbers, Bing Xia, Dik C. van Gent, Jeroen Essers, Haico van Attikum, Arnab Ray Chaudhuri, Peter Bouwman, Jos Jonkers
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6171–6182.
https://doi.org/10.1158/0008-5472.CAN-21-1415
Published: 15 December 2021
View article titled, A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair
Open the PDF for A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair in another window
Includes: Supplementary data
Journal Articles

Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts

Jessica Giordano, Xing Yi Woo, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Francesco Galimi, Andrea Bertotti, Adam Lafferty, Alice C. O'Farrell, Elodie Modave, Diether Lambrechts, Petra ter Brugge, Violeta Serra, Elisabetta Marangoni, Rania El Botty, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Bingliang Fang, Jack Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Jeffrey A. Moscow, Carol J. Bult, Claudio Isella, Livio Trusolino, Annette T. Byrne, Jos Jonkers, Jeffrey H. Chuang, Enzo Medico, EurOPDX consortium & PDXNET consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2020-1118
Published: 15 August 2020
View article titled, Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts
Journal Articles

Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Jong-Il Kim, Han-Kwang Yang, Charles Lee, Dennis A. Dean, Brandi Davis-Dusenbery, Yvonne A. Evrard, James H. Doroshow, Alana L. Welm, Bryan Welm, Michael T. Lewis, Bingliang Fang, Jack A. Roth, Funda Meric-Bernstam, Meenhard Herlyn, Michael Davies, Li Ding, Shunqiang Li, Ramaswamy Govindan, Claudio Isella, Jeffrey A. Moscow, Livio Trusolino, Annette Byrne, Jos Jonkers, Carol J. Bult, Enzo Medico, Jeffrey H. Chuang, PDXNET consortium & EurOPDX consortium
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1673.
https://doi.org/10.1158/1538-7445.AM2020-1673
Published: 15 August 2020
View article titled, Abstract 1673: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Journal Articles

Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts

Emilie Vinolo, Joaquin Arribas, Andrea Bertotti, Alejandra Bruna, Annette T. Byrne, Robert B. Clarke, Nathalie Conte, Steven de Jong, Didier Decaudin, Zdenka Dudova, Jos Jonkers, Daniela Krasser, Ales Krenek, Luisa Lanfrancone, Eleonora Leucci, Elisabetta Marangoni, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Jens Henrik Norum, Hector G. Palmer, Alejandro Piris Gimenez, Leo Price, Sergio Roman-Roman, Francesca Sarno, Violeta Serra, Laura Soucek, Livio Trusolino, Marieke van de Ven, Luca Vezzadini, Alberto Villanueva, Andrea Wutte, Enzo Medico, on behalf of the EurOPDX Research Infrastructure
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1685.
https://doi.org/10.1158/1538-7445.AM2020-1685
Published: 15 August 2020
View article titled, Abstract 1685: The EurOPDX Research Infrastructure: Supporting European and worldwide cancer research with patient-derived xenografts
Journal Articles

Abstract B37: Understanding DCIS initiation and progression using PDX and genetically engineered mouse and rat models

Stefan Hutten, Catrin Lutz, Colinda Scheele, Madelon Badoux, Timo Eijkman, Stefano Annunziatio, Jelle Wesseling, Jos Jonkers
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B37.
https://doi.org/10.1158/1538-7445.CAMODELS2020-B37
Published: 02 June 2020
View article titled, Abstract B37: Understanding DCIS initiation and progression using PDX and genetically engineered mouse and rat models
Journal Articles

Abstract IA18: Genetic dissection of breast cancer development and therapy resistance in mouse models

Jos Jonkers
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): IA18.
https://doi.org/10.1158/1538-7445.CAMODELS2020-IA18
Published: 02 June 2020
View article titled, Abstract IA18: Genetic dissection of breast cancer development and therapy resistance in mouse models
Journal Articles

Abstract PHB04: Predictive modeling, applied to genetically engineered mouse models of breast or lung cancer, provides insights into major oncogenic pathways

