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Journal Articles

Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Ryan Kennington, Gareth Mitchell, Emily Payne, Niraja Bhachech, Jonathan A. Fletcher, Ting Liu, Matt van de Rijn, Sarah Amend, Kenneth J. Pienta, Joshua D. Schiffman, Lisa M. Abegglen

Cancer Res (2024) 84 (6_Supplement): 1991.

https://doi.org/10.1158/1538-7445.AM2024-1991

Published: 22 March 2024

View article titled, Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Journal Articles

Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Lisa M. Abegglen, Niraja Bhachech, Gareth Mitchell, Ryan Kennington, Brad Nelson, Miranda Sharp, Matthew Buccilli, Anthony Iovino, Aarushi Rohaj, Jonathan A. Fletcher, Ting Liu, Matt van de Rijn, Sarah R. Amend, Kenneth J. Pienta, Joshua D. Schiffman

Cancer Res (2023) 83 (7_Supplement): 1686.

https://doi.org/10.1158/1538-7445.AM2023-1686

Published: 04 April 2023

View article titled, Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Journal Articles

Abstract 3887: ATP-binding pocket substitutions as secondary or tertiary in-cis mutations are major on-target ripretinib resistance mechanisms in gastrointestinal stromal tumor

Cancer Res (2023) 83 (7_Supplement): 3887.

https://doi.org/10.1158/1538-7445.AM2023-3887

Published: 04 April 2023

View article titled, Abstract 3887: ATP-binding pocket substitutions as secondary or tertiary in-cis mutations are major on-target ripretinib resistance mechanisms in gastrointestinal stromal tumor

Journal Articles

Abstract 5648: Response and resistance to CDK2 and CDK4/6 inhibition in GIST

Inga-Marie Schaefer, Meijun Z. Lundberg, Matthew L. Hemming, Sinem K. Saka, Matthew P. Serrata, Isabel Goldaracena, Ninning Liu, Peng Yin, Joao A. Paulo, Steven Gygi, George D. Demetri, Ewa Sicinska, Adrian Mariño-Enríquez, Jason L. Hornick, Chandrajit P. Raut, Wen-Bin Ou, Jonathan A. Fletcher

Cancer Res (2022) 82 (12_Supplement): 5648.

https://doi.org/10.1158/1538-7445.AM2022-5648

Published: 15 June 2022

View article titled, Abstract 5648: Response and resistance to CDK2 and CDK4/6 inhibition in GIST

Journal Articles

Abstract 3767: FBXO32 ubiquitin ligase mediates apoptosis evasion and adaptation to KIT inhibition in gastrointestinal stromal tumor - GIST

Alfonso García Valverde, Jordi Rosell, Daniel Pilco Janeta, Sergi Sayols, Claudia Valverde, Anna Esteve, Marta Gut, Jordi Barretina, George D. Demetri, Jonathan A. Fletcher, Joan Carles, Joaquín Arribas, César Serrano

Cancer Res (2020) 80 (16_Supplement): 3767.

https://doi.org/10.1158/1538-7445.AM2020-3767

Published: 15 August 2020

View article titled, Abstract 3767: FBXO32 ubiquitin ligase mediates apoptosis evasion and adaptation to KIT inhibition in gastrointestinal stromal tumor - GIST

Journal Articles

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Weicai Chen, Ye Kuang, Hai-Bo Qiu, Zhifa Cao, Yuqing Tu, Qing Sheng, Grant Eilers, Quan He, Hai-Long Li, Meijun Zhu, Yuexiang Wang, Rongqing Zhang, Yeqing Wu, Fanguo Meng, Jonathan A. Fletcher, Wen-Bin Ou

Cancer Res (2017) 77 (18): 5107–5117.

https://doi.org/10.1158/0008-5472.CAN-17-0917

Published: 14 September 2017

View article titled, Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

Includes: Supplementary data

Journal Articles

KIT Oncogenic Mutations: Biologic Insights, Therapeutic Advances, and Future Directions

Jonathan A. Fletcher

Cancer Res (2016) 76 (21): 6140–6142.

https://doi.org/10.1158/0008-5472.CAN-16-2646

Published: 31 October 2016

View article titled, KIT Oncogenic Mutations: Biologic Insights, Therapeutic Advances, and Future Directions

Journal Articles

Abstract 377: Novel mTOR inhibitor MLN0128 inhibits imatinib-resistant GIST more potently than rapalogues by abrogating AKT and 4EBP1 activation

Thomas Mühlenberg, Julia Ketzer, Jonathan A. Fletcher, Sebastian Bauer

Cancer Res (2016) 76 (14_Supplement): 377.

