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Journal Articles

Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[¹⁸F]Fluorothymidine in Preclinical Models of Lung Cancer

Sonja Schelhaas, Annelena Held, Lydia Wachsmuth, Sven Hermann, Davina J. Honess, Kathrin Heinzmann, Donna-Michelle Smith, John R. Griffiths, Cornelius Faber, Andreas H. Jacobs

Cancer Res (2016) 76 (24): 7096–7105.

https://doi.org/10.1158/0008-5472.CAN-16-1479

Published: 15 December 2016

View article titled, Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[18F]Fluorothymidine in Preclinical Models of Lung Cancer

Includes: Supplementary data

Journal Articles

Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells.

Anne-Christine LF Wong Te Fong, Chris Jones, John R. Griffiths, Martin O. Leach, Yuen-Li Chung

Cancer Res (2013) 73 (8_Supplement): 5640.

https://doi.org/10.1158/1538-7445.AM2013-5640

Published: 15 April 2013

View article titled, Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells.

Journal Articles

Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

Mounia Beloueche-Babari, Vaitha Arunan, Helen Troy, Robert H. te Poele, Anne-Christine Wong Te Fong, L. Elizabeth Jackson, Geoffrey S. Payne, John R. Griffiths, Ian R. Judson, Paul Workman, Martin O. Leach, Yuen-Li Chung

Cancer Res (2012) 72 (4): 990–1000.

https://doi.org/10.1158/0008-5472.CAN-11-2688

Published: 14 February 2012

View article titled, Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

Includes: Supplementary data

Journal Articles

Abstract 3788: Autophagy induced by DCA, PI3K inhibition or starvation results in reduced lactate production measured in real-time by DNP 13C MRS

Yuen-Li Chung, Gigin Lin, Helen Troy, Anne-Christine Wong Te Fong, L Elizabeth Jackson, Deborah K. Hill, Matthew Orton, Dow-Mu Koh, Simon P. Robinson, Ian R. Judson, John R. Griffiths, Martin O. Leach, Thomas R. Eykyn

Cancer Res (2011) 71 (8_Supplement): 3788.

https://doi.org/10.1158/1538-7445.AM2011-3788

Published: 15 April 2011

View article titled, Abstract 3788: Autophagy induced by DCA, PI3K inhibition or starvation results in reduced lactate production measured in real-time by DNP 13C MRS

Journal Articles

Abstract 5277: Non-invasive metabolic biomarkers of histone deacetylase inhibition in human colon cancer cells and tumors

Mounia Beloueche-Babari, Vaitha Arunan, Helen Troy, L Elizabeth Jackson, Anne-Christine Wong, Paul Workman, Ian Judson, John R. Griffiths, Martin O. Leach, Yuen-Li Chung

Cancer Res (2011) 71 (8_Supplement): 5277.

https://doi.org/10.1158/1538-7445.AM2011-5277

Published: 15 April 2011

View article titled, Abstract 5277: Non-invasive metabolic biomarkers of histone deacetylase inhibition in human colon cancer cells and tumors

Journal Articles

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

Nada M.S. Al-Saffar, Helen Troy, Ana Ramírez de Molina, Laura E. Jackson, Basetti Madhu, John R. Griffiths, Martin O. Leach, Paul Workman, Juan C. Lacal, Ian R. Judson, Yuen-Li Chung

Cancer Res (2006) 66 (1): 427–434.

https://doi.org/10.1158/0008-5472.CAN-05-1338

Published: 05 January 2006

View article titled, Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

Journal Articles

Tumor overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126

Elizabeth R. Cullis, Tammy L. Kalber, Susan E. Ashton, John R. Griffiths, Anderson J. Ryan, Simon P. Robinson

Cancer Res (2005) 65 (9_Supplement): 1376.

