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John M. Maris
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Journal Articles

Abstract 1201: The PLK4 inhibitor RP-1664 drives centriole modulation and single agent tumor regressions in preclinical neuroblastoma models

Minu Samanta, Daivd Groff, Isabel Soria-Bretones, Joanna Li, Parham Nejad, Elliot Goodfellow, Alvin Farrel, Khushbu Patel, Kateryna Krytska, Steven B. Neuhauser, Timothy M. Stearns, Yael P. Mossé, JD Schonhoft, Marc L. Hyer, Michal Zimmermann, Gary Marshall, John M. Maris
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1201.
https://doi.org/10.1158/1538-7445.AM2025-1201
Published: 21 April 2025
View articletitled, Abstract 1201: The PLK4 inhibitor RP-1664 drives centriole modulation and single agent tumor regressions in preclinical neuroblastoma models
Journal Articles

Abstract 2600: A human stem cell model of neuroblastoma reveals candidate drivers of tumorigenesis on chromosome 17q

Wanqi Fang, Bo Cheng, Steven J. Pastor, Ivana Barbaric, Anestis Tsakiridis, Tania Porras, Hong-Wei Wu, Chintan Parekh, Shahab Asgharzadeh, John M. Maris, Miller Huang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2600.
https://doi.org/10.1158/1538-7445.AM2025-2600
Published: 21 April 2025
View articletitled, Abstract 2600: A human stem cell model of neuroblastoma reveals candidate drivers of tumorigenesis on chromosome 17q
Journal Articles

Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers

Hua Tian, Eric Wegrzyniak, Ya-Wen Lu, Jeffrey T. Mihalic, Ryan Rountree, Tina Acholla, Bikash Adhikari, Karthik Arumugam, Paul Auger, Graham Carlson, Robert Cass, Coleen E. Casey, Abhinav Chaterjee, Lorenz Eing, James Iuliano, Adrienne Le, Yifan Li, Victoria Louie, Filippo Marchioni, Daniel Medina-Cleghorn, Isabel Morgado, Michael Mormino, Madeleine Nemchek, Erick Palomares, Rusha Sardhara, Julie Sheung, Sangita Sridharan, Gintvile Valinciute, Dipna Venkatachalam, Simon Vezina-Dawod, Derek Wodka, Stephanie Yung, Martin Eilers, John M. Maris, Yael P. Mossé, Martine F. Roussel, Elmar Wolf, Gwenn M. Hansen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6379.
https://doi.org/10.1158/1538-7445.AM2025-6379
Published: 21 April 2025
View articletitled, Abstract 6379: Identification of selective, orally bioavailable aurora A degraders for treatment of pediatric and adult cancers
Journal Articles

Abstract 7041: The CLK/DYRK inhibitor SM09419 shows potent efficacy across a broad panel of pediatric preclinical xenograft models - A report from the Pediatric Preclinical In Vivo Testing Consortium (PIVOT)

Richard B. Lock, Raushan Kurmasheva, Kathryn Evans, David Groff, Ben Watts, Kateryna Krytska, Christopher M. Smith, Faith N. Key, Daniella Cofini, Miguel Agoncillo, Steven Neuhauser, Timothy M. Stearns, Emily L. Jocoy, Jee Young Kwon, Jeffrey H. Chuang, Beverly A. Teicher, Richard Gorlick, Yael P. Mossé, John M. Maris, Peter J. Houghton, Carol J. Bult, Malcolm A. Smith
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7041.
https://doi.org/10.1158/1538-7445.AM2025-7041
Published: 21 April 2025
View articletitled, Abstract 7041: The CLK/DYRK inhibitor SM09419 shows potent efficacy across a broad panel of pediatric preclinical xenograft models - A report from the Pediatric Preclinical In Vivo Testing Consortium (PIVOT)
Journal Articles

