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Jos H. Beijnen
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Journal Articles

Abstract 6322: The role of multidrug efflux transporters and CYP3A in the pharmacokinetics and tissue distribution of abemaciclib and its active metabolites

Alejandra Martinez Chavez, Matthijs M. Tibben, Maria C. Lebre, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6322.
https://doi.org/10.1158/1538-7445.AM2020-6322
Published: 15 August 2020
View article titled, Abstract 6322: The role of multidrug efflux transporters and CYP3A in the pharmacokinetics and tissue distribution of abemaciclib and its active metabolites
Journal Articles

Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib

Wenlong Li, Matthijs Tibben, Yaogeng Wang, Maria C. Lebre, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1268.
https://doi.org/10.1158/1538-7445.AM2019-1268
Published: 01 July 2019
View article titled, Abstract 1268: The impact of P-glycoprotein, breast cancer resistance protein and CYP3A on pharmacokinetics and metabolism of galunisertib
Journal Articles

Abstract LB-255: Acquired and intrinsic resistance to vemurafenib in BRAFv600e-driven melanoma brain metastases

Mark C. de Gooijer, Ping Zhang, Levi C. Buil, Stephan Freriks, Gang Li, Jos H. Beijnen, Olaf Van Tellingen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-255.
https://doi.org/10.1158/1538-7445.AM2019-LB-255
Published: 01 July 2019
View article titled, Abstract LB-255: Acquired and intrinsic resistance to vemurafenib in BRAF<sup>v600e</sup>-driven melanoma brain metastases
Journal Articles

Abstract 3771: Splenic macrophages induce chemotherapy resistance via DNA damage repair

Julia M. Houthuijzen, Laura G.M. Daenen, Jeanine M.L. Roodhart, Klaas M. Govaert, Michelle E. Smith, Juergen Thomale, Sahar J. Sadatmand, Hilde Rosing, Fabian Kruse, Nico van Rooijen, Jos H. Beijnen, Piet Borst, Sven Rottenberg, Bodduluri Haribabu, Emile E. Voest
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3771.
https://doi.org/10.1158/1538-7445.AM2014-3771
Published: 01 October 2014
View article titled, Abstract 3771: Splenic macrophages induce chemotherapy resistance via DNA damage repair
Journal Articles

Abstract 3791: Milk thistle as an inhibitor of PXR-mediated CYP3A4 induction

Kim D. Mooiman, Roel F.M. Maas-Bakker, Jos H. Beijnen, Jan H.M. Schellens, Irma Meijerman
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3791.
https://doi.org/10.1158/1538-7445.AM2012-3791
Published: 15 April 2012
View article titled, Abstract 3791: Milk thistle as an inhibitor of PXR-mediated CYP3A4 induction
Journal Articles

Abstract 5687: Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer

Pieter J. Gaillard, Werner Gladdines, Chantal C.M. Appeldoorn, Jaap Rip, Willem J. Boogerd, Jos H. Beijnen, Dieta Brandsma, Olaf van Tellingen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5687.
https://doi.org/10.1158/1538-7445.AM2012-5687
Published: 15 April 2012
View article titled, Abstract 5687: Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer
Journal Articles

Abstract 5718: Implementation of μ-Image Guided Radio-Therapy in the treatment of experimental glioma mouse models: Assessment of the potential of agents that interfere with DNA repair

Mark C. de Gooijer, Fan Lin, Alessia Gasparini, Nienke A. de Vries, Levi C.M. Buil, Tom Wurdinger, Jan-Jakob Sonke, Jos H. Beijnen, Olaf Van Tellingen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5718.
https://doi.org/10.1158/1538-7445.AM2012-5718
Published: 15 April 2012
View article titled, Abstract 5718: Implementation of μ-Image Guided Radio-Therapy in the treatment of experimental glioma mouse models: Assessment of the potential of agents that interfere with DNA repair
Journal Articles

Abstract 761: Phase I interaction study of docetaxel with supplementation of St. John's wort

Andrew K.L. Goey, Irma Meijerman, Hilde Rosing, Marianne Keessen, Jos H. Beijnen, Jan H.M. Schellens
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 761.
https://doi.org/10.1158/1538-7445.AM2012-761
Published: 15 April 2012
View article titled, Abstract 761: Phase I interaction study of docetaxel with supplementation of St. John's wort
Journal Articles

Abstract 373: Allometric scaling of the pharmacokinetics of pegylated liposomal anticancer drugs

Whitney P. Caron, Harvey Clewell, Robert Dedrick, Ramesh K. Ramanathan, Ning Yu, Jan H. Schellens, Jos H. Beijnen, William C. Zamboni
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 373.
https://doi.org/10.1158/1538-7445.AM2011-373
Published: 15 April 2011
View article titled, Abstract 373: Allometric scaling of the pharmacokinetics of pegylated liposomal anticancer drugs
Journal Articles

Abstract 1294: Metabolism and excretion of eribulin in patients with advanced solid tumors

Anne-Charlotte Dubbelman, Marja Mergui-Roelvink, Barbara Koetz, Margarita Lymboura, Larisa Reyderman, Arturo Lopez-Anaya, Hilde Rosing, Serena Marchetti, Jos H. Beijnen, Jan HM Schellens
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1294.
https://doi.org/10.1158/1538-7445.AM2011-1294
Published: 15 April 2011
View article titled, Abstract 1294: Metabolism and excretion of eribulin in patients with advanced solid tumors
Journal Articles

