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John M. Mariadason
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Journal Articles

Abstract 1995: DUSP4 loss enhances resistance to encorafenib plus cetuximab in BRAF mutant colorectal cancer

Kristen Needham, Fiona Chionh, Stan Kaczmarczyk, Connor Kearney, Laura Jenkins, Ian Luk, John M. Mariadason
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1995.
https://doi.org/10.1158/1538-7445.AM2024-1995
Published: 22 March 2024
View article titled, Abstract 1995: DUSP4 loss enhances resistance to encorafenib plus cetuximab in <em>BRAF</em> mutant colorectal cancer
Journal Articles

Abstract 2698: TCF-1 is a critical regulator of intraepithelial lymphocytes in colorectal carcinoma

Marina H. Yakou, Sonia Ghilas, Kelly Tran, Yang Liao, Shoukat Afshar-Sterle, Anita Kumari, Kevin Schmid, Christine Dijkstra, Chantelle Inguanti, Simone Ostrouska, Jordan Wilcox, Maxine Smith, Pavitha Parathan, Amr Allam, Hai-Hui Xue, Gabrielle T. Belz, John M. Mariadason, Andreas Behren, Grant R. Drummond, Roland Ruscher, David S. Williams, Bhupinder Pal, Wei Shi, Matthias Ernst, Dinesh Raghu, Lisa A. Mielke
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2698.
https://doi.org/10.1158/1538-7445.AM2024-2698
Published: 22 March 2024
View article titled, Abstract 2698: TCF-1 is a critical regulator of intraepithelial lymphocytes in colorectal carcinoma
Journal Articles

Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death

Laura J. Jenkins, Ian Y. Luk, Walter D. Fairlie, Erinna F. Lee, Michelle Palmieri, Kael L. Schoffer, Tao Tan, Irvin Ng, Natalia Vukelic, Sharon Tran, Janson Tse, Rebecca Nightingale, Zakia Alam, Fiona Chionh, George Iatropoulos, Matthias Ernst, Shoukat Afshar-Sterle, Jayesh Desai, Peter Gibbs, Oliver M. Sieber, Amardeep S. Dhillon, Niall C. Tebbutt, John M. Mariadason
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_1): B014.
https://doi.org/10.1158/1538-7445.CRC22-B014
Published: 01 December 2022
View article titled, Abstract B014: Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death
Journal Articles

Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in BRAF mutant colorectal cancer cells

Laura J. Jenkins, Fiona Chionh, Ian Y. Luk, Erinna F. Lee, Amardeep S. Dhillon, Niall Tebbutt, Walter D. Fairlie, John M. Mariadason
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2492.
https://doi.org/10.1158/1538-7445.AM2019-2492
Published: 01 July 2019
View article titled, Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in <em>BRAF</em> mutant colorectal cancer cells
Journal Articles

Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis

Sarah Bazzocco, Jose Higinio Dopeso, Águeda Martínez-Barriocanal, Estefanía Anguita, Rocio Nieto, Alex Sanchez, John M. Mariadason, Diego Arango
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 840.
https://doi.org/10.1158/1538-7445.AM2019-840
Published: 01 July 2019
View article titled, Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis
Journal Articles

Abstract 3089: Combining MEK and HDAC inhibitors as a therapeutic strategy to promote differentiation of colorectal cancer

Laura J. Jenkins, Ian Y. Luk, Janson W. Tse, Jennifer Mooi, Amardeep S. Dhillon, John M. Mariadason
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3089.
https://doi.org/10.1158/1538-7445.AM2017-3089
Published: 01 July 2017
View article titled, Abstract 3089: Combining MEK and HDAC inhibitors as a therapeutic strategy to promote differentiation of colorectal cancer
Journal Articles

Abstract 3529: Investigating the in vivo role of the EHF transcription factor in intestinal epithelial differentiation

Camilla M. Reehorst, Ian Y. Luk, Rebecca Nightingale, Mercedes Davalos-Salas, Amardeep S. Dhillon, John M. Mariadason
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3529.
https://doi.org/10.1158/1538-7445.AM2017-3529
Published: 01 July 2017
View article titled, Abstract 3529: Investigating the in vivo role of the EHF transcription factor in intestinal epithelial differentiation
Journal Articles

