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John L. Magnani
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Journal Articles

Abstract CT144: Development of GMI-1359, a novel agent targeting tumor-microenvironment cross-talk in bone metastatic cancer

P. Kelly Marcom, Trevor T. Price, Andrew S. Murray, William E. Fogler, John L. Magnani, Helen Thackray, Eric Feldman, Dorothy Sipkins
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT144.
https://doi.org/10.1158/1538-7445.AM2021-CT144
Published: 01 July 2021
View article titled, Abstract CT144: Development of GMI-1359, a novel agent targeting tumor-microenvironment cross-talk in bone metastatic cancer
Journal Articles

Abstract LB164: A novel glycomimetic compound (GMI-1757) with dual functional antagonism to E-selectin and galectin-3 attenuates fibrosis, facilitates mononuclear cell infiltration and optimizes anti-PD-L1 therapeutic activity in a pancreatic adenocarcinoma model

William E. Fogler, Theodore A. Smith, Ji-Won Lee, Silvia Locatelli-Hoops, David Stewart, John Peterson, John L. Magnani
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB164.
https://doi.org/10.1158/1538-7445.AM2021-LB164
Published: 01 July 2021
View article titled, Abstract LB164: A novel glycomimetic compound (GMI-1757) with dual functional antagonism to E-selectin and galectin-3 attenuates fibrosis, facilitates mononuclear cell infiltration and optimizes anti-PD-L1 therapeutic activity in a pancreatic adenocarcinoma model
Journal Articles

Abstract 6038: Combined targeting of E-selectin/CXCR4 and FLT3 by GMI-1359 and sorafenib effectively reduces leukemia cell burden and protects normal hematopoiesis in a patient-derived AML xenograft model

Weiguo Zhang, Kyung Hee Chang, Mahesh Basyal, Yannan Jia, Lauren Ostermann, William E. Fogler, John L. Magnani, Michael Andreeff
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6038.
https://doi.org/10.1158/1538-7445.AM2020-6038
Published: 15 August 2020
View article titled, Abstract 6038: Combined targeting of E-selectin/CXCR4 and FLT3 by GMI-1359 and sorafenib effectively reduces leukemia cell burden and protects normal hematopoiesis in a patient-derived AML xenograft model
Journal Articles

Abstract 5867: Transcriptome profiling of ST3GAL4 and FUT7 in multiple tumor types and prognostic value in adult acute myeloid leukemia

William E. Fogler, Vince Deng, David Stewart, Michael Jarman, Simone Daminelli, Adrian Carr, John L. Magnani
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5867.
https://doi.org/10.1158/1538-7445.AM2020-5867
Published: 15 August 2020
View article titled, Abstract 5867: Transcriptome profiling of ST3GAL4 and FUT7 in multiple tumor types and prognostic value in adult acute myeloid leukemia
Journal Articles

Abstract 486: Enhanced survival of lethally-irradiated mice with HSC reconstitution in combination with the E-selectin antagonist, GMI-1271 (uproleselan)

William E. Fogler, Dylan Daniel, Sheri Barnes, Alden Wong, David Draper, John L. Magnani
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 486.
https://doi.org/10.1158/1538-7445.AM2020-486
Published: 15 August 2020
View article titled, Abstract 486: Enhanced survival of lethally-irradiated mice with HSC reconstitution in combination with the E-selectin antagonist, GMI-1271 (uproleselan)
Journal Articles

Abstract 2867: Glycomimetic antagonist of E-selectin, GMI-1271, enhances therapeutic activity of the hypomethylating agent 5-azacitidine in the KG1 model of AML

Theodore A. Smith, William E. Fogler, Ji-Won Lee, John L. Magnani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2867.
https://doi.org/10.1158/1538-7445.AM2018-2867
Published: 01 July 2018
View article titled, Abstract 2867: Glycomimetic antagonist of E-selectin, GMI-1271, enhances therapeutic activity of the hypomethylating agent 5-azacitidine in the KG1 model of AML
Journal Articles

