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John S. Holcenberg
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Journal Articles

Intrathecal 6-Mercaptopurine: Preclinical Pharmacology, Phase I/II Trial, and Pharmacokinetic Study

Peter C. Adamson, Frank M. Balis, Carola A. Arndt, John S. Holcenberg, Prem K. Narang, Robert F. Murphy, Andrea J. Gillespie, David G. Poplack
Journal: Cancer Research
Cancer Res (1991) 51 (22): 6079–6083.
Published: 01 November 1991
View article titled, Intrathecal 6-Mercaptopurine: Preclinical Pharmacology, Phase I/II Trial, and Pharmacokinetic Study
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Journal Articles

Pharmacology and Phase I Trial of High-Dose Oral Leucovorin plus 5-Fluorouracil in Children with Refractory Cancer: A Report from the Children's Cancer Study Group

Ramesh Patel, Edward M. Newman, Doris G. Villacorte, Judith K. Sato, Gregory H. Reaman, Jerry Z. Finklestein, Mark D. Krailo, G. Denman Hammond, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1991) 51 (18): 4871–4875.
Published: 01 September 1991
View article titled, Pharmacology and Phase I Trial of High-Dose Oral Leucovorin plus 5-Fluorouracil in Children with Refractory Cancer: A Report from the Children's Cancer Study Group
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Journal Articles

Pharmacology of Fludarabine Phosphate after a Phase I/II Trial by a Loading Bolus and Continuous Infusion in Pediatric Patients

Vassilios I. Avramis, Josette Champagne, Judith Sato, Mark Krailo, Lawrence J. Ettinger, David G. Poplack, Jerry Finklestein, Gregory Reaman, G. Denman Hammond, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1990) 50 (22): 7226–7231.
Published: 01 November 1990
View article titled, Pharmacology of Fludarabine Phosphate after a Phase I/II Trial by a Loading Bolus and Continuous Infusion in Pediatric Patients
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Journal Articles

Biochemical Pharmacology of High Dose 1-β-d-Arabinofuranosylcytosine in Childhood Acute Leukemia1

Vassilios I. Avramis, Robert Biener, Mark Krailo, Jerry Finklestein, Lawrence Ettinger, Michael Willoughby, Stuart E. Siegel, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1987) 47 (24_Part_1): 6786–6792.
Published: 15 December 1987
View article titled, Biochemical Pharmacology of High Dose 1-β-<sc>d</sc>-Arabinofuranosylcytosine in Childhood Acute Leukemia<sup>1</sup>
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Journal Articles

Pediatric Phase I Trial and Pharmacokinetic Study of Trimetrexate

Frank M. Balis, Ramesh Patel, Enrique Luks, Karen M. Doherty, John S. Holcenberg, Charlotte Tan, Gregory H. Reaman, Jean Belasco, Lawrence J. Ettinger, Solomon Zimm, David G. Poplack
Journal: Cancer Research
Cancer Res (1987) 47 (18): 4973–4976.
Published: 01 September 1987
View article titled, Pediatric Phase I Trial and Pharmacokinetic Study of Trimetrexate
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Journal Articles

Effect of 5-Azacytidine and Congeners on DNA Methylation and Expression of Deoxycytidine Kinase in the Human Lymphoid Cell Lines CCRF/CEM/0 and CCRF/CEM/dCk-

Bruno E. Antonsson, Vassilios I. Avramis, Jonathan Nyce, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1987) 47 (14): 3672–3678.
Published: 01 July 1987
View article titled, Effect of 5-Azacytidine and Congeners on DNA Methylation and Expression of Deoxycytidine Kinase in the Human Lymphoid Cell Lines CCRF/CEM/0 and CCRF/CEM/dCk<sup>-</sup>
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Journal Articles

Tissue Nitrogen-sparing Effect of High Protein Diet in Mice with or without Ascites Tumor Treated with Acinetobacter Glutaminase-Asparaginase

C. Lawrence Kien, Alfred J. Anderson, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1985) 45 (10): 4876–4882.
Published: 01 October 1985
View article titled, Tissue Nitrogen-sparing Effect of High Protein Diet in Mice with or without Ascites Tumor Treated with <em>Acinetobacter</em> Glutaminase-Asparaginase
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Journal Articles

Pediatric Phase I Trial and Pharmacokinetic Study of Tiazofurin (NSC 286193)

Frank M. Balis, Beverly J. Lange, Roger J. Packer, John S. Holcenberg, Lawrence J. Ettinger, Stephen E. Sallan, Richard L. Heideman, Solomon Zimm, William A. Smithson, Nancy A. Cogliano-Shutta, Gregory H. Reaman, David G. Poplack
Journal: Cancer Research
Cancer Res (1985) 45 (10): 5169–5172.
Published: 01 October 1985
View article titled, Pediatric Phase I Trial and Pharmacokinetic Study of Tiazofurin (NSC 286193)
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Journal Articles

Phase I and Clinical Pharmacological Study of Mercaptopurine Administered as a Prolonged Intravenous Infusion

