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Jordan M. Winter
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Journal Articles

Abstract C046: Targeting wild-type IDH1 sensitizes homologous recombination proficient pancreatic cancer to PARP inhibition

Mehrdad Zarei, Omid Hajihassani, Hallie J. Graor, Soubhi Tahhan, Alexander W. Loftus, Faith Nakazzi, Semmer A. Ali, Parnian Naji, Luke D. Rothermel, Jonothan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C046.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C046
Published: 15 September 2024
View article titled, Abstract C046: Targeting wild-type IDH1 sensitizes homologous recombination proficient pancreatic cancer to PARP inhibition
Journal Articles

IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer

Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Alexander W. Loftus, Hallie J. Graor, Faith Nakazzi, Parnian Naji, Christina S. Boutros, Vinayak Uppin, Ali Vaziri-Gohar, Akram Shalaby, John M. Asara, Luke D. Rothermel, Jonathan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024)
https://doi.org/10.1158/0008-5472.CAN-23-1895
Published: 06 June 2024
View article titled, IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer
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Includes: Supplementary data
Journal Articles

Abstract 445: Determining the molecular and biologic effects of HER3 and IDH1 antagonism on liver endothelium-PDAC crosstalk

Christina S. Boutros, Alexander W. Loftus, Moeez Rathore, Mehrdad Zarei, Kimberly Curry, Jordan M. Winter, Rui Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 445.
https://doi.org/10.1158/1538-7445.AM2024-445
Published: 22 March 2024
View article titled, Abstract 445: Determining the molecular and biologic effects of HER3 and IDH1 antagonism on liver endothelium-PDAC crosstalk
Journal Articles

Abstract 7125: Inhibition of IDH1 impairs homologous recombination and induces sensitivity to PARP inhibitor in pancreatic cancer

Mehrdad Zarei, Omid Hajihassani, Hallie J. Graor, Alexander W. Loftus, Soubhi Tahhan, Faith Nakazzi, Parnian Naji, Luke D. Rothermel, Jonothan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7125.
https://doi.org/10.1158/1538-7445.AM2024-7125
Published: 22 March 2024
View article titled, Abstract 7125: Inhibition of IDH1 impairs homologous recombination and induces sensitivity to PARP inhibitor in pancreatic cancer
Journal Articles

Abstract 991: Unraveling the role of nicotinamide adenine dinucleotide precursors in pancreatic cancer biology

Faith Nakazzi, Mehrad Zarei, Hallie J. Graor, Alexander W. Loftus, Omid Hajihassanni, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 991.
https://doi.org/10.1158/1538-7445.AM2024-991
Published: 22 March 2024
View article titled, Abstract 991: Unraveling the role of nicotinamide adenine dinucleotide precursors in pancreatic cancer biology
Journal Articles

Abstract 3078: Role of HuR in metabolic reprogramming of BRAF mutant melanoma treated with dabrafenib

Alexander Loftus, Mehrdad Zarei, Hallie Graor, Omid Hajihassani, Christina Boutros, Jordan M. Winter, Luke D. Rothermel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3078.
https://doi.org/10.1158/1538-7445.AM2024-3078
Published: 22 March 2024
View article titled, Abstract 3078: Role of HuR in metabolic reprogramming of BRAF mutant melanoma treated with dabrafenib
Journal Articles

Abstract A105: Wild-type IDH1 inhibition enhances chemotherapy response in pancreatic cancer

Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Alexander W. Loftus, Luke D. Rothermel, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A105.
https://doi.org/10.1158/1538-7445.PANCA2023-A105
Published: 16 January 2024
View article titled, Abstract A105: Wild-type IDH1 inhibition enhances chemotherapy response in pancreatic cancer
Journal Articles

Abstract 3701: Targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer

Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Hallie J. Graor, Arian Hajihassani, Alexander W. Loftus, Luke D. Rothermel, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3701.
https://doi.org/10.1158/1538-7445.AM2023-3701
Published: 04 April 2023
View article titled, Abstract 3701: Targeting wild-type IDH1 enhances chemosensitivity in pancreatic cancer
Journal Articles

Abstract 4839: Chemotherapy alters mitochondrial metabolism in melanoma

Alexander W. Loftus, Mehrdad Zarei, Omid Hajihassani, Johnathan J. Hue, Hallie J. Graor, Ali Vaziri-Gohar, Jordan M. Winter, Luke D. Rothermel
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4839.
https://doi.org/10.1158/1538-7445.AM2023-4839
Published: 04 April 2023
View article titled, Abstract 4839: Chemotherapy alters mitochondrial metabolism in melanoma
Journal Articles

Abstract 2321: IDO1 is a potential target to combat pancreatic cancer-associated depression

Jonathan J. Hue, Hallie J. Graor, Mehrdad Zarei, Ali Vaziri-Gohar, Erryk S. Katayama, Karen Ji, Omid Hajihassani, Alexander W. Loftus, Luke D. Rothermel, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2321.
https://doi.org/10.1158/1538-7445.AM2022-2321
Published: 15 June 2022
View article titled, Abstract 2321: IDO1 is a potential target to combat pancreatic cancer-associated depression
Journal Articles

Abstract 3133: Glucose is important for macrophage metabolism and response to immunotherapy in a pancreatic cancer model

Jonathan J. Hue, Mehrdad Zarei, Hallie J. Graor, Erryk S. Katayama, Omid Hajihassani, Alexander W. Loftus, Luke D. Rothermel, Ali Vaziri-Gohar, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3133.
https://doi.org/10.1158/1538-7445.AM2022-3133
Published: 15 June 2022
View article titled, Abstract 3133: Glucose is important for macrophage metabolism and response to immunotherapy in a pancreatic cancer model
Journal Articles

