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John R. Mackey
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Journal Articles

Abstract CT194: N-myristoylation inhibitor zelenirstat: New mechanistic insights and efficacy signals from a first in human phase I study

Free
Luc Gerard Berthiaume, Erwan Beauchamp, Jay Gamma, Rony Pain, Morris A. Kostiuk, Christopher R. Cromwell, Eman W. Moussa, Olivier Julien, Basil P. Hubbard, John Kuruvilla, Laurie H. Sehn, Jennifer Spratlin, Rahima Jamal, Randeep Sangha, John R. Mackey
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT194.
https://doi.org/10.1158/1538-7445.AM2024-CT194
Published: 05 April 2024
View articletitled, Abstract CT194: N-myristoylation inhibitor zelenirstat: New mechanistic insights and efficacy signals from a first in human phase I study
Journal Articles

Abstract 5662: Targeting N-myristoylation for therapy of adult acute myeloid leukemia

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Jay Gamma, Aishwarya Iyer, Megan Yap, Zoulika Zak, Krista Vincent, Cassidy Ekstrom, Qiang Liu, Erwan Beauchamp, Lynne Postovit, Jean Wang, John R. Mackey, Naveen Pemmaraju, Gautam Borthakur, Joseph Brandwein, Luc Berthiaume
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5662.
https://doi.org/10.1158/1538-7445.AM2022-5662
Published: 15 June 2022
View articletitled, Abstract 5662: Targeting N-myristoylation for therapy of adult acute myeloid leukemia
Journal Articles

Abstract 1782: N-myristoyltransferase proteins in breast cancer: Prognostic relevance and validation as a new drug target

Free
John R. Mackey, Justine Lai, Utkarsh Chauhan, Wei-Feng Dong, Darryl Glubrect, Sunita Ghosh, Gilbert Bigras, Raymond Lai, Luc G. Berthiaume
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1782.
https://doi.org/10.1158/1538-7445.AM2020-1782
Published: 15 August 2020
View articletitled, Abstract 1782: N-myristoyltransferase proteins in breast cancer: Prognostic relevance and validation as a new drug target
Journal Articles

Abstract 5156: Targeting N-myristoylation in B-cell lymphomas as a therapeutic strategy

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Erwan Beauchamp, Megan C. Yap, Maneka A. Perinpanayagam, Jay M. Gamma, Krista M. Vincent, Raymond Lai, Wei-Feng Dong, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Lynne Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, John R. Mackey, Luc G. Berthiaume
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5156.
https://doi.org/10.1158/1538-7445.AM2020-5156
Published: 15 August 2020
View articletitled, Abstract 5156: Targeting N-myristoylation in B-cell lymphomas as a therapeutic strategy
Journal Articles

Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

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Cody W. Lewis, Amirali B. Bukhari, Edric J. Xiao, Won-Shik Choi, Joanne D. Smith, Ellen Homola, John R. Mackey, Shelagh D. Campbell, Armin M. Gamper, Gordon K. Chan
Journal: Cancer Research
Cancer Res (2019) 79 (23): 5971–5985.
https://doi.org/10.1158/0008-5472.CAN-19-1961
Published: 02 December 2019
View articletitled, Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition
Open the PDF for Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 3046: Targeting N-myristoylation in B cell lymphomas as a therapeutic strategy

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John R. Mackey, Erwan Beauchamp, Megan C. Yap, Aishwarya Iyer, Maneka A. Perinpanayagam, Krista M. Vincent, Abass M. Al-Momany, Ryan J. Heit, Jacky Y. Sim, Raymond Lai, Wei-feng Dong, Manikandan Lakshmanan, Anandhkumar Raju, Vinay Tergaonkar, Soo Yong Tan, Soon Thye Lim, Lynne M. Postovit, Kevin D. Read, David W. Gray, Paul G. Wyatt, Luc G. Berthiaume
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3046.
https://doi.org/10.1158/1538-7445.AM2019-3046
Published: 01 July 2019
View articletitled, Abstract 3046: Targeting N-myristoylation in B cell lymphomas as a therapeutic strategy
Journal Articles

