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John Tellew
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Journal Articles

Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Darrin D. Stuart, Wenlin Shao, Yuji Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacey Rivera, Fang Shen, Joshua Korn, Lesley A. Mathews Griner, Giselle Nishiguchi, Benjamin Taft, Lifeng Wan, Sharadha Subramanian, Yan Lou, Lina Setti, Matthew Burger, Victor Tamez, Alice Rico, Robert Aversa, John Tellew, Jacob R. Haling, Valery Polyakov, Amy Lambert, Richard Zang, Ann Van Abbema, Mohamad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, William R. Sellers, Savithri Ramurthy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): DDT01-04.
https://doi.org/10.1158/1538-7445.AM2018-DDT01-04
Published: 01 July 2018
View article titled, Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor
Journal Articles

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Wenlin Shao, Yuji M. Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner, Gisele Nishiguchi, Alice Rico, John Tellew, Jacob R. Haling, Robert Aversa, Valery Polyakov, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, Savithri Ramurthy, William R. Sellers, Darrin D. Stuart
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1537–1548.
https://doi.org/10.1158/0008-5472.CAN-17-2033
Published: 14 March 2018
View article titled, Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Open the PDF for Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF in another window
Includes: Supplementary data
Journal Articles

Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Wenlin Shao, Yuji Mishina, Yun Feng, Giordano Caponigro, Savithri Ramurthy, Vesselina Cooke, Lesley Griner, Gisele Nishiguchi, Alice Rico, Ben Taft, Matthew Burger, Huw Tanner, Valery Polyakov, Brent Appleton, John Tellew, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Darrin Stuart
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 330.
https://doi.org/10.1158/1538-7445.AM2016-330
Published: 15 July 2016
View article titled, Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation
Journal Articles

Abstract 3790: Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor

Darrin D. Stuart, Nanxin Li, Daniel J. Poon, Kimberly Aardalen, Susan Kaufman, Hanne Merritt, Fernando Salangsang, Edward Lorenzana, Allen Li, Majid Ghoddusi, Giordano Caponigro, Frank Sun, Swarupa Kulkarni, Shefali Kakar, Nancy Turner, Richard Zang, John Tellew, Nancy Pryer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3790.
https://doi.org/10.1158/1538-7445.AM2012-3790
Published: 15 April 2012
View article titled, Abstract 3790: Preclinical profile of LGX818: A potent and selective RAF kinase inhibitor
Journal Articles

Abstract 20: Raf kinase inhibitors can induce Raf dimerization, downstream signaling, and cell growth

Tobi Nagel, Kevin Shoemaker, Nanxin Li, Marco Wallroth, Hanne Merritt, John Chan, Susan Kaufman, Brent Appleton, Yongjin Xu, Matthew Holderfield, Daniel Poon, John Tellew, Darrin Stuart
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 20.
https://doi.org/10.1158/1538-7445.AM10-20
Published: 15 April 2010
View article titled, Abstract 20: Raf kinase inhibitors can induce Raf dimerization, downstream signaling, and cell growth