https://doi.org/10.1158/1538-7445.AM2016-377

Published: 15 July 2016

View article titled, Abstract 377: Novel mTOR inhibitor MLN0128 inhibits imatinib-resistant GIST more potently than rapalogues by abrogating AKT and 4EBP1 activation

Journal Articles

Abstract 290: NF1 loss modulates cellular fitness in KIT-mutant gastrointestinal stromal tumor (GIST)

Adrian Marino-Enriquez, Bin Li, Nacef Bahri, Alexandra Lauria, Yuexiang Wang, Jonathan A. Fletcher

Cancer Res (2016) 76 (14_Supplement): 290.

https://doi.org/10.1158/1538-7445.AM2016-290

Published: 15 July 2016

View article titled, Abstract 290: NF1 loss modulates cellular fitness in KIT-mutant gastrointestinal stromal tumor (GIST)

Journal Articles

Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma

Cancer Res (2016) 76 (2): 319–328.

https://doi.org/10.1158/0008-5472.CAN-15-0751

Published: 14 January 2016

View article titled, Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma

Includes: Supplementary data

Journal Articles

Abstract 607: Genomic analyses and novel models validate CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans

Adrian Marino-Enriquez, Grant Eilers, Jeffrey Czaplinski, Mark Mayeda, Derrick Tao, Meijun Zhu, Jason L. Hornick, Ewa Sicinska, Andrew J. Wagner, Jonathan A. Fletcher

Cancer Res (2015) 75 (15_Supplement): 607.

https://doi.org/10.1158/1538-7445.AM2015-607

Published: 01 August 2015

View article titled, Abstract 607: Genomic analyses and novel models validate CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans

Journal Articles

Abstract 1309: Identification of aurora kinase a as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

Chun-Nan Yeh, Chueh-Chuan Yen, Yeng-Yang Chen, Chi-Tung Cheng, Shih-Chiang Huang, Ting-Wei Chang, Fang-Yi Yao, Yung-Chan Lin, Yao-Shan Wen, Kun-Chun Chiang, Jen-Shi Chen, Ta-Sen Yeh, Cheng-Hwai Tzeng, Ta-Chung Chao, Jonathan A. Fletcher

Cancer Res (2014) 74 (19_Supplement): 1309.

https://doi.org/10.1158/1538-7445.AM2014-1309

Published: 01 October 2014

View article titled, Abstract 1309: Identification of aurora kinase a as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

Journal Articles

Abstract 5136: HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

Wen-bin Ou, Hailong Li, Li Liu, Shengmei Zhou, Ye Kuang, Ziqin Yan, Zhe Jiang, Si Shi, Fanguo Meng, Qing Sheng, Haimeng Zhou, Jonathan A. Fletcher

Cancer Res (2014) 74 (19_Supplement): 5136.

https://doi.org/10.1158/1538-7445.AM2014-5136

Published: 01 October 2014

View article titled, Abstract 5136: HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

Journal Articles

DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors

Susanne Simon, Florian Grabellus, Loretta Ferrera, Luis Galietta, Benjamin Schwindenhammer, Thomas Mühlenberg, Georg Taeger, Grant Eilers, Juergen Treckmann, Frank Breitenbuecher, Martin Schuler, Takahiro Taguchi, Jonathan A. Fletcher, Sebastian Bauer

Cancer Res (2013) 73 (12): 3661–3670.

https://doi.org/10.1158/0008-5472.CAN-12-3839

Published: 13 June 2013

View article titled, DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors

Includes: Supplementary data

Journal Articles

Abstract 2168: Dual targeting of the AKT/mTOR signaling pathwayinhibits mesothelioma: Targeted therapies against multiple activated receptor tyrosine kinases.

Shengmei Zhou, Li Liu, Weijiang Hu, Hailong Li, Fanguo Meng, Haimeng Zhou, Jonathan A. Fletcher, Wenbin Ou

Cancer Res (2013) 73 (8_Supplement): 2168.

https://doi.org/10.1158/1538-7445.AM2013-2168

Published: 15 April 2013

View article titled, Abstract 2168: Dual targeting of the AKT/mTOR signaling pathwayinhibits mesothelioma: Targeted therapies against multiple activated receptor tyrosine kinases.