Abstract 5211: Dual E-selectin and CXCR4 inhibition reduces tumor growth and metastatic progression in an orthotopic model of osteosarcoma

Wei Ju, Choh L. Yeung, Arnulfo Mendoza, Meera Murgai, Sabina Kaczanowska, Jennifer Zhu, Shil Patel, David A. Stewart, William E. Fogler, John L. Magnani, Rosandra N. Kaplan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5211.
https://doi.org/10.1158/1538-7445.AM2018-5211
Published: 01 July 2018
View article titled, Abstract 5211: Dual E-selectin and CXCR4 inhibition reduces tumor growth and metastatic progression in an orthotopic model of osteosarcoma
Journal Articles

Abstract 1757: Mobilization of tumor-primed, marrow-infiltrating lymphocytes into peripheral blood with inhibitors of E-selectin or E-selectin and CXCR4

William E. Fogler, Theodore A. Smith, Rachel K. King, John L. Magnani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1757.
https://doi.org/10.1158/1538-7445.AM2018-1757
Published: 01 July 2018
View article titled, Abstract 1757: Mobilization of tumor-primed, marrow-infiltrating lymphocytes into peripheral blood with inhibitors of E-selectin or E-selectin and CXCR4
Journal Articles

Abstract 5005: Inhibition of E-selectin or E-selectin together with CXCR4 resensitizes multiple myeloma to treatment

Barbara Muz, Henna Y. Bazai, Anita Sekula, William E. Fogler, Ted Smith, John L. Magnani, Abdel Kareem Azab
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5005.
https://doi.org/10.1158/1538-7445.AM2017-5005
Published: 01 July 2017
View article titled, Abstract 5005: Inhibition of E-selectin or E-selectin together with CXCR4 resensitizes multiple myeloma to treatment
Journal Articles

Abstract 3284: Targeting E-selectin/CXCR4 with GMI-1359 effectively mobilizes bone marrow leukemia cells and enhances FLT3 inhibitor-induced anti-leukemia efficacy in a murine acute myeloid leukemia model

Weiguo Zhang, Hong Mu, Qi Zhang, Nalini B. Patel, William E. Fogler, John L. Magnani, Michael Andreeff
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3284.
https://doi.org/10.1158/1538-7445.AM2016-3284
Published: 15 July 2016
View article titled, Abstract 3284: Targeting E-selectin/CXCR4 with GMI-1359 effectively mobilizes bone marrow leukemia cells and enhances FLT3 inhibitor-induced anti-leukemia efficacy in a murine acute myeloid leukemia model
Journal Articles

Abstract 902: A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) delays pancreatic tumor metastasis and significantly alters the pancreatic tumor microenvironment

Maria M. Steele, William E. Fogler, John L. Magnani, Michael A. Hollingsworth
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 902.
https://doi.org/10.1158/1538-7445.AM2016-902
Published: 15 July 2016
View article titled, Abstract 902: A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) delays pancreatic tumor metastasis and significantly alters the pancreatic tumor microenvironment
Journal Articles

Abstract 425: A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) prevents pancreatic tumor metastasis and improves chemotherapy

Maria M. Steele, William E. Fogler, John L. Magnani, Michael A. Hollingsworth
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 425.
https://doi.org/10.1158/1538-7445.AM2015-425
Published: 01 August 2015
View article titled, Abstract 425: A small molecule glycomimetic antagonist of E-selectin and CXCR4 (GMI-1359) prevents pancreatic tumor metastasis and improves chemotherapy
Journal Articles

Abstract 428: Dual E-selectin and CXCR4 inhibition reduces tumor growth and increases the sensitivity to docetaxel in experimental bone metastases of prostate cancer

Giovanni L. Gravina, Andrea Mancini, Alessandro Colapietro, Simona D. Monache, Adriano Angelucci, Alessia Calgani, William E. Fogler, John L. Magnani, Claudio Festuccia
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 428.
https://doi.org/10.1158/1538-7445.AM2015-428
Published: 01 August 2015
View article titled, Abstract 428: Dual E-selectin and CXCR4 inhibition reduces tumor growth and increases the sensitivity to docetaxel in experimental bone metastases of prostate cancer
Journal Articles

