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John T. Isaacs
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Journal Articles

Abstract 4345: Molecular pathology studies reveal PD1+ CD8 T cell density correlates with response to supraphysiological testosterone treatment in pre-treatment biopsies and MYC mRNA and protein correlate with response after treatment

Carolina Gomes Alexandre, Jessica Hicks, Tracy Jones, John T Isaacs, Kiara Bowers, Alyza Skist, Laura Sena, Jennifer Meyers, Emmanuel Antonarakis, David Sanin, Hanfei Qi, Samuel Denmeade, Mark Markowski, Srinivasan Yegnasubramanian, Angelo De Marzo
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4345.
https://doi.org/10.1158/1538-7445.AM2023-4345
Published: 04 April 2023
View article titled, Abstract 4345: Molecular pathology studies reveal PD1+ CD8 T cell density correlates with response to supraphysiological testosterone treatment in pre-treatment biopsies and MYC mRNA and protein correlate with response after treatment
Journal Articles

Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

Jesse C. Patterson, Andreas Varkaris, Peter J.P. Croucher, Maya Ridinger, Susan Dalrymple, Mannan Nouri, Fang Xie, Shohreh Varmeh, Oliver Jonas, Matthew A. Whitman, Sen Chen, Saleh Rashed, Lovemore Makusha, Jun Luo, John T. Isaacs, Mark G. Erlander, David J. Einstein, Steven P. Balk, Michael B. Yaffe
Journal: Cancer Research
Cancer Res (2023) 83 (2): 219–238.
https://doi.org/10.1158/0008-5472.CAN-22-1533
Published: 18 January 2023
View article titled, Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 653: Molecular pathology of metastatic prostatic adenocarcinoma treated with bipolar androgen therapy (BAT) reveals a correlation between MYC mRNA and protein

Carolina Gomes Alexandre, Tracy Jones, Jessica L. Hicks, John T. Isaacs, Anuj Gupta, Alyza Skaist, Laura Sena, Jennifer Meyers, Emmanuel Antonarakis, Mark Markowski, Samuel Denmeade, Srinivasan Yegnasubramanian, Angelo Michael De Marzo
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 653.
https://doi.org/10.1158/1538-7445.AM2022-653
Published: 15 June 2022
View article titled, Abstract 653: Molecular pathology of metastatic prostatic adenocarcinoma treated with bipolar androgen therapy (BAT) reveals a correlation between MYC mRNA and protein
Journal Articles

Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

Rajendra Kumar, Janet Mendonca, Olutosin Owoyemi, Kavya Boyapati, Naiju Thomas, Suthicha Kanacharoen, Max Coffey, Deven Topiwala, Carolina Gomes, Busra Ozbek, Tracy Jones, Marc Rosen, Liang Dong, Sadie Wiens, W. Nathaniel Brennen, John T. Isaacs, Angelo M. De Marzo, Mark C. Markowski, Emmanuel S. Antonarakis, David Z. Qian, Kenneth J. Pienta, Drew M. Pardoll, Michael A. Carducci, Samuel R. Denmeade, Sushant K. Kachhap
Journal: Cancer Research
Cancer Res (2021) 81 (23): 5948–5962.
https://doi.org/10.1158/0008-5472.CAN-20-3607
Published: 01 December 2021
View article titled, Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression

Robert M. Hughes, Brian W. Simons, Hamda Khan, Rebecca Miller, Valentina Kugler, Samantha Torquato, Debebe Theodros, Michael C. Haffner, Tamara Lotan, Jessie Huang, Elai Davicioni, Steven S. An, Ryan C. Riddle, Daniel L.J. Thorek, Isla P. Garraway, Elana J. Fertig, John T. Isaacs, W. Nathaniel Brennen, Ben H. Park, Paula J. Hurley
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (14): 3636–3650.
https://doi.org/10.1158/0008-5472.CAN-18-2931
Published: 15 July 2019
View article titled, Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression
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Includes: Supplementary data
Journal Articles

Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer

Emmanuel S. Antonarakis, Changxue Lu, Hao Wang, Brandon Luber, Mary Nakazawa, Jeffrey C. Roeser, Yan Chen, Helen L. Fedor, Tamara L. Lotan, Angelo M. De Marzo, John T. Isaacs, William B. Isaacs, Rosa Nadal, Channing J. Paller, Samuel R. Denmeade, Michael A. Carducci, Mario A. Eisenberger, Jun Luo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2910.
https://doi.org/10.1158/1538-7445.AM2014-2910
Published: 01 October 2014
View article titled, Abstract 2910: Androgen receptor splice variant-7 predicts resistance to enzalutamide in patients with castration-resistant prostate cancer
Journal Articles

Enhancement of the T-cell Armamentarium as a Cell-Based Therapy for Prostate Cancer

W. Nathaniel Brennen, Charles G. Drake, John T. Isaacs
Journal: Cancer Research
Cancer Res (2014) 74 (13): 3390–3395.
https://doi.org/10.1158/0008-5472.CAN-14-0249
Published: 30 June 2014
View article titled, Enhancement of the T-cell Armamentarium as a Cell-Based Therapy for Prostate Cancer
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Journal Articles

Abstract B21: Mesenchymal stem cells (MSCs) as a selective delivery vehicle for a PSA-activated protoxin for advanced prostate cancer

W. Nathaniel Brennen, Samuel R. Denmeade, John T. Isaacs
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): B21.
https://doi.org/10.1158/1538-7445.PRCA2012-B21
Published: 09 May 2013
View article titled, Abstract B21: Mesenchymal stem cells (MSCs) as a selective delivery vehicle for a PSA-activated protoxin for advanced prostate cancer
Journal Articles

Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment

John T. Isaacs, Lizamma Antony, Susan L. Dalrymple, W. Nathaniel Brennen, Stephanie Gerber, Hans Hammers, Michel Wissing, Sushant Kachhap, Jun Luo, Li Xing, Per Björk, Anders Olsson, Anders Björk, Tomas Leanderson
Journal: Cancer Research
Cancer Res (2013) 73 (4): 1386–1399.
https://doi.org/10.1158/0008-5472.CAN-12-2730
Published: 14 February 2013
View article titled, Tasquinimod Is an Allosteric Modulator of HDAC4 Survival Signaling within the Compromised Cancer Microenvironment
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Includes: Supplementary data
Journal Articles

Abstract 5699: Mesenchymal stem cells (MSCs) as a selective delivery vehicle for a PSA-activated protoxin for advanced prostate cancer

Shuangling Chen, Nathaniel Brennen, Robert A. Brodsky, Linzhao Cheng, Samuel R. Denmeade, John T. Isaacs
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5699.
https://doi.org/10.1158/1538-7445.AM2012-5699
Published: 15 April 2012
View article titled, Abstract 5699: Mesenchymal stem cells (MSCs) as a selective delivery vehicle for a PSA-activated protoxin for advanced prostate cancer
Journal Articles

Abstract 4701: Tasquinimod suppresses the adaptive stress response within sites of prostate cancer via disrupting zinc-dependent Histone Deacetylase 4 signaling.

Lizamma Antony, Susan Dalrymple, Stephanie Gerber, Hans Hammers, Sushant Kachhap, Per Bjork, Anders Olsson, Tomas Leanderson, John T. Isaacs
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4701.
https://doi.org/10.1158/1538-7445.AM2012-4701
Published: 15 April 2012
View article titled, Abstract 4701: Tasquinimod suppresses the adaptive stress response within sites of prostate cancer via disrupting zinc-dependent Histone Deacetylase 4 signaling.
Journal Articles

Abstract 2326: Loss of prostate-specific antigen slows growth and alters the extracellular proteome of LNCaP human prostate cancer cells

Simon A. Williams, Christine A. Jelinek, Robert J. Cotter, John T. Isaacs, Samuel R. Denmeade
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2326.
https://doi.org/10.1158/1538-7445.AM10-2326
Published: 15 April 2010
View article titled, Abstract 2326: Loss of prostate-specific antigen slows growth and alters the extracellular proteome of LNCaP human prostate cancer cells
Journal Articles

