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Journal Articles

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Cancer Res (2024) 84 (7): 1084–1100.

https://doi.org/10.1158/0008-5472.CAN-23-2659

Published: 01 April 2024

View article titled, The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

Includes: Supplementary data

Journal Articles

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

Juwina Wijaya, BaoHan T. Vo, Jingjing Liu, Beisi Xu, Gang Wu, Yao Wang, Junmin Peng, Jin Zhang, Laura J. Janke, Brent A. Orr, Jiyang Yu, Martine F. Roussel, John D. Schuetz

Cancer Res (2020) 80 (7): 1524–1537.

https://doi.org/10.1158/0008-5472.CAN-19-2054

Published: 02 April 2020

View article titled, An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

Includes: Supplementary data

Journal Articles

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

Marie Morfouace, Satish Cheepala, Sadhana Jackson, Yu Fukuda, Yogesh T. Patel, Soghra Fatima, Daisuke Kawauchi, Anang A. Shelat, Clinton F. Stewart, Brian P. Sorrentino, John D. Schuetz, Martine F. Roussel

Cancer Res (2015) 75 (18): 3879–3889.

https://doi.org/10.1158/0008-5472.CAN-15-0030

Published: 14 September 2015

View article titled, ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

Includes: Supplementary data

Journal Articles

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Shinjiro Nagai, Kazumasa Takenaka, Deepa Nachagari, Charles Rose, Kali Domoney, Daxi Sun, Alex Sparreboom, John D. Schuetz

Cancer Res (2011) 71 (5): 1781–1791.

https://doi.org/10.1158/0008-5472.CAN-10-1919

Published: 01 March 2011

View article titled, Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Includes: Supplementary data

Journal Articles

Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Brian D. Furmanski, Ken-ichi Fujita, Li Lie, Shelley Orwick, Praveen Potukuchi, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker

Cancer Res (2010) 70 (8_Supplement): 1528.

https://doi.org/10.1158/1538-7445.AM10-1528

Published: 15 April 2010

View article titled, Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Journal Articles

Cell Survival under Stress Is Enhanced by a Mitochondrial ATP-Binding Cassette Transporter That Regulates Hemoproteins

John Lynch, Yu Fukuda, Partha Krishnamurthy, Guoqing Du, John D. Schuetz

Cancer Res (2009) 69 (13): 5560–5567.

https://doi.org/10.1158/0008-5472.CAN-09-0078

Published: 01 July 2009

View article titled, Cell Survival under Stress Is Enhanced by a Mitochondrial ATP-Binding Cassette Transporter That Regulates Hemoproteins

Includes: Supplementary data

Journal Articles

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

Partha Krishnamurthy, Matthias Schwab, Kazumasa Takenaka, Deepa Nachagari, Jessica Morgan, Mark Leslie, Weinan Du, Kelli Boyd, Meyling Cheok, Hiromitsu Nakauchi, Catia Marzolini, Richard B. Kim, Balasubramanian Poonkuzhali, Erin Schuetz, William Evans, Mary Relling, John D. Schuetz

Cancer Res (2008) 68 (13): 4983–4989.

https://doi.org/10.1158/0008-5472.CAN-07-6790

Published: 01 July 2008

View article titled, Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

Includes: Supplementary data

Journal Articles

Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution

Kazumasa Takenaka, Jessica A. Morgan, George L. Scheffer, Masashi Adachi, Clinton F. Stewart, Daxi Sun, Markos Leggas, Karin F.K. Ejendal, Christine A. Hrycyna, John D. Schuetz

Cancer Res (2007) 67 (14): 6965–6972.

https://doi.org/10.1158/0008-5472.CAN-06-4720

Published: 17 July 2007

View article titled, Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution

Includes: Supplementary data

Journal Articles

Gefitinib Modulates the Function of Multiple ATP-Binding Cassette Transporters In vivo

Markos Leggas, John C. Panetta, Yanli Zhuang, John D. Schuetz, Brad Johnston, Feng Bai, Brian Sorrentino, Sheng Zhou, Peter J. Houghton, Clinton F. Stewart

Cancer Res (2006) 66 (9): 4802–4807.

https://doi.org/10.1158/0008-5472.CAN-05-2915

Published: 01 May 2006

View article titled, Gefitinib Modulates the Function of Multiple ATP-Binding Cassette Transporters In vivo

Journal Articles

Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues

Markos Leggas, Rodica P. Bunaciu, Michael J. Roberts, Guoqing Du, Jatinder Lamba, George L. Scheffer, Clinton F. Stewart, John D. Schuetz

Cancer Res (2006) 66 (8_Supplement): 141.

Published: 15 April 2006

View article titled, Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues

Journal Articles

Functional interaction between Mrp4 (abcc4) and Bcrp (abcg2) as revealed by the single and double-knockout mouse

Kazumasa Takenaka, Jessica Morgan, Masashi Adachi, Daxi Sun, Clinton Stewart, Markos Leggas, Karin F Ejendal, Christine A Hrycyna, John D Schuetz

Cancer Res (2006) 66 (8_Supplement): 144.

Published: 15 April 2006

View article titled, Functional interaction between Mrp4 (abcc4) and Bcrp (abcg2) as revealed by the single and double-knockout mouse

Journal Articles

Stable MRP4 knockdown via retroviral vector mediated short interfering RNA (siRNA) sensitizes neuroblastoma (NB) cell lines to camptothecin analogs in vitro.

P. Kellie Turner, Stacy L. Throm, Charles H. Fraga, John D. Schuetz, Clinton F. Stewart

Cancer Res (2006) 66 (8_Supplement): 1277.

Published: 15 April 2006

View article titled, Stable MRP4 knockdown via retroviral vector mediated short interfering RNA (siRNA) sensitizes neuroblastoma (NB) cell lines to camptothecin analogs in vitro.