Published: 01 May 2005

View article titled, Tumor overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126

Journal Articles

Tumor response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) measured by dynamic contrast-enhanced magnetic resonance imaging in a rat model

Lesley D. McPhail, Dominick J. O. McIntyre, Christian Ludwig, John R. Griffiths, Lloyd R. Kelland, Simon P. Robinson

Cancer Res (2005) 65 (9_Supplement): 1375.

Published: 01 May 2005

View article titled, Tumor response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) measured by dynamic contrast-enhanced magnetic resonance imaging in a rat model

Journal Articles

Response of murine liver metastasis to the vascular-disrupting agent ZD6126 assessed by susceptibility MRI

Tammy L. Kalber, John R. Griffiths, John C. Waterton, Anderson J. Ryan, Simon P. Robinson

Cancer Res (2005) 65 (9_Supplement): 894.

Published: 01 May 2005

View article titled, Response of murine liver metastasis to the vascular-disrupting agent ZD6126 assessed by susceptibility MRI

Journal Articles

Tumor dose response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) assessed by in vivo magnetic resonance spectroscopy

Lesley D. McPhail, Yuen-Li Chung, Basetti Madhu, Simon Clark, John R. Griffiths, Lloyd R. Kelland, Simon P. Robinson

Cancer Res (2004) 64 (7_Supplement): 12.

Published: 01 April 2004

View article titled, Tumor dose response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) assessed by in vivo magnetic resonance spectroscopy

Journal Articles

Effects of Overexpression of Dimethylarginine Dimethylaminohydrolase on Tumor Angiogenesis Assessed by Susceptibility Magnetic Resonance Imaging

Vassiliki Kostourou, Simon P. Robinson, Guy St. J. Whitley, John R. Griffiths

Cancer Res (2003) 63 (16): 4960–4966.

Published: 26 August 2003

View article titled, Effects of Overexpression of Dimethylarginine Dimethylaminohydrolase on Tumor Angiogenesis Assessed by Susceptibility Magnetic Resonance Imaging

Journal Articles

Metabolic Changes Detected by in Vivo Magnetic Resonance Studies of HEPA-1 Wild-Type Tumors and Tumors Deficient in Hypoxia-inducible Factor-1β (HIF-1β): Evidence of an Anabolic Role for the HIF-1 Pathway

John R. Griffiths, Paul M. J. McSheehy, Simon P. Robinson, Helen Troy, Yuen-Li Chung, Russell D. Leek, Kaye J. Williams, Ian J. Stratford, Adrian L. Harris, Marion Stubbs

Cancer Res (2002) 62 (3): 688–695.

Published: 01 February 2002

View article titled, Metabolic Changes Detected by in Vivo Magnetic Resonance Studies of HEPA-1 Wild-Type Tumors and Tumors Deficient in Hypoxia-inducible Factor-1β (HIF-1β): Evidence of an Anabolic Role for the HIF-1 Pathway

Journal Articles

Metabolites of 2′-Fluoro-2′-deoxy-d-glucose Detected by ¹⁹F Magnetic Resonance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1

Paul M. J. McSheehy, Martin O. Leach, Ian R. Judson, John R. Griffiths

Cancer Res (2000) 60 (8): 2122–2127.

Published: 01 April 2000

View article titled, Metabolites of 2′-Fluoro-2′-deoxy-<sc>d</sc>-glucose Detected by 19F Magnetic Resonance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1

Journal Articles

Carbogen Breathing Increases 5-Fluorouracil Uptake and Cytotoxicity in Hypoxic Murine RIF-1 Tumors: A Magnetic Resonance Study in Vivo

Paul M. J. McSheehy, Simon P. Robinson, Agatha S. E. Ojugo, Eric O. Aboagye, Mark B. Cannell, Martin O. Leach, Ian R. Judson, John R. Griffiths

Cancer Res (1998) 58 (6): 1185–1194.