Abstract LB-210: Impact of ABC-transporters in the blood-brain barrier on the efficacy of the PARP inhibitor ABT-888 against transplanted and spontaneous murine brain tumors

Lin Fan, Mark C. de Gooijer, Jan H. Beumer, Susan M. Christner, Jos H. Beijnen, Olaf Van Tellingen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-210.
https://doi.org/10.1158/1538-7445.AM2011-LB-210
Published: 15 April 2011
View article titled, Abstract LB-210: Impact of ABC-transporters in the blood-brain barrier on the efficacy of the PARP inhibitor ABT-888 against transplanted and spontaneous murine brain tumors
Journal Articles

Abstract 697: Mesenchymal stem cell-induced resistance: Implications for reversible resistance

Laura Daenen, Jeanine M.L. Roodhart, Edwin C.A. Stigter, Jos H. Beijnen, Rene H. Medema, Arjan B. Brenkman, Emile E. Voest
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 697.
https://doi.org/10.1158/1538-7445.AM2011-697
Published: 15 April 2011
View article titled, Abstract 697: Mesenchymal stem cell-induced resistance: Implications for reversible resistance
Journal Articles

Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment

Seng Chuan Tang, Jurjen S. Lagas, Nienke Lankheet, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1518.
https://doi.org/10.1158/1538-7445.AM10-1518
Published: 15 April 2010
View article titled, Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment
Journal Articles

Abstract 4187: A rapid and robust transgenic high-grade glioma mouse model for therapy-intervention studies

Nienke A. de Vries, Sophia W. Bruggeman, Hilda I. de Vries, John Zevenhoven, Tessa Buckle, Bob C. Hamans, William P. Leenders, Jos H. Beijnen, Maarten van Lohuizen, Anton J.M. Berns, Olaf van Tellingen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4187.
https://doi.org/10.1158/1538-7445.AM10-4187
Published: 15 April 2010
View article titled, Abstract 4187: A rapid and robust transgenic high-grade glioma mouse model for therapy-intervention studies
Journal Articles

Abstract 5537: GSH-conjugation improves efficacy of Doxil against intracranial xenografts

Olaf van Tellingen, Dieta Brandsma, Chantal C.M. Appeldoorn, M Francesca Manca, Jaap Rip, Rick Dorland, Joan M.R van Kregten, Willem J. Boogerd, Jos H. Beijnen, Pieter J. Gaillard
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5537.
https://doi.org/10.1158/1538-7445.AM10-5537
Published: 15 April 2010
View article titled, Abstract 5537: GSH-conjugation improves efficacy of Doxil against intracranial xenografts
Journal Articles

Abstract LB-301: The impact of Abcb1 and Abcg2 on the brain penetration of PI3K-mTOR inhibitors

Lin Fan, Mark C. de Gooijer, Levi Buil, Nienke A. de Vries, Jos H. Beijnen, Olaf van Tellingen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-301.
https://doi.org/10.1158/1538-7445.AM10-LB-301
Published: 15 April 2010
View article titled, Abstract LB-301: The impact of Abcb1 and Abcg2 on the brain penetration of PI3K-mTOR inhibitors
Journal Articles

Abstract LB-49: ABC transporters in the blood-brain barrier limit the brain penetration of the PARP inhibitor ABT-888

Lin Fan, Mark C. de Gooijer, Jan H. Beumer, Susan M. Christner, Jos H. Beijnen, Olaf van Tellingen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-49.
https://doi.org/10.1158/1538-7445.AM10-LB-49
Published: 15 April 2010
View article titled, Abstract LB-49: ABC transporters in the blood-brain barrier limit the brain penetration of the PARP inhibitor ABT-888
Journal Articles

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar, Cornelia M.M. van der Kruijssen, Antonius E. van Herwaarden, Ji-Ying Song, Rogier W. Rooswinkel, Olaf van Tellingen, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8996–9002.
https://doi.org/10.1158/0008-5472.CAN-09-2915
Published: 30 November 2009
View article titled, Absence of Both Cytochrome <em>P</em>450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity
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Includes: Supplementary data
Journal Articles

ABC- transporter studies of Gimatecan (7-t-butoxyiminomethylcamptothecin) in comparison to topotecan

Serena Marchetti, Roos Oostendorp, Dick Pluim, Olaf Van Tellingen, Alfred H. Schinkel, Richard Versace, Jos H. Beijnen, Roberto Mazzanti, Jan H. Schellens
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 145.
Published: 15 April 2006
View article titled, ABC- transporter studies of Gimatecan (7-t-butoxyiminomethylcamptothecin) in comparison to topotecan
Journal Articles

The novel orally available taxane derivative BMS-275,183 is a substrate for P-glycoprotein (Pgp, MDR1) and MRP2 and interacts with benzimidazole proton pump inhibitors.

Serena Marchetti, Dick Pluim, Olaf Van Tellingen, Thomas W. Griffin, Michael H. Woo, Jos H. Beijnen, Roberto Mazzanti, Jan H. Schellens
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1272.
Published: 15 April 2006
View article titled, The novel orally available taxane derivative BMS-275,183 is a substrate for P-glycoprotein (Pgp, MDR1) and MRP2 and interacts with benzimidazole proton pump inhibitors.