Journal Articles

Abstract 3855: Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors

Johanna Falkenhorst, Thomas Mühlenberg, Susanne Simon, Sonja Ecken, Joern Henze, Florian Grabellus, Frank Breitenbücher, Martin Schuler, Jonathan A. Fletcher, Sebastian Bauer

Cancer Res (2012) 72 (8_Supplement): 3855.

https://doi.org/10.1158/1538-7445.AM2012-3855

Published: 15 April 2012

View article titled, Abstract 3855: Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors

Journal Articles

Abstract 5005: Large-scale DNA methylation profiling in gastrointestinal stromal tumors (GIST) reveals epigenetic regulation of SPP1 as an independent prognostic factor

Florian Haller, Jitao David Zhang, Yasser Riazalhosseini, Aoife Ward, Aleksandra Balwierz, Bernhard Korn, Inga-Marie Schaefer, Silke Cameron, B. Michael Ghadimi, Abbas Agaimy, Jonathan A. Fletcher, Jörg Hoheisel, Stefan Wiemann, Özgür Sahin

Cancer Res (2012) 72 (8_Supplement): 5005.

https://doi.org/10.1158/1538-7445.AM2012-5005

Published: 15 April 2012

View article titled, Abstract 5005: Large-scale DNA methylation profiling in gastrointestinal stromal tumors (GIST) reveals epigenetic regulation of SPP1 as an independent prognostic factor

Journal Articles

Abstract LB-270: Genomic amplification of c-Jun activates genes that promote proliferation and cell migration in liposarcoma

Stefano Sioletic, Ewa Sicinska, Massimo Loda, Christopher D.M. Fletcher, Jonathan A. Fletcher, George D. Demetri, Eric L. Snyder

Cancer Res (2012) 72 (8_Supplement): LB-270.

https://doi.org/10.1158/1538-7445.AM2012-LB-270

Published: 15 April 2012

View article titled, Abstract LB-270: Genomic amplification of c-Jun activates genes that promote proliferation and cell migration in liposarcoma

Journal Articles

Abstract 5364: AURA kinases as markers and targets in GIST

Chueh-Chuan Yen, Yeh Chun-Nan, Tsann-Long Hwang, Miin-Fu Chen, Cheng-Hwai Tzeng, Ta-Chung Chao, Jonathan A. Fletcher

Cancer Res (2011) 71 (8_Supplement): 5364.

https://doi.org/10.1158/1538-7445.AM2011-5364

Published: 15 April 2011

View article titled, Abstract 5364: AURA kinases as markers and targets in GIST

Journal Articles

Abstract 952: Protein kinase C theta (PKCθ) and c-Jun regulate proliferation through cyclin D1 in KIT-independent gastrointestinal stromal tumors

Wen-Bin Ou, Christopher D.M. Fletcher, George D. Demetri, Jonathan A. Fletcher

Cancer Res (2011) 71 (8_Supplement): 952.

https://doi.org/10.1158/1538-7445.AM2011-952

Published: 15 April 2011

View article titled, Abstract 952: Protein kinase C theta (PKCθ) and c-Jun regulate proliferation through cyclin D1 in KIT-independent gastrointestinal stromal tumors

NARROW

Abstract 1991: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy, contribute to chemoresistance, and lead to higher rates of metastatic recurrence

Abstract 1686: Leiomyosarcoma poly-aneuploid cancer cells form in response to chemotherapy and contribute to chemoresistance

Abstract 3887: ATP-binding pocket substitutions as secondary or tertiary in-cis mutations are major on-target ripretinib resistance mechanisms in gastrointestinal stromal tumor

Abstract 5648: Response and resistance to CDK2 and CDK4/6 inhibition in GIST

Abstract 3767: FBXO32 ubiquitin ligase mediates apoptosis evasion and adaptation to KIT inhibition in gastrointestinal stromal tumor - GIST

Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors

KIT Oncogenic Mutations: Biologic Insights, Therapeutic Advances, and Future Directions

Abstract 377: Novel mTOR inhibitor MLN0128 inhibits imatinib-resistant GIST more potently than rapalogues by abrogating AKT and 4EBP1 activation

Abstract 290: NF1 loss modulates cellular fitness in KIT-mutant gastrointestinal stromal tumor (GIST)

Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma

Abstract 607: Genomic analyses and novel models validate CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans

Abstract 1309: Identification of aurora kinase a as an unfavorable prognostic factor and potential treatment target for metastatic gastrointestinal stromal tumors

Abstract 5136: HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors

Abstract 2168: Dual targeting of the AKT/mTOR signaling pathwayinhibits mesothelioma: Targeted therapies against multiple activated receptor tyrosine kinases.

Abstract 3855: Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumors

Abstract 5005: Large-scale DNA methylation profiling in gastrointestinal stromal tumors (GIST) reveals epigenetic regulation of SPP1 as an independent prognostic factor

Abstract LB-270: Genomic amplification of c-Jun activates genes that promote proliferation and cell migration in liposarcoma

Abstract 5364: AURA kinases as markers and targets in GIST

Abstract 952: Protein kinase C theta (PKCθ) and c-Jun regulate proliferation through cyclin D1 in KIT-independent gastrointestinal stromal tumors

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