Abstract 4728: Histone deacetylase inhibitors induce apoptosis in multiple tumor types through induction of ATF3

Anderly C. Chueh, Janson Tse, Paul Ioannidis, Lars Tögel, Bee S. Tan, Mercedes Davlos-Salas, Rebecca Nightingale, Matthew R. Thompson, Bryan Williams, Michael Dickinson, Amardeep S. Dhillon, John M. Mariadason
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4728.
https://doi.org/10.1158/1538-7445.AM2016-4728
Published: 15 July 2016
View article titled, Abstract 4728: Histone deacetylase inhibitors induce apoptosis in multiple tumor types through induction of ATF3
Journal Articles

Abstract 2058: RHOA inactivation enhances Wnt signaling and promotes colorectal cancer

Paulo Rodrigues, Irati Macaya, Sarah Bazzocco, Elena Andretta, Rocco Mazzolini, Higinio Dopeso, Silvia Mateo-Lozano, Josipa Bilic, Fernando Cartón-García, Rocio Nieto, Lucia Suárez-López, Elsa Afonso, Stefania Landolfi, Javier Hernandez-Losa, Kazuto Kobayashi, Santiago Ramón y Cajal, Josep Tabernero, Niall C. Tebbutt, John M. Mariadason, Simo Schwartz Jr, Diego Arango
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2058.
https://doi.org/10.1158/1538-7445.AM2015-2058
Published: 01 August 2015
View article titled, Abstract 2058: RHOA inactivation enhances Wnt signaling and promotes colorectal cancer
Journal Articles

Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer

Ian Y. Luk, Hoanh Tran, Janson W. Tse, Anderly C. Chueh, Fiona Chionh, Nicholas J. Clemons, John M. Mariadason
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2339.
https://doi.org/10.1158/1538-7445.AM2014-2339
Published: 01 October 2014
View article titled, Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer
Journal Articles

Abstract 2835: Telomere length: A novel biomarker for anti-EGFR therapy in colorectal cancer

Titto A. Augustine, Mahadi A. Baig, John M. Mariadason, Radhashree Maitra, Sanjay Goel
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2835.
https://doi.org/10.1158/1538-7445.AM2014-2835
Published: 01 October 2014
View article titled, Abstract 2835: Telomere length: A novel biomarker for anti-EGFR therapy in colorectal cancer
Journal Articles

Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN

Janson W. Tse, Anderly C. Chueh, Ian Y. Luk, Fiona Chionh, Yvonne Yeung, Georgia A. Corner, Dominic C. Ng, Hoanh Tran, Amardeep S. Dhillon, John M. Mariadason
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5112.
https://doi.org/10.1158/1538-7445.AM2014-5112
Published: 01 October 2014
View article titled, Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN
Journal Articles

Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer

Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony W. Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor, Jennifer L. Wilding, David Bicknell, Ian P.M. Tomlinson, Walter F. Bodmer, John M. Mariadason, Oliver M. Sieber
Journal: Cancer Research
Cancer Res (2014) 74 (12): 3238–3247.
https://doi.org/10.1158/0008-5472.CAN-14-0013
Published: 12 June 2014
View article titled, Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
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Includes: Supplementary data
Journal Articles

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

Nicholas I. Fleming, Robert N. Jorissen, Dmitri Mouradov, Michael Christie, Anuratha Sakthianandeswaren, Michelle Palmieri, Fiona Day, Shan Li, Cary Tsui, Lara Lipton, Jayesh Desai, Ian T. Jones, Stephen McLaughlin, Robyn L. Ward, Nicholas J. Hawkins, Andrew R. Ruszkiewicz, James Moore, Hong-Jian Zhu, John M. Mariadason, Antony W. Burgess, Dana Busam, Qi Zhao, Robert L. Strausberg, Peter Gibbs, Oliver M. Sieber
Journal: Cancer Research
Cancer Res (2013) 73 (2): 725–735.
https://doi.org/10.1158/0008-5472.CAN-12-2706
Published: 16 January 2013
View article titled, <em>SMAD2</em>, <em>SMAD3</em> and <em>SMAD4</em> Mutations in Colorectal Cancer
Open the PDF for <em>SMAD2</em>, <em>SMAD3</em> and <em>SMAD4</em> Mutations in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2629: Sustained immediate-early gene induction is linked to histone deacetylase inhibitor-induced apoptosis in multiple tumour types

Anderly C. Chueh, Lars Togel, John M. Mariadason
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2629.
https://doi.org/10.1158/1538-7445.AM2011-2629
Published: 15 April 2011
View article titled, Abstract 2629: Sustained immediate-early gene induction is linked to histone deacetylase inhibitor-induced apoptosis in multiple tumour types
Journal Articles

Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

Manickam Janakiraman, Efsevia Vakiani, Zhaoshi Zeng, Christine A. Pratilas, Barry S. Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Ricarte Filho, Yogindra Persaud, Douglas A. Levine, James A. Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit
Journal: Cancer Research
Cancer Res (2010) 70 (14): 5901–5911.
https://doi.org/10.1158/0008-5472.CAN-10-0192
Published: 14 July 2010
View article titled, Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer
Open the PDF for Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer in another window
Includes: Supplementary data
Journal Articles

Altered Dynamics of Intestinal Cell Maturation in Apc1638N/+ Mice

Donghai Wang, Rossanna C. Pezo, Georgia Corner, Cristina Sison, Martin L. Lesser, Shailesh M. Shenoy, John M. Mariadason, Robert H. Singer, Leonard H. Augenlicht
Journal: Cancer Research
Cancer Res (2010) 70 (13): 5348–5357.
https://doi.org/10.1158/0008-5472.CAN-09-4593
Published: 30 June 2010
View article titled, Altered Dynamics of Intestinal Cell Maturation in <em>Apc<sup>1638N/+</sup></em> Mice
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Includes: Supplementary data
Journal Articles

Abstract 4921: Selective promoter methylation of the cell differentiation marker, intestinal alkaline phosphatase (iALP), in microsatellite unstable colon cancer

Joongho Shin, Azadeh Azarbayejani, Victoria Lai, Naseem Ahmed, Richard Hodin, Madhu Malo, Diego Arango, Thomas Weber, John M. Mariadason
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4921.
https://doi.org/10.1158/1538-7445.AM10-4921
Published: 15 April 2010
View article titled, Abstract 4921: Selective promoter methylation of the cell differentiation marker, intestinal alkaline phosphatase (iALP), in microsatellite unstable colon cancer
Journal Articles

Abstract 5756: The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis

Higinio Dopeso, Silvia Mateo-Lozano, Veronica Davalos, Rocco Mazzolini, Paulo Rodrigues, Laura Lagares-Tena, Julian Ceron, Jordi Romero, Felip Vilardell, Stefania Landolfi, Javier Hernández-Losa, Andrew J. Wilson, Santiago Ramon y Cajal, Gabriel Capella, Lauri A. Aaltonen, John M. Mariadason, Simo Schwartz Jr, Arango Diego
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5756.
https://doi.org/10.1158/1538-7445.AM10-5756
Published: 15 April 2010
View article titled, Abstract 5756: The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis
Journal Articles

Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction

Andrew J. Wilson, Anderly C. Chueh, Lars Tögel, Georgia A. Corner, Naseem Ahmed, Sanjay Goel, Do-Sun Byun, Shannon Nasser, Michele A. Houston, Minaxi Jhawer, Helena J.M. Smartt, Lucas B. Murray, Courtney Nicholas, Barbara G. Heerdt, Diego Arango, Leonard H. Augenlicht, John M. Mariadason
Journal: Cancer Research
Cancer Res (2010) 70 (2): 609–620.
https://doi.org/10.1158/0008-5472.CAN-09-2327
Published: 13 January 2010
View article titled, Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction
Open the PDF for Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction in another window
Includes: Supplementary data