Abstract 7040: The B7-H3 targeting antibody-drug conjugate (ADC) vobramitamab duocarmazine (vobra duo) is potently effective against a broad panel of pediatric solid tumor xenograft models: A study from the Pediatric Preclinical In Vivo Testing (PIVOT) Consortium

Haiying Tang, Edward Favours, Samson Ghilu, Peyton Wong, Vanessa Del Pozo, Abhik Bandyopadhyay, Elena Mironova, Eric J. Earley, Stephen W. Erickson, David Groff, Beverly A. Teicher, Kateryna Krytska, Matthew Tsang, Yael P. Mosse, E. Anders Kolb, Matthew Stephens, Steve Neuhauser, Tim Stearns, Jeff Chuang, Emily L. Jocoy, Jee Young Kwon, Carol Bult, Malcolm A. Smith, John M. Maris, Richard G. Gorlick, Peter J. Houghton, Raushan Kurmasheva
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7040.
https://doi.org/10.1158/1538-7445.AM2025-7040
Published: 21 April 2025
View articletitled, Abstract 7040: The B7-H3 targeting antibody-drug conjugate (ADC) vobramitamab duocarmazine (vobra duo) is potently effective against a broad panel of pediatric solid tumor xenograft models: A study from the Pediatric Preclinical In Vivo Testing (PIVOT) Consortium
Journal Articles

Abstract B062: VCAN+ macrophages promote neuroblastoma cell growth, migration, and adrenergic to mesenchymal transition via the HB-EGF/ERBB signaling axis

Rumeysa Biyik-Sit, Wenbao Yu, Chia-Hui Chen, Anusha Thadi, Minxing Pang, Liron D. Grossmann, Tasleema Patel, Daniel Martinez, Lea F. Surrey, Michael D. Hogarty, Kathrin Bernt, Nancy Zhang, John M. Maris, Kai Tan
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B062.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B062
Published: 05 September 2024
View articletitled, Abstract B062: VCAN+ macrophages promote neuroblastoma cell growth, migration, and adrenergic to mesenchymal transition via the HB-EGF/ERBB signaling axis
Journal Articles

Abstract 1090: GPC2 directed CAR T cells are efficacious against fusion-positive and fusion-negative rhabdomyosarcomas

Rawan Shraim, Patrick M. Schuerch, Anna Maria Giudice, Karina L. Conkrite, Amber K. Weiner, Alexander B. Radaoui, Brian Mooney, Raushan T. Kurmasheva, Peter J. Houghton, Gregg B. Morin, Yael B. Mosse, Poul H. Sorensen, Benjamin A. Garcia, Ahmet Sacan, John M. Maris, Kristopher R. Bosse, Sharon J. Diskin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1090.
https://doi.org/10.1158/1538-7445.AM2024-1090
Published: 22 March 2024
View articletitled, Abstract 1090: GPC2 directed CAR T cells are efficacious against fusion-positive and fusion-negative rhabdomyosarcomas
Journal Articles

Abstract 5121: Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies

Timothy T. Spear, Elisabeth Posthill, David Groff, Anna M. Giudice, Kristopher R. Bosse, Leyuan Ma, Stephen P. Schoenberger, John M. Maris
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5121.
https://doi.org/10.1158/1538-7445.AM2024-5121
Published: 22 March 2024
View articletitled, Abstract 5121: Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies
Journal Articles

Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors

Apexa Modi, Gonzalo Lopez, Karina L. Conkrite, Chun Su, Tsz Ching Leung, Sathvik Ramanan, Elisabetta Manduchi, Matthew E. Johnson, Daphne Cheung, Samantha Gadd, Jinghui Zhang, Malcolm A. Smith, Jaime M. Guidry Auvil, Soheil Meshinchi, Elizabeth J. Perlman, Stephen P. Hunger, John M. Maris, Andrew D. Wells, Struan F.A. Grant, Sharon J. Diskin
Journal: Cancer Research
Cancer Res (2023) 83 (20): 3462–3477.
https://doi.org/10.1158/0008-5472.CAN-22-3186
Published: 13 October 2023
View articletitled, Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors
Open the PDF for Integrative Genomic Analyses Identify LncRNA Regulatory Networks across Pediatric Leukemias and Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 6714: ALCAM promotes neuroblastoma proliferation, migration, and immune evasion

