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Jorge S. Reis-Filho
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Journal Articles

Abstract 2801: Detection of biallelic loss of DNA repair genes in formalin-fixed, paraffin embedded (FFPE) tumor samples using a novel tumor-only sequencing panel with error correction

Dominik Glodzik, Pier Selencia, Ryan Rogge, Ian M. Silverman, Michael Zinda, Maria Koehler, Robert D. Daber, Verity Johnson, Jorge S. Reis-Filho, Victoria Rimkunas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2801.
DOI: https://doi.org/10.1158/1538-7445.AM2022-2801
Published: 15 June 2022
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Journal Articles

Abstract LB517A: The role of EGFR in resistance to tucatinib and its therapeutic implications

Jamunarani Veeraraghavan, Fu-Tien Liao, Tia Gordon, Pier Selenica, Sarmistha Nanda, Lanfang Qin, Yingjie Zhu, Juber A. Patel, Andrea Gazzo, Fabio Stossi, Michael A. Mancini, Carolina Gutierrez, Britta Weigelt, Jorge S. Reis-Filho, C. Kent Osborne, Mothaffar F. Rimawi, Rachel Schiff
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB517A.
DOI: https://doi.org/10.1158/1538-7445.AM2022-LB517A
Published: 15 June 2022
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Journal Articles

Abstract 1787: Statin therapy enhances the efficacy of HER2 directed antibody-drug conjugates in breast cancer

Bo Liu, Joshua Z. Drago, Yi Rao, Patricia R. Pereira, Anton Safonov, Antonio Marra, Mehnaj S. Ahmed, Shanu Modi, Jorge S. Reis-Filho, Filippo Montemurro, Pedram Razavi, Jason S. Lewis, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1787.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1787
Published: 15 June 2022
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Journal Articles

Abstract CT030: Genomic and pathologic determinants of response to RP-3500, an ataxia telangiectasia and Rad3-related inhibitor (ATRi), in patients (pts) with DNA damage repair (DDR) loss-of-function (LOF) mutant tumors in the Phase 1/2 TRESR trial

Timothy A. Yap, Ian M. Silverman, Elisa Fontana, Elizabeth Lee, David Spigel, Martin Højgaard, Stephanie Lheureux, Niharika Mettu, Benedito A. Carneiro, Louise Carter, Ruther Plummer, Joseph D. Schonhoft, Danielle Ulanet, Parham Nejad, Peter Manley, Jorge S. Reis-Filho, Yi Xu, Victoria Rimkunas, Maria Koehler, Ezra Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT030.
DOI: https://doi.org/10.1158/1538-7445.AM2022-CT030
Published: 15 June 2022
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Journal Articles

Abstract 5688: RNA-mediated DNA repair: A novel repair pathway in homologous recombination-deficient cancers

Manisha Jalan, Juber Patel, Kyrie S Olsen, Sana Ahmed-Seghir, Daniel S Higginson, Jorge S Reis-Filho, Nadeem Riaz, Simon N Powell
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5688.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5688
Published: 15 June 2022
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Journal Articles

Abstract PD14-03: Genetic and epigenetic basis of invasive lobular carcinomas lacking CDH1-alterations

Fatemeh Derakhshan, Higinio Dopeso, Arnaud Da Cruz Paula, Pier Selenica, Antonio Marra, Edaise M da Silva, Andrea Gazzo, Shirin Issa Bhaloo, Dara S Ross, Anne Grabenstetter, Sarat Chandarlapaty, Pedram Razavi, Hannah Y. Wen, Hong Zhang, Edi Brogi, Britta Weigelt, Fresia Pareja, Jorge S. Reis-Filho
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD14-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD14-03
Published: 15 February 2022
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Journal Articles

Abstract PD11-02: Subtyping invasive carcinomas and high-risk lesions for machine learning based breast pathology

Matthew G Hanna, Patricia Raciti, Alican Bozkurt, Ran Godrich, Julian Viret, Donghun Lee, Philippe Mathieu, Matthew Lee, Eugene Vorontsov, Tomer Sabo, Felipe C Geyer, Jorge S Reis-Filho, Leo Grady, Thomas Fuchs, Christopher Kanan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD11-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD11-02
Published: 15 February 2022
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Journal Articles