Abstract 1476: Stability of circulating microRNA for plasma and serum biomarker studies

Erryk S. Katayama, Jonathan J. Hue, Mehrdad Zarei, Hallie J. Graor, Omid Hajihassani, Ali Vaziri-Gohar, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1476.
https://doi.org/10.1158/1538-7445.AM2022-1476
Published: 15 June 2022
View article titled, Abstract 1476: Stability of circulating microRNA for plasma and serum biomarker studies
Journal Articles

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer

Aditi Jain, Lebaron C. Agostini, Grace A. McCarthy, Saswati N. Chand, AnnJosette Ramirez, Avinoam Nevler, Joseph Cozzitorto, Christopher W. Schultz, Cinthya Yabar Lowder, Kate M. Smith, Ian D. Waddell, Maria Raitses-Gurevich, Chani Stossel, Yulia Glick Gorman, Dikla Atias, Charles J. Yeo, Jordan M. Winter, Kenneth P. Olive, Talia Golan, Michael J. Pishvaian, Donald Ogilvie, Dominic I. James, Allan M. Jordan, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4491–4502.
https://doi.org/10.1158/0008-5472.CAN-18-3645
Published: 03 September 2019
View article titled, Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer
Open the PDF for Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-117: Increased peripheral glucose levels restores chemotherapeutic efficacy in a mouse model of pancreatic cancer

Ali Vaziri-Gohar, Imran Khokhar, George Titomihelakis, Jonathan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-117.
https://doi.org/10.1158/1538-7445.AM2019-LB-117
Published: 01 July 2019
View article titled, Abstract LB-117: Increased peripheral glucose levels restores chemotherapeutic efficacy in a mouse model of pancreatic cancer
Journal Articles

Abstract 1973: Targeting PARG in pancreatic cancer: Implications for synthetic lethal therapeutic strategies

Saswati N. Chand, AnnJosette Ramirez, Aditi Jain, Avinoam Nevler, Cinthya Yabar-Lowder, Joseph A. Cozzitorto, Dominic I. James, Allan Jordan, Kate M. Smith, Ian Waddell, Charles J. Yeo, Jordan M. Winter, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1973.
https://doi.org/10.1158/1538-7445.AM2018-1973
Published: 01 July 2018
View article titled, Abstract 1973: Targeting PARG in pancreatic cancer: Implications for synthetic lethal therapeutic strategies
Journal Articles

Abstract 1961: Gaps in the armor: Targeting HuR to sensitize pancreatic cancer

Christopher W. Schultz, Kevin O'Hayer, Teena Dhir, Oloruntoba Bolaji, Kathryn M. Bormes, Samantha Z. Brown, Henry Thomsett, Saswati Chand, Aditi Jain, Wei Jiang, Grace McCarthy, Charles J. Yeo, Austin Goetz, Avinoam Nevler, Jonathan R. Brody, Jordan M. Winter, Ranjan Preet, Dan Dixon, Jessica Bowers, Kelly Rhodes, Robert Getts
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1961.
https://doi.org/10.1158/1538-7445.AM2018-1961
Published: 01 July 2018
View article titled, Abstract 1961: Gaps in the armor: Targeting HuR to sensitize pancreatic cancer
Journal Articles

Abstract 4441: Functional and clinical implications of an INDEL within the HuR regulatory region of the mitotic kinase inhibitor WEE1

Samantha Z. Brown, Avinoam Nevler, Henry T. Thomsett, Shruti Lal, Mahsa Zarei, Fernando Blanco, Joseph A. Cozzitorto, Alexis L. Norris-Kirby, Charles J. Yeo, Jordan M. Winter, James R. Eshleman, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4441.
https://doi.org/10.1158/1538-7445.AM2018-4441
Published: 01 July 2018
View article titled, Abstract 4441: Functional and clinical implications of an INDEL within the HuR regulatory region of the mitotic kinase inhibitor WEE1
Journal Articles

Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors

Saswati N. Chand, Mahsa Zarei, Matthew J. Schiewer, Akshay R. Kamath, Carmella Romeo, Shruti Lal, Joseph A. Cozzitorto, Avinoam Nevler, Laura Scolaro, Eric Londin, Wei Jiang, Nicole Meisner-Kober, Michael J. Pishvaian, Karen E. Knudsen, Charles J. Yeo, John M. Pascal, Jordan M. Winter, Jonathan R. Brody
Journal: Cancer Research
Cancer Res (2017) 77 (18): 5011–5025.
https://doi.org/10.1158/0008-5472.CAN-16-2704
Published: 14 September 2017
View article titled, Posttranscriptional Regulation of <em>PARG</em> mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Open the PDF for Posttranscriptional Regulation of <em>PARG</em> mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells

Mahsa Zarei, Shruti Lal, Seth J. Parker, Avinoam Nevler, Ali Vaziri-Gohar, Katerina Dukleska, Nicole C. Mambelli-Lisboa, Cynthia Moffat, Fernando F. Blanco, Saswati N. Chand, Masaya Jimbo, Joseph A. Cozzitorto, Wei Jiang, Charles J. Yeo, Eric R. Londin, Erin L. Seifert, Christian M. Metallo, Jonathan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2017) 77 (16): 4460–4471.
https://doi.org/10.1158/0008-5472.CAN-17-0015
Published: 14 August 2017
View article titled, Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
Open the PDF for Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 100: Pancreatic cancer cells rely on the NADPH producing enzyme, IDH1, for adaptive survival against acute metabolic stress

Ali Vaziri-Gohar, Mahsa Zarei, Jonathan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 100.
https://doi.org/10.1158/1538-7445.AM2017-100
Published: 01 July 2017
View article titled, Abstract 100: Pancreatic cancer cells rely on the NADPH producing enzyme, IDH1, for adaptive survival against acute metabolic stress