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John D. Minna
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Journal Articles

Abstract 4450: MYC upregulates MCT4 expression and promotes metabolic reprogramming and enhanced lactate utilization in LKB1-deficient NSCLC

Yu Qian, David Molkentine, Yifan Kong, Qian Huang, Chendong Yang, Alissa Poteete, Alvaro P. Guimaraes, Peixin Jiang, Ferdinandos Skoulidis, Alexandre Reuben, John D. Minna, Ralph J. DeBerardinis, John V. Heymach
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4450.
https://doi.org/10.1158/1538-7445.AM2024-4450
Published: 22 March 2024
View article titled, Abstract 4450: MYC upregulates MCT4 expression and promotes metabolic reprogramming and enhanced lactate utilization in LKB1-deficient NSCLC
Journal Articles

Abstract 1793: Transmembrane serine protease TMPRSS11B promotes tumorigenesis in lung squamous cell carcinoma through enhanced lactate export and modulation of the tumor microenvironment

Hari Shankar Sunil, Barrett L. Updegraff, Jingfei Zhu, Lisa Thomas, Bret M. Evers, Jean R. Clemenceau, Isabel Barnfather, John D. Minna, Ralph J. Deberardinis, Trudy G. Oliver, Tae Hyun Hwang, Kathryn A. O'Donnell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1793.
https://doi.org/10.1158/1538-7445.AM2024-1793
Published: 22 March 2024
View article titled, Abstract 1793: Transmembrane serine protease TMPRSS11B promotes tumorigenesis in lung squamous cell carcinoma through enhanced lactate export and modulation of the tumor microenvironment
Journal Articles

Abstract 7528: Coordinated regulation of critical immune checkpoint proteins by the integrated stress response (ISR) pathway in lung cancer

Shayna Elizabeth Thomas-Jardin, Shruthy Suresh, Cheryl Lewis, Chul Ahn, Bret M. Evers, John D. Minna, Kathryn A. O'Donnell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7528.
https://doi.org/10.1158/1538-7445.AM2024-7528
Published: 22 March 2024
View article titled, Abstract 7528: Coordinated regulation of critical immune checkpoint proteins by the integrated stress response (ISR) pathway in lung cancer
Journal Articles

Abstract 3685: Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy

Hari Shankar Sunil, Barrett Updegraff, Jingfei Zhu, Bret M. Evers, John D. Minna, Ralph J. Deberardinis, Trudy G. Oliver, Kathryn A. O'Donnell
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3685.
https://doi.org/10.1158/1538-7445.AM2023-3685
Published: 04 April 2023
View article titled, Abstract 3685: Targeting a novel cell surface serine protease TMPRSS11B for lung cancer therapy
Journal Articles

Abstract 2690: In vivo CRISPR screen identifies SOAT1 as a chemotherapy chemosensitizing target for non-small cell lung cancer (NSCLC)

Long Shan Li, Kenneth Huffman, Huiyu Li, Michael Peyton, Hyunsil Park, Kimberley Avila, Luc Girard, Mathew Augustine, Joshua T. Mendell, John D. Minna
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2690.
https://doi.org/10.1158/1538-7445.AM2023-2690
Published: 04 April 2023
View article titled, Abstract 2690: <em>In vivo</em> CRISPR screen identifies SOAT1 as a chemotherapy chemosensitizing target for non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 271: MYC mediates enhanced lactate reutilization and resistance to anti-angiogenesis therapy in preclinical models of LKB1-deficient NSCLC

Yu Qian, David Molkentine, Chendong Yang, Ana Galan Cobo, Irene Guijarro, Minghao Dang, Alissa Poteete, Peixin Jiang, Ferdinandos Skoulidis, Linghua Wang, Alexandre Reuben, John D. Minna, Ralph J. DeBerardinis, John V. Heymach
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 271.
https://doi.org/10.1158/1538-7445.AM2023-271
Published: 04 April 2023
View article titled, Abstract 271: MYC mediates enhanced lactate reutilization and resistance to anti-angiogenesis therapy in preclinical models of LKB1-deficient NSCLC
Journal Articles

Abstract LB030: Mechanisms of ERK action in MEK inhibitor-insensitive lung cancers

Ana Martin-Vega, Svetlana Eartnest, John D. Minna, Jane E. Johnson, Melanie H. Cobb
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB030.
https://doi.org/10.1158/1538-7445.AM2022-LB030
Published: 15 June 2022
View article titled, Abstract LB030: Mechanisms of ERK action in MEK inhibitor-insensitive lung cancers
Journal Articles