Abstract PD11-01: An artificial intelligence-based predictor of CDH1 biallelic mutations and invasive lobular carcinoma

Jorge S Reis-Filho, Fresia Pareja, Fatemeh Derakhshan, David N Brown, Jillian Sue, Pier Selenica, Yi Kan Wang, Arnaud Da Cruz Paula, Monami Banerjee, Zahra Ebrahimzadeh, Manuel Isava, Matthew Lee, Ran Godrich, Adam Casson, Ruben Padron, George Shaikovski, Alexander van Eck, Antonio Marra, Higinio Dopeso, Hannah Y Wen, Edi Brogi, Matthew G Hanna, Chris Kanan, Jeremy D Kunz, Felipe C Geyer, Carla Leibowitz, David Klimstra, Leo Grady, Thomas J Fuchs
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD11-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD11-01
Published: 15 February 2022
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Journal Articles

Abstract PD1-06: Apobec mutagenesis is a pervasive feature of poor prognosis breast cancer associating with ESR1 wild type, endocrine resistant disease

Antonio Marra, Andrea Gazzo, Pier Selenica, Xin Pei, Avantika Gupta, Fresia Pareja, Giuseppe Curigliano, Reuben Harris, Nadeem Riaz, Jorge S. Reis-Filho, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD1-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD1-06
Published: 15 February 2022
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Journal Articles

Abstract P2-06-04: Pathognomonic long molecule footprints of backup repair pathways in homologous recombination deficient cancers

Jeremy Setton, Kevin Hadi, Huasong Tian, Arnaud Da Cruz Paula, Joel Rosiene, Zi-Ning Choo, Julie Behr, Xiaotong Yao, Olivier Elemento, Britta Weigelt, Nadeem Riaz, Jorge S Reis-Filho, Marcin Imielinski, Simon N Powell
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P2-06-04.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P2-06-04
Published: 15 February 2022
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Journal Articles

Abstract P4-01-01: Resistance to next generation tyrosine kinase inhibitors (TKIs) in HER2-positive breast cancer (BC): Role of HER and PIK3CA mutations and development of new treatment strategies and study models

Sreyashree Bose, Ragini Mistry, Chia Chia Liu, Sarmistha Nanda, Lanfang Qin, Pier Selenica, Andrea Gazzo, Yingjie Zhu, Michael A. Mancini, Fabio Stossi, Irmina Diala, Lisa D. Eli, Britta Weigelt, Jorge S. Reis-Filho, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff, Jamunarani Veeraraghavan
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-01-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-P4-01-01
Published: 15 February 2022
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Journal Articles

Abstract GS3-03: Genomic analysis of 733 HER2+ breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities

Emanuela Ferraro, Alison Smith, Anton Safonov, Paulino Tallon De Lara, Cristina Bernado', Enrique J. Arenas Lahuerta, Joaquín Arribas, David Solit, Jorge S. Reis-Filho, Neal Rosen, Larry Norton, Shanu Modi, Mark E. Robson, Chau T. Dang, Giuseppe Curigliano, Sarat Chandarlapaty, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS3-03.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS3-03
Published: 15 February 2022
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Journal Articles

Abstract GS4-08: Comprehensive genomic profiling of patients with breast cancer identifies germline-somatic interactions mediating therapy resistance

Anton Safonov, Chai Bandlamudi, Paulino Tallón de Lara, Emanuela Ferraro, Fatemeh Derakhshan, Marie Will, Mark Donoghue, Pier Selenica, Joshua Drago, Ezra Rosen, Carlos dos Anjos, Elaine Walsh, Elizabeth A Comen, Mehnaj Ahmed, Barbara Acevedo, Ahmet Zehir, Michael F Berger, David Solit, Larry Norton, Ronglai Shen, Zsofia Stadler, Simon Powell, Jorge S Reis-Filho, Sarat Chandarlapaty, Mark Robson, Pedram Razavi
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): GS4-08.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-GS4-08
Published: 15 February 2022
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Journal Articles