Jarrett Lindsay, Minu Samanta, Nathan Kendsersky, Jonathan Gaither, Molly Christie, Kyabeth Torres-Rodriguez, Catherine Wingrove, John M. Maris
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6714.
https://doi.org/10.1158/1538-7445.AM2023-6714
Published: 04 April 2023
View articletitled, Abstract 6714: ALCAM promotes neuroblastoma proliferation, migration, and immune evasion
Journal Articles

Abstract 4515: PIONEER: harnessing multi-omics data to enhance immunotherapeutic target discovery and development

Amber K. Weiner, Hemma Murali, Rawan Shraim, Karina L. Conkrite, Alexander B. Radaoui, Daniel Martinez, Brian Mooney, Sandra E. Spencer Miko, Gian Negri, Alberto Delaidelli, Caitlyn de Jong, Yuankun Zhu, Allison P. Heath, Jennifer Pogoriler, Yael P. Mosse, Deanne M. Taylor, Poul H. Sorensen, Gregg B. Morin, Benjamin A. Garcia, John M. Maris, Sharon J. Diskin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4515.
https://doi.org/10.1158/1538-7445.AM2023-4515
Published: 04 April 2023
View articletitled, Abstract 4515: PIONEER: harnessing multi-omics data to enhance immunotherapeutic target discovery and development
Journal Articles

Abstract 2593: A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma

Hai-Feng Zhang, Alberto Delaidelli, Sumreen Javed, Busra Turgu, Christopher S. Hughes, Xiaqiu Yang, Michael Lizardo, Daniel Martinez, John M. Maris, Kristopher R. Bosse, Karla C. Williams, Poul H. Sorensen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2593.
https://doi.org/10.1158/1538-7445.AM2023-2593
Published: 04 April 2023
View articletitled, Abstract 2593: A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma
Journal Articles

Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma

Nathan M. Kendsersky, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Michal Odrobina, Kimberly Stegmaier, John M. Maris
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3889.
https://doi.org/10.1158/1538-7445.AM2022-3889
Published: 15 June 2022
View articletitled, Abstract 3889: Identification of ADRN-specific, MES-specific, and pan-subtype therapeutic targets in neuroblastoma
Journal Articles

Abstract 699: NF-kB is a master regulator of resistance to therapy in high-risk neuroblastoma

Liron D. Grossmann, Yasin Uzun, Jarrett Lindsay, Chia-Hui Chen, Catherine Wingrove, Peng Gao, Anusha Thadi, Quinlen Marshall, Nathan M. Kendsersky, Lea Surrey, Daniel Martinez, Emily Mycek, Colleen Casey, Kateryna Krytska, Matthew Tsang, Adam Wolpaw, David N. Groff, Erin Runbeck, Jayne McDevitt, Dinh Diep, Tasleema Patel, Kathrin M. Bernt, Chi Dang, Kun Zhang, Yael P. Mosse, Kai Tan, John M. Maris
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 699.
https://doi.org/10.1158/1538-7445.AM2022-699
Published: 15 June 2022
View articletitled, Abstract 699: NF-kB is a master regulator of resistance to therapy in high-risk neuroblastoma
Journal Articles

Abstract 6051: Longitudinal single-cell sequencing of high-risk neuroblastoma tumors reveals intrinsic and extrinsic mechanisms of therapy resistance