The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells

Donald J. Vander Griend, Wouter L. Karthaus, Susan Dalrymple, Alan Meeker, Angelo M. DeMarzo, John T. Isaacs
Journal: Cancer Research
Cancer Res (2008) 68 (23): 9703–9711.
https://doi.org/10.1158/0008-5472.CAN-08-3084
Published: 01 December 2008
View article titled, The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells
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Journal Articles

A Dimeric Peptide That Binds Selectively to Prostate-Specific Membrane Antigen and Inhibits its Enzymatic Activity

Saurabh Aggarwal, Pratap Singh, Ozlem Topaloglu, John T. Isaacs, Samuel R. Denmeade
Journal: Cancer Research
Cancer Res (2006) 66 (18): 9171–9177.
https://doi.org/10.1158/0008-5472.CAN-06-1520
Published: 18 September 2006
View article titled, A Dimeric Peptide That Binds Selectively to Prostate-Specific Membrane Antigen and Inhibits its Enzymatic Activity
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Journal Articles

Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells

Ivan V. Litvinov, Donald J. Vander Griend, Yi Xu, Lizamma Antony, Susan L. Dalrymple, John T. Isaacs
Journal: Cancer Research
Cancer Res (2006) 66 (17): 8598–8607.
https://doi.org/10.1158/0008-5472.CAN-06-1228
Published: 01 September 2006
View article titled, Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells
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Includes: Supplementary data
Journal Articles

Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells

Christopher J. Strock, Jong-In Park, Eric K. Nakakura, G. Steven Bova, John T. Isaacs, Douglas W. Ball, Barry D. Nelkin
Journal: Cancer Research
Cancer Res (2006) 66 (15): 7509–7515.
https://doi.org/10.1158/0008-5472.CAN-05-3048
Published: 02 August 2006
View article titled, Cyclin-Dependent Kinase 5 Activity Controls Cell Motility and Metastatic Potential of Prostate Cancer Cells
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Includes: Multimedia, Supplementary data
Journal Articles

Prostate-Specific Membrane Antigen (PSMA) targeted prodrug “smartbombs” as therapy for prostate cancer

Annastasiah Mhaka, Pratap Singh, Marc Rosen, Craig A. Dionne, Soeren B. Christensen, John T. Isaacs, Samuel R. Denmeade
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 725.
Published: 15 April 2006
View article titled, Prostate-Specific Membrane Antigen (PSMA) targeted prodrug “smartbombs” as therapy for prostate cancer
Journal Articles

Role of Notch-1 and E-Cadherin in the Differential Response to Calcium in Culturing Normal versus Malignant Prostate Cells

Susan Dalrymple, Lizamma Antony, Yi Xu, Aarti R. Uzgare, Julia T. Arnold, Jurga Savaugeot, Lori J. Sokoll, Angelo M. De Marzo, John T. Isaacs
Journal: Cancer Research
Cancer Res (2005) 65 (20): 9269–9279.
https://doi.org/10.1158/0008-5472.CAN-04-3989
Published: 17 October 2005
View article titled, Role of Notch-1 and E-Cadherin in the Differential Response to Calcium in Culturing Normal versus Malignant Prostate Cells
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Journal Articles

Androgen Receptor (AR) functions as a tumor suppressor gene in normal prostate, but as an oncogene in cancer

Ivan V. Litvinov, Angelo Demarzo, John T. Isaacs
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 226.
Published: 01 May 2005
View article titled, Androgen Receptor (AR) functions as a tumor suppressor gene in normal prostate, but as an oncogene in cancer
Journal Articles

Enhanced Redundancy in Akt and Mitogen-activated Protein Kinase-induced Survival of Malignant versus Normal Prostate Epithelial Cells

Aarti R. Uzgare, John T. Isaacs
Journal: Cancer Research
Cancer Res (2004) 64 (17): 6190–6199.
https://doi.org/10.1158/0008-5472.CAN-04-0968
Published: 01 September 2004
View article titled, Enhanced Redundancy in Akt and Mitogen-activated Protein Kinase-induced Survival of Malignant <em>versus</em> Normal Prostate Epithelial Cells
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