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Jonathan W. Simons
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Journal Articles

The 19th Annual Prostate Cancer Foundation Scientific Retreat

Guneet Walia, Kenneth J. Pienta, Jonathan W. Simons, Howard R. Soule
Journal: Cancer Research
Cancer Res (2013) 73 (16): 4988–4991.
https://doi.org/10.1158/0008-5472.CAN-12-4576
Published: 13 August 2013
View articletitled, The 19th Annual Prostate Cancer Foundation Scientific Retreat
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Includes: Supplementary data
Journal Articles

Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing

Michael F. Berger, Michael S. Lawrence, Francesca Demichelis, Yotam Drier, Kristian Cibulskis, Andrey Y. Sivachenko, Andrea Sboner, Raquel Esgueva, Dorothee Pflueger, Carrie Sougnez, Robert Onofrio, Scott L. Carter, Kyung Park, Lukas Habegger, Lauren Ambrogio, Timothy Fennell, Melissa Parkin, Gordon Saksena, Douglas Voet, Alex H. Ramos, Trevor J. Pugh, Jane Wilkinson, Sheila Fisher, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jonathan W. Simons, Naoki Kitabayashi, Theresa Y. MacDonald, Philip W. Kantoff, Lynda Chin, Stacey B. Gabriel, Mark B. Gerstein, Todd R. Golub, Matthew Meyerson, Ashutosh Tewari, Eric S. Lander, Gad Getz, Mark A. Rubin, Levi A. Garraway
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3925.
https://doi.org/10.1158/1538-7445.AM2011-3925
Published: 15 April 2011
View articletitled, Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing
Journal Articles

Insulin-like Growth Factor-I–Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells

Tisheeka R. Graham, Haiyen E. Zhau, Valerie A. Odero-Marah, Adeboye O. Osunkoya, K. Sean Kimbro, Mourad Tighiouart, Tongrui Liu, Jonathan W. Simons, Ruth M. O'Regan
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2479–2488.
https://doi.org/10.1158/0008-5472.CAN-07-2559
Published: 01 April 2008
View articletitled, Insulin-like Growth Factor-I–Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
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Journal Articles

Antitumor Effect of 2-Methoxyestradiol in a Rat Orthotopic Brain Tumor Model

Seung-Hee Kang, Heidi T. Cho, Sarojini Devi, Zhaobin Zhang, Daniel Escuin, Zhongxing Liang, Hui Mao, Daniel J. Brat, Jeffrey J. Olson, Jonathan W. Simons, Theresa M. LaVallee, Paraskevi Giannakakou, Erwin G. Van Meir, Hyunsuk Shim
Journal: Cancer Research
Cancer Res (2006) 66 (24): 11991–11997.
https://doi.org/10.1158/0008-5472.CAN-06-1320
Published: 18 December 2006
View articletitled, Antitumor Effect of 2-Methoxyestradiol in a Rat Orthotopic Brain Tumor Model
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Journal Articles

WWP1 E3 ubiquitin ligase is a potential oncogene in human prostate and breast cancer

Ceshi Chen, Wei Zhou, John Petros, Henry F. Frierson, Jr., Robert L. Vessella, Qunna Li, Jonathan W. Simons, Jin-Tang Dong
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 607–608.
Published: 15 April 2006
View articletitled, WWP1 E3 ubiquitin ligase is a potential oncogene in human prostate and breast cancer
Journal Articles

MSF-A Interacts with Hypoxia-Inducible Factor-1α and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis

Sharon Amir, Ruoxiang Wang, Haim Matzkin, Jonathan W. Simons, Nicola J. Mabjeesh
Journal: Cancer Research
Cancer Res (2006) 66 (2): 856–866.
https://doi.org/10.1158/0008-5472.CAN-05-2738
Published: 19 January 2006
View articletitled, MSF-A Interacts with Hypoxia-Inducible Factor-1α and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis
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Includes: Supplementary data
Journal Articles

Increased degradation of KLF5 transcription factor through ubiquitin-proteasome pathway in prostate and breast carcinogenesis

