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Journal Articles

Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy

Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W. Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qiang Xiang, Ling-Zhi Wang, Boon Cher Goh, De-Chen Lin, Wee Joo Chng, Soo-Yong Tan, Sudhakar Jha, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2023) 83 (6): 922–938.
https://doi.org/10.1158/0008-5472.CAN-21-3052
Published: 15 March 2023
View article titled, Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
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Includes: Supplementary data
Journal Articles

RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling

Xin-Yi Loh, Qiao-Yang Sun, Ling-Wen Ding, Anand Mayakonda, Nachiyappan Venkatachalam, Mei-Shi Yeo, Tiago C. Silva, Jin-Fen Xiao, Ngan B. Doan, Jonathan W. Said, Xue-Bin Ran, Si-Qin Zhou, Pushkar Dakle, Pavithra Shyamsunder, Angele Pei-Fern Koh, Ruby Yun-Ju Huang, Benjamin P. Berman, Soo-Yong Tan, Henry Yang, De-Chen Lin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2020) 80 (2): 219–233.
https://doi.org/10.1158/0008-5472.CAN-18-2796
Published: 15 January 2020
View article titled, RNA-Binding Protein <em>ZFP36L1</em> Suppresses Hypoxia and Cell-Cycle Signaling
Open the PDF for RNA-Binding Protein <em>ZFP36L1</em> Suppresses Hypoxia and Cell-Cycle Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 4188: Multitargeted tyrosine kinase inhibitor identified as potential therapeutic intervention for liposarcoma using high-throughput profiling

Deepika Kanojia, Manoj Garg, Jakki Martinez, Anand M.T., Samuel B Luty, Ngan B Doan, Jonathan W Said, Jeffrey W Tyner, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4188.
https://doi.org/10.1158/1538-7445.AM2017-4188
Published: 01 July 2017
View article titled, Abstract 4188: Multitargeted tyrosine kinase inhibitor identified as potential therapeutic intervention for liposarcoma using high-throughput profiling
Journal Articles

Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma

Ye Chen, Liang Xu, Marina Dutra-Clarke, Anand Mayakonda, De-Chen Lin, Lynnette Koh, Yuk Kien Chong, Edwin Sandanaraj, Vikas Madan, Henry Yang, Ngan Doan, Jonathan W. Said, William H. Yong, Markus Müschen, Beng Ti Ang, Carol Tang, Joshua J. Breunig, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1524.
https://doi.org/10.1158/1538-7445.AM2017-1524
Published: 01 July 2017
View article titled, Abstract 1524: BCL6 modulates the TP53 and STAT pathways in glioma
Journal Articles

Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target

Liang Xu, Ye CHEN, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Markus Müschen, Joshua J. Breunig, De-Chen Lin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2569.
https://doi.org/10.1158/1538-7445.AM2017-2569
Published: 01 July 2017
View article titled, Abstract 2569: BCL6 promotes glioma and serves as a novel therapeutic target
Journal Articles

CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling

Haibo Sun, De-Chen Lin, Qi Cao, Xiao Guo, Helene Marijon, Zhiqiang Zhao, Sigal Gery, Liang Xu, Henry Yang, Brendan Pang, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W. Said, Peiguo Chu, Anand Mayakonda, Tom Thomas, Charles Forscher, Erkan Baloglu, Sharon Shacham, Raja Rajalingam, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2016) 76 (9): 2687–2697.
https://doi.org/10.1158/0008-5472.CAN-15-1572
Published: 01 May 2016
View article titled, CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling
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Includes: Supplementary data
Journal Articles

Abstract A2-20: Integrative study of genomic alterations in liposarcoma

Deepika Kanojia, Manoj Garg, Yasunobu Nagata, Dhong Hyun Lee, Hans-Ulrich Klein, Christoph Bartenhagen, Anand M T, Ngan B Doan, Jonathan W Said, Henry Yang, Charles Forscher, Martin Dugas, Seishi Ogawa, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-20.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-20
Published: 15 November 2015
View article titled, Abstract A2-20: Integrative study of genomic alterations in liposarcoma
Journal Articles