Solomon Zimm, Lawrence J. Ettinger, John S. Holcenberg, Barton A. Kamen, Teresa J. Vietti, Jean Belasco, Nancy Cogliano-Shutta, Frank Balis, Lawrence E. Lavi, Jerry M. Collins, David G. Poplack
Journal: Cancer Research
Cancer Res (1985) 45 (4): 1869–1873.
Published: 01 April 1985
View article titled, Phase I and Clinical Pharmacological Study of Mercaptopurine Administered as a Prolonged Intravenous Infusion
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Journal Articles

Prevention of Methotrexate Cytotoxicity by Asparaginase Inhibition of Methotrexate Polyglutamate Formation

Jacques Jolivet, Diane E. Cole, John S. Holcenberg, David G. Poplack
Journal: Cancer Research
Cancer Res (1985) 45 (1): 217–220.
Published: 01 January 1985
View article titled, Prevention of Methotrexate Cytotoxicity by Asparaginase Inhibition of Methotrexate Polyglutamate Formation
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Journal Articles

Effects of Single-Dose and Fractionated Cranial Irradiation on Rat Brain Accumulation of Methotrexate

Barton A. Kamen, John E. Moulder, Larry E. Kun, Barbara J. Ring, Susan M. Adams, Brian L. Fish, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1984) 44 (11): 5092–5094.
Published: 01 November 1984
View article titled, Effects of Single-Dose and Fractionated Cranial Irradiation on Rat Brain Accumulation of Methotrexate
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Journal Articles

Levels of 2′-Deoxycoformycin, Adenosine, and Deoxyadenosine in Patients with Acute Lymphoblastic Leukemia

Peter M. Venner, Robert I. Glazer, Julie Blatt, Stephan Sallan, Gaston Rivera, John S. Holcenberg, Jeffrey Lipton, Sharon B. Murphy, David G. Poplack
Journal: Cancer Research
Cancer Res (1981) 41 (11_Part_1): 4508–4511.
Published: 01 November 1981
View article titled, Levels of 2′-Deoxycoformycin, Adenosine, and Deoxyadenosine in Patients with Acute Lymphoblastic Leukemia
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Journal Articles

l-Asparaginase Pharmacokinetics and Asparagine Levels in Cerebrospinal Fluid of Rhesus Monkeys and Humans1

Riccardo Riccardi, John S. Holcenberg, Daniel L. Glaubiger, James H. Wood, David G. Poplack
Journal: Cancer Research
Cancer Res (1981) 41 (11_Part_1): 4554–4558.
Published: 01 November 1981
View article titled, <sc>l</sc>-Asparaginase Pharmacokinetics and Asparagine Levels in Cerebrospinal Fluid of Rhesus Monkeys and Humans<sup>1</sup>
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Journal Articles

Nitrogen Utilization in Mice Bearing Ehrlich Ascites Tumor Treated with Acinetobacter Glutaminase-Asparaginase

Craig L. Kien, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1981) 41 (6): 2051–2055.
Published: 01 June 1981
View article titled, Nitrogen Utilization in Mice Bearing Ehrlich Ascites Tumor Treated with <em>Acinetobacter</em> Glutaminase-Asparaginase
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Journal Articles

Amino Acid Utilization and Urine Protein Excretion in Children Treated with Succinylated Acinetobacter Glutaminase-Asparaginase

Craig L. Kien, John S. Holcenberg
Journal: Cancer Research
Cancer Res (1981) 41 (6): 2056–2062.
Published: 01 June 1981
View article titled, Amino Acid Utilization and Urine Protein Excretion in Children Treated with Succinylated <em>Acinetobacter</em> Glutaminase-Asparaginase
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Journal Articles

Human Pharmacology and Toxicology of Succinylated Acinetobacter Glutaminase-Asparaginase

John S. Holcenberg, Luis D. Borella, Bruce M. Camitta, Barbara J. Ring
Journal: Cancer Research
Cancer Res (1979) 39 (8): 3145–3151.
Published: 01 August 1979
View article titled, Human Pharmacology and Toxicology of Succinylated <em>Acinetobacter</em> Glutaminase-Asparaginase
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Journal Articles

Effect of Acinetobacter Glutaminase-Asparaginase Treatment on Free Amino Acids in Mouse Tissues

John S. Holcenberg, Esther Tang, William C. Dolowy
Journal: Cancer Research
Cancer Res (1975) 35 (5): 1320–1325.
Published: 01 May 1975
View article titled, Effect of <em>Acinetobacter</em> Glutaminase-Asparaginase Treatment on Free Amino Acids in Mouse Tissues
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Journal Articles

Therapeutic Properties of a New Glutaminase-Asparaginase Preparation and the Influence of the Lactate Dehydrogenaseelevating Virus

Vernon Riley, Darrel Spackman, M. A. Fitzmaurice, Joseph Roberts, John S. Holcenberg, William C. Dolowy
Journal: Cancer Research
Cancer Res (1974) 34 (2): 429–438.
Published: 01 February 1974
View article titled, Therapeutic Properties of a New Glutaminase-Asparaginase Preparation and the Influence of the Lactate Dehydrogenaseelevating Virus
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