Julio Banga, Lucien Frappart, Jan Hasenauer, Yann Herault, Jos Jonkers, David Koubi, Bodo Lange, Glenn Terje Lines, Aspasia Plouidou, Oliver Rinner
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): PHB04.
https://doi.org/10.1158/1538-7445.CAMODELS2020-PHB04
Published: 02 June 2020
View article titled, Abstract PHB04: Predictive modeling, applied to genetically engineered mouse models of breast or lung cancer, provides insights into major oncogenic pathways
Journal Articles

Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms

Koen Schipper, Anne Paulien Drenth, Eline van der Burg, Samuel Cornelissen, Sjoerd Klarenbeek, Micha Nethe, Jos Jonkers
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1486–1497.
https://doi.org/10.1158/0008-5472.CAN-19-3607
Published: 02 April 2020
View article titled, Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms
Open the PDF for Truncated ASPP2 Drives Initiation and Progression of Invasive Lobular Carcinoma via Distinct Mechanisms in another window
Includes: Supplementary data
Journal Articles

Abstract P6-15-07: Impact of increased mammary adiposity on DCIS progression

Mathilde Matthea Machteld Almekinders, Michael Schaapveld, Bram Thijssen, Ingrid Hofland, Marjolijn Mertz, Dennis Peters, Annegien Broeks, Lodewijk Wessels, Wilbert Zwart, Jos Jonkers, Esther Lips, Christine Desmedt, Jelle Wesseling, on behalf of the PRECISION Team
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-15-07.
https://doi.org/10.1158/1538-7445.SABCS19-P6-15-07
Published: 15 February 2020
View article titled, Abstract P6-15-07: Impact of increased mammary adiposity on DCIS progression
Journal Articles

Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors

Marco Barazas, Alessia Gasparini, Yike Huang, Asli Küçükosmanoğlu, Stefano Annunziato, Peter Bouwman, Wendy Sol, Ariena Kersbergen, Natalie Proost, Renske de Korte-Grimmerink, Marieke van de Ven, Jos Jonkers, Gerben R. Borst, Sven Rottenberg
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (3): 452–460.
https://doi.org/10.1158/0008-5472.CAN-18-2077
Published: 01 February 2019
View article titled, Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors
Open the PDF for Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors in another window
Includes: Supplementary data
Journal Articles

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547

Sjors M. Kas, Julian R. de Ruiter, Koen Schipper, Eva Schut, Lorenzo Bombardelli, Ellen Wientjens, Anne Paulien Drenth, Renske de Korte-Grimmerink, Sunny Mahakena, Christopher Phillips, Paul D. Smith, Sjoerd Klarenbeek, Koen van de Wetering, Anton Berns, Lodewyk F.A. Wessels, Jos Jonkers
Journal: Cancer Research
Cancer Res (2018) 78 (19): 5668–5679.
https://doi.org/10.1158/0008-5472.CAN-18-0757
Published: 01 October 2018
View article titled, Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547
Open the PDF for Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547 in another window
Includes: Supplementary data
Journal Articles

Abstract 5381: Understanding the genesis and oncogenic consequences of tandem duplicator phenotypes in human cancers

Francesca Menghi, Floris Barthel, Vinod Yadav, Ming Tang, Bo Ji, Gregory Carter, Jos Jonkers, Roel Verhaak, Ralph Scully, Ed Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5381.
https://doi.org/10.1158/1538-7445.AM2018-5381
Published: 01 July 2018
View article titled, Abstract 5381: Understanding the genesis and oncogenic consequences of tandem duplicator phenotypes in human cancers
Journal Articles

Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models

Enzo Medico, Mohamed Bentires-Alj, Andrew V. Biankin, Alejandra Bruna, Annette T. Byrne, Carlos Caldas, Robert B. Clarke, Georges Coukos, Olivier Elemento, Manuel Hidalgo, Giorgio Inghirami, Steven de Jong, Jos Jonkers, Ales Krenek, Eleonora Leucci, Gunhild Mari Maelandsmo, Michaela Th. Mayrhofer, Terrence F. Meehan, Simone P. Niclou, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Leo Price, Sergio Roman-Roman, Livio Trusolino, Luca Vezzadini, Alberto Villanueva, Emilie Vinolo, on behalf of the EurOPDX Consortium
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 985.
https://doi.org/10.1158/1538-7445.AM2018-985
Published: 01 July 2018
View article titled, Abstract 985: The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models