Abstract 3212: Metastatic breast cancer cell communication within a pro-dormancy bone marrow niche

Trevor T. Price, Clara H. Lee, Qing Cheng, H. Kim Lyerly, William E. Fogler, John L. Magnani, Dorothy A. Sipkins
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3212.
https://doi.org/10.1158/1538-7445.AM2015-3212
Published: 01 August 2015
View article titled, Abstract 3212: Metastatic breast cancer cell communication within a pro-dormancy bone marrow niche
Journal Articles

Abstract 4503: A small molecule glycomimetic antagonist of E-selectin (GMI-1271) prevents pancreatic tumor metastasis and offers a novel treatment for improved efficacy of chemotherapy

Maria M. Steele, Prakash Radhakrishnan, John L. Magnani, Michael A. Hollingsworth
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4503.
https://doi.org/10.1158/1538-7445.AM2014-4503
Published: 01 October 2014
View article titled, Abstract 4503: A small molecule glycomimetic antagonist of E-selectin (GMI-1271) prevents pancreatic tumor metastasis and offers a novel treatment for improved efficacy of chemotherapy
Journal Articles

Abstract 4039: Exploration of a potent E-Selectin antagonist (GMI-1271) as a potential novel therapeutic for treating breast cancer metastasis to the bone and lung

Mark Esposito, John L. Magnani, Yibin Kang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4039.
https://doi.org/10.1158/1538-7445.AM2014-4039
Published: 01 October 2014
View article titled, Abstract 4039: Exploration of a potent E-Selectin antagonist (GMI-1271) as a potential novel therapeutic for treating breast cancer metastasis to the bone and lung
Journal Articles

Abstract 4831: Breast cancer cells metastasize to bone through E-selectin+ vascular gateways

Trevor Price, Monika Burness, Ayelet Sivan, Renee Cheng, John L. Magnani, Dorothy A. Sipkins
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4831.
https://doi.org/10.1158/1538-7445.AM2014-4831
Published: 01 October 2014
View article titled, Abstract 4831: Breast cancer cells metastasize to bone through E-selectin+ vascular gateways
Journal Articles

Characterization of Monoclonal Antibodies B1 and B3 That React with Mucinous Adenocarcinomas

Ira Pastan, Elizabeth T. Lovelace, Maria G. Gallo, Angelina V. Rutherford, John L. Magnani, Mark C. Willingham
Journal: Cancer Research
Cancer Res (1991) 51 (14): 3781–3787.
Published: 01 July 1991
View article titled, Characterization of Monoclonal Antibodies B1 and B3 That React with Mucinous Adenocarcinomas
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Journal Articles

Monoclonal Antibodies Reactive with Mucin Glycoproteins Found in Sera from Breast Cancer Patients

Peter S. Linsley, Joseph P. Brown, John L. Magnani, Diane Horn
Journal: Cancer Research
Cancer Res (1988) 48 (8): 2138–2148.
Published: 01 April 1988
View article titled, Monoclonal Antibodies Reactive with Mucin Glycoproteins Found in Sera from Breast Cancer Patients
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Journal Articles

Analysis of a Human Tumor-associated Glycoprotein (TAG-72) Identified by Monoclonal Antibody B72.3

Virginia G. Johnson, Jeffrey Schlom, Andrew J. Paterson, Jeffrey Bennett, John L. Magnani, David Colcher
Journal: Cancer Research
Cancer Res (1986) 46 (2): 850–857.
Published: 01 February 1986
View article titled, Analysis of a Human Tumor-associated Glycoprotein (TAG-72) Identified by Monoclonal Antibody B72.3
Open the PDF for Analysis of a Human Tumor-associated Glycoprotein (TAG-72) Identified by Monoclonal Antibody B72.3 in another window