Journal Articles

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Clinton F. Stewart, Markos Leggas, John D. Schuetz, John C. Panetta, Pamela J. Cheshire, Jennifer Peterson, Najat Daw, Jesse J. Jenkins, III, Richard Gilbertson, Glen S. Germain, Franklin C. Harwood, Peter J. Houghton

Cancer Res (2004) 64 (20): 7491–7499.

https://doi.org/10.1158/0008-5472.CAN-04-0096

Published: 15 October 2004

View article titled, Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Journal Articles

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Peter J. Houghton, Glen S. Germain, Franklin C. Harwood, John D. Schuetz, Clinton F. Stewart, Elisabeth Buchdunger, Peter Traxler

Cancer Res (2004) 64 (7): 2333–2337.

https://doi.org/10.1158/0008-5472.CAN-03-3344

Published: 01 April 2004

View article titled, Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Journal Articles

Multidrug resistance protein 4 (Mrp4) is expressed at the blood-cerebrospinal and blood-brain barriers and restricts topotecan brain penetration

Markos Leggas, Masashi Adachi, Daxi Sun, Guoqing Du, Kelly E. Mercer, John C. Panetta, Yanli Zhuang, George L. Scheffer, Rik J. Scheper, Peter Wielinga, Piet Borst, Clinton F. Stewart, John D. Schuetz

Cancer Res (2004) 64 (7_Supplement): 115–116.

Published: 01 April 2004

View article titled, Multidrug resistance protein 4 (Mrp4) is expressed at the blood-cerebrospinal and blood-brain barriers and restricts topotecan brain penetration

Journal Articles

The stem cell marker (ABCG2) enhances hypoxic cell survival through interactions with heme

Partha C. Krishnamurthy, Douglas D. Ross, Takeo Nakanishi, Kim Bailey-Dell, Sheng Zhou, Kelly E. Mercer, Balazs Sarkadi, Brian P. Sorrentino, John D. Schuetz

Cancer Res (2004) 64 (7_Supplement): 119.

Published: 01 April 2004

View article titled, The stem cell marker (ABCG2) enhances hypoxic cell survival through interactions with heme

Journal Articles

Gefitinib (’Iressa’, ZD1839) is a BCRP and MDR1 inhibitor.

Markos Leggas, John D. Schuetz, John C. Panetta, Brad Johnston, Feng Bai, Sheng Zhou, Brian Sorrentino, Christopher M. Waters, Peter J. Houghton, Clinton F. Stewart

Cancer Res (2004) 64 (7_Supplement): 568.

Published: 01 April 2004

View article titled, Gefitinib (’Iressa’, ZD1839) is a BCRP and MDR1 inhibitor.

Journal Articles

The mitochondrial transporter ABCB6 promotes hypoxic survival and its expression is regulated by hypoxic signals

Partha C. Krishnamurthy, Guoqing Du, Tony Vu, Daxi Sun, John D. Schuetz

Cancer Res (2004) 64 (7_Supplement): 333.

Published: 01 April 2004

View article titled, The mitochondrial transporter ABCB6 promotes hypoxic survival and its expression is regulated by hypoxic signals

Journal Articles

Identification of a New P-glycoprotein-like ATP-binding Cassette Transporter Gene That Is Overexpressed during Hepatocarcinogenesis

Katryn N. Furuya, Grace Bradley, Daxi Sun, Erin G. Schuetz, John D. Schuetz

Cancer Res (1997) 57 (17): 3708–3716.

Published: 01 September 1997

View article titled, Identification of a New P-glycoprotein-like ATP-binding Cassette Transporter Gene That Is Overexpressed during Hepatocarcinogenesis

Journal Articles

Alteration of the Secondary Structure of Newly Synthesized DNA from Murine Bone Marrow Cells by 5-Fluorouracil

John D. Schuetz, James M. Collins, Hugh J. Wallace, Robert B. Diasio

Cancer Res (1986) 46 (1): 119–123.

Published: 01 January 1986

View article titled, Alteration of the Secondary Structure of Newly Synthesized DNA from Murine Bone Marrow Cells by 5-Fluorouracil

NARROW

The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy

Deoxycytidine Kinase Modulates the Impact of the ABC Transporter ABCG2 on Clofarabine Cytotoxicity

Abstract 1528: Abcc4 (Mrp4)-deficiency leads to decreased oral absorption of dasatinib

Cell Survival under Stress Is Enhanced by a Mitochondrial ATP-Binding Cassette Transporter That Regulates Hemoproteins

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution

Gefitinib Modulates the Function of Multiple ATP-Binding Cassette Transporters In vivo

Immunohistochemical analysis of multidrug resistance associated protein-4 (MRP4) expression in human normal and tumor tissues

Functional interaction between Mrp4 (abcc4) and Bcrp (abcg2) as revealed by the single and double-knockout mouse

Stable MRP4 knockdown via retroviral vector mediated short interfering RNA (siRNA) sensitizes neuroblastoma (NB) cell lines to camptothecin analogs in vitro.

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Multidrug resistance protein 4 (Mrp4) is expressed at the blood-cerebrospinal and blood-brain barriers and restricts topotecan brain penetration

The stem cell marker (ABCG2) enhances hypoxic cell survival through interactions with heme

Gefitinib (’Iressa’, ZD1839) is a BCRP and MDR1 inhibitor.

The mitochondrial transporter ABCB6 promotes hypoxic survival and its expression is regulated by hypoxic signals

Identification of a New P-glycoprotein-like ATP-binding Cassette Transporter Gene That Is Overexpressed during Hepatocarcinogenesis

Alteration of the Secondary Structure of Newly Synthesized DNA from Murine Bone Marrow Cells by 5-Fluorouracil

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