Yasin Uzun, Liron D. Grossmann, Chia-Hui Chen, Anusha Thadi, Chi-Yun Wu, Peng Gao, Dinh Diep, Lea Surrey, Daniel Martinez, Tasleema Patel, Qi Qiu, Sarah Johnson, Wenbao Yu, Shane Drabings, Changya Chen, Yuxuan Hu, Gregory Chen, Derek A. Oldridge, Kun Zhang, Hao Wu, Kathrin Bernt, Nancy Zhang, John M. Maris, Kai Tan
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6051.
https://doi.org/10.1158/1538-7445.AM2022-6051
Published: 15 June 2022
View articletitled, Abstract 6051: Longitudinal single-cell sequencing of high-risk neuroblastoma tumors reveals intrinsic and extrinsic mechanisms of therapy resistance
Journal Articles

Abstract 2006: Preclinical evaluation of dual AURKA (LY3295668) and BCL2 (venetoclax) inhibition in neuroblastoma (NB)

David Groff, Colleen Casey, Kateryna krytska, Matthew Tsang, Christina Acholla, John M. Maris, Yael P. Mosse
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2006.
https://doi.org/10.1158/1538-7445.AM2022-2006
Published: 15 June 2022
View articletitled, Abstract 2006: Preclinical evaluation of dual AURKA (LY3295668) and BCL2 (venetoclax) inhibition in neuroblastoma (NB)
Journal Articles

Abstract LB188: Identification of intrinsic molecular vulnerabilities in inherited and treatment-related hypermutant patient-derived glioma cell line models

Laura Scolaro, Nuno Miguel Nunes, Michelle Kushida, David C. Schultz, Sara Cherry, Kanupriya Whig, Peter Dirks, Uri Tabori, John M. Maris
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB188.
https://doi.org/10.1158/1538-7445.AM2022-LB188
Published: 15 June 2022
View articletitled, Abstract LB188: Identification of intrinsic molecular vulnerabilities in inherited and treatment-related hypermutant patient-derived glioma cell line models
Journal Articles

Abstract 1493: Discovery and CAR T targeting of lineage-restricted neuroblastoma oncoproteins

Mark Yarmarkovich, John M. Warrington, Quinlen F. Marshall, Helena Shen, Wei Li, Matt Beasley, Moreno Di Marco, Stefan Stevanovic, Nikolaos G. Sgourakis, Dimiter Dimitrov, Peter Smith, John M. Maris
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1493.
https://doi.org/10.1158/1538-7445.AM2021-1493
Published: 01 July 2021
View articletitled, Abstract 1493: Discovery and CAR T targeting of lineage-restricted neuroblastoma oncoproteins
Journal Articles

Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma

Sabine Heitzeneder, Kristopher R. Bosse, Zhongyu Zhu, Dontcho Jelev, Shaurya Dhingra, Robbie Majzner, Elena Sotillo-Pineiro, Samantha Buongervino, Peng Xu, Jing Huang, Alberto Delaidelli, Martin Hasselblatt, Kevin Parker, Hima Anbunathan, Anya Alag, Jennifer Hwang, Min Huang, Dorota D. Klysz, Johanna L. Theruvath, Jose G. Vilches-Moure, Ansuman T. Satpathy, Poul H. Sorensen, Dimiter S. Dimitrov, John M. Maris, Crystal L. Mackall
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1548.
https://doi.org/10.1158/1538-7445.AM2021-1548
Published: 01 July 2021
View articletitled, Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma
Journal Articles

Abstract CT029: Pediatric phase 2 trial of the WEE1 inhibitor adavosertib (AZD1775) and irinotecan: A Children's Oncology Group Study (ADVL1312)

Kristina A. Cole, Heba Ijaz, Lea Surrey, Mariarita Santi-vicini, Xiaowei Liu, Charles G. Minard, John M. Maris, Stephan Voss, Elizabeth Fox, Brenda Weigal
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT029.
https://doi.org/10.1158/1538-7445.AM2021-CT029
Published: 01 July 2021
View articletitled, Abstract CT029: Pediatric phase 2 trial of the WEE1 inhibitor adavosertib (AZD1775) and irinotecan: A Children's Oncology Group Study (ADVL1312)