Abstract PD8-06: Acquired resistance to tucatinib is associated with EGFR amplification in HER2+ breast cancer (BC) models and can be overcome by a more complete blockade of HER receptor layer

Jamunarani Veeraraghavan, Sreyashree Bose, Ragini Mistry, Pier Selenica, Sarmistha Nanda, Lanfang Qin, Andrea Gazzo, Yingjie Zhu, Michael A Mancini, Fabio Stossi, Britta Weigelt, Jorge S Reis-Filho, C. Kent Osborne, Mothaffar F Rimawi, Rachel Schiff
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD8-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD8-06
Published: 15 February 2022
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Journal Articles

Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors

Yanyan Cai, Guotai Xu, Fan Wu, Flavia Michelini, Carmen Chan, Xuan Qu, Pier Selenica, Erik Ladewig, Pau Castel, Yuanming Cheng, Alison Zhao, Komal Jhaveri, Eneda Toska, Marta Jimenez, Alexandra Jacquet, Alicia Tran-Dien, Fabrice Andre, Sarat Chandarlapaty, Jorge S. Reis-Filho, Pedram Razavi, Maurizio Scaltriti
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2470–2480.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-3232
Published: 01 May 2021
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Includes: Supplementary data
Journal Articles

Abstract PD6-02: Digital MammaPrint and BluePrint using machine learning and whole slide imaging

Annuska M Glas, Jorge S Reis-Filho, Diederik Wehkamp, Belma Dodgas, Leonie Delahaye, Ran Godrich, Jeroen Mollink, Adam Casson, Anke Witteveen, Julian Viret, Donghun Lee, Matthew Lee, Hugo Horlings, Leo Grady, Thomas Fuchs, William Audeh, Christopher Kanan, Laura J van't Veer
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD6-02.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PD6-02
Published: 15 February 2021
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Journal Articles

Abstract 709: The utility of plasma ctDNA for detection of KRAS G12C and other mutations in lung cancers

Yonina R. Murciano-Goroff, Kathryn C. Arbour, Michael D. Offin, Hai-Yan Y. Tu, Emily S. Lebow, Tristan S. Shaffer, Caterina Bertucci, Syed A. Hosseini, Kavita Garg, Lee P. Lim, Mark Li, Jason C. Chang, Jorge S. Reis-Filho, Pedram Razavi, James M. Isbell, Gregory J. Riely, David M. Hyman, Piro Lito, Bob T. Li
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 709.
DOI: https://doi.org/10.1158/1538-7445.AM2020-709
Published: 15 August 2020
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Journal Articles

Abstract P2-10-01: The genomic landscape of breast cancer in African American women

Cristian Serna-Tamayo, Joshua Z Drago, Carlos Dos Anjos, Joshua Herbert, Fresia Pareja, Shanu Modi, Komal Jhaveri, Chau Dang, David B Solit, Larry Norton, Mauricio Scaltriti, Jorge S Reis-Filho, Sarat Chandarlapaty, Mark E. Robson, Pedram Razavi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P2-10-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P2-10-01
Published: 15 February 2020
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Journal Articles

Abstract P4-17-01: Genomic profiling of primary and metastatic breast cancer in men

Joshua Z Drago, Cristian Serna-Tamayo, Carlos H Dos Anjos, David N Brown, Shanu Modi, Komal Jhaveri, David B Solit, Tiffany A Traina, Sarat Chandarlapaty, Jorge S Reis-Filho, Mark E Robson, Ayca Gucalp, Pedram Razavi
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P4-17-01.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-P4-17-01
Published: 15 February 2020
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Journal Articles

Abstract PD8-06: The genomic landscape of metastatic special histologic types of breast cancer

Fresia Pareja, Simon SK Lee, Francisco Beca, Lorenzo Ferrando, Pier Selenica, David N Brown, Hannah Y Wen, Hong Zhang, Edi Brogi, Pedram Razavi, Sarat Chandarlapaty, Britta Weigelt, Jorge S Reis-Filho
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD8-06.
DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD8-06
Published: 15 February 2020
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