Abstract 2868: SETDB1 accelerates non-small cell lung cancer (NSCLC) tumorigenesis through WNT signalling pathway

Qiaoyang Sun, Lingwen Ding, Jinfen Xiao, Lee Goodglick, David Chia, Vei Mah, Mohammad Alavi, Ngan Doan, Jonathan W. Said, Henry Yang, H.Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2868.
https://doi.org/10.1158/1538-7445.AM2015-2868
Published: 01 August 2015
View article titled, Abstract 2868: SETDB1 accelerates non-small cell lung cancer (NSCLC) tumorigenesis through WNT signalling pathway
Journal Articles

Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma

Liang Xu, De-Chen Lin, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shi-zhu Yu, Michael Kahn, Dong Yin, Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 122.
https://doi.org/10.1158/1538-7445.AM2015-122
Published: 01 August 2015
View article titled, Abstract 122: PARK2 is a negative regulator of Wnt and EGFR pathways in glioma
Journal Articles

Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma

De-Chen Lin, Liang Xu, Ye Chen, Haiyan Yan, Masaharu Hazawa, Ngan Doan, Jonathan W. Said, Ling-Wen Ding, Li-Zhen Liu, Henry Yang, Shizhu Yu, Michael Kahn, Dong Yin, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1815–1827.
https://doi.org/10.1158/0008-5472.CAN-14-1433
Published: 30 April 2015
View article titled, Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma
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Includes: Supplementary data
Journal Articles

Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR

Manoj Garg, Deepika Kanojia, Ryoko Okamoto, Vikas Madan, Wenwen Chien, Abhishek Sampath, Ling-Wen Ding, Meng Xuan, Jonathan W Said, Ngan Doan, Li-Zhen Liu, Henry Yang, Sigal Gery, Gleen D Braunstein, H.Phillip Koeffler
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5570.
https://doi.org/10.1158/1538-7445.AM2014-5570
Published: 01 October 2014
View article titled, Abstract 5570: Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR
Journal Articles

Abstract 2819: Efficacy and safety of the Ad-GM·CAIX dendritic cell-based vaccine in treating in vivo metastatic renal cell carcinoma compared to sunitinib monotherapy and simultaneous vaccine-sunitinib combination therapy

Edward N. Rampersaud, Jonathan W. Said, Adrian Bot, Frédéric D. Birkhäuser, Nils Kroeger, Gang Zeng, Fairooz F. Kabbinavar, Antoni Ribas, Allan J. Pantuck, Arie S. Belldegrun, Joseph Riss
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2819.
https://doi.org/10.1158/1538-7445.AM2014-2819
Published: 01 October 2014
View article titled, Abstract 2819: Efficacy and safety of the Ad-GM·CAIX dendritic cell-based vaccine in treating <em>in vivo</em> metastatic renal cell carcinoma compared to sunitinib monotherapy and simultaneous vaccine-sunitinib combination therapy
Journal Articles

Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models.

Nicholas G. Nickols, Fei Yang, Benjamin C. Li, Georgi K. Marinov, Jonathan W. Said, Peter B. Dervan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1130.
https://doi.org/10.1158/1538-7445.AM2013-1130
Published: 15 April 2013
View article titled, Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models.
Journal Articles

Abstract 1563: In vivo safety and efficacy of a novel dendritic cell based Ad-GMCAIX vaccine with activity against renal cell carcinoma