Abstract 1827: CD70 is a novel therapeutic target for EGFR mutant NSCLC with acquired, EMT-associated EGFR TKI resistance

Monique B. Nilsson, Yan Yang, Sonia Patel, Simon Heeke, Xiuning Le, Thiru Aruguman, Jacqulyne Robichaux, Xiaoxing Yu, Alissa Poteete, Xiaoyang Ren, Lixia Diao, Li Shen, Qi Wang, Fahao Zhang, Leticia Campos Clemente, Luisa Solis Soto, Chunhua Shi, Hai Tran, Jason Bock, Jing Wang, Ignacio I. Wistuba, John D. Minna, John V. Heymach
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1827.
https://doi.org/10.1158/1538-7445.AM2022-1827
Published: 15 June 2022
View article titled, Abstract 1827: CD70 is a novel therapeutic target for EGFR mutant NSCLC with acquired, EMT-associated EGFR TKI resistance
Journal Articles

Abstract B037: Characterizing and targeting polyaneuploid/polyploid giant cancer cells (PACCs/PGCCs)

Vural Tagal, Uttam K. Tambar, Michael G. Roth, John D. Minna
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): B037.
https://doi.org/10.1158/1538-7445.EVODYN22-B037
Published: 15 May 2022
View article titled, Abstract B037: Characterizing and targeting polyaneuploid/polyploid giant cancer cells (PACCs/PGCCs)
Journal Articles

Lung Cancer Cell of Origin: Controversy and Clinical Translational Implications

Jihan K. Osborne, John D. Minna
Journal: Cancer Research
Cancer Res (2022) 82 (6): 972–973.
https://doi.org/10.1158/0008-5472.CAN-22-0301
Published: 15 March 2022
View article titled, Lung Cancer Cell of Origin: Controversy and Clinical Translational Implications
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Journal Articles

Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations

Paul Yenerall, Rahul K. Kollipara, Kimberley Avila, Michael Peyton, Christopher A. Eide, Daniel Bottomly, Shannon K. McWeeney, Yan Liu, Kenneth D. Westover, Brian J. Druker, John D. Minna, Ralf Kittler
Journal: Cancer Research
Cancer Res (2021) 81 (18): 4685–4695.
https://doi.org/10.1158/0008-5472.CAN-21-1153
Published: 15 September 2021
View article titled, Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations
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Includes: Supplementary data
Journal Articles

Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers

Mitchell S. von Itzstein, David E. Gerber, John D. Minna
Journal: Cancer Research
Cancer Res (2021) 81 (13): 3441–3443.
https://doi.org/10.1158/0008-5472.CAN-21-0706
Published: 01 July 2021
View article titled, Contemporary Lung Cancer Screening and the Promise of Blood-Based Biomarkers
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Journal Articles

Abstract 702: Single-cell expression landscape of SARS-CoV-2 receptor ACE2 and host proteases in human lung adenocarcinoma

Guangchun Han, Ansam Sinjab, Kieko Hara, Warapen Treekitkarnmongkol, Patrick Brennan, Kyle Chang, Elena Bokatenkova, Beatriz Sanchez-Espiridion, Carmen Behrens, Luisa M. Solis, Boning Gao, Luc Girard, Jianjun Zhang, Boris Sepesi, Tina Cascone, Lauren A. Byers, Don L. Gibbons, Jichao Chen, Seyed Javad Moghaddam, Edwin J. Ostrin, Paul Scheet, Junya Fujimoto, Jerry Shay, John V. Heymach, John D. Minna, Steven Dubinett, Ignacio I. Wistuba, Christopher S. Stevenson, Avrum E. Spira, Linghua Wang, Humam Kadara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 702.
https://doi.org/10.1158/1538-7445.AM2021-702
Published: 01 July 2021
View article titled, Abstract 702: Single-cell expression landscape of SARS-CoV-2 receptor <em>ACE2</em> and host proteases in human lung adenocarcinoma
Journal Articles

Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis

Mingrui Zhu, Yi Huang, Matthew E. Bender, Luc Girard, Rahul Kollipara, Buse Eglenen-Polat, Yujiro Naito, Trisha K. Savage, Kenneth E. Huffman, Shohei Koyama, Atsushi Kumanogoh, John D. Minna, Jane E. Johnson, Esra A. Akbay
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1813–1826.
https://doi.org/10.1158/0008-5472.CAN-20-2808
Published: 01 April 2021
View article titled, Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis
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Includes: Supplementary data
Journal Articles

SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine

Ilgen Mender, Kimberly Batten, Michael Peyton, Aishwarya Vemula, Crystal Cornelius, Luc Girard, Boning Gao, John D. Minna, Jerry W. Shay
Journal: Cancer Research
Cancer Res (2020) 80 (5): 929–936.
https://doi.org/10.1158/0008-5472.CAN-19-2257
Published: 02 March 2020
View article titled, <em>SLC43A3</em> Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine
Open the PDF for <em>SLC43A3</em> Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine in another window
Includes: Supplementary data
Journal Articles

LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma

Ana Galan-Cobo, Piyada Sitthideatphaiboon, Xiao Qu, Alissa Poteete, Marlese A. Pisegna, Pan Tong, Pei-Hsuan Chen, Lindsey K. Boroughs, Mirna L.M. Rodriguez, Winter Zhang, Francesco Parlati, Jing Wang, Varsha Gandhi, Ferdinandos Skoulidis, Ralph J. DeBerardinis, John D. Minna, John V. Heymach
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3251–3267.
https://doi.org/10.1158/0008-5472.CAN-18-3527
Published: 01 July 2019
View article titled, LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in <em>KRAS</em>-Mutant Lung Adenocarcinoma
Open the PDF for LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in <em>KRAS</em>-Mutant Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis

Xiang Yan, Xiaoshan Zhang, Li Wang, Ran Zhang, Xingxiang Pu, Shuhong Wu, Lei Li, Pan Tong, Jing Wang, Qing H. Meng, Vanessa B. Jensen, Luc Girard, John D. Minna, Jack A. Roth, Stephen G. Swisher, John V. Heymach, Bingliang Fang
Journal: Cancer Research
Cancer Res (2019) 79 (1): 125–132.
https://doi.org/10.1158/0008-5472.CAN-18-1938
Published: 02 January 2019
View article titled, Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
Open the PDF for Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis in another window
Includes: Supplementary data
Journal Articles

HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress

Brandt A. Nichols, Nathaniel W. Oswald, Elizabeth A. McMillan, Kathleen McGlynn, Jingsheng Yan, Min S. Kim, Janapriya Saha, Prema L. Mallipeddi, Sydnie A. LaDuke, Pamela A. Villalobos, Jaime Rodriguez-Canales, Ignacio I. Wistuba, Bruce A. Posner, Anthony J. Davis, John D. Minna, John B. MacMillan, Angelique W. Whitehurst
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6196–6208.
https://doi.org/10.1158/0008-5472.CAN-18-1377
Published: 01 November 2018
View article titled, HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress
Open the PDF for HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress in another window
Includes: Supplementary data
Journal Articles

Abstract 2015: Exosomes secreted by highly migratory premalignant lung epithelial cells promote epithelial mesenchymal transition and migration

Manash K. Paul, Suman Dutta, Bharti Bisht, Salehi-Rad Ramin, Paul Pagano, Gal Bitan, John D. Minna, Steven M. Dubinett
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2015.
https://doi.org/10.1158/1538-7445.AM2018-2015
Published: 01 July 2018
View article titled, Abstract 2015: Exosomes secreted by highly migratory premalignant lung epithelial cells promote epithelial mesenchymal transition and migration
Journal Articles

Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells

Tonya C. Walser, Zhe Jing, Linh M. Tran, Ying Q. Lin, Natalie Yakobian, Gerald Wang, Kostyantyn Krysan, Li X. Zhu, Sherven Sharma, Mi-Heon Lee, John A. Belperio, Aik T. Ooi, Brigitte N. Gomperts, Jerry W. Shay, Jill E. Larsen, John D. Minna, Long-sheng Hong, Michael C. Fishbein, Steven M. Dubinett
Journal: Cancer Research
Cancer Res (2018) 78 (8): 1986–1999.
https://doi.org/10.1158/0008-5472.CAN-17-0315
Published: 12 April 2018
View article titled, Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells
Open the PDF for Silencing the Snail-Dependent RNA Splice Regulator ESRP1 Drives Malignant Transformation of Human Pulmonary Epithelial Cells in another window
Includes: Supplementary data