Published: 01 March 1998

View article titled, Carbogen Breathing Increases 5-Fluorouracil Uptake and Cytotoxicity in Hypoxic Murine RIF-1 Tumors: A Magnetic Resonance Study in Vivo

Journal Articles

Preclinical Evaluation of the Fluorinated 2-Nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) Acetamide (SR-4554) as a Probe for the Measurement of Tumor Hypoxia

Eric O. Aboagye, Ross J. Maxwell, Andrew B. Kelson, Michael Tracy, Alexander D. Lewis, Martin A. Graham, Michael R. Horsman, John R. Griffiths, Paul Workman

Cancer Res (1997) 57 (15): 3314–3318.

Published: 01 August 1997

View article titled, Preclinical Evaluation of the Fluorinated 2-Nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) Acetamide (SR-4554) as a Probe for the Measurement of Tumor Hypoxia

Journal Articles

Metabolic Consequences of a Reversed pH Gradient in Rat Tumors

Marion Stubbs, Loreta Rodrigues, Franklyn A. Howe, Jian Wang, Kyu-Shik Jeong, Richard L. Veech, John R. Griffiths

Cancer Res (1994) 54 (15): 4011–4016.

Published: 01 August 1994

View article titled, Metabolic Consequences of a Reversed pH Gradient in Rat Tumors

Journal Articles

³¹P-Nuclear Magnetic Resonance Spectroscopy Studies of the Response of Rat Mammary Tumors to Endocrine Therapy

Loreta M. Rodrigues, Caroline J. Midwood, R. Charles Coombes, Anthony N. Stevens, Marion Stubbs, John R. Griffiths

Cancer Res (1988) 48 (1): 89–93.

Published: 01 January 1988

View article titled, 31P-Nuclear Magnetic Resonance Spectroscopy Studies of the Response of Rat Mammary Tumors to Endocrine Therapy

NARROW

Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3′-Deoxy-3′-[¹⁸F]Fluorothymidine in Preclinical Models of Lung Cancer

Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells.

Histone Deacetylase Inhibition Increases Levels of Choline Kinase α and Phosphocholine Facilitating Noninvasive Imaging in Human Cancers

Abstract 3788: Autophagy induced by DCA, PI3K inhibition or starvation results in reduced lactate production measured in real-time by DNP 13C MRS

Abstract 5277: Non-invasive metabolic biomarkers of histone deacetylase inhibition in human colon cancer cells and tumors

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

Tumor overexpression of inducible nitric oxide synthase (iNOS) increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126

Tumor response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) measured by dynamic contrast-enhanced magnetic resonance imaging in a rat model

Response of murine liver metastasis to the vascular-disrupting agent ZD6126 assessed by susceptibility MRI

Tumor dose response to 5,6-dimethylxanthenone-4-acetic acid (DMXAA) assessed by in vivo magnetic resonance spectroscopy

Effects of Overexpression of Dimethylarginine Dimethylaminohydrolase on Tumor Angiogenesis Assessed by Susceptibility Magnetic Resonance Imaging

Metabolic Changes Detected by in Vivo Magnetic Resonance Studies of HEPA-1 Wild-Type Tumors and Tumors Deficient in Hypoxia-inducible Factor-1β (HIF-1β): Evidence of an Anabolic Role for the HIF-1 Pathway

Metabolites of 2′-Fluoro-2′-deoxy-d-glucose Detected by ¹⁹F Magnetic Resonance Spectroscopy in Vivo Predict Response of Murine RIF-1 Tumors to 5-Fluorouracil1

Carbogen Breathing Increases 5-Fluorouracil Uptake and Cytotoxicity in Hypoxic Murine RIF-1 Tumors: A Magnetic Resonance Study in Vivo

Preclinical Evaluation of the Fluorinated 2-Nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) Acetamide (SR-4554) as a Probe for the Measurement of Tumor Hypoxia

Metabolic Consequences of a Reversed pH Gradient in Rat Tumors

³¹P-Nuclear Magnetic Resonance Spectroscopy Studies of the Response of Rat Mammary Tumors to Endocrine Therapy

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