Frédéric D. Birkhäuser, Richard C. Koya, Caleb Neufeld, Xuyang Lu, Ewa D. Micewicz, Thinle Chodon, Mohammad Atefi, Nils Kroeger, Edward N. Rampersaud, Gadisetti VR Chandramouli, Gang Li, Jonathan W. Said, Antoni Ribas, William H. McBride, Fairooz F. Kabbinavar, Allan J. Pantuck, Arie S. Belldegrun, Joseph Riss
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1563.
https://doi.org/10.1158/1538-7445.AM2012-1563
Published: 15 April 2012
View article titled, Abstract 1563: <em>In vivo</em> safety and efficacy of a novel dendritic cell based Ad-GMCAIX vaccine with activity against renal cell carcinoma
Journal Articles

Abstract 2101: GBM: miR-34a acts as a tumor suppressor and prognosis maker as well as modulating EGFR

Dong Yin, Seishi Ogawa, Norihiko Kawamata, Nils H. Thoennissen, Weikai Chen, Amanda Leiter, Michelle Ham, Ngan B B. Doan, Jonathan W. Said, Keith L. Black, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2101.
https://doi.org/10.1158/1538-7445.AM10-2101
Published: 15 April 2010
View article titled, Abstract 2101: <em>GBM: miR-34a</em> acts as a tumor suppressor and prognosis maker as well as modulating EGFR
Journal Articles

Abstract 5383: Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer

Gabriela B. Iwanski, Nils H. Thoennissen, Dhong Hyung Tony Lee, Ngan B. Doan, Brandon Castor, Alison Le, Melvin Toh, Carsten Bokemeyer, Jonathan W. Said, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5383.
https://doi.org/10.1158/1538-7445.AM10-5383
Published: 15 April 2010
View article titled, Abstract 5383: Cucurbitacin B, a novel <em>in vivo</em> potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
Journal Articles

Abstract 5396: Synergistic effect of cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma

Dhong Hyun Lee, Nils H. Thoennissen, Catherine B. Goff, Gabriela B. Iwanski, Ngan B. Doan, Melvin Toh, Tak Chan, Jonathan W. Said, H Phillip Koeffler
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5396.
https://doi.org/10.1158/1538-7445.AM10-5396
Published: 15 April 2010
View article titled, Abstract 5396: Synergistic effect of cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma
Journal Articles

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

Nils H. Thoennissen, Gabriela B. Iwanski, Ngan B. Doan, Ryoko Okamoto, Patricia Lin, Sam Abbassi, Jee Hoon Song, Dong Yin, Melvin Toh, Wei Dong Xie, Jonathan W. Said, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2009) 69 (14): 5876–5884.
https://doi.org/10.1158/0008-5472.CAN-09-0536
Published: 15 July 2009
View article titled, Cucurbitacin B Induces Apoptosis by Inhibition of the <em>JAK/STAT</em> Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells
Open the PDF for Cucurbitacin B Induces Apoptosis by Inhibition of the <em>JAK/STAT</em> Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract #5228: CTGF induces cell growth in vitro and vivo, migration as well as drug resistance in glioblastoma multiform

Dong Yin, James O'Kelly, Daning Lu, Dong Xie, Michelle Ham, Ngan B Doan, Charles Wang, Jonathan W. Said, Keith L Black, H. Phillip Koeffler
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5228.
Published: 01 May 2009
View article titled, Abstract #5228: CTGF induces cell growth in vitro and vivo, migration as well as drug resistance in glioblastoma multiform
Journal Articles

Targeted Deletion of Hepatic Igf1 in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression

Makoto Anzo, Laura J. Cobb, David L. Hwang, Hemal Mehta, Jonathan W. Said, Shoshana Yakar, Derek LeRoith, Pinchas Cohen
Journal: Cancer Research
Cancer Res (2008) 68 (9): 3342–3349.
https://doi.org/10.1158/0008-5472.CAN-07-3165
Published: 01 May 2008
View article titled, Targeted Deletion of Hepatic <em>Igf1</em> in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression
Open the PDF for Targeted Deletion of Hepatic <em>Igf1</em> in TRAMP Mice Leads to Dramatic Alterations in the Circulating Insulin-Like Growth Factor Axis but Does Not Reduce Tumor Progression in another window