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John Paul Shen
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Journal Articles

Abstract 3275: Bromodomain and extraterminal (BET) protein inhibition sensitize BRAFV600E colorectal cancer to standard targeted therapies

Hey Min Lee, Stefania Napolitano, Alexy Sorokin, Melanie N. Woods, Saikat Chowdhury, Jumanah Y. Alshenaifi, Anand K. Singh, John Paul Shen, Funda Meric-Bernstam, Kunal Rai, Scott Kopetz
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3275.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3275
Published: 15 June 2022
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Journal Articles

Abstract 5794: Gene expression analysis of appendiceal adenocarcinomas highlights tumor heterogeneity between high and low-grade

Yue Gu, Abdelrahman M. Yousef, Saikat Chowdhury, John Paul Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5794.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5794
Published: 15 June 2022
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Journal Articles

Abstract 6066: Elucidating cancer stem cells heterogeneity in colorectal cancer by single-cell RNA sequencing

Kangyu Lin, John Paul Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6066.
DOI: https://doi.org/10.1158/1538-7445.AM2022-6066
Published: 15 June 2022
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Journal Articles

Abstract 1246: Consensus molecular subtypes (CMS) of colorectal cancer predict anti-EGFR response irrespective of tumor sidedness

Saikat Chowdhury, Ria Gupta, Valsala Haridas, Mohammad A. Zeineddine, Scott Kopetz, John Paul Shen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1246.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1246
Published: 15 June 2022
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Journal Articles

Abstract LB264: Oncogenic KRASG12C dependency in colorectal cancer

Oluwadara Coker, Alexey Sorokin, Kelly Gale, Fengqin Gao, John Paul Shen, Lawrence Kwong, Ji Wu, Hey Min Lee, Melanie Woods, Oscar Villareal, Scott Kopetz
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB264.
DOI: https://doi.org/10.1158/1538-7445.AM2021-LB264
Published: 01 July 2021
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Journal Articles

Abstract 2133: Systematic mapping of genetic interactions in human cancer cells reveals context dependent cancer signaling pathways

Samson H. Fong, Brent M. Kuenzi, John Lee, Kyle Sanchez, Ana Bojorquez-Gomez, Kyle Ford, Brenton P. Munson, Katherine Licon, Jeff Hager, John Paul Shen, Jason F. Kreisberg, Prashant Mali, Trey Ideker
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2133.
DOI: https://doi.org/10.1158/1538-7445.AM2021-2133
Published: 01 July 2021
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Journal Articles

Abstract A07: Transcriptional profiling confirms appendiceal adenocarcinoma is distinct from colorectal cancer, in vivo models needed

John Paul Shen, Saikat Chowdhury, Ji Wu, Keith Fournier, Scott Kopetz, Kanwal Raghav
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): A07.
DOI: https://doi.org/10.1158/1538-7445.CAMODELS2020-A07
Published: 02 June 2020
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Journal Articles

Novel Third-Generation EGFR Tyrosine Kinase Inhibitors and Strategies to Overcome Therapeutic Resistance in Lung Cancer

Ayesha Murtuza, Ajaz Bulbul, John Paul Shen, Parissa Keshavarzian, Brian D. Woodward, Fernando J. Lopez-Diaz, Scott M. Lippman, Hatim Husain
Journal: Cancer Research
Cancer Res (2019) 79 (4): 689–698.
DOI: https://doi.org/10.1158/0008-5472.CAN-18-1281
Published: 15 February 2019
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Includes: Supplementary data
Journal Articles

Abstract 3299: High-throughput combinatorial CRISPR-Cas9 gene knockout reveals most genetic interactions are context dependent

John Paul Shen, Dongxin Zhao, Brenton Munson, Amanda Birmingham, Roman Sasik, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Alex Beckett, Kyle Salinas Sanchez, Prashant Mali, Trey Ideker
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3299.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3299
Published: 01 July 2018
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Journal Articles

Abstract 3039: Combinatorial CRISPR-Cas9 gene knockout to enable genetic interaction mapping in human cells

John Paul Shen, Dongxin Zhao, Roman Sasik, Jens Luebeck, Ana Bojorquez-Gomez, Katherine Licon, Trey Ideker, Prashant Mali
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3039.
DOI: https://doi.org/10.1158/1538-7445.AM2017-3039
Published: 01 July 2017
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Journal Articles

Abstract NG02: A network of deeply conserved synthetic-lethal interactions for exploration of precision cancer therapy

John Paul Shen, Rohith Srivas, Chih Cheng Yang, Su Ming Sun, Jian Feng Li, Andrew Gross, James Jensen, Kate Licon, Ana Bojoquez-Gomez, Kristin Klepper, Haico van Attikum, Pedro Aza-Blanc, Robert Sobol, Trey Ideker
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): NG02.
DOI: https://doi.org/10.1158/1538-7445.AM2016-NG02
Published: 15 July 2016
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Journal Articles

Abstract 129: RAD17 loss of function is synthetically lethal with the checkpoint kinase inhibitors AZD7762 or MK-1775

John Paul Shen, Rohith Srivas, Ana Bojorquez-Gomez, Katherine Licon, Vignesh Sivaganesh, Jia L. Xu, Huwate Yeerna, Andrew Gross, Jian Feng Li, Robert Sobol, Trey Ideker
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 129.
DOI: https://doi.org/10.1158/1538-7445.AM2015-129
Published: 01 August 2015
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