Ceshi Chen, Xiaodong Sun, Qimei Ran, Xiaohong Cheng, Jonathan W. Simons, Jin-Tang Dong
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 436.
Published: 01 May 2005
View articletitled, Increased degradation of KLF5 transcription factor through ubiquitin-proteasome pathway in prostate and breast carcinogenesis
Journal Articles

Interstitial pressure stress augments hypoxia induced hypoxia-inducible factor 1alpha: Results from an in vitro experimental model

Meredith Holley, Margaret Willard, Ruoxiang Wang, Jonathan W. Simons, Hua Zhong
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 262–263.
Published: 01 May 2005
View articletitled, Interstitial pressure stress augments hypoxia induced hypoxia-inducible factor 1alpha: Results from an in vitro experimental model
Journal Articles

Frequent somatic mutations of the ATBF1 transcription factor in human prostate cancer

Xiaodong Sun, Henry F. Frierson, Changling Li, Ceshi Chen, Qimei Ran, Kristen Otto, Brandi Cantarel, Allen Gao, John Petros, Yutaka Miura, Jonathan W. Simons, Robert L. Vessella, Jin-Tang Dong
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 677.
Published: 01 May 2005
View articletitled, Frequent somatic mutations of the ATBF1 transcription factor in human prostate cancer
Journal Articles

HIF-1: A new master terrorist gene identified, profiled and targetted.

Jonathan W. Simons
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1312.
Published: 01 April 2004
View articletitled, HIF-1: A new master terrorist gene identified, profiled and targetted.
Journal Articles

Geldanamycin Induces Degradation of Hypoxia-inducible Factor 1α Protein via the Proteosome Pathway in Prostate Cancer Cells

Nicola J. Mabjeesh, Dawn E. Post, Margaret T. Willard, Balveen Kaur, Erwin G. Van Meir, Jonathan W. Simons, Hua Zhong
Journal: Cancer Research
Cancer Res (2002) 62 (9): 2478–2482.
Published: 01 May 2002
View articletitled, Geldanamycin Induces Degradation of Hypoxia-inducible Factor 1α Protein via the Proteosome Pathway in Prostate Cancer Cells
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Journal Articles

A Phase I Trial of CV706, a Replication-competent, PSA Selective Oncolytic Adenovirus, for the Treatment of Locally Recurrent Prostate Cancer following Radiation Therapy

Theodore L. DeWeese, Henk van der Poel, Shidong Li, Bahar Mikhak, Renee Drew, Marti Goemann, Ulrike Hamper, Robert DeJong, Nicholas Detorie, Ronald Rodriguez, Thomas Haulk, Angelo M. DeMarzo, Steven Piantadosi, D. C. Yu, Yu Chen, Daniel R. Henderson, Michael A. Carducci, William G. Nelson, Jonathan W. Simons
Journal: Cancer Research
Cancer Res (2001) 61 (20): 7464–7472.
Published: 01 October 2001
View articletitled, A Phase I Trial of CV706, a Replication-competent, PSA Selective Oncolytic Adenovirus, for the Treatment of Locally Recurrent Prostate Cancer following Radiation Therapy
Open the PDF for A Phase I Trial of CV706, a Replication-competent, PSA Selective Oncolytic Adenovirus, for the Treatment of Locally Recurrent Prostate Cancer following Radiation Therapy in another window
Journal Articles

Angiogenesis and Prostate Cancer: Identification of A Molecular Progression Switch

Wendy J. Huss, Colleen F. Hanrahan, Roberto J. Barrios, Jonathan W. Simons, Norman M. Greenberg
Journal: Cancer Research
Cancer Res (2001) 61 (6): 2736–2743.
Published: 03 March 2001
View articletitled, Angiogenesis and Prostate Cancer: Identification of A Molecular Progression Switch
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Journal Articles

Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics

Hua Zhong, Kelly Chiles, David Feldser, Erik Laughner, Colleen Hanrahan, Maria-Magdalena Georgescu, Jonathan W. Simons, Gregg L. Semenza
Journal: Cancer Research
Cancer Res (2000) 60 (6): 1541–1545.
Published: 01 March 2000
View articletitled, Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics
Open the PDF for Modulation of Hypoxia-inducible Factor 1α Expression by the Epidermal Growth Factor/Phosphatidylinositol 3-Kinase/PTEN/AKT/FRAP Pathway in Human Prostate Cancer Cells: Implications for Tumor Angiogenesis and Therapeutics in another window
Journal Articles

Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases

Hua Zhong, Angelo M. De Marzo, Erik Laughner, Michael Lim, David A. Hilton, David Zagzag, Peter Buechler, William B. Isaacs, Gregg L. Semenza, Jonathan W. Simons
Journal: Cancer Research
Cancer Res (1999) 59 (22): 5830–5835.
Published: 01 November 1999
View articletitled, Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
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Journal Articles

Induction of Immunity to Prostate Cancer Antigens: Results of a Clinical Trial of Vaccination with Irradiated Autologous Prostate Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-stimulating Factor Using ex Vivo Gene Transfer

Jonathan W. Simons, Bahar Mikhak, Ju-Fay Chang, Angelo M. DeMarzo, Michael A. Carducci, Michael Lim, Christine E. Weber, Angelo A. Baccala, Marti A. Goemann, Shirley M. Clift, Dale G. Ando, Hyam I. Levitsky, Lawrence K. Cohen, Martin G. Sanda, Richard C. Mulligan, Alan W. Partin, H. Ballentine Carter, Steven Piantadosi, Fray F. Marshall, William G. Nelson
Journal: Cancer Research
Cancer Res (1999) 59 (20): 5160–5168.
Published: 01 October 1999
View articletitled, Induction of Immunity to Prostate Cancer Antigens: Results of a Clinical Trial of Vaccination with Irradiated Autologous Prostate Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-stimulating Factor Using ex Vivo Gene Transfer
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Journal Articles

Increased Expression of Hypoxia Inducible Factor-1α in Rat and Human Prostate Cancer

Hua Zhong, Faton Agani, Angelo A. Baccala, Erik Laughner, Natalia Rioseco-Camacho, William B. Isaacs, Jonathan W. Simons, Gregg L. Semenza
Journal: Cancer Research
Cancer Res (1998) 58 (23): 5280–5284.
Published: 01 December 1998
View articletitled, Increased Expression of Hypoxia Inducible Factor-1α in Rat and Human Prostate Cancer
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Journal Articles

Prostate Attenuated Replication Competent Adenovirus (ARCA) CN706: A Selective Cytotoxic for Prostate-specific Antigen-positive Prostate Cancer Cells

Ron Rodriguez, Eric R. Schuur, Ho Yeong Lim, Gail A. Henderson, Jonathan W. Simons, Daniel R. Henderson
Journal: Cancer Research
Cancer Res (1997) 57 (13): 2559–2563.
Published: 01 July 1997
View articletitled, Prostate Attenuated Replication Competent Adenovirus (ARCA) CN706: A Selective Cytotoxic for Prostate-specific Antigen-positive Prostate Cancer Cells
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Journal Articles

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer

Jonathan W. Simons, Elizabeth M. Jaffee, Christine E. Weber, Hyam I. Levitsky, William G. Nelson, Michael A. Carducci, Audrey J. Lazenby, Lawrence K. Cohen, Christy C. Finn, Shirley M. Clift, Karen M. Hauda, Lisa A. Beck, Kristen M. Leiferman, Albert H. Owens, Jr., Steven Piantadosi, Glenn Dranoff, Richard C. Mulligan, Drew M. Pardoll, Fray F. Marshall
Journal: Cancer Research
Cancer Res (1997) 57 (8): 1537–1546.
Published: 01 April 1997
View articletitled, Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer
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Journal Articles

Endothelin-1 Production and Decreased Endothelin B Receptor Expression in Advanced Prostate Cancer

Joel B. Nelson, Kirk Chan-Tack, Sean P. Hedican, Scott R. Magnuson, Terry J. Opgenorth, G. Steven Bova, Jonathan W. Simons
Journal: Cancer Research
Cancer Res (1996) 56 (4): 663–668.
Published: 01 February 1996
View articletitled, Endothelin-1 Production and Decreased Endothelin B Receptor Expression in Advanced Prostate Cancer
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