Abstract 3043: Examination of NMT1 and NMT2 as independent prognostic markers and novel drug targets in adult acute myeloid leukemia

Free
John R. Mackey, Aishwarya Iyer, Megan C. Yap, Zoulika Zak, Krista Vincent, Erwan Beauchamp, Lynne M. Postovit, Joseph Brandwein, Luc G. Berthiaume
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3043.
https://doi.org/10.1158/1538-7445.AM2019-3043
Published: 01 July 2019
View articletitled, Abstract 3043: Examination of NMT1 and NMT2 as independent prognostic markers and novel drug targets in adult acute myeloid leukemia
Journal Articles

Abstract B37: Small nucleolar RNAs – New players in breast cancer prognosis

Free
Preethi Krishnan, Sunita Ghosh, Bo Wang, Dongping Li, Richard Berendt, John R. Mackey, Olga Kovalchuk, Sambasivarao Damaraju
Journal: Cancer Research
Cancer Res (2016) 76 (6_Supplement): B37.
https://doi.org/10.1158/1538-7445.NONRNA15-B37
Published: 13 May 2016
View articletitled, Abstract B37: Small nucleolar RNAs – New players in breast cancer prognosis
Journal Articles

Abstract P3-06-48: Pharmacogenetic dosing of epirubicin in FEC chemotherapy

Free
John R Mackey, Edith Pituskin, Ann Vlahadamis, Katia Tonkin, Karen King, Sanraj Basi, Maria Ho, Judith Meza-Junco, Anil Joy, Dick Au, Sambasivarao Damaraju, Michael B Sawyer
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P3-06-48.
https://doi.org/10.1158/1538-7445.SABCS14-P3-06-48
Published: 01 May 2015
View articletitled, Abstract P3-06-48: Pharmacogenetic dosing of epirubicin in FEC chemotherapy
Journal Articles

Abstract 1376: Exercise alters breast cancer phenotype through distinct reductions in host-derived proinflammatory growth factor ligands.

Free
Oliver Glass, Brant A. Inman, Kerry S. Courneya, John R. Mackey, Erik Nelson, Zachary Hartman, Lee W. Jones
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1376.
https://doi.org/10.1158/1538-7445.AM2013-1376
Published: 15 April 2013
View articletitled, Abstract 1376: Exercise alters breast cancer phenotype through distinct reductions in host-derived proinflammatory growth factor ligands.
Journal Articles

β1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer

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David Lesniak, Yaoxian Xu, Jean Deschenes, Raymond Lai, John Thoms, David Murray, Sunita Gosh, John R. Mackey, Siham Sabri, Bassam Abdulkarim
Journal: Cancer Research
Cancer Res (2009) 69 (22): 8620–8628.
https://doi.org/10.1158/0008-5472.CAN-09-1591
Published: 11 November 2009
View articletitled, β1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer
Open the PDF for β1-Integrin Circumvents the Antiproliferative Effects of Trastuzumab in Human Epidermal Growth Factor Receptor-2–Positive Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines

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Henriette Gourdeau, Marilyn L. Clarke, France Ouellet, Delores Mowles, Milada Selner, Annie Richard, Nola Lee, John R. Mackey, James D. Young, Jacques Jolivet, Ronald G. Lafrenière, Carol E. Cass
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7217–7224.
Published: 01 October 2001
View articletitled, Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines
Open the PDF for Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines in another window
Journal Articles

Functional Nucleoside Transporters Are Required for Gemcitabine Influx and Manifestation of Toxicity in Cancer Cell Lines

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John R. Mackey, Rajam S. Mani, Milada Selner, Delores Mowles, James D. Young, Judith A. Belt, Charles R. Crawford, Carol E. Cass
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4349–4357.
Published: 01 October 1998
View articletitled, Functional Nucleoside Transporters Are Required for Gemcitabine Influx and Manifestation of Toxicity in Cancer Cell Lines
Open the PDF for Functional Nucleoside Transporters Are Required for Gemcitabine Influx and Manifestation of Toxicity in Cancer Cell Lines in another window