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John M. Asara
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Journal Articles

IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer

Mehrdad Zarei, Omid Hajihassani, Jonathan J. Hue, Alexander W. Loftus, Hallie J. Graor, Faith Nakazzi, Parnian Naji, Christina S. Boutros, Vinayak Uppin, Ali Vaziri-Gohar, Akram S. Shalaby, John M. Asara, Luke D. Rothermel, Jonathan R. Brody, Jordan M. Winter
Journal: Cancer Research
Cancer Res (2024) 84 (18): 3072–3085.
https://doi.org/10.1158/0008-5472.CAN-23-1895
Published: 16 September 2024
View articletitled, IDH1 Inhibition Potentiates Chemotherapy Efficacy in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex

Andrii Kovalenko, Andres Sanin, Kosmas Kosmas, Long Zhang, Ji Wang, Elie W. Akl, Krinio Giannikou, Clemens K. Probst, Thomas R. Hougard, Ryan W. Rue, Vera P. Krymskaya, John M. Asara, Hilaire C. Lam, David J. Kwiatkowski, Elizabeth P. Henske, Harilaos Filippakis
Journal: Cancer Research
Cancer Res (2021) 81 (8): 2086–2100.
https://doi.org/10.1158/0008-5472.CAN-20-2218
Published: 15 April 2021
View articletitled, Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex
Open the PDF for Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex in another window
Includes: Supplementary data
Journal Articles

Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Hilaire C. Lam, Christian V. Baglini, Alicia Llorente Lope, Andrey A. Parkhitko, Heng-Jia Liu, Nicola Alesi, Izabela A. Malinowska, Darius Ebrahimi-Fakhari, Afshin Saffari, Jane J. Yu, Ana Pereira, Damir Khabibullin, Barbara Ogorek, Julie Nijmeh, Taylor Kavanagh, Adam Handen, Stephen Y. Chan, John M. Asara, William M. Oldham, Maria T. Diaz-Meco, Jorge Moscat, Mustafa Sahin, Carmen Priolo, Elizabeth P. Henske
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5424.
https://doi.org/10.1158/0008-5472.CAN-20-3417
Published: 02 December 2020
View articletitled, Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Open the PDF for Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis in another window
Journal Articles

Abstract 1788: A high-throughput chemical genetic screen reveals SALL4-induced metabolic vulnerabilities in cancer

Justin L. Tan, Feng Li, Joanna Z. Yeo, Kol Jia Yong, Mahmoud A. Bassal, Guo Hao Ng, May Yin Lee, Chung Yan Leong, Hong Kee Tan, Chan-Shuo Wu, Bee Hui Liu, Hon Man Chan, Zi Hui Tan, Yun Shen Chan, Siyu Wang, Zhi Han Lim, Tan Boon Toh, Lissa Hooi, Kia Ngee Low, Siming Ma, Nikki R. Kong, Alicia J. Stein, Yue Wu, Matan T. Thangavelu, Atsushi Suzuki, Giridharan Periyasamy, John M. Asara, Yock Young Dan, Glenn K. Bonney, Edward K. Chow, Guo-Dong Lu, Huck Hui Ng, Yoganathan Kanagasundaram, Siew Bee Ng, Wai Leong Tam, Li Chai, Daniel G. Tenen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1788.
https://doi.org/10.1158/1538-7445.AM2020-1788
Published: 15 August 2020
View articletitled, Abstract 1788: A high-throughput chemical genetic screen reveals SALL4-induced metabolic vulnerabilities in cancer
Journal Articles

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

Hilaire C. Lam, Christian V. Baglini, Alicia Llorente Lope, Andrey A. Parkhitko, Heng-Jia Liu, Nicola Alesi, Izabela A. Malinowska, Darius Ebrahimi-Fakhari, Afshin Saffari, Jane J. Yu, Ana Pereira, Damir Khabibullin, Barbara Ogorek, Julie Nijmeh, Taylor Kavanagh, Adam Handen, Stephen Y. Chan, John M. Asara, William M. Oldham, Maria T. Diaz-Meco, Jorge Moscat, Mustafa Sahin, Carmen Priolo, Elizabeth P. Henske
Journal: Cancer Research
Cancer Res (2017) 77 (12): 3255–3267.
https://doi.org/10.1158/0008-5472.CAN-16-2458
Published: 14 June 2017
View articletitled, p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Open the PDF for p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis in another window
Includes: Supplementary data
Journal Articles

Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma

Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Christine Chio, John M. Asara, John D. Minna, David A. Tuveson, Ralph J. DeBerardinis, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B04.
https://doi.org/10.1158/1538-7445.PANCA16-B04
Published: 14 December 2016
View articletitled, Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity

Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Marina P. Gehring, Katja Helenius, Athalia R. Pyzer, Lily C. Wang, Jesse Novak, Olivier Elemento, Thomas B. Thornley, John M. Asara, John G. Clohessy, Kathy Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Sabina Signoretti, Steven P. Balk, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4979.
https://doi.org/10.1158/1538-7445.AM2016-4979
Published: 15 July 2016
View articletitled, Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity
Journal Articles

Abstract 2650: PI 3-Kinase inhibitors enhance the synthetic lethality of Parp inhibitors

Ashish P. Juvekar, Sina Yadegarynia, Hai Hu, Costas A. Lyssiotis, Hui Liu, John M. Asara, Ralph Scully, Lewis C. Cantley, Gerburg M. Wulf
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2650.
https://doi.org/10.1158/1538-7445.AM2015-2650
Published: 01 August 2015
View articletitled, Abstract 2650: PI 3-Kinase inhibitors enhance the synthetic lethality of Parp inhibitors
Journal Articles

Abstract B09: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation

Che-Hung Shen, Ping Yuan, Rolando Perez-Lorenzo, Yaqing Zhang, Sze Xian Lee, Yang Ou, Li Cai, John M. Asara, Lewis C. Cantley, Bin Zheng
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): B09.
https://doi.org/10.1158/1538-7445.MEL2014-B09
Published: 16 July 2015
View articletitled, Abstract B09: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation
Journal Articles

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma

Patricia Maiso, Daisy Huynh, Michele Moschetta, Antonio Sacco, Yosra Aljawai, Yuji Mishima, John M. Asara, Aldo M. Roccaro, Alec C. Kimmelman, Irene M. Ghobrial
Journal: Cancer Research
Cancer Res (2015) 75 (10): 2071–2082.
https://doi.org/10.1158/0008-5472.CAN-14-3400
Published: 13 May 2015
View articletitled, Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain

Jinyu Chen, Ho-Jeong Lee, Xuefeng Wu, Lei Huo, Sun-Jin Kim, Lei Xu, Yan Wang, Junqing He, Lakshmi R. Bollu, Guang Gao, Fei Su, James Briggs, Xiaojing Liu, Tamar Melman, John M. Asara, Isaiah J. Fidler, Lewis C. Cantley, Jason W. Locasale, Zhang Weihua
Journal: Cancer Research
Cancer Res (2015) 75 (3): 554–565.
https://doi.org/10.1158/0008-5472.CAN-14-2268
Published: 01 February 2015
View articletitled, Gain of Glucose-Independent Growth upon Metastasis of Breast Cancer Cells to the Brain
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Includes: Supplementary data
Journal Articles

Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Haoqiang Ying, Hailei Zhang, Jonathan L. Coloff, Haiyan Yan, Wei Wang, Shujuan Chen, Andrea Viale, Hongwu Zheng, Ji-hye Paik, Carol Lim, Alexander R. Guimaraes, Alec C. Kimmelman, Eric S. Martin, Jeffery Chang, Aram Hezel, Samuel R. Perry, Jian Hu, Boyi Gan, Yonghong Xiao, John M. Asara, Ralph Weissleder, Y. Alan Wang, Costas A. Lyssiotis, Lynda Chin, Lewis C. Cantley, Ronald A. DePinho, Sujun Hua, Gerald C. Chu, Eliot Fletcher-Sananikone, Jason W. Locasale, Jaekyoung Son
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A101.
https://doi.org/10.1158/1538-7445.PANCA2012-A101
Published: 03 April 2014
View articletitled, Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Journal Articles

MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors

Alexa B. Turke, Youngchul Song, Carlotta Costa, Rebecca Cook, Carlos L. Arteaga, John M. Asara, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3228–3237.
https://doi.org/10.1158/0008-5472.CAN-11-3747
Published: 01 July 2012
View articletitled, MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors
Open the PDF for MEK Inhibition Leads to PI3K/AKT Activation by Relieving a Negative Feedback on ERBB Receptors in another window
Includes: Supplementary data
Journal Articles

Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer

Xuemei Yang, Alexa B. Turke, Jie Qi, Youngchul Song, Brent N. Rexer, Todd W. Miller, Pasi A. Jänne, Carlos L. Arteaga, Lewis C. Cantley, Jeffrey A. Engelman, John M. Asara
Journal: Cancer Research
Cancer Res (2011) 71 (18): 5965–5975.
https://doi.org/10.1158/0008-5472.CAN-11-0445
Published: 13 September 2011
View articletitled, Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer
Open the PDF for Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5121: A targeted approach to identify activators of class IA phosphoinositide-3-kinase in cancers using tandem mass spectrometry

John M. Asara, Lewis C. Cantley, Jeffrey A. Engelman
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5121.
https://doi.org/10.1158/1538-7445.AM2011-5121
Published: 15 April 2011
View articletitled, Abstract 5121: A targeted approach to identify activators of class IA phosphoinositide-3-kinase in